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Racemic Medical Research Studies

Up-to-date List of Racemic Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Racemic Medical Research Studies

Rank Status Study
1 Recruiting CYP2B6 Polymorphisms in Methadone
Condition: Healthy Volunteers
Interventions: Drug: Racemic methadone HC1;   Drug: Oral deuterated Racemic methadone HCl,
Outcome Measures: The effects of methadone on healthy volunteers;   Methadone and bupropion concentration;   Methadone and bupropion clearance from the body;   Oral methadone and bupropion absorption;   Influence of CYP2B6*6 hetero or homozyge genotype on the above primary and secondary outcomes
2 Recruiting Efficacy of Chemotherapy, Associated to Either Cetuximab or Bevacizumab, in KRAS Wild-type Metastatic Colorectal Cancer Patients With Progressive Disease After Receiving First-line Treatment With Bevacizumab
Condition: Colorectal Cancer
Interventions: Drug: Oxaliplatin;   Drug: Folinic Acid;   Drug: 5-fluoro-uracil;   Drug: Irinotecan;   Drug: Bevacizumab;   Drug: Cetuximab
Outcome Measures: Progression-free survival (PFS) at 4 months;   Objective response rate (OR);   Progression-free survival (PFS);   Overall survival (OS);   Overall survival from the date of the first-line chemotherapy used on the metastatic disease;   Treatment tolerance;   Quality of life
3 Not yet recruiting Phase III, Evaluate Noninferiority Between Levobupivacaine and Bupivacaine in Spinal Anesthesia.
Condition: Orthopedic Disorder of Spine.
Interventions: Drug: Levobupivacaine;   Drug: Bupivacaine
Outcome Measures: Time of latency to achieve sensitive block of T10.;   Duration time of the sensory block of T10.;   Sensory block intensity.;   Motor block duration.;   Cardiovascular safety.;   Block failure.;   Adverse events.
4 Recruiting Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)
Conditions: Stress Disorders, Post-Traumatic;   PTSD;   Depression;   Anxiety Disorder
Interventions: Drug: Midazolam;   Drug: Ketamine
Outcome Measures: Impact of Event Scale - Revised (IES-R);   Clinician-Administered PTSD Scale (CAPS);   Quick Inventory of Depressive Symptomatology - Self Report (QIDS-SR);   Montgomery-Asberg Depression Rating Scale (MADRS);   Hopkins Verbal Learning Test (HVLT)
5 Recruiting CYP2B6 Polymorphisms in Ketamine
Condition: Healthy Volunteers
Intervention: Drug: ketamine
Outcome Measures: The effects of CYP2B6 genetic variants on ketamine metabolism and clearance by CYP2B6*6 hetero or homozygote genotype.;   ketamine concentration;   norketamine formation clearances and by genotype
6 Recruiting Trial Comparing Adjuvant Chemotherapy With Gemcitabine Versus mFolfirinox to Treat Resected Pancreatic Adenocarcinoma
Condition: Pancreatic Adenocarcinoma (Ductal Adenocarcinoma)
Intervention: Drug: Arm B : mFolfirinox
Outcome Measures: disease-free survival (DFS);   Overall survival;   Specific survival
7 Unknown  Study of Ketamine Administered Intravenously and by Sublingual Wafer
Condition: Pain
Intervention:
Outcome Measure:
8 Not yet recruiting The Effect and Safety of Low Dose Nebulized Epinephrine in Croup
Conditions: Croup;   Epinephrine Neublizer Treatment
Interventions: Drug: conventional dose epinephrine;   Drug: low dose epinephrine
Outcome Measures: the difference of Westley croup score between baseline and 30 minutes after neublized treatment;   the incidence of use of additional neublized treatment;   Westley croup score;   the side effect of epinephrine;   respiratory rate, oxygen saturation;   health care utilization- length of stay in emergency department, admission rate, revisit dut to croup symptom;   treatment failure;   rebound effect
9 Recruiting MEGA (Met or EGFR Inhibition in Gastroesophageal Adenocarcinoma): FOLFOX Alone or in Combination With AMG 102 or Panitumumab as First-line Treatment in Patients With Advanced Gastroesophageal Adenocarcinoma
Conditions: Malignant Neoplasm of Esophagus;   Malignant Neoplasm of Stomach
Interventions: Drug: Oxaliplatin;   Drug: Folinic Acid;   Drug: 5-fluoro-uracil;   Drug: panitumumab;   Drug: AMG102
Outcome Measures: Progression-free survival at 4 months;   Progression-free survival;   Overall survival;   Time to progression;   Objective tumor response rate (OR) (= complete responses [CR] + partial responses [PR]) according to RECIST V1.1;   Objective response duration;   Disease control rate (Complete Response + Partial Response + stable disease [SD]);   Tolerance of the treatment
10 Recruiting Heated High Flow Oxygen Use in Infants With Bronchiolitis and Hypoxia
Conditions: Bronchiolitis;   Hypoxia
Intervention: Procedure: Oxygen delivery
Outcome Measures: CSS Scores;   PEWS Score
11 Unknown  Randomized Controlled Trial Comparing Standard Versus Positive Pressure Nebulization in Infants With Bronchiolitis to Reduce Hospital Admissions
Condition: Bronchiolitis
Interventions: Device: Positive Airway Pressure nebulization;   Device: Standard passive nebulization of respiratory medications
Outcome Measures: Hospitalization Rates;   Change in bronchiolitis Score;   Change in Oxygen Saturation;   Intensive Care Unit Admission Rate;   Length of Stay;   Unscheduled Return to the Emergency Department
12 Recruiting An Observational Study to Evaluate the Safety and Efficacy of FOLFIRI / FOLFOX Plus Cetuximab as First-line Therapy in Patients With KRAS Wild-type Metastatic Colorectal Cancer
Condition: Colorectal Neoplasms
Intervention: Drug: Cetuximab
Outcome Measures: Safety and tolerability evaluated based on the incidence and severity of AEs.;   Response rate
13 Recruiting Pilot Study: Lipoic Acid and Omega-3 Fatty Acids for Alzheimer's Prevention
Condition: Treated Hypertension
Intervention: Drug: Lipoic Acid plus Omega-3 Fatty Acids
Outcome Measures: Trails Making Test Part B (executive function);   white matter hyperintensity volume (brain MRI)
14 Not yet recruiting Home Oxygen Therapy in Bronchiolitis
Condition: Bronchiolitis
Intervention: Other: Oxygen Therapy
Outcome Measures: Home oxygen therapy in the ambulatory treatment of bronchiolitis;   daycare(patients) and work (parents) lost because of the illness.
15 Recruiting Intravenous Ketamine in the Treatment of Obsessive-Compulsive Disorder
Condition: Obsessive Compulsive Disorder
Interventions: Drug: Ketamine;   Drug: Midazolam
Outcome Measures: Change in Y-BOCCS from baseline to 24-hours after ketamine administration;   Percentage of patients who meet response and remission
16 Recruiting Colorectal Cancer (CRC) Cetuximab Elderly Frail
Condition: Colorectal Cancer Metastatic
Interventions: Drug: Cetuximab;   Drug: 5-fluorouracil;   Drug: leucovorin
Outcome Measures: Progression free survival;   Overall Survival;   Response Rate;   Change in Instrumental Activities of Daily Living (IADL) score;   Change in G8 geriatric assessment screening tool;   Change in social situation;   Score of Quality of Life (EORTC-QLQ C30 and QLQ-ELD14);   Occurrence of adverse events;   Health Economy assessments;   Score of elderly minimal dataset comprehensive geriatric assessment (EMDCGA), as evaluated by G8 instrument;   Score of elderly minimal dataset comprehensive geriatric assessment (EMDCGA), as evaluated by Instrumental Activities of Daily Life (IADL) questionnaire;   Score of elderly minimal dataset comprehensive geriatric assessment (EMDCGA), as evaluated by social situation questionnaire
17 Not yet recruiting Lipoic Acid and Omega-3 Fatty Acids for Cognitive Impairment in Multiple Sclerosis
Conditions: Multiple Sclerosis;   Cognition
Interventions: Drug: Alpha lipoic acid and omega-3 fatty acids;   Drug: Placebo
Outcome Measure: Cognitive Test
18 Recruiting Methylphenidate as Treatment Option of Fatigue in Multiple Sclerosis
Conditions: Multiple Sclerosis;   Fatigue
Interventions: Drug: Methylphenidate modified release;   Drug: Maltodextrin
Outcome Measures: Change of Fatigue as measured by Fatigue Severity Scale;   Change of Fatigue as measured by Modified Fatigue Impact Scale (MFIS)

These studies may lead to new treatments and are adding insight into Racemic etiology and treatment.

A major focus of Racemic research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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