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Paranasal Medical Research Studies

Up-to-date List of Paranasal Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Paranasal Medical Research Studies

Rank Status Study
1 Recruiting Prospective Evaluation of Anorganic Bovine Bone Mineral Versus Calcium Phosphosilicate Alloplastic Bone Putty in Direct Sinus Augmentation: a Spilt-mouth Study
Conditions: Sinus Floor Augmentation;   Maxillary Sinus
Interventions: Procedure: Calcium phosphosilicate alloplastic bone putty in direct sinus augmentation;   Procedure: Anorganic bovine bone mineral in direct sinus augmentation
Outcome Measures: Percentage of new bone growth in the maxillary sinus;   Gain in vertical bone height;   Radiographic bone density;   Primary implant stability;   Marginal bone level maintenance
2 Unknown  Effectiveness of Methylene Blue Guidance in Total Excision of Pilonidal Sinus.
Condition: Pilonidal Sinus
Intervention: Procedure: Pilonidal sinus excision
Outcome Measure: Histopathologic detection of any evidence of pilonidal sinus disease in the cavity excision material not dyed by methylene blue
3 Recruiting Induction Therapy-Docetaxel, Cisplatin and Fluorouracil in Untreated Advanced Squamous Cell or Undifferentiated Carcinoma of the PARANASAL SINUSes
Conditions: Paranasal Sinus Neoplasms;   Squamous Cell Carcinoma
Interventions: Drug: Docetaxel;   Drug: 5-Fluorouracil;   Drug: Cisplatin
Outcome Measure: Number of Patients with Complete + Partial Response
4 Recruiting Photon/Proton Radiation Therapy for Cancers of the Nasal Cavity and/or PARANASAL SINUSes
Conditions: Cancers of Nasal Cavity;   Cancers of Paranasal Sinuses
Intervention: Other: Xerostomia questionnaire
Outcome Measures: Grade 3 or higher of xerostomia Incidence of Xerostomia;   Collect and analyze tumor control outcomes
5 Recruiting Stenting of Venous Sinus Stenosis for Medically Refractory Idiopathic Intracranial Hypertension
Condition: Idiopathic Intracranial Hypertension
Intervention: Procedure: Stenting of the venous sinus
Outcome Measures: Normalized CSF pressure post venous stenting;   Assess the long-term success of this treatment in terms of clinical recurrence rate and long-term patency of the sinus.
6 Recruiting Video Assisted Ablation of Pilonidal Sinus Versus Conventional Treatment
Condition: Chronic Sacrococcygeal Pilonidal Sinus
Interventions: Procedure: Video assisted ablation of pilonidal sinus;   Procedure: Bascom Cleft lift procedure
Outcome Measures: Infection;   recurrence;   return at work;   Pain;   satisfaction
7 Recruiting A Comparison of Bone Formation With Three Different Bone Graft Materials Following Sinus Graft
Condition: Inadequate Bone Height in Maxillary Posterior Area
Interventions: Procedure: Sinus augmentation;   Drug: Equimatrix;   Drug: OSSIF-i sem;   Drug: Bio-oss
Outcome Measures: A histomorphometric measurement of the percentage of vital bone in a total amount of bone.;   A histomorphometric measurement of the percentage of non-vital bone and connective tissue.
8 Unknown  Mid-line Excision Versus Karydakis Operation for Pilonidal Sinus
Condition: Pilonidal Sinus
Interventions: Procedure: Surgery for pilonidal disease, midline excision;   Procedure: Surgery for pilonidal disease, Karydakis operation
Outcome Measures: time to complete wound healing;   health-related quality of life;   time needed returning to normal physical activity after operation;   days spent on sick-leave;   health care costs and total costs;   postoperative wound infection rate;   recurrence rate
9 Recruiting Ablation of Inappropriate Sinus Tachycardia
Condition: Inappropriate Sinus Tachycardia
Intervention: Procedure: electrophysiology study and radiofrequency ablation
Outcome Measures: Improvement in:symptoms(palpitations);quality of life;resting heart rate;mean 24 hour heart rate;heart rate variability;;   duration of symptom limited Bruce protocol exercise treadmill test;duration of exercise test required to increase rate by 20%.
10 Recruiting Microarray Analysis of Sinus Samples From Patients With and Without Chronic Rhinosinusitis
Condition: Maxillary Sinusitis
Intervention: Procedure: Specimen collection
Outcome Measures: Microbial community profiling using the PhyloChip, MycoChip, and ViroChip will yield vast quantities of data to be reduced in dimensions for interpretation. Pathogens detected in the nasal mucus of patients with CRS will be compared to healthy controls.;   The presence or absence of a given microorganism will be compared to previously published data obtained using either traditional culture methods or other genomic methods.
11 Unknown  Videoendoscopic Pilonidal Sinus Surgery
Conditions: Recurrence;   Postoperative Complication
Intervention: Procedure: videoendoscopic resection of pilonidal sinus
Outcome Measures: recurrence rates;   postoperative complications, wound healing
12 Unknown  RV Septal Versus Minimized RV Pacing in Sick Sinus Syndrome
Condition: Sick Sinus Syndrome
Intervention: Procedure: pacemaker implantation, AAI(R)-DDD(R) versus DDD(R)
Outcome Measures: end-systolic LV volume;   left ventricular ejection fraction (LV-EF);   TAPSE;   echocardiographic parameter of dyssynchrony;   peak VO2, VO2 AT, VO2/HR, VE/VCO2 slope;   quality of life-scores;   AF burden;   % ventricular pacing;   LV end diastolic volume
13 Unknown  Clinical Investigation to Assess the Safety and Feasibility of the Crestal, Minimal-invasive Sinus Floor Augmentation With the Pressure Chamber Drill (DKK) and the Sinus Vibration Pump (SVP)
Condition: Insufficient Bone Mass in the Maxilla for Dental Implants
Interventions: Device: minimal-invasive sinus floor augmentation with the DKK and SVP (JEDER Syst.);   Device: minimal invasive crestal sinus lift with the JEDER Systh.
Outcome Measure: perforation rate of the subantral membrane in the sinus maxillaris
14 Recruiting Study for the Management of Pediatric Chronic Rhinosinusitis With or Without Balloon Sinuplasty
Condition: Rhinitis + Sinusitis, Pediatric Chronic Rhinosinusitis
Interventions: Device: Acclarent Relieva Balloon Sinuplasty;   Procedure: Adenoidectomy + Maxillary Sinus Irrigation
Outcome Measure: Quality of life (QoL) outcomes between Adenoidectomy + Maxillary sinus irrigation with or without the use of balloon dilation or maxillary sinus ostia.
15 Not yet recruiting Reducing Atrial Pacing Rate to Reduce Atrial Fibrillation in Patients With Sick Sinus Syndrome.
Conditions: Sinus Node Disease;   Atrial Fibrillation
Interventions: Device: DDDR-60;   Device: DDD-40
Outcome Measures: Time to first episode of AF>6 min detected by the pacemaker;   Time to first episode of AF>6 hours detected by the pacemaker;   Time to first episode of AF>24 hours detected by the pacemaker;   Time to DC cardioversion or medical cardioversion for AF;   Time to stroke, TCI, or thromboembolic event;   Time to death;   QOL;   6MHWT;   Time to need for reprogramming of the pacing rate (cross-over)
16 Unknown  Normal PARANASAL SINUSes Microflora Study
Conditions: Paranasal Sinuses;   Flora
Intervention:
Outcome Measure: presence of bacteria in normal paranasal sinuses
17 Recruiting (PROGRESS) Safety and Efficacy of the Propel Mini Steroid-Eluting Sinus Implant in Frontal Sinus
Condition: Chronic Sinusitis
Intervention: Device: PROPEL Mini Sinus Implant
Outcome Measure: Reduction in the need for post-operative interventions
18 Recruiting Use of the Neovasc Coronary Sinus Reducer System for the Treatment of Refractory Angina Pectoris in Patients With Ngina Class 3-4 Who Are Not Candidates for Revascularization
Condition: Refractory Angina
Intervention: Device: Neovac coronary sinus reducer
Outcome Measure: Canadian Cardiovascular Society Angina Score
19 Recruiting Comparison of Incidence Between Two Techniques
Condition: Edentulous Posterior Maxilla
Interventions: Procedure: internal maxillary sinus floor elevation technique;   Procedure: external maxillary sinus floor elevation technique
Outcome Measures: Compare incidence of Schneiderian membrane perforation;   Compare discomfort;   Compare long term complications;   Compare the amount of analgesic taken postoperatively;   Compare pain;   Compare Bleeding;   Compare Swelling
20 Recruiting Rates of Middle Meatal Synechia Formation Following Functional Endoscopic Sinus Surgery
Condition: Sinusitis.
Interventions: Device: Silastic Spacer;   Device: Merocel Spacer
Outcome Measures: Incidence of middle meatal synechiae after functional endoscopic sinus surgery in silastic versus merocel groups.;   Incidence of postoperative synechiae in 6-day versus 14-day postoperative spacer removal groups.

These studies may lead to new treatments and are adding insight into Paranasal etiology and treatment.

A major focus of Paranasal research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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