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Pregabalin 75mg Medical Research Studies

Up-to-date List of Pregabalin 75mg Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Pregabalin 75mg Medical Research Studies

Rank Status Study
1 Recruiting Validation of a French Version of the Confusion Assessment Method (CAM)
Conditions: Confusion;   Delirium
Interventions: Other: Psychiatric evaluation;   Other: Geriatric evaluation
Outcome Measures: CAM French Version: diagnostic properties;   Reliability and quality of the french version of the CAM;   Feasibility of scoring with the French version of the Delirium Index;   Diagnostic properties of alternative algorithms constructed from items of CAM (French version)
2 Recruiting Confusion in the Elderly After Colon Surgery
Conditions: Confusion;   Inflammation;   Acute Phase Reaction;   Surgery;   Delirium
Intervention:
Outcome Measures: Confusion;   degree of inflammation;   presence of electrolyte imbalance;   pituitary-thyroid axis disruption;   liver function tests;   nutritional status
3 Not yet recruiting Inadequate Emergence After Laparoscopic Surgery in Trendelemburg Position
Conditions: Delayed Emergence From Anesthesia;   Delirium, Cause Unknown;   Confusion;   Disorientation on Emergence
Intervention:
Outcome Measure: Inadequate emergence after anaesthesia
4 Recruiting Perioperative Cognitive Protection - Cognitive Exercise and Cognitive Reserve (The Neurobics Trial)
Condition: Delirium
Interventions: Other: Mini-Mental State Examination;   Other: Self-Administered Gerocognitive Examination;   Other: Geriatric Depression Scale;   Other: Charlson Comorbidity Index;   Other: Short Form (36) Health Survey;   Other: Confusion Assessment Method;   Other: Memorial Delirium Assessment Scale
Outcome Measure: Reduction in the incidence of Post-Operative Delirium (%)
5 Recruiting Instruments for Delirium Assessment Regarding to Analgesia Sedation and Ventilator Status
Condition: Delirium
Intervention:
Outcome Measures: Sensitivity of the delirium screening/diagnosing tool "Confusion Assessment Method for the ICU (CAM-ICU)" regarding sedation and ventilator status.;   Sensitivity of the delirium-screening tool "Intensive-Care Delirium Screening Checklist(ICDSC)" regarding sedation and ventilator status.;   Sensitivity of the delirium screening tool "Nursing Delirium Screening Scale (Nu-DESC)" regarding sedation and ventilator status.;   Specificity of the "Confusion Assessment Method for the ICU (CAM-ICU)", the "Intensive Care Delirium Screening Checklist (ICDSC)" and the "Nursing Delirium Screening Scale" regarding sedation and ventilator status.;   Calculation and Analysis of the positive predictive values of the assessed delirium-screening scales.;   Incidence of delirium;   Incidence of Subsyndromale Delirium (SSD);   Analgesia;   Ventilator status;   Administered neuroleptics, cumulative;   Administered analgesics, cumulative;   Administered sedatives, cumulative;   Severity of illness;   Antibiotics/infections;   ICU length of stay;   Duration of mechanical ventilation;   Discharge mode;   28-day mortality;   Specificity of the "Confusion Assessment Method for the ICU (CAM-ICU)", the "Intensive Care Delirium Screening Checklist (ICDSC)" and the "Nursing Delirium Screening Scale" regarding analgesia.;   Sensitivity of the "Confusion Assessment Method for the ICU (CAM-ICU)", the "Intensive Care Delirium Screening Checklist (ICDSC)" and the "Nursing Delirium Screening Scale" regarding analgesia.
6 Recruiting Hip Fracture Surgery in Elderly Patients
Condition: Delirium
Interventions: Drug: Xenon;   Drug: Sevoflurane
Outcome Measures: Post Operative Delirium diagnosed with the Confusion Assessment Method within four days post-surgery;   Post Operative Delirium diagnosed with the Confusion Assessment Method from day 5 post surgery to discharge from hospital;   Sequential Organ Failure Assessment from day 1 to day 4 post-surgery;   Recovery Parameters;   economic parameters;   Safety Parameters
7 Unknown  Use of a Vibrotactile Sensory Prosthesis in Patients With Postural Imbalance and Spatial Disorientation
Conditions: Vestibular Diseases;   Peripheral Neuropathies;   Proprioceptive Disorders;   Hemispatial Neglect
Intervention: Device: Vibrotactile feedback
Outcome Measure: Mean time reaction to the perturbation with the feedback
8 Not yet recruiting The Effect of Clonidine-enhanced Sedation on Delirium in Ventilated Critically Ill Patients
Condition: Delirium
Interventions: Drug: Clonidine;   Drug: SodiumChloride
Outcome Measures: CAM-ICU (Confusion Assessment Method for the Intesive Care Unit);   Signs of agitation;   Opiate use;   Sedative use;   Anti-psychotic use;   Ventilation free days;   Sedation free days
9 Recruiting Predicting the Risk of Post-operative Delirium: Use of Neuropsychology, Serum and CSF Biomarkers and Genetics to Predict Risk of Post-operative Delirium
Condition: Delirium
Intervention:
Outcome Measures: Incidence of inpatient post-operative delirium as measured using the confusion assessment method (CAM);   Post-operative cognitive dysfunction
10 Unknown  Influence of Light Therapy on Confusion in Patients at the Intensive Care Unit
Conditions: Delirium;   Intensive Care Unit Syndrome
Intervention:
Outcome Measures: Duration of delirium, defined in days;   Incidence of delirium in the patient group receiving bright light therapy and in the group receiving environmental light;   CAM-scores of the ICU nurses;   Dosage of haloperidol use in delirious patients receiving bright light therapy and those receiving environmental light;   Duration of haldol use in delirious patients receiving bright light therapy and those receiving environmental light;   Mortality of delirious patients in the ICU and in the hospital, comparing those who receive bright light therapy with those who receive environmental light;   Duration of mechanical ventilation in delirious patients receiving bright light therapy and those receiving environmental light;   Duration of admission of delirious patients in the ICU and in the hospital, comparing those who receive bright light therapy with those who receive environmental light;   Duration of admission in the ICU and in the hospital, comparing those who receive bright light therapy with those who receive environmental light
11 Unknown  Prevalence of Delirium in Patients Undergoing Cardiac Surgery
Condition: Heart Disease
Intervention:
Outcome Measure:
12 Not yet recruiting Melatonin for Delirium Prophylaxis
Condition: Delirium
Interventions: Drug: Melatonin;   Other: Placebo
Outcome Measures: Delirium (Confusion Assessment Method);   Confusion (Confusion Assessment Method scores);   Mortality;   Use of restraints;   Code White (Violence)
13 Unknown  Automated Visual Monitoring for Improving Patient Safety (VIPSafe)
Condition: Postoperative Confusion
Intervention:
Outcome Measure:
14 Recruiting Preventing Post-Operative Delirium in Patients Undergoing a Pneumonectomy, Esophagectomy or Thoracotomy
Conditions: Delirium;   Cognitive Impairment;   Post-traumatic Stress Disorder;   Depression;   Anxiety
Interventions: Drug: Haloperidol;   Drug: Placebo
Outcome Measures: Efficacy of low-dose Haloperidol in reducing delirium incidence;   Efficacy of low-dose Haloperidol in reducing delirium duration and severity;   Efficacy of low-dose Haloperidol in reducing ICU and hospital length of stay;   Efficacy of low-dose Haloperidol in reducing cognitive impairment at post-operative follow-up
15 Recruiting Opioid Effects on Cognitive Function Following Colonoscopy
Conditions: Digestive System Diseases;   Disorientation
Interventions: Drug: Fentanyl;   Drug: Alfentanil;   Drug: Propofol
Outcome Measures: cognitive dysfunction;   Patient and endoscopist satisfaction;   Pain;   Side effects
16 Recruiting Haloperidol Prophylaxis in Cardiac Surgery for Patients at Risk for Delirium
Condition: Postoperative Confusion
Interventions: Drug: Haloperidol;   Drug: Placebo
Outcome Measures: Feasibility of conducting a trial utilizing low dose Haloperidol use in patients post cardiac surgery;   Safety monitoring of low dose Haloperidol use in patients post cardiac surgery;   The incidence of delirium;   Delirium severity;   Total length of stay (LOS), with breakdown for intensive care unit (ICU) days and ward days;   Duration of delirium
17 Recruiting Impact of a Telephonic Monitoring During Inter-treatment Intervals on Emotional State, Quality of Life and Toxicities, on Neo Adjuvant or Adjuvant Chemotherapy-treated Patients
Conditions: Non-metastatic Patients With Breast Cancer;   Non-metastatic Patients With Colon Cancer;   Non-metastatic Patients With Rectal Cancer;   Patients Undergoing Adjuvant Chemotherapy
Intervention: Other: Clinical and psychosocial phone calls
Outcome Measures: emotional state (anxiety, depression, confusion, angry, fatigue, force and interpersonal relation);   Evolution of emotional states scores;   toxicities;   quality of life;   anxiety;   caregiver mood states;   patient satisfaction;   relationship between psychosocial criteria and anxiety
18 Recruiting Pharmacological Management of Delirium
Conditions: Delirium;   Cognitive Impairment
Interventions: Behavioral: Reduced exposure to anticholinergics;   Procedure: Reduced exposure to benzodiazepines;   Drug: Haloperidol;   Procedure: Usual care
Outcome Measures: Delirium severity, days free of delirium and coma, measured by DRS-R-98, CAM-ICU, and RASS;   Length of stay;   Mortality;   Hospital-acquired complications related to delirium or delirium management
19 Recruiting Post-Operative Delirium in Elderly Surgical Patients
Conditions: Hip Fractures;   Delirium
Interventions: Device: Maintenance of level of awareness by use of a BIS monitor & the OASS.;   Device: Maintenance of level of awareness by use of a BIS monitor and the OASS.
Outcome Measures: Presence of delirium;   Change in functional status
20 Recruiting Efficacy and Safety of Risperidone and Trazodone Monotherapy and Combination Therapy in Critically Ill Patients With Delirium
Conditions: Delirium;   Agitation
Interventions: Drug: Risperidone;   Drug: Trazodone;   Drug: Placebo
Outcome Measures: The number of days patients are without delirium during the study period (delirium-free days);   Daily prevalence of delirium as indicated by a positive Confusion Assessment Method in the ICU (CAM-ICU);   Resolution of delirium as indicated by a negative Confusion Assessment Method in the ICU (CAM-ICU) for more than 24 hours;   The number of patients who require rescue medications, the type of rescue medications utilized, and the amount of rescue medications per day;   The number of patients who receive sedative agents, amount of midazolam equivalents per day, and the number of days in which patients receive a sedative agent;   The number of patients who receive pain medications, amount of fentanyl equivalents per day, and the number of days in which patients receive a pain medication;   The number of hours spent agitated (RASS score between +4 and +2) as a percent of the time that the study drug was administered;   The number of hours spent excessively sedated or in a coma state (RASS score between -4 to -5) as a percent of the time that the study drug was administered;   The duration of mechanical ventilation from initial intubation to extubation as long as the patient remained extubated for more than 48 hours.;   The number of days that the patients were alive and breathing without assistance during the study period (ventilator-free days);   The number of episodes and number of patients who experience clinically significant QTc prolongation (≥ 500 msec or an increase of more than 60 msec from baseline);   The number of episodes and number of patients who experience clinically significant extrapyramidal effects (as evidenced by a positive Simpson-Angus Scale Score);   All-cause mortality and 28-day mortality

These studies may lead to new treatments and are adding insight into Pregabalin 75mg etiology and treatment.

A major focus of Pregabalin 75mg research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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