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Parasitic Medical Research Studies

Up-to-date List of Parasitic Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Parasitic Medical Research Studies

Rank Status Study
1 Recruiting Parasitic Infections of the Gastrointestinal Tract
Conditions: Amebiasis;   Cryptosporidiosis;   Giardiasis;   Parasitic Disease;   Parasitic Intestinal Disease
Outcome Measure:
2 Recruiting Evaluation, Treatment and Monitoring of Patients With a Known or Suspected Parasitic Infection
Conditions: Chagas Disease;   Malaria;   Parasitic Disease;   Trypanosomiasis
Outcome Measure:
3 Recruiting Evaluation of Oral Activated Charcoal on the Ability of an Antimalarial Drug to Kill Parasites in Malian Children With Mild Malaria
Condition: Malaria
Intervention: Drug: Oral Activated Charcoal
Outcome Measures: To compare parasite clearance half- life in patients treated with oAC + IV AS or IV AS;   Serum cytokine levels 2, 24, and 48 hours;   Whole- blood transcriptional profiles at 0, 24 ans 48 h;   To assess the safety of adjunct treatment with oAC
4 Available Compassionate Use of Triclabendazole for the Treatment of Parasites (Prior to FDA Approval; Expanded Access Program)
Condition: Parasitic Disease
Intervention: Drug: Triclabendazole
Outcome Measure:
5 Recruiting Activation and Function of Eosinophils in Conditions With Blood or Tissue Eosinophilia
Conditions: Asthma;   Eosinophilia;   Helminthiasis;   Hypersensitivity;   Parasitic Disease
Outcome Measure:
6 Recruiting Parasitic Clearance and Recurrence Rates Among Patients With Vivax Malaria
Condition: Parasitemia
Interventions: Drug: Artemisinin combination therapies (ACT)will be used for Chloroquine resistant P.vivax;   Drug: Chloroquine and Primaquine
Outcome Measures: To measure recurrence rates among patients with vivax malarial infection put on standard dose of Chloroquine and Primaquine;   Genotyping of P.vivax strains in Bhutan.
7 Recruiting Tracking Resistance to Artemisinin (TRAC)
Condition: Falciparum Malaria
Interventions: Drug: Artesunate 2;   Drug: Artesunate 4
Outcome Measures: Parasite clearance rate;   Parasite clearance time;   Parasite reduction rates and ratios;   Time for parasite count to fall;   Fever clearance time;   Gametocytemia in patients;   Gametocyte carriage rates;   In vitro susceptibility of P.falciparum to artemisinins;   Pharmacokinetics relationships for artesunate and Dihydroartemisinin (DHA);   Parasite molecular markers of drug resistance;   Identification of host factors that correlate with slow parasite clearance;   Efficacy at D42;   Pharmacodynamics relationships for artesunate and Dihydroartemisinin (DHA)
8 Unknown  Time to Infection With Malaria Parasites
Condition: Plasmodium Falciparum Malaria
Outcome Measure:
9 Recruiting Host and Parasite Factors That Influence Susceptibility to Malaria Infection and Disease During Pregnancy and Early Childhood in Ouelessebougou and Bamako, Mali
Condition: Malaria
Outcome Measure: Changes in blood pressure related to malaria in pregnancy and clinical malaria in infants and children
10 Unknown  Human African Trypanosomiasis: First in Man Clinical Trial of a New Medicinal Product, the SCYX-7158
Conditions: Trypanosomiasis;   Trypanosomiasis, African;   Protozoan Infections;   Parasitic Diseases
Interventions: Drug: SCYX-7158;   Drug: Placebo
Outcome Measures: Occurence of adverse events (AEs);   Pharmacokinetic (blood concentration of SCYX-7158 and metabolite);   Pharmacokinetic (urine concentration of SCYX-7158 and metabolite)
11 Recruiting Artemisinin-resistant Malaria in Cambodia
Condition: Plasmodium Falciparum Malaria
Outcome Measure:
12 Unknown  Parasite-based Diagnosis for Malaria in Uganda: Feasibility and Cost-Effectiveness
Conditions: Fever;   Malaria
Intervention: Device: Field microscopy and Paracheck Pf®
Outcome Measures: diagnostic test validity; unit cost per malaria case diagnosed and treated with Artemether-Lumefantrine; total savings associated with treatment of confirmed malaria cases; compliance with directives for use of rapid test or microscopy;   unit cost of non-malaria febrile treatment; therapeutic behaviour in light of pressure to prescribe antimalarials
13 Recruiting Comparison of Two Antimalarial Drugs Regimens in Patient With Plasmodium Vivax Malaria in Thailand
Condition: Acute Uncomplicated Malaria With P.Vivax Infection
Interventions: Drug: Artesunate;   Drug: Chloroquine
Outcome Measures: Parasite Clearance Rate;   Relapse rate of P. vivax;   Parasite clearance time;   Parasite density time;   Fever clearance time;   Proportion of patients with gametocytemia;   In vitro antimalarial drug susceptibility
14 Not yet recruiting Assessment of Artesunate/Mefloquine in the Peruvian Amazon
Condition: Malaria, Falciparum
Interventions: Drug: Artesunate;   Drug: Mefloquine
Outcome Measures: Parasite clearance time;   Parasite reduction rates and ratios;   Time for parasite count to fall;   Fever clearance time;   Gametocyte carriage rates
15 Recruiting Evaluation of SP Resistance and Effectiveness of IPTp in Nigeria
Condition: Pregnancy Complications Parasitic
Intervention: Drug: Efficacy of suphladoxine/pyrimethamine as IPTp
Outcome Measures: To determine the efficacy of SP-IPTp for clearing peripheral malaria parasiteamia in asymptomatic primi and secondi gravid women;   To determine the efficacy of SP-IPTp in preventing new infections in primi- and secundi-gravid women;   To estimate the prevalence of molecular markers of SP resistance in primi- and secundi-gravid women
16 Recruiting Primaquine's Gametocytocidal Efficacy in Malaria Asymptomatic Carriers
Condition: Malaria
Interventions: Drug: DHA-PPQ;   Drug: PQ (0.75);   Drug: PQ (0.4);   Drug: PQ (0.2)
Outcome Measures: Prevalence of P. falciparum gametocyte carriers (QT-NASBA);   Prevalence of P.Falciparum gametocytes carriers;   Proportion of individuals infectious to mosquitoes (DMFA);   Haemoglobin change;   Prevalence of infection (asexual stages);   Proportion of participants with recurrent infection (PCR adjusted and unadjusted);   Occurrence of adverse events (AEs) and serious adverse events (SAEs)
17 Recruiting Harmonized AS/MQ Efficacy Study - Thailand
Condition: Malaria
Intervention: Drug: Artesunate/mefloquine (AS/MQ)
Outcome Measures: Parasite clearance rate;   Number of patients with prolonged parasite clearance times, adequate drug levels and positive molecular markers of parasite resistance.
18 Recruiting A Phase I/IIa Study of the Safety, Immunogenicity and Efficacy of FMP2.1/AS01B, an Asexual Blood-Stage Vaccine for Plasmodium Falciparum Malaria
Condition: Plasmodium Falciparum Malaria
Intervention: Biological: FMP2.1/AS01B
Outcome Measure: PCR-derived parasite multiplication rate (PMR)
19 Recruiting Evaluation of a Rapid Diagnostic Device, CL Detect, for the Diagnosis of Cutaneous Leishmaniasis in Tunisia
Condition: Skin Diseases, Parasitic
Intervention: Other: No Intervention
Outcome Measure: Positive result for CL Detect
20 Not yet recruiting Postpartum Deworming: Improving Breastfeeding and Optimizing Infant Growth
Condition: Intestinal Diseases, Parasitic
Intervention: Drug: Albendazole
Outcome Measures: Mean (± standard deviation) weight gain (kg);   Infant morbidity;   Maternal hemoglobin levels and anemia;   Breastfeeding practices;   Maternal energy levels;   Maternal STH infection;   Breast milk quality;   Breast milk quantity transferred from mother to infant

These studies may lead to new treatments and are adding insight into Parasitic etiology and treatment.

A major focus of Parasitic research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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