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Perifosine Medical Research Studies

Up-to-date List of Perifosine Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Perifosine Medical Research Studies

Rank Status Study
1 Recruiting Study of Single Agent Perifosine for Recurrent Pediatric Solid Tumors
Condition: Solid Tumors
Intervention: Drug: Perifosine
Outcome Measures: Maximum Tolerated Dose (MTD) of Perifosine monotherapy in children with cancer;   To determine whether pharmacokinetic serum levels correlate with toxicity;   If previously resected tissue is available, determine whether molecular features predict response including Elevated PI3K/AKT/mTOR signaling, Elevated RAS/MAPK signaling, Cell cycle markers
2 Recruiting Nelfinavir and Lenalidomide/Dexamethasone in Patients With Progressive Multiple Myeloma That Have Failed Lenalidomide-containing Therapy
Condition: Multiple Myeloma
Interventions: Drug: Nelfinavir;   Drug: Lenalidomide;   Drug: Dexamethasone
Outcome Measures: Phase I: Dose limiting toxicity;   Phase II: Overall response;   Phase I/II: Frequency and percent of occurrence of adverse events during each cycle of treatment, and within patients;   Phase I/II: Disease control, i.e. no progression at 16 weeks after start of trial therapy;   Phase I/II: Duration of response;   Phase I/II: Overall survival;   Phase I/II: Progression free survival;   Phase I/II: Time to progression;   Phase I: Overall response

These studies may lead to new treatments and are adding insight into Perifosine etiology and treatment.

A major focus of Perifosine research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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