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Pulmonary Embolism Medical Research Studies

Up-to-date List of Pulmonary Embolism Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Pulmonary Embolism Medical Research Studies

Rank Status Study
1 Recruiting Long Term Study Looking at the Effects of Treating Submassive Pulmonary Embolism With Ultra-sound Accelerated Thrombolysis
Condition: Treatment of Submassive Pulmonary Embolism
Intervention: Other: Ultra sound energy along with tPA to treat submassive Pulmonary Embolism
Outcome Measures: Change in Right Ventricular:Left Ventricular ratio;   recurrent pulmonary embolism
2 Unknown  Assessing the Prognosis of Pulmonary Embolism Using Clinical and Imaging Biomarkers (Retrospective & Prospective )
Condition: Pulmonary Embolism
Intervention:
Outcome Measures: The clinical and Imaging Biomarkers associated with Pulmonary Embolism (PE).;   Pulmonary Embolism (PE) risk prediction rule.
3 Recruiting Prospective Study on the Treatment of Unsuspected Pulmonary Embolism in Cancer Patients
Condition: Unsuspected Pulmonary Embolism
Intervention: Drug: Heparin, fondaparinux, vitamin-K antagonists, aspirin
Outcome Measures: Recurrent (symptomatic) vein thromboembolism, including Pulmonary Embolism and deep vein thrombosis;   Major, clinically relevant non-major bleeding, and minor bleeding
4 Recruiting Pulmonary Embolism and Stroke in Patient With Patent Foramen Ovale
Conditions: Recent Stroke;   Pulmonary Embolism;   Patent Foramen Ovale
Intervention:
Outcome Measure: Incidence of recent ischemic stroke in patients hospitalized for a recent Pulmonary Embolism with comparison in two groups with and without PFO
5 Recruiting Pulmonary Embolism Response to Fragmentation, Embolectomy, & Catheter Thrombolysis: PERFECT
Condition: Pulmonary Embolism
Intervention: Procedure: Catheter directed debulking of Pulmonary Embolus
Outcome Measures: Resolution of hypoxia;   Survival from acute PE;   Stabilization of hemodynamics;   Clinical practice patterns across centers
6 Recruiting Pulmonary Embolism Diagnosis: Ultrasound Wells Score vs Traditional Wells Score
Condition: Pulmonary Embolism
Intervention:
Outcome Measures: ultrasound Wells score vs traditional Wells score diagnostic performance.;   Failure rate and efficiency of traditional and US Wells
7 Unknown  Factor XIII and Pulmonary Embolism in Neurosurgical Patients
Conditions: Brain Tumor;   Vascular Lesion;   Factor XIII Deficiency;   Pulmonary Embolism
Intervention:
Outcome Measure: Incidence of Pulmonary Embolisms following Factor XIII substitution
8 Unknown  Compare Technegas Ventilation-Perfusion SPECT and Xenon Ventilation-Perfusion Planar Imaging for Pulmonary Embolism
Condition: Pulmonary Embolism
Interventions: Drug: Technegas V/Q SPECT;   Drug: Xenon-133
Outcome Measures: Sensitivity of Technegas V/Q SPECT for the diagnosis of PE;   Specificity of Technegas V/Q SPECT for the diagnosis of PE.;   Accuracy of Technegas V/Q SPECT and Xenon V/Q Planar imaging for diagnosis of PE;   Positive predictive value of imaging for diagnosis of PE;   Negative predictive value of imaging for diagnosis of PE;   Likelihood ratio for diagnosis of PE;   Safety of Technegas in patients with possible PE
9 Recruiting Frequency of Diagnostic Symptomatic Pulmonary Embolism's in Patients Hospitalized for Clinical Exacerbation of Chronic Obstructive Pulmonary Disease (COPD)
Conditions: Chronic Obstructive Pulmonary Disease;   Patients Hospitalized for a COPD Exacerbation
Intervention: Other: PEP
Outcome Measures: Frequency of Pulmonary Embolism in patients hospitalized for a clinical exacerbation of COPD.;   The rate of Pulmonary Embolism diagnosed during the 3 month follow-up in patients whom Pulmonary Embolism was initially excluded when they've been included in the study
10 Not yet recruiting Pulmonary Embolism and PCT. PE-PCT Study
Condition: Pulmonary Embolism With Pulmonary Infarction and Fever
Intervention: Procedure: Procalcitonin algorithm
Outcome Measures: Percentage of patient treated by antibiotics in each group;   Percentage of death;   Percentage of antibiotics stop;   Rate of new hospitalization during the following month
11 Recruiting Nitric Oxide to Treat Pulmonary Embolism
Condition: Pulmonary Embolism
Interventions: Drug: Nitric Oxide;   Drug: Oxygen
Outcome Measure: RV function and viability
12 Not yet recruiting Pulmonary Embolism as a Cause of COPD Exacerbations
Conditions: Pulmonary Embolism;   Chronic Obstructive Pulmonary Disease
Intervention: Procedure: Diagnostic and therapeutic strategy: Highly sensitive D-dimer testing and, if positive, multidetector computed tomographic pulmonary angiography (MDCT).
Outcome Measures: All-cause mortality, symptomatic venous thromboembolism recurrence, or need for readmission.;   All-cause mortality;   Symptomatic recurrent venous thromboembolism;   Hospitalization;   Major bleeding;   Clinically relevant non major bleeding;   Serious adverse events
13 Recruiting Age-adjusted D-dimer Cut-off Levels to Rule Out Pulmonary Embolism
Condition: Pulmonary Embolism
Intervention: Other: Evaluation of a modified DD cut-off to rule out PE
Outcome Measures: The main outcome is the rate of thromboembolic events during a formal 3-month follow-up in patients not anticoagulated on the basis of a PE ruled out by the association mentioned here above.;   Prospective validation of the simplified revised Geneva score.
14 Recruiting Comparison of Thrombgolytic and Anticoagulation Therapy in Submassive Pulmonary Embolism
Condition: Pulmonary Embolism
Interventions: Drug: Actilyse (Thrombolytic therapy);   Drug: Heparine (Standard anticoagulation therapy)
Outcome Measures: Clinical manifestations of right ventricular failure and pulmonary hypertension and cardiovascular-related death;   Pulmonary hypertension;   Cardiovascular-related deaths;   Echocardiographic manifestations of right ventricular failure and pulmonary hypertension.
15 Unknown  Pulmonary Embolism: Multifunctional Assessment of Prognosis
Condition: Pulmonary Embolism
Intervention:
Outcome Measure:
16 Unknown  Ruling Out Pulmonary Embolism During Pregnancy:a Multicenter Outcome Study
Conditions: Pulmonary Embolism;   Deep Vein Thrombosis
Intervention: Other: Pregnant patients with suspected PE will undergo a strategy based on clinical probability assessment, D-dimer, lower limb vein ultrasonography and MSCT.
Outcome Measures: Proportion of patients with a symptomatic thromboembolic event in the three month follow-up among those in whom PE was ruled out by the diagnostic strategy and who were left untreated by anticoagulants.;   Efficacy of non invasive testing;   Proportion of patients with a negative D-dimer result;   Proportion of patients with a lower limb venous ultrasound showing a proximal DVT
17 Not yet recruiting Diuretic Versus Placebo in Pulmonary Embolism
Condition: Pulmonary Embolism With Right Ventricle Enlargement
Interventions: Drug: Diuretics : Furosemide;   Drug: Placebo
Outcome Measures: Primary end point will be a combined clinical criterion, to reach the primary endpoint, patients have to meet all the following criteria: - Urine output> 0.5ml/kg/h - Normalization of clinical parameters of simplified PESI score;   patients have to meet all the four following criteria: - Urine output> 0.5ml/kg/h over 24 hours - Normalization of clinical parameters of simplified PESI score - Urine output;   - Composite criteria including death, need for catecholamine, cardiac arrest and mechanical ventilation during hospitalization and at 1 month from inclusion - NYHA score;   o RV/LV ratio and decrease from baseline o Systolic pulmonary pressure and decrease from baseline o Tricuspid annular plane systolic expansion (TAPSE) at o Tricuspid annular plane systolic expansion (TAPSE) variation from baseline;   - NT-proBNP or BNP decrease at 24hours - Creatinin and liver enzymes variations at 24hours
18 Recruiting Magnetic Resonance Imaging Combined With Venous Ultrasonography of the Legs for Pulmonary Embolism
Condition: Pulmonary Embolism
Intervention: Procedure: MRI combined with venous ultrasonography of the legs
Outcome Measures: To assess diagnostic performances of MRI combined with venous ultrasonography of the legs in reference to Multi-Detector Computed Tomography and 3 months clinical follow-up;   To assess the diagnostic accuracy of a strategy combining clinical probability, D-dimer measurement, MRI and venous ultrasonography of the legs for PE;   To assess diagnostic performances of each MRI sequence combined or not to venous ultrasonography of the legs in reference to Multi-Detector Computed Tomography and 3 months clinical follow-up;   inter-reader agreement for MRI
19 Unknown  Low Dose Rt-PA for Acute Normotensive Pulmonary Embolism With RVD
Conditions: Pulmonary Thromboembolisms;   Pulmonary Embolism
Interventions: Drug: Recombinant tissue plasminogen activator (rt-PA);   Drug: Low Molecular Weight Heparin
Outcome Measures: the composite end point of death from any cause or treatment failure,recurrence of VTE;   improvements of right ventricular functions on echocardiogram and pulmonary artery obstruction on CT angiographs;   serious life threatening bleeding such as cerebral hemorrhage and other major bleeding episodes;   clinical relevant non-major bleedings
20 Recruiting Multicenter, Nonrandomized, Prospective Study of Pulmonary Embolism Removal With the AngioJet 6F Ultra System
Condition: Pulmonary Embolism
Intervention: Device: AngioJet Ultra PE Thrombectomy System
Outcome Measure: RV to LV Ratio

These studies may lead to new treatments and are adding insight into Pulmonary Embolism etiology and treatment.

A major focus of Pulmonary Embolism research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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