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Pitocin Medical Research Studies

Up-to-date List of Pitocin Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Pitocin Medical Research Studies

Rank Status Study
1 Recruiting Recovery of Oxytocin Responsiveness in Pregnant Human Myometrial Explants After Oxytocin-Induced Desensitization
Condition: Postpartum Hemorrhage
Intervention: Drug: Oxytocin
Outcome Measures: Amplitude of contraction;   frequency of contraction;   Integrated area under response curve (AUC);   basal tone
2 Not yet recruiting A Randomized Trial Comparing Oxytocin and Oxytocin + Ergometrine for Prevention of Postpartum Haemorrhage at Caesarean Section
Condition: Prevention of Post Partum Haemorrhage
Interventions: Drug: Oxytocin;   Drug: Oxytocin ergometrine
Outcome Measures: Blood loss;   Side effects of oxytocin compared to oxytocin + ergometrine;   Need for additional uterotonics;   Number of units blood transfused
3 Not yet recruiting Premature Rupture of Mambrane and Unfavourable Cervix
Condition: Cervix; Insufficient Dilatation in Labor
Interventions: Device: COOK RIPENENIG BALLOON+PITOCN;   Drug: Pitocin;   Other: double balloonand oxytocin;   Other: ballon and oxytocin;   Procedure: double balloonand and oxytocin
Outcome Measure: PPROM/PROM to delivery interval
4 Recruiting Foley Bulb Induction With and Without Simultaneous Use of Oxytocin
Condition: Induction of Labor
Intervention: Drug: Oxytocin
Outcome Measures: induction time to delivery;   Mode of delivery;   estimated blood loss;   uterine atony;   chorioamnionitis;   neonatal birthweight
5 Recruiting Oxytocin Infusions and Blood Loss in Patients Undergoing Elective Cesarean Delivery.
Condition: Postpartum Hemorrhage
Intervention: Drug: Oxytocin Infusion
Outcome Measures: Total estimated blood loss;   hemoglobin indices after cesarean delivery;   Non-invasive Hb levels;   Thromboelastographic indices;   Oxytocin related side-effects
6 Recruiting Oxytocin and CBSST for People With Schizophrenia
Conditions: Cognitive Behavioral Social Skills Training + Oxytocin;   Cognitive Behavioral Social Skills Training + Placebo
Interventions: Drug: CBSST with Oxytocin;   Drug: CBSST with Placebo
Outcome Measures: Determine if CBSST + oxytocin compared to CBSST + placebo is associated with improved social function.;   Determine if CBSST + oxytocin compared to CBSST + placebo is associated with increased incidence of side effects.
7 Not yet recruiting Oxytocin Trial in Prader-Willi Syndrome
Condition: Prader Willi Syndrome
Interventions: Drug: Intranasal oxytocin;   Other: Placebo
Outcome Measures: Safety of intranasal oxytocin in children with Prader-Willi syndrome;   Evaluation of food intake in Prader-Willi syndrome
8 Recruiting Examining Dose-Related Effects of Oxytocin on Social Cognition Across Populations
Conditions: Borderline Personality Disorder;   BPD;   Schizotypal Personality Disorder;   SPD
Interventions: Drug: Syntocinon 24 Intranasal Units (IU);   Drug: Syntocinon 40 Intranasal Units (IU);   Drug: Intranasal Placebo
Outcome Measures: Movie for the Assessment of Social Cognition (MASC);   Reading of the Mind in the Eyes
9 Recruiting Association Between Fluid Administration, Oxytocin Administration, and Fetal Heart Rate Changes
Conditions: Pregnancy;   Labor Pain
Interventions: Drug: Lactated Ringers bolus of 1000 mL;   Drug: Lactated Ringers infusion @ 125 ml/hr;   Drug: Routine oxytocin;   Drug: Half-dose oxytocin
Outcome Measure: Incidence of non-reassuring fetal heart rate tracings during the first 60 minutes after the placement of epidural analgesia
10 Recruiting Intramuscular Versus Intravenous Prophylactic Oxytocin for Hemorrhage After Vaginal Delivery
Condition: Postpartum Hemorrhage
Intervention: Drug: intarvenous and intramusculer 10 IU oxytocin
Outcome Measures: early postpartum hemorrhage;   Blood transfusion requirement
11 Unknown  Oxytocin in Cesarean Delivery
Condition: Post Partum Hemorrhage
Intervention: Drug: Oxytocin versus oxytocin-ergometrine
Outcome Measures: Uterine tone;   Plasma levels of oxytocin;   Subjective side effects
12 Recruiting Study of Wellness Behaviors as a Function of Oxytocin vs Placebo
Conditions: Sustained Positive Emotions;   Sustained Positive Behavior Change
Interventions: Drug: Oxytocin;   Drug: Placebo (for oxytocin);   Behavioral: Lovingkindness Meditation;   Behavioral: Mindfulness Meditation
Outcome Measures: Change in positive emotions (as measured by the Modified Daily Emotions Scale);   Change in nonconscious incentive salience (as measured by the Affect Misattribution Procedure).;   Changes in meditation time;   Cardiac Vagal Tone
13 Not yet recruiting Oxytocin and Pain Sensitivity and Threshold
Condition: Pai
Interventions: Drug: Intranasal Oxytocin;   Drug: Placebo (saline)
Outcome Measures: Pain sensitivity and threshold;   Side effects of Oxytocin
14 Recruiting FOLCROM Trial: Foley Catheter in Rupture of Membranes
Conditions: Premature Rupture of Membranes;   Cervical Ripening
Interventions: Device: Foley Catheter;   Drug: Oxytocin
Outcome Measures: Time from induction of labor until delivery;   Rate of chorioamnionitis excluding all those who were hospitalized with preterm premature rupture of membranes (PPROM) prior to 34 0/7 weeks;   Rate of vaginal delivery within 12 hours from placement of Foley catheter or start time of oxytocin;   Rate of vaginal delivery within 24 hours from placement of Foley catheter or start time of oxytocin;   Duration of first, second and third stage of labor (minutes) for those undergoing vaginal deliveries;   Rate of failed induction of labor as the indication for cesarean;   Rate of Endomyometritis;   Maternal length of stay, from admission to discharge and from delivery to discharge;   Rate of five minute Apgar score < 5;   Arterial Cord blood gas (pH), when obtained;   Rate of Neonatal Sepsis;   Neonatal Intensive Care Unit (NICU) admission rate;   Neonatal length of stay;   Histologic chorioamnionitis/funisitis;   Time from induction to delivery (minutes) excluding all those who were hospitalized with PPROM prior to 34 0/7 weeks;   Overall Cesarean Delivery;   Rate of Chorioamnionitis
15 Not yet recruiting Intranasal Oxytocin and Learning in Autism
Condition: Autism Spectrum Disorders
Interventions: Drug: Syntocinon (synthetic oxytocin);   Other: Placebo
Outcome Measures: Change from Baseline to Post-testing on the The Part/Whole Identity Test;   Change from Baseline to Post-testing on the Reading the Mind in the Eyes Task;   Change from Baseline to Post-testing on measures of social attention, reward/motivation, perception and cognition
16 Recruiting In-vitro Myometrial Contractility After Oxytocin Pre-exposure in Women With Advanced Maternal Age and Morbid Obesity
Condition: Postpartum Hemorrhage
Intervention: Drug: Oxytocin
Outcome Measures: Motility index;   Amplitude of contraction;   Integrated area under response curve (AUC);   Frequency of contraction
17 Unknown  Breast Stimulation Versus Pitocin for Induction of Labor
Condition: Labor Induction
Interventions: Drug: Oxytocin;   Procedure: breast pump nipple stimulation
Outcome Measures: time from induction to delivery;   fetal distress (monitor assessment, cord ph);   cesarean section rate
18 Recruiting Brain Dynamics of Oxytocin
Condition: Healthy Adults
Interventions: Drug: Syntocinon Nasal Spray, 40IU;   Drug: Syntocinon Placebo Formulation, 40IU
Outcome Measures: MRI data;   MEG Data;   Behavioral (neuroeconomic) task assessing "trust.";   Graph Theory (fMRI);   Complexity Analyses (fMRI);   System Identification (fMRI);   Graph Theory (MEG);   Complexity Analyses (MEG);   System Identification (MEG);   GABA concentrations
19 Recruiting Intranasal Oxytocin and Learning in Autism
Condition: Autism Spectrum Disorders
Intervention: Drug: Intranasal Oxytocin (Trade name: Syntocinon)
Outcome Measures: Change from Baseline to Post-testing (after max. 12 days) on the Part/Whole Identity Test (LFI Skills Battery);   Change from Baseline to Post-testing (after max. 12 days) on the Reading the Mind in the Eyes Test (Child version);   Changes from Baseline to Post-testing (after max. 12 days) on measures of social attention, reward/motivation, perception, and cognition
20 Not yet recruiting INtranasal OXyTocin for the Treatment of Autism Spectrum Disorders
Condition: Autism Spectrum Disorder
Interventions: Drug: Intranasal Oxytocin;   Drug: Placebo
Outcome Measures: To identify the effect of IN oxytocin (IN-OXT) vs. placebo on social function in adults with ASD.;   To identify the effect of IN oxytocin (IN-OXT) vs. placebo on continuous measures of social cognition and responsiveness in adults with ASD.;   To determine the safety and tolerability of IN-OXT in adults with ASD.;   To examine the effect of IN-OXT vs. placebo on quality of life and anxiety.

These studies may lead to new treatments and are adding insight into Pitocin etiology and treatment.

A major focus of Pitocin research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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