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Prasugrel Hydrochloride Medical Research Studies

Up-to-date List of Prasugrel Hydrochloride Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Prasugrel Hydrochloride Medical Research Studies

Rank Status Study
1 Not yet recruiting Study of Survivors of Different Types of Cardiac Arrest and Their Neurological Recovery
Conditions: Postcardiac Arrest;   Pulseless Electrical Activity;   Asystole
Interventions: Other: No treatment;   Other: Therapeutic hypothermia
Outcome Measures: Cerebral performance category score on hospital discharge;   Hospital length of stay postcardiac arrest;   Intensive care unit length of stay postCardiac Arrest;   Neurological status after hospital discharge
2 Recruiting Therapeutic Hypothermia to Improve Survival After Cardiac Arrest in Pediatric Patients-THAPCA-IH [In Hospital] Trial
Condition: Cardiac Arrest
Interventions: Procedure: Therapeutic Hypothermia;   Procedure: Therapeutic Normothermia
Outcome Measures: Survival with good neurobehavioral outcome;   Survival;   Change in neurobehavioral function from pre-Cardiac Arrest to 12 months post-Cardiac Arrest;   Neuropsychological scores (for participants who survive);   Neurological abnormality scores (for participants who survive)
3 Recruiting REASON 1 Trial: Sonography in Cardiac Arrest
Conditions: Cardiac Arrest;   Pulseless Electrical Activity;   Asystole
Intervention:
Outcome Measures: Number of patients that survive to Hospital Discharge;   The number of patients that demonstrate a Return of Spontaneous Circulation;   The number of patients that survive to hospital admission
4 Recruiting Improving Cardiac Arrest Diagnostic Accuracy of Emergency Medical Dispatchers
Condition: Cardiac Arrest
Intervention: Behavioral: Education
Outcome Measures: Frequency and impact of agonal breathing on Cardiac Arrest diagnosis;   Completion of dispatch assisted cardiopulmonary resuscitation instructions
5 Unknown  Coenzyme Q10 in Post-Cardiac Arrest Cerebral Resuscitation
Conditions: Cardiac Arrest;   Sudden Cardiac Arrest
Interventions: Dietary Supplement: Coenzyme Q10;   Dietary Supplement: Placebo
Outcome Measures: Prevalence of low serum CoQ10 levels in Cardiac Arrest Patients;   Comparison of serum CoQ10 levels randomized to supplementation vs. placebo
6 Recruiting COOL-ARREST Pilot Study to Assess Intravascular Temperature Management (IVTM) in the Treatment of Cardiac Arrest
Condition: Out of Hospital Cardiac Arrest
Intervention: Device: ZOLL Intravascular Temperature Management System (IVTM)
Outcome Measures: Proportion of subjects in which IVTM can therapeutically cool patients as a measure of Performance;   Ability to Enroll Subjects, Proportion of those Enrolled that Complete the Study Protocol and Time to complete Enrollment of 50 Subjects Defined as Retention;   Incident Adverse Events Defined as Safety
7 Recruiting Finding the Optimal Cooling tempeRature After Out-of-HoSpiTal Cardiac Arrest
Condition: Out-Of-Hospital Cardiac Arrest.
Interventions: Device: Target Temperature Management of 34°C;   Device: Target Temperature Management of 32°C;   Device: Target Temperature Management of 33°C
Outcome Measures: Fraction of subjects surviving with good neurologic outcome(modified Rankin Score (mRS) ≤ 3) at 90 days after out-of-hospital Cardiac Arrest.;   Fraction of subjects with good neurologic outcome (mRS ≤ 3) at discharge after out-of-hospital Cardiac Arrest;   Identify possible covariates influencing survival with good neurological outcome.;   To assess safety with each target temperature with regard to bleeding, infection, renal impairment, hypokalemia and arrhythmia.
8 Not yet recruiting Augmented Multimodal Neurologic Monitoring in High Risk Survivors of Cardiac Arrest
Condition: Cardiac Arrest
Interventions: Device: QFlow 500™ Perfusion Probe (Hemedex, Cambridge, MA);   Device: Spencer Probe Depth Electrode (Ad-Tech Medical, Racine, WI)
Outcome Measures: Spreading depolarizations;   Occult seizures;   Cerebral hypoperfusion;   Clinically significant bleeding;   Monitor-associated infection;   Device malfunction
9 Unknown  LUCAS Chest Compressor Versus Manual Chest Compression in Out-of-hospital Sudden Cardiac Arrest. LUCAT Trial
Condition: Sudden Cardiac Arrest
Interventions: Device: LUCAS (Lund University Cardiac Assist Sysrem);   Other: Manual chest compressions
Outcome Measures: Survival at hospital admittance;   Survival on discharge from hospital (or 30 days if not applicable) in acceptable neurological state (CPC scale 1 or 2);   Restoration of spontaneous circulation;   EndTidal CO2 values;   SOFA scale values;   Days before discharge from Intensive Care Unit (ICU) / Coronary Care Unit (CCU);   Metabolic (pH, lactate) and inflamatory (leukocytes, C reactive protein) parameters;   Epidemiology of Out-of-Hospital Cardiac Arrest;   To obtain a blood sample for genetic and biological studies;   Left ventricular function
10 Not yet recruiting Direct or Subacute Coronary Angiography for Out-of-hospital Cardiac Arrest
Condition: Out-of-Hospital Cardiac Arrest
Interventions: Procedure: Acute coronary angiography;   Other: Routine care  ICU;   Other: Routine care STEMI
Outcome Measures: Care deviations (All deviations that may affect the patients safety during prehospital and hospital care);   Prehospital timeframes;   Logistics (Logistics problems associated with randomization / inclusion);   Prognostic factors (blood acidity (pH, lactate), oxygen saturation (PaO2), blood sugar level, electrolytes);   Monitoring of circulation;   Supportive care (differences in need of supportive care in terms of circulation with drugs (inotropes) and mechanical devices);   Cardiac assessment (Echo, biochemical markers);   Delay to standard treatment;   Study events (serious adverse events);   Health economics (Length of stay );   Survival;   Cardiac function (left ventricular function);   ECG findings (ie How often is ischemic signs missing in first ECG but changes in the coronary arteries can be seen at coronary angiography post resuscitation after Cardiac Arrest);   Neurologic function;   Hemodynamic measures (measured by Vigileo or equivalent method)
11 Recruiting SEVOflurane Inhalation in Cardiac Arrest Resuscitated Patients Treated With Therapeutic Hypothermia
Conditions: Cardiac Arrest;   Therapeutic Hypothermia
Intervention: Drug: sevoflurane
Outcome Measures: Determination of the feasibility of a sedation with inhalated sevoflurane in Cardiac Arrest resuscitated patients;   Determination of neurological prognostic of patients at ICU and hospital discharge;   Determination of systemic complications and organ failures during hospitalisation;   Evaluation of systemic inflammation and evolution with cytokines;   Evaluation of markers specific of brain ischemia (S100 protein and neuron-specific enolase)
12 Not yet recruiting When Cooling a Patient After Cardiac Arrest, Does Use of a Neuromuscular Blocking Agent Make Your Job Easier?
Condition: Postcardiac Arrest Therapeutic Hypothermia
Interventions: Drug: Cisatracurium infusion;   Drug: Cisatracurium prn bolus
Outcome Measures: Time to attaining target temperature (hours).;   Cerebral performance category score on hospital discharge.;   Hospital length of stay postCardiac Arrest (days).;   Intensive care unit length of stay postCardiac Arrest (days).
13 Recruiting Hyperinvasive Approach in Cardiac Arrest
Condition: Out-of Hospital Cardiac Arrest
Interventions: Device: Prehospital mechanical compression device, intraarrest cooling and in hospital ECLS (LUCAS, Rhinochill, PLS ECMO);   Other: Standard care
Outcome Measures: Composite endpoint of survival with good neurological outcome (CPC 1-2).;   Neurological recovery;   Cardiac recovery
14 Recruiting Circulating Biomarkers Predict Neurological Outcome After Cardiac Arrest
Condition: Cardiac Arrest
Intervention:
Outcome Measures: cerebral performance Category(CPC) of Participants;   survival of participants
15 Recruiting Mild Versus Moderate Therapeutic Hypothermia in Out-of-hospital Cardiac Arrest Patients
Condition: Cardiac Arrest
Intervention: Other: Therapeutic Hypothermia
Outcome Measures: Number of participants with death or poor neurologic outcome at 6 months;   Number of mortality;   Number of participants with stroke;   Number of participants with bleeding;   Length of stay in the unit;   Length of stay in the hospital;   Number of participants with cardiogenic shock;   Number of participants with repeat circulatory arrest requiring cardiopulmonary resuscitation (CPR);   Number of participants with seizures;   Number of participants with renal failure requiring renal replacement therapy;   Number of participants with ventilator associated pneumonia;   Number of participants with stent thrombosis;   Number of participants discharged home
16 Recruiting Reoxygenation After Cardiac Arrest (REOX Study)
Condition: Cardiac Arrest
Intervention:
Outcome Measures: Plasma isoprostanes/isofurans (mechanistic outcome);   Modified Rankin Scale (mRS) (primary neurological outcome)
17 Recruiting Cognitive Auditory Evoked Potential After Cardiac Arrest: Interest of Mismatch negativiTY
Conditions: Coma;   Cardiac Arrest
Intervention: Procedure: Auditory-evoked potentials
Outcome Measures: CPC score of 1 or 2 (favorable outcome);   Awakeness;   Time of realization of the cortical auditory-evoked potential;   CPC score of 1 or 2 at ICU discharge;   Length of mechanical ventilation, ICU stay, hospital stay and vital status at discharge;   CPC score of 1 or 2 at hospital discharge
18 Recruiting Plasma Neutrophil Gelatinase-associated Lipocalin (NGAL) as Early Biomarker for Renal Dysfunction and Good Neurologic Outcome in Out of Hospital Cardiac Arrest Patients
Condition: Post Cardiac Arrest Patient Who Was Treated by Hypothermia Protocol
Intervention: Biological: Serum NGAL level
Outcome Measure: Predictive value of plasma NGAL for acute kidney injury and cerebral dysfunction following out of hospital Cardiac Arrest.
19 Not yet recruiting Seizure Detection Using SEDline During Therapeutic Hypothermia in Cardiac Arrest Victims
Condition: Cardiac Arrest
Intervention: Device: Frontal 4 channel EEG
Outcome Measures: Accuracy of SEDline for seizure detection;   Sensitivity of SEDline for seizure detection;   Specificity;   Positive predictive value;   Negative predictive value;   Area under receiver operating characteristics curve (AUC) of SEDline for seizure detection
20 Recruiting Evaluation of the Quality of Cardio-Pulmonary Resuscitation (CPR) in Cardiac Arrest Patients
Condition: Cardiac Arrest
Intervention:
Outcome Measures: The success rate of current guidelines (depth and frequency of chest compression, epidemiology);   Quality of life after CA;   Invasive arterial pressures, cerebral oxygenation (NIRS), EtCO2;   survival of cardiac arrest

These studies may lead to new treatments and are adding insight into Prasugrel Hydrochloride etiology and treatment.

A major focus of Prasugrel Hydrochloride research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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