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Relistor Medical Research Studies

Up-to-date List of Relistor Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Relistor Medical Research Studies

Rank Status Study
1 Recruiting Methylnaltrexone Pharmacokinetics in Neurointensive Care Patients
Condition: Opioid Use, Unspecified With Other Opioid-induced Disorder
Intervention: Drug: Methylnaltrexone
Outcome Measure: Pharmacokinetic parameters of methylnaltrexone (Cmax, tmax, area under the curve, total clearance, halflife, accumulation ratio, renal clearance)
2 Recruiting Methylnaltrexone for Opioid Induced Constipation
Condition: Constipation
Intervention: Drug: methylnaltrexone
Outcome Measures: Rescue-free laxation response;   Time to first laxation;   Number of laxations;   Laxation within 4 hours;   laxation within 4 hours after each dose;   laxation within 24 hours after each dose;   laxation within 4 hours after 4 out of 7 doses
3 Unknown  Methylnaltrexone for Treatment of Opiate-Induced Constipation in the Intensive Care Unit
Condition: Opioid-induced Constipation
Interventions: Drug: Methylnaltrexone Bromide;   Drug: Placebo-Normal Saline
Outcome Measures: A significantly higher incidence of a rescue free laxation with methylnaltrexone within 4 hours +- 45 minutes.;   Decreased need for rescue medications to have a bowel movement in the treatment arm vs placebo.
4 Unknown  Effect of Methylnaltrexone (Relistor) on Digestion and Tolerance to Tube Feeding in Patients Treated With Opiates
Condition: Tube Feeding
Interventions: Drug: Methylnaltrexone;   Drug: Saline injection
Outcome Measures: Hydrogen breath test measure of bowel transit;   Gastric residual volume measurement
5 Recruiting Methylnaltrexone Use for Opioid-induced Postoperative Constipation
Condition: Constipation
Interventions: Drug: Methylnaltrexone;   Drug: Senna, docusate sodium, bisacodyl, magnesium hydroxide, Miralax
Outcome Measures: reduction of post-operative opioid induced constipation;   time to ambulation in post-operative pediatric spinal fusion patients
6 Unknown  Study Evaluating The Safety Of Subcutaneous Methylnaltrexone In Treatment Of Opioid-Induced Constipation
Condition: Opioid-Induced Constipation
Intervention: Drug: Methylnaltrexone bromide
Outcome Measures: Collection of adverse events, vital sign measurements, and laboratory assessments.;   No secondary endpoints
7 Recruiting Dasatinib, Bevacizumab, Paclitaxel in Patients With Advanced Malignancies
Condition: Advanced Cancer
Interventions: Drug: Dasatinib;   Drug: Bevacizumab;   Drug: Paclitaxel
Outcome Measure: Maximum Tolerated Dose (MTD) of Dasatinib, Bevacizumab and Paclitaxel + or - Methylnaltrexone

These studies may lead to new treatments and are adding insight into Relistor etiology and treatment.

A major focus of Relistor research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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