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Renal Failure Acute Medical Research Studies

Up-to-date List of Renal Failure Acute Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Renal Failure Acute Medical Research Studies

Rank Status Study
1 Recruiting Sodium Bicarbonate to Prevent Acute Kidney Injury in Children Undergoing Cardiac Surgery
Conditions: Acute Kidney Injury;   Congenital Heart Disease
Interventions: Drug: Sodium Bicarbonate;   Drug: Sodium Chloride
Outcome Measures: Acute Kidney Injury;   Duration of acute kidney injury;   Cumulative fluid balance;   Hospital and intensive care unit length of stay;   Need for dialysis;   Incidence of acute kidney injury according to changes in serum NGAL.;   Length of mechanical ventilation;   Change in acid-base status
2 Recruiting L-Arginine, Symmetrical and Asymmetrical Dimethylarginine (SDMA/ADMA) in Acute Kidney Injury (AKI)
Condition: Acute Kidney Injury
Outcome Measures: Difference in serum ADMA level between acute kidney injury and renal recovery;   Difference in serum SDMA level between acute kidney injury and renal recovery;   Associations between ADMA/SDMA serum level and all cause mortality;   Associations between ADMA/SDMA serum level and parameters of arterial stiffness;   Associations between ADMA/SDMA serum level and parameters of renal function
3 Recruiting Predicting Acute Kidney Injury After Coronary Artery Bypass Graft
Conditions: Coronary Artery Bypass Surgery;   Acute Kidney Injury;   Creatinine;   Mortality
Intervention: Procedure: Coronary artery bypass surgery
Outcome Measures: Acute kidney injury diagnosis defined by RIFLE criteria;   Acute kidney injury as defined by AKIN (acute kidney injury network) criteria
4 Recruiting Establish and Apply the Evaluation System of Ultrasonic Integrated Technology for Prevention and Treatment of Acute Kidney Injury
Condition: Acute Kidney Injury
Intervention: Other: kidney ultrasound
Outcome Measure: compare the results of kidney ultrasound with biomarkers of acute kidney injury
5 Not yet recruiting Pharmacokinetic Study of 48-hour Sevoflurane Inhalation Using a Disposable Delivery System (AnaConDa©) in ICU Patients With Acute Kidney Injury
Condition: Acute Kidney Injury
Intervention: Drug: Sedation with sevoflurane during 48-hr in ICU
Outcome Measures: Determination of plasmatic concentrations of sevoflurane before using AnaConda® system;   Determination of plasmatic concentrations of HFIP and fluoride
6 Recruiting Inferior Vena Cava (IVC) Size in Acute Renal Failure
Condition: Acute Renal Failure
Intervention: Other: Ultrasound for measurement of Inferior Vena Cava size.
Outcome Measures: percentage of patients with improved Creatinine level in group 1 and 2;   glomerular filtration rate (GFR), changes in hemodynamic parameters (mean arterial blood pressure, urine output, pressors requirement )and Partial oxygen pressure (PO2) /Fio2 in group 1 and group 2
7 Unknown  Neutrophil Gelatinase-Associated Lipocalin: Biomarker of Acute Kidney Injury After Cardiac Surgery
Condition: Early Acute Kidney Injury
Outcome Measure: Evaluate the urinary excretion of NGAL as a marker of early development of acute kidney injury in patients undergoing cardiac surgery
8 Recruiting PRevention of Acute Kidney Injury Initiated With Electronic Surveillance Enhancement
Condition: Acute Kidney Injury
Interventions: Other: Conventional management arm;   Other: AKI sniffer instigated AKI management
Outcome Measure: Change in acute kidney injury as measured by the Acute Kidney Injury Network Staging System
9 Recruiting Early Goal Directed Therapy for Acute Kidney Injury
Condition: Kidney Injury, Acute
Intervention: Procedure: Early goal directed therapy during 6 hours after occurence of the early phase of acute kidney injury
Outcome Measures: Observation of acute kidney injury;   Organ failure during first 48 hours and during stay on intensive care unit;   Duration of stay on intensive care unit and in hospital;   Mortality during stay on intensive care unit
10 Recruiting Exploring the Relationship Among BNP, Fluid Status and Acute Kidney Injury in Critically Ill Patients
Condition: Acute Kidney Injury (Nontraumatic)
Outcome Measures: Change from Baseline in serum creatinine level at 3 months;   Mortality
11 Recruiting Viral Illness in Pediatric Critical Care: Incidence Timing & Severity of Associated Heart Dysfunction & Acute Kidney Injury
Conditions: Heart Failure;   Acute Kidney Injury
Outcome Measures: Myocardial dysfunction, as defined by a low ejection fraction on an Echocardiogram.;   Acute Kidney Injury (AKI) as defined by the meeting of the pediatric RIFLE criteria.
12 Recruiting Acute Kidney Injury Following Paediatric Cardiac Surgery
Condition: Acute Kidney Injury
Intervention: Procedure: cardiac surgery
Outcome Measures: change from baseline in annexin V positive microvesicles;   change from baseline in microvesicles derived miRNA;   Eligibility;   Recruitment;   Protocol non-adherence;   Acute Kidney Injury;   Variation in Renal inflammation;   Incidence of Acute Lung Injury - Low Cardiac Output;   Incidence of Low Cardiac Output;   Variation in pro-coagulant potential of microvesicles;   Variations in sources of microvesicles;   Variations in systemic inflammatory cytokine response
13 Recruiting A Study of THR-184 in Patients at Risk of Developing Cardiac Surgery Associated-Acute Kidney Injury (CSA-AKI)
Condition: Acute Kidney Injury
Intervention: Drug: THR-184
Outcome Measures: Incidence of acute kidney injury (AK);   Duration, severity, and incidence (SCr based) of AKI
14 Unknown  The Use of Nesiritide in Thoracic Aneurysm Repair to Prevent Acute Renal Failure
Conditions: Cardiovascular Disease;   Acute Renal Failure;   Death
Intervention: Drug: Nesiritide
Outcome Measures: Need for dialysis and/or mortality;   Rise in serum creatinine;   blood urea nitrogen
15 Recruiting Acute Kidney Injury Biomarkers: Diagnosis and Application in Pre-operative Period of Liver Transplantation
Condition: Liver Transplantation
Outcome Measures: Development of Acute Kidney Injury based on novel biomarkers;   Short and long term renal outcomes;   Association of urine chemistry and microscopy to predict acute kidney injury
16 Unknown  Evaluating Novel Biomarkers in Acute Kidney Injury
Condition: Acute Kidney Injury
Interventions: Other: Proteomic assay;   Other: Blood sampling;   Other: Biomarker sampling
Outcome Measure: Development of acute kidney injury
17 Recruiting Incidence, Risk Factors, and Risk Model of Acute Kidney Injury in Pediatric Patients Who Undergoing Surgery for Congenital Heart Disease
Condition: Patients Undergoing Surgery for Congenital Heart Disease
Intervention: Procedure: surgery for congenital heart disease
Outcome Measures: acute kidney injury diagnosis defined by RIFLE criteria;   Acute kidney injury as defined by AKIN (acute kidney injury network) criteria
18 Recruiting Mesenchymal Stem Cells In Cisplatin-Induced Acute Renal Failure In Patients With Solid Organ Cancers
Conditions: Solid Tumors;   Acute Kidney Injury
Intervention: Biological: Mesenchymal stromal cell infusion
Outcome Measures: Serum creatinine concentration.;   Neutrophil gelatinase-associated lipocalin (NGAL);   N-acetyl-p- D glucosaminidase enzyme (NAG)
19 Unknown  Study of Heat Shock Proteins as Prognostic Factor of Acute Renal Failure in Children (HSP-Study)
Condition: Kidney Failure, Acute
Outcome Measure: Acute renal failure.
20 Recruiting Impact of CVVHD With Increased Adsorption Membranes in Septic Acute Kidney Injury
Conditions: Severe Sepsis;   Septic Shock;   Acute Kidney Injury
Interventions: Other: CVVHD;   Other: CVVH
Outcome Measures: Non survival inferiority;   Immunomodulating capacity;   Renal depuration capacity.;   Hemodynamics and respiratory variations.;   Technical CRRT efficiency;   Clinical efficiency;   Safety technical superiority.

These studies may lead to new treatments and are adding insight into Renal Failure Acute etiology and treatment.

A major focus of Renal Failure Acute research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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