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Propo Medical Research Studies

Up-to-date List of Propo Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Propo Medical Research Studies

Rank Status Study
1 Recruiting Propofol vs Propofol + Benzo/Opiates in High Risk Group
Conditions: Sleep Apnea, Obstructive;   Obesity
Interventions: Drug: Propofol Alone;   Drug: Propofol+Benzo/Opioids
Outcome Measures: Frequency of airway maneuvers;   Frequency of other sedation related complications;   Compare Propofol doses between the two groups;   Predictors of sedation related complications;   Patient tolerance as assessed by the patient, endoscopist and CRNAs will be compared between the two groups;   Frequency of symptoms of nausea and vomiting will be compared between the two groups
2 Recruiting Randomized Clinical Trial of Propofol, 1:1 and 4:1 Combination of Propofol and Ketamine for Procedural Sedation
Condition: Procedural Sedation
Interventions: Drug: Propofol;   Drug: 1:1 Propofol/Ketamine;   Drug: 4:1 Propofol/Ketamine
Outcome Measures: Clinical interventions during sedation;   Hypoxia;   Respiratory depression;   Procedural pain and recall
3 Unknown  Propofol Administered by Gastroenterologists by Target Controlled Infusion Pump During Endoscopy
Conditions: Sedation;   Endoscopy
Interventions: Drug: Propofol;   Drug: Midazolam
Outcome Measures: Endoscopist's satisfaction (Visual Analog Scale) about sedation;   Patient's satisfaction (Visual Analog Scale) about sedation at the end of procedure;   Patient's satisfaction (Visual Analog Scale) about sedation at 24-48 hours after procedure;   Time (minutes) to dischargeability of patient from endoscopic unit;   Number of Participants with Adverse Events as a Measure of Safety
4 Not yet recruiting Optimizing Propofol Dosing for (Preterm) Newborn Infants That Need Endotracheal Intubation
Conditions: Anesthesia Intubation Complication;   Premature Birth of Newborn;   Other Preterm Infants;   Propofol Overdose
Intervention: Drug: Propofol
Outcome Measures: adequate Propofol dose;   Determine a valid sedation assessment scale;   to determine an age specific Propofol PK/PD model;   aEEG / NIRS
5 Not yet recruiting Comparison of Propofol/Alfentanil With Propofol/Ketamine
Condition: Lung Disease
Interventions: Drug: Propofol;   Drug: Ketamine;   Drug: Alfentanil
Outcome Measures: Percutaneous carbon dioxide tension;   oxygen saturation;   heart rate;   Non-invasive blood pressure;   Oxygen supplementation;   Naso/oropharyngeal tube insertion;   A questionnaire evaluating pain and discomfort;   A questionnaire evaluating the quality of sedation;   Total Propofol dosage;   Time to full awakening and orientation;   Time to discharge
6 Recruiting Sedation MRI - Propofol Versus Propofol-Ketamin in Children
Condition: Sedation
Interventions: Drug: Propofol;   Drug: Ketamine-Propofol
Outcome Measures: Recovery time;   Demission time;   PONV;   Cerebral perfusion;   Incidence of emergence delirium;   Quality of sedation;   respiratory and cardiovascular adverse events
7 Recruiting Comparison of Different Propofol Formulations With or Without Remifentanil
Condition: Anesthesia
Interventions: Drug: Propofol (Astra-Zeneca), NaCl 0.9%;   Drug: Propofol 1% (Astra-Zeneca) and remifentanil;   Drug: Propofol (Astra-Zeneca) and remifentanil;   Drug: Propofol (B-Braun) and NaCl 0.9%;   Drug: Propofol (B-Braun) and remifentanil
Outcome Measures: necessary dose of Propofol to obtain the induction of anesthesia (defined by a bispectral index < 60 over 30 continuous seconds);   calculated concentrations of Propofol at the end of the anesthetic induction;   pain at injection;   heart rate modifications induced by anesthetic induction;   patient's satisfaction;   arterial pressure modifications induced by anesthetic induction;   Disappearance of the eyelash reflex
8 Unknown  Validation Study of Covariates Model (VaSCoM) for Propofol
Condition: Target Controlled Infusion of Propofol
Intervention: Drug: Propofol
Outcome Measures: Performance error of predicted blood Propofol concentration (venous blood samples);   Depth of anaesthesia;   Comparison of performance errors calculated from venous blood samples to performance errors calculated from arterial blood samples
9 Recruiting Combination Ketamine and Propofol vs Propofol for Emergency Department Sedation: A Prospective Randomized Trial
Condition: Sedation
Interventions: Procedure: 1:1 ketamine-Propofol mixture sedation;   Procedure: Propofol Sedation
Outcome Measures: airway complications;   subclinical respiratory depression;   satisfaction
10 Recruiting Esmolol Pretreatment on Pain During Injection of Propofol
Condition: Pain
Interventions: Drug: Normal saline;   Drug: Esmolol;   Drug: Remifentanil;   Drug: Propofol
Outcome Measure: Pain on injection of Propofol
11 Recruiting Non-anesthesiologist Administered Propofol Sedation for Colonoscopy - a Randomized Clinical Trial
Conditions: Digestive System Diseases;   Colonoscopy Sedation
Interventions: Drug: Non-anesthesiologist Propofol sedation;   Drug: Propofol sedation administered by an anesthesiologist;   Procedure: Colonoscopy
Outcome Measures: Minor adverse events;   Propofol dosage;   Patient satisfaction;   colonoscopy quality indicators;   Patient satisfaction 2
12 Recruiting Comparison of Propofol 1mg/kg and Propofol 0.5mg/kg for Prevention of Emergence Agitation in Children Undergoing Strabismus Surgery During Sevoflurane Anesthesia
Condition: Strabismus
Interventions: Drug: Injection of Propofol 1.0mg/kg;   Drug: Propofol 0.5mg/kg;   Drug: normal saline
Outcome Measures: The incidence of the emergence agitation;   the emergence time
13 Unknown  Safety and Efficacy of Propofol Only Sedation in Oral and Maxillofacial Surgery
Conditions: Procedural Sedation;   Propofol
Intervention: Drug: Propofol
Outcome Measures: Pre-Sedation Behavioral Sate;   Efficacy of Sedation;   Adverse outcome;   Adverse outcomes;   Patient Satisfaction;   Level of sedation;   Surgeon satisfaction
14 Unknown  Propofol and Remifentanyl Versus Midazolam and Fentanyl for Diagnostic Colonoscopy in Patients With Compensated Cirrhosis Child A-B
Condition: Liver Disease
Interventions: Drug: Propofol and Remifentnyl;   Drug: midazolam and fentanyl;   Drug: midazolam anf fentanyl
Outcome Measure: Safety and efficacy of Propofol in liver diseases
15 Unknown  Propofol Patient-controlled Sedation for Endoscopic Retrograde Cholangiopancreatography
Condition: Endoscopic Retrograde Cholangiopancreatography
Interventions: Drug: Propofol sedation by nurse anaesthestist;   Drug: Patient-controlled Propofol sedation
Outcome Measures: treatability;   safety
16 Unknown  Pharmacokinetics of Propofol in Morbidly Obese Patients
Condition: Obesity, Morbid
Intervention: Drug: Propofol
Outcome Measure: Propofol plasma concentrations
17 Unknown  Thiopental Versus Propofol During Magnetic Resonance Imagining in Children: Something Old, Something New
Condition: Complications
Intervention: Drug: Propofol and Thiopental
Outcome Measures: presedation behavior;   to determine optimal dose of Propofol and thiopental during MRI;   UMSS score;   Side effects of sedation;   recovery times
18 Recruiting The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane
Conditions: Cerebral Hypoxia;   Postoperative Cognitive Dysfunction
Interventions: Procedure: Propofol;   Procedure: sevoflurane
Outcome Measures: the change in jugular vein bulb oxygen saturation between Propofol and sevoflurane general anesthesia;   the incidence of postoperative cognitive disfunction(POCD)between Propofol and sevoflurane general anesthesia;   the change in the level of serum BDNF(brain-derived neurotrophic factor ) between Propofol and sevoflurane anesthesia;   the change in the level of serum s-100β between Propofol and sevoflurane anesthesia
19 Recruiting Post Anesthesia Emergence and Behavioral Changes in Children Undergoing MRI
Condition: Delirium on Emergence
Interventions: Drug: Propofol;   Drug: Sevoflurane;   Drug: Isoflurane
Outcome Measures: Incidence of delirium on emergence;   Incidence of airway complications
20 Unknown  Evaluation of Bacterial and Fungal Contamination During Propofol Continuous Infusion
Condition: Drug Contamination
Interventions: Drug: EDTA without re-filling;   Other: Propofol syringe re-filling with Propofol containing EDTA;   Other: Target controlled infusion of Propofol without EDTA;   Other: Re-filling of syringe with Propofol without EDTA
Outcome Measure: Existence of bacterial and/or fungal contamination during different technics of Propofol continuous infusion

These studies may lead to new treatments and are adding insight into Propo etiology and treatment.

A major focus of Propo research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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