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Perphenazine Medical Research Studies

Up-to-date List of Perphenazine Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Perphenazine Medical Research Studies

Rank Status Study
1 Recruiting A Double-Blind, Controlled Study of Aripiprazole in Co-Morbid Schizophrenia and Cocaine Dependence
Conditions: Schizophrenia;   Cocaine Dependence
Interventions: Drug: Aripiprazole;   Drug: Perphenazine
Outcome Measures: The proportion of negative urine drug screen results will be significantly greater in the subjects treated with aripiprazole than in those treated with Perphenazine.;   The mean total self-report cocaine use days will be significantly fewer in subjects treated with aripiprazole than in those treated with Perphenazine.;   The mean cocaine craving scores will be lower in subjects treated with aripiprazole than in those treated with Perphenazine.
2 Recruiting Clinical Trial to Evaluate the Efficacy of Treatment vs Discontinuation in a First Episode of Non-affective Psychosis
Condition: Psychosis Nos/Other
Interventions: Drug: Discontinuation antipsychotic treatment;   Drug: Antipsychotic treatment
Outcome Measure: Risk of relapse
3 Unknown  Donepezil Treatment of Psychotic Symptoms in Dementia Patients
Condition: Dementia of Alzheimer Type
Intervention: Drug: donepezil
Outcome Measures: Possitive and Negative Syndrome Scale;   Clinical Global Impression
4 Recruiting Efficacy and Safety of Fosaprepitant Dimeglumine in Preventing Chemotherapy-Induced Nausea and Vomiting (MK-0517-031 AM4)
Condition: Chemotherapy-Induced Nausea and Vomiting
Interventions: Drug: Fosaprepitant dimeglumine;   Drug: Fosaprepitant Placebo;   Drug: Dexamethasone;   Drug: Ondansetron;   Drug: Dexamethasone Placebo;   Drug: Ondansetron Placebo;   Drug: Rescue Therapy
Outcome Measures: Number of participants with Complete Response from 25 to 120 hours after initiation of MEC.;   Number of participants with infusion-site thrombophlebitis;   Number of participants with severe infusion-site reactions, including site pain, or site redness (erythema) or site hardness (induration);   Number of participants with Complete Response from 0 to 120 hours after initiation of MEC;   Number of participants with Complete Response from 0 to 24 hours after initiation of MEC;   Number of participants with No Vomiting from 0 to 120 hours after initiation of MEC
5 Recruiting Effects of Paliperidone Palmitate Versus Oral Antipsychotics on Clinical Outcomes and MRI Measures
Conditions: Schizophrenia;   Schizophreniform
Interventions: Drug: paliperidone palmitate;   Drug: oral antipsychotics
Outcome Measures: The primary objective of this study is to compare the effects of paliperidone vs. "standard treatment" on changes in brain parenchymal volume;   : To conduct a comparison study of the effects of paliperidone vs "oral antipsychotic treatment" on brain structure as measured using MR scanning in the two treatment groups and versus normal controls.
6 Unknown  Reducing Antipsychotic-Induced Weight Gain in Children With Metformin
Conditions: Obesity;   Weight Gain;   Psychotropic Induced Weight Gain
Intervention: Drug: Metformin
Outcome Measures: Change in weight;   Weight trajectory based on length of intervention and factors that predict response to Metformin
7 Recruiting Effect of Minocycline on Pain Caused by Nerve Damage
Condition: Neuropathic Pain Caused by Lumbar Radicular Pain
Interventions: Drug: Minocycline;   Drug: placebo;   Drug: Amitriptyline
Outcome Measures: Pain intensity;   neuropathic pain diagnostic questionnaire (DN4) score;   Amount of rescue medication taken
8 Unknown  Efficacy of Gabapentin or Amitriptyline to Reduce Postoperative Pain After Lumbar Laminectomy and Diskectomy
Conditions: Herniated Disc;   Intervertebral Disc Displacement
Intervention: Drug: Gabapentin , Amitriptyline
Outcome Measures: 30% reduction in opium consumption in either study arms compared to the placebo group;   30% reduction in pain according to visual analogue scale in either study arms compared to the placebo group
9 Unknown  Study With Amitriptylin to Evaluate the Efficacy of Melatonin in Treatment of Migraine
Condition: Migraine
Interventions: Drug: Amitriptyline;   Drug: Melatonin;   Drug: Placebo
Outcome Measures: Change in number of headache days from baseline to month 3 after treatment.;   Proportion of patients responding to treatment. Change from Baseline Phase to Double-Blind Phase in number of monthly migraine attacks,monthly migraine days, number of days/month requiring rescue medication.
10 Recruiting Pharmacological Conditioning of Sleep Patterns in Healthy Participants Using Amitriptylin
Condition: Healthy Participants
Interventions: Drug: Amitriptyline;   Drug: Placebo
Outcome Measures: Objective Total Sleep Time;   Percentage of rapid eye movement (REM) sleep
11 Unknown  Tricyclic Antidepressants (TCAs) on Gastric Emptying
Condition: Functional Dyspepsia
Interventions: Drug: Desipramine;   Drug: Amitriptyline
Outcome Measures: Gastric emptying;   Gastric volume
12 Recruiting Interpersonal Psychotherapy for Treatment Resistant Depression
Condition: Treatment Resistant Depression
Interventions: Other: IPT+ antidepressant drugs;   Drug: fluoxetine;   Drug: sertraline;   Drug: paroxetine;   Drug: Citalopram;   Drug: escitalopram;   Drug: fluvoxamine;   Drug: Venlafaxine;   Drug: Duloxetine;   Drug: Bupropion;   Drug: Lithium;   Drug: Risperidone;   Drug: tranylcypromine;   Drug: Imipramine;   Drug: amitriptyline;   Drug: Clomipramine;   Drug: nortriptyline;   Drug: trazodone;   Drug: Mirtazapine;   Drug: sulpiride
Outcome Measures: Hamilton Depression Scale (HAM-D) - continuous;   Beck depression Inventory (BDI)
13 Recruiting Immune-Pineal Axis Function in Fibromyalgia
Condition: Fibromyalgia
Interventions: Drug: Melatonin and Placebo;   Drug: Amitriptyline and Placebo;   Drug: Melatonin and Amitriptylin
Outcome Measures: Change from Baseline in pain on Fibromyalgia Impact Questionnaire (FIQ) at week 6;   Change from Baseline in Pain Pressure Threshold (PPT) at week 6;   Change from Baseline Brain-derived neurotrophic factor at week 6;   Change from Baseline of the Pittsburgh Sleep Quality Index (PSQI) at week 6;   Change from Baseline of the Pain Catastrophizing Scale at week 6
14 Recruiting Safety and Efficacy Study Comparing ETS6103 With Amitriptyline in the Treatment of Major Depressive Disorder (MDD)
Condition: Major Depressive Disorder
Interventions: Drug: ETS6103 (low dose);   Drug: ETS6103 (high dose);   Drug: Amitriptyline
Outcome Measures: The mean difference in baseline-adjusted (Montgomery-Asberg Depression Scale) MADRS score at the end of treatment.;   Assessment of MADRS score throughout the randomised study period;   Assessment of Clinical Global Impression (CGI) of Severity / Improvement Scale
15 Recruiting Amitriptyline to Prevent Headache After Traumatic Brain Injury
Conditions: Brain Injuries;   Post-Traumatic Headache
Intervention: Drug: Amitriptyline
Outcome Measures: Frequency and severity of headaches;   Headache Impact Test - 6;   Rivermead Post-Concussion Symptoms Questionnaire (RPQ);   Short Form-12® Health Survey (SF-12);   Number of participants with adverse events;   Headache characteristic survey;   Insomnia Severity Index;   Patient Health Questionnaire-9 (PHQ-9;   Rey Auditory Verbal Learning Test;   Trail Making Test;   Wechsler Adult Intelligence Scale (WAIS) IV Digit Symbol
16 Unknown  Amitriptyline or Pregabalin to Treat Neuropathic Pain in Incurable Cancer
Conditions: Cancer;   Neuralgia
Interventions: Drug: amitriptyline;   Drug: pregabalin
Outcome Measures: VAS score;   EQ-5D, McGill, EORTC-C30, HADS
17 Recruiting Trial of Amitriptyline for Chronic Oral Food Refusal in Children 9 Months to 8 Years of Age
Condition: Chronic Oral Food Refusal
Interventions: Drug: Amitriptyline 1 mg/kg;   Drug: Placebo
Outcome Measures: To assess the efficacy of amitriptyline in a 24-week outpatient multi-disciplinary protocol for transitioning children from tube to oral feeding;   To assess the role of pain in the efficacy of amitriptyline in the 24-week outpatient multidisciplinary protocol.
18 Unknown  Anti-inflammatory Pulmonal Therapy of Cystic Fibrosis (CF) Patients With Amitriptyline and Placebo
Conditions: Cystic Fibrosis;   Pneumonia
Interventions: Drug: Amitriptyline;   Drug: Mannite
Outcome Measures: Improvement of the lung function parameter FEV1 (absolute and relative to baseline) under verum and placebo;   Increase in lung function measurements;   Ceramide concentration in epithelial cells;   Inflammation status;   Bacteriological and cell status;   Side effects
19 Unknown  A Study to Compare the Pharmacokinetic Profiles of Etravil® Tablet 10mg and Etravil® Tablet 25mg
Condition: Depression
Interventions: Drug: Etravil 10mg Tablet;   Drug: Etravil 25mg Tablet
Outcome Measures: Cmax of Amitryptiline in plasma;   AUClast of amityptyline in plasma;   Tmax of amityptyline in plasma;   terminal half-life (t1/2) of amityptyline in plasma;   CL/F of amityptyline in plasma
20 Recruiting The Childhood and Adolescent Migraine Prevention Study
Conditions: Migraine;   Migraine Disorders;   Headache
Interventions: Drug: Amitriptyline;   Drug: Topiramate;   Drug: Placebo
Outcome Measures: Reduction in Migraine Frequency (amitriptyline and topiramate);   Reduction in absolute migraine disability score on PedMIDAS;   Safety and tolerability of amitriptyline and topiramate;   Occurrence of treatment-emergent serious adverse events;   Reduction in absolute migraine frequency days

These studies may lead to new treatments and are adding insight into Perphenazine etiology and treatment.

A major focus of Perphenazine research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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