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Restlessness Medical Research Studies

Up-to-date List of Restlessness Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Restlessness Medical Research Studies

Rank Status Study
1 Not yet recruiting Vasculaire Leg Compression Device for the Treatment of Restless Legs Syndrome - A Prospective Clinical Study
Conditions: Restless Legs Syndrome,;   Restless Legs,;   Ekbom Syndrome
Intervention: Device: Venous Health Systems Vasculaire Leg Compression Device
Outcome Measures: The Restless Legs Syndrome Rating Scale;   The Restless Legs Syndrome-Quality of Life Instrument (RLS-QLI);   The Epworth Sleepiness Scale (ESS);   The Johns Hopkins Restless Legs Severity Scale (JHRLS);   The International Restless Legs Syndrome Rating Scale
2 Not yet recruiting Ketamine Versus Haloperidol for Severe Agitation Outside the Hospital
Condition: Agitation
Interventions: Drug: Ketamine;   Drug: Haloperidol
Outcome Measures: Time from injection of drug to adequate sedation, defined as a score of 0 or less on the AMSS.;   Number of participants intubated.;   venous pH;   serum potassium;   Total time the participant is a patient in the Emergency Department.;   Number of patients admitted versus number of patients discharged.;   venous lactate;   Number of patients experiencing laryngospasm.;   Number of patients experiencing dystonia.
3 Not yet recruiting Effect of Deksmedetomidine and Remifentanil in Extubation Agitation
Condition: Agitation
Interventions: Drug: deksmedetomidine;   Drug: Remifentanil;   Drug: Saline
Outcome Measures: To asses postoperative agitation score by Riker sedation agitation scale;   Yo asses postoperative side effects emesis, vomitting or pain
4 Unknown  Pre-hospital Agitation and Sedation Trial: A Randomized Controlled Trial of Haloperidol Versus Midazolam for the Sedation of the Agitated Patient
Condition: Agitation
Interventions: Drug: Haloperidol;   Drug: Midazolam
Outcome Measure: Time to sedation
5 Recruiting Loxapine in the Management of Restlessness During Mechanical Ventilation Weaning
Condition: Restlessness
Interventions: Drug: loxapine;   Drug: Placebo
Outcome Measures: Weaning period;   total duration of mechanical ventilation;   incidence of unexpected extubations;   clinical and biological respiratory parameters;   incidence of mechanical ventilation related complications;   incidence of adverse events, related and non related to the treatment;   mortality rate;   factors associated to weaning failure
6 Recruiting Stress Biomarkers Among Patients Undergoing Treatment for Excited Delirium and Severe Pain in the Emergency Department
Conditions: Agitation;   Excited Delirium;   Pain
Intervention:
Outcome Measures: Change in Altered Mental Status Score;   Change in Visual Analog Scale Pain Score;   Change in Serum Total Catecholamines;   Length of Hospital Stay;   Mortality;   Complications;   Change in Heart Rate;   Change in Systolic Blood Pressure;   Change in Mean Arterial Pressure;   Disposition;   Change in Body Temperature;   Change in end tidal carbon dioxide;   Change in Oxygen Saturation
7 Recruiting Reducing Agitation in People With Dementia: the Customized Activity Trial
Condition: Dementia
Interventions: Behavioral: Tailored Activity Program;   Other: Home Safety and Education Program
Outcome Measures: Frequency of Agitated Behavior in person with dementia;   Frequency of agitated behaviors and quality of life in person with dementia;   Caregiver wellbeing and time spent providing care;   Cost effectiveness
8 Unknown  The Effect of Intramuscular Dexmedetomidine on Emergence Agitation in Children Undergoing With or Without Tube Insertion Under General Anesthesia
Condition: Myringotomy
Intervention: Drug: Dexmedetomidine
Outcome Measures: Participant's Severity of Emergent Agitation (EA) using the Pediatric Anesthesia Emergence Delirium (PAED) scale in PACU (Post-Op Area).;   Participant's Severity of Emergent Agitation (EA) in PACU (Post-Op Area) through Day 3 Post-Op using the Postanesthesia Discharge Scoring System (PADSS) score.;   Participant's Severity of Emergent Agitation (EA) in PACU (Post-Op Area) through Day 3 Post-Op using the PADSS score.
9 Recruiting Blinded, Randomized Study of Gabapentin (Neurontin®) and Gabapentin Enacarbil (Horizant™) in Restless Leg Syndrome
Condition: Restless Leg Syndrome
Interventions: Drug: Gabapentin immediate release (Neurontin);   Drug: Gabapentin enacarbil extended release (Horizant)
Outcome Measures: International Restless Leg Syndrome Rating Scale (IRLS);   Restless Leg Syndrome Quality of Life Scale (RLSQoL)
10 Recruiting Safety and Tolerability Study of Flexible Dosing of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type
Conditions: Agitation Associated With;   Alzheimer's Disease;   Alzheimer's Type;   Mental Disorder;   Nervous System Diseases
Intervention: Drug: Brexpiprazole, OPC-34712
Outcome Measures: Change in the Cohen-Mansfield Agitation Inventory (CMAI) total score;   Change in the Clinical Global Impression Severity of Illness (CGI-S) score, as related to symptoms of agitation
11 Recruiting A Study of Three Fixed-doses of Brexpiprazole in the Treatment of Subjects With Agitation Associated With Dementia of the Alzheimer's Type
Conditions: Agitation Associated With;   Alzheimer's Disease;   Alzheimer's Type;   Mental Disorder;   Nervous System Diseases
Intervention: Drug: Brexpiprazole, OPC-34712
Outcome Measures: The primary outcome is the change in the Cohen-Mansfield Agitation Inventory (CMAI) total score;   The secondary outcome is the change in the Clinical Global Impression-Severity of Illness (CGI-S) score, as related to symptoms of agitation
12 Unknown  Restless Legs Syndrome With Iron Deficiency or Anaemia in the 3rd Trimester of Pregnancy
Conditions: Restless Leg Syndrome;   Iron Deficiency Anemia
Intervention: Drug: ferric carboxymaltose
Outcome Measures: Primary endpoint: = 50% reduction of RLS symptoms as measured by International Restless Legs Study Group (IRLSS);   Reduction of Periodic Limb Movements in Sleep (PLMS) ≥50% as measured with actimetry;   Improvement of sleep according to the Pittsburgh Sleep Quality Questionnaire (PSQI);   Improvement of sleepiness using Epworth Sleepiness Scale (ESS);   Improvement of fatigue using Fatigue Severity Scale (FSS);   Safety of ferric carboxymaltose during pregnancy in the 3rd trimester;   Parameters of the newborn baby (apgar, umbilical artery pH, weight, mode of delivery)
13 Unknown  Treatment Routes for Exploring Agitation
Conditions: Dementia;   Behavior Problems
Interventions: Behavioral: TREA (Treatment Routes for Exploring Agitation);   Behavioral: Placebo Control Group
Outcome Measures: Agitation Behavior Mapping Instrument (ABMI);   affect/mood measured by Lawton's behavior stream assessment
14 Recruiting Dexmedetomidine to Prevent Agitation After Free Flap Surgery
Conditions: Agitation;   Delirium
Interventions: Drug: Dexmedetomidine;   Drug: Saline placebo
Outcome Measures: agitation in PACU;   postoperative delirium
15 Recruiting Can Acetaminophen Given 1-2 Hours to Children Before Ear Tube Surgery Reduce Agitation After Anesthesia?
Conditions: Emergence Agitation;   Pain
Intervention: Drug: Acetaminophen
Outcome Measures: Emergence Agitation;   Pain
16 Recruiting Restless Leg Syndrome and Severe Preeclampsia
Conditions: Restless Leg Syndrome;   Severe Preeclampsia
Intervention:
Outcome Measure: Restless Leg Syndrome
17 Unknown  Neuroma Injections to Treat Restless Legs Syndrome - RCT
Condition: Restless Legs Syndrome
Interventions: Drug: equal parts of 0.5% plain Marcaine and 2% lidocaine mixed with 0.8 mg Depo-medrol/4% absolute alcohol in a total injection volume of 1 ml;   Drug: Normal saline - 1ml
Outcome Measure: International Restless Legs Rating Scale
18 Recruiting Investigation of Efficacy of incobotulinumtoxinA (Xeomin) in Relieving Symptoms of Restless Leg Syndrome.
Condition: Restless Leg Syndrome
Interventions: Drug: incobotulinumtoxinA;   Drug: Placebo
Outcome Measures: Restless Leg Syndrome Rating Scale;   Epworth Sleep Scale
19 Recruiting Probiotics in the Treatment of Iron Deficiency in Children With Restless Leg Syndrome
Conditions: Iron Deficiency;   Restless Leg Syndrome
Interventions: Dietary Supplement: Probiotics;   Dietary Supplement: Placebo
Outcome Measures: Change in Ferritin and CRP Levels;   Restless Leg Questionnaire
20 Unknown  IM Olanzapine Versus IM Haloperidol Plus Lorazepam for Acute Agitation in Schizophrenia
Conditions: Schizophrenia;   Schizoaffective Disorder;   Agitation
Interventions: Drug: IM olanzapine;   Drug: haloperidol plus lorazepam IM
Outcome Measures: Positive and Negative Symptom Scale Excited Component (PANSS-EC);   Agitation-Calmness Evaluation Scale (ACES)

These studies may lead to new treatments and are adding insight into Restlessness etiology and treatment.

A major focus of Restlessness research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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