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Precedex Medical Research Studies

Up-to-date List of Precedex Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Precedex Medical Research Studies

Rank Status Study
1 Recruiting Dexmedetomidine in Spinal Anesthesia
Conditions: Blood Pressure;   Anxiety
Interventions: Drug: Dexmedetomidine;   Drug: Dexmedetomidine with heavy bupivacaine
Outcome Measures: Hemodynamic effects;   Patient's comfortability and anxiety
2 Recruiting Dexmedetomidine-ketamine in Femur Proximal Fracture Patients
Condition: Pain
Interventions: Drug: Dexmedetomidine;   Drug: Fentanyl;   Drug: Ketamine
Outcome Measures: Pain score using five scales;   Quality of patient positioning
3 Recruiting Efficacy of Single-Shot Dexmedetomidine Versus Placebo in Preventing Pediatric Emergence Delirium in Strabismus Surgery
Conditions: Strabismus;   Delirium on Emergence;   Pediatric Disorders
Interventions: Drug: Dexmedetomidine;   Other: Placebo
Outcome Measures: Efficacy of Single-Shot Dexmedetomidine versus Placebo in Preventing Pediatric Emergence Delirium in Strabismus Surgery;   Post operative interventions
4 Recruiting Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft
Conditions: Unstable Angina;   Coronary Artery Bypass Graft;   Dexmedetomidine;   Lidocaine;   Myocardial Injury;   Arrhythmia;   Blood Electrolyte Balance
Interventions: Drug: Lidocaine infusion;   Drug: Dexmedetomidine infusion
Outcome Measures: Myocardial injury marker;   The blood sodium, potassium, calcium level;   The incidence of arrhythmia during and after the surgery;   Postoperative ICU stay, Hospital stay, Extubation time;   Inotropics use during and after the surgery;   The incidence of hypokalemia
5 Recruiting Pilot Study Comparing Treatment With Dexmedetomidine to Midazolam for Symptom Control in Advanced Cancer Patients
Conditions: Pain Intractable;   Delirium;   Dyspnea;   Nausea
Interventions: Drug: Dexmedetomidine;   Drug: Midazolam
Outcome Measures: Number of subjects needed to recruit for a multicenter double blind randomized controlled phase III trial comparing dexmedetomidine to midazolam for symptom control in advanced cancer patients;   Change in pain (0 to 10 numerical scale);   Change in dyspnea (0 to 10 numerical scale);   Change in nausea (0 to 10 numerical scale);   Change in delirium (16 item clinician rated scale);   Rousability (10 point scale);   Acceptable symptom control (yes/no)
6 Recruiting Intranasal Dexmedetomidine Premedication
Condition: Benign Neoplasm of Vocal Fold - Glottis
Interventions: Drug: Dexmedetomidine;   Drug: placebo
Outcome Measures: Extubation time after intranasal dexmedetomidine premedication;   Sedation level;   The occurrence of perioperative adverse events;   Hemodynamic responses
7 Not yet recruiting Dexmedetomidine on Pediatric Heart Operation
Condition: Acute Renal Injury
Interventions: Drug: Dexmedetomidine;   Drug: no dexmedetomidine
Outcome Measure: renal function
8 Not yet recruiting Effect of Intravenous Dexmedetomidine on Analgesic Duration of Infraclavicular Block
Condition: Postoperative Pain
Interventions: Drug: Dexmedetomidine;   Drug: Propofol;   Procedure: Infraclavicular block
Outcome Measure: The duration of sensory infraclavicular block in patients scheduled for upper limb surgery.
9 Unknown  Safety Evaluation of Dexmedetomidine for EBUS-TBNA
Condition: Lung Cancer
Interventions: Drug: Remifentanil;   Drug: Dexmedetomidine
Outcome Measures: Major adverse events;   Vocal cord movement;   Sedation scores;   Aldrete scores in the post anesthesia care unit;   Nausea and vomiting;   Cumulative dose of remifentanil or dexmedetomidine;   Total dose of lidocaine;   Total dose of vasopressor;   Coughing episodes;   Endoscopist satisfaction;   Recall;   Pain associated with the procedure (VAS);   Patient satisfaction
10 Unknown  Dexmedetomidine to Lessen Intensive Care Unit (ICU) Agitation
Condition: Delirium
Interventions: Drug: Dexmedetomidine;   Drug: Saline placebo
Outcome Measures: Ventilator-free hours;   Time to ICU discharge;   Overall ICU length of stay;   Time to first extubation;   Time taken to achieve a satisfactory sedation score;   %ICU time spent with a satisfactory sedation score;   %ICU time spent with a satisfactory delirium score;   Time taken to achieve a satisfactory agitation score;   %ICU time spent with a satisfactory agitation score;   Need for supplementary sedative medication;   Need for mechanical restraint;   Need for supplementary antipsychotic medication;   Need for tracheostomy;   Acute hospital length of stay;   Discharge destination;   Daily SOFA score;   ICU mortality;   Hospital mortality;   Duration and rate of vasopressor support;   Need for insertion of a new central venous catheter to facilitate vasopressor / inotropic support;   Requirement for reintubation
11 Recruiting Use of Dexmedetomidine in Acute Stroke and Cerebral Vasospasm Interventions
Conditions: Stroke;   Brain Ischemia;   Vasospasm, Intracranial;   Hemorrhage, Intracranial
Interventions: Drug: Dexmedetomidine;   Drug: Fentanyl;   Drug: Midazolam
Outcome Measures: Numbers of patient movements (events) that delay or adversely affect the procedure performance and safety.;   Preserved neurological examination.;   Maintenance of optimal sedation target in both groups.
12 Not yet recruiting Study of Use of Dexmedetomidine for Regional Anesthesia
Conditions: Patients Scheduled for Upper Extremity Surgeries (Vascular Occlusion Syndrome, Acute Compartment Syndrome, Capral Tunnell Syndrome Etc.);   Will Participate in the Study.;   Focus of the Study is to Determine:;   the Optimal Dose of Dexmedetomidine Added to Lidocaine;   for Infra- and Supra-clavicular Brachial Plexus Block.
Intervention: Drug: Precedex injection
Outcome Measure: Pain scores on Visual Analog Scale will be measured
13 Unknown  The Effect of Dexmedetomidine on Emergence Agitation in Children Undergoing a Surgery Under Desflurane Anesthesia
Condition: Psychomotor Agitation
Interventions: Drug: Dexmedetomidine;   Drug: 0.9% Normal Saline
Outcome Measures: Agitation score;   Oculomotor reflex
14 Recruiting Comparison of Dexmedetomidine and Propofol-Remifentanil Conscious Sedation for Awake Craniotomy for Tumor Surgery
Condition: Brain Tumor
Interventions: Drug: Dexmedetomidine;   Drug: Propofol;   Drug: Remifentanil
Outcome Measures: Ability to perform intra-operative mapping during awake craniotomy;   Incidence of complications (respiratory depression, failure to provide adequate analgesia);   Patient and surgeon satisfaction to the corresponding anesthetic technique
15 Recruiting Dexmedetomidine to Prevent Agitation After Free Flap Surgery
Conditions: Agitation;   Delirium
Interventions: Drug: Dexmedetomidine;   Drug: Saline placebo
Outcome Measures: agitation in PACU;   postoperative delirium
16 Recruiting Dexmedetomidine in Different Dose Levels as Adjuvant to Bupivacaine-induced Ultrasound-guided Femoral Nerve Block.
Conditions: Dexmedetomidine and Femoral Nerve Block,;   Arthroscopic Knee Surgery and Pain
Interventions: Drug: peri-neural dexmedetomidine as adjuvant to bupivacaine in femoral nerve block;   Drug: Placebo
Outcome Measures: duration of sensory block;   Time to first request of postoperative rescue analgesic;   Onset of sensory block;   Onset of motor block;   visual analogue pain scores (VAS);   Richmond Agitation-Sedation Score (RASS);   duration of motor block;   total morphine consumption;   perioperative hemodynamic parameters;   incidence of side effects.
17 Recruiting The Effects of Dexmedetomidine to Postoperative Awakening and Extubation-related Changes in Blood Pressure
Condition: Hypertension
Interventions: Drug: Dexmedetomidine;   Other: Saline (placebo)
Outcome Measures: Highest value of systolic blood pressure during extubation period;   Risk index calculated from systolic blood pressure value and time spent in that value.
18 Recruiting Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery
Condition: Heart Disease
Interventions: Drug: Dexmedetomidine;   Drug: Placebo
Outcome Measures: Sedation Outcome of patients assigned to dexmedetomidine or placebo.;   Sedation Outcome of patients assigned to dexmedetomidine or placebo
19 Recruiting Intranasal Dexmedetomidine Sedation for Pediatric CT Imaging
Conditions: Traumatic Brain Injury;   Children
Intervention: Drug: Dexmedetomidine
Outcome Measures: Rates of sedation failure with intranasal dexmedetomidine for sedation for pediatric CT imaging;   Safety of IN dexmedetomidine for pediatric CT imaging
20 Recruiting Dexmedetomidine (Precedex®) for Severe Alcohol Withdrawal Syndrome (AWS) and Alcohol Withdrawal Delirium (AWD)
Conditions: Alcohol Withdrawal Delirium;   Alcohol Withdrawal Associated Autonomic Hyperactivity;   Alcohol Withdrawal Hallucinosis;   Alcohol Withdrawal-Induced Delirium Tremens
Interventions: Drug: Dexmedetomidine;   Drug: Placebo
Outcome Measures: The length of ICU stay defined as the time between randomization and ICU transfer orders.;   The number of delirium-free and ventilator-free days during the first 28 days of hospitalization;   The length in days of the hospital stay;   Scores at hospital discharge on the Mini Mental Exam, Beck Depression Inventory, Beck Anxiety Inventory and PTSD checklist.;   Resource utilization costs associated with this hospitalization.;   Predefined adverse events;   average MINDS score

These studies may lead to new treatments and are adding insight into Precedex etiology and treatment.

A major focus of Precedex research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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