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Riociguat Medical Research Studies

Up-to-date List of Riociguat Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Riociguat Medical Research Studies

Rank Status Study
1 Not yet recruiting Prospective, Non-interventional, Multi-center Post-authorization Safety Study of Riociguat for Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Condition: Hypertension, Pulmonary
Intervention: Drug: Riociguat (ADEMPAS, BAY63-2521)
Outcome Measures: Number of participants with treatment emergent adverse events and adverse drug reactions;   Change in 6-Minute Walking Distance;   Time to Clinical Worsening
2 Not yet recruiting Efficacy Study of Riociguat and Its Effects on Exercise Performance and Pulmonary Artery Pressure at High Altitude
Conditions: Hypertension, Pulmonary;   Altitude Sickness
Intervention: Drug: Riociguat
Outcome Measures: Change from Baseline in Pulmonary Artery Pressure;   Change from Baseline in Radial Arterial Pressure;   Change from Baseline in Arterial Oxygen Saturation (PaO2);   Change from Baseline in Ventilation Rate;   Change from Baseline in Work Rate at Exhaustion;   Change from Baseline in Cardiac Output
3 Recruiting Riociguat Clinical Effects Studied in Patients With Insufficient Treatment Response to Phosphodiesterase-5 Inhibitor
Condition: Hypertension, Pulmonary
Intervention: Drug: Riociguat (Adempas, BAY63-2521)
Outcome Measures: Change from baseline in 6 minute walking distance;   Change in cardiac index;   Change in N-terminal pro-brain natriuretic peptide;   Change in World Health Organization functional class;   Proportion of patients with clinical worsening;   Change in quality of life (Qol) (EuroQol questionnaire)
4 Not yet recruiting BAY63-2521,Oral Contraceptiva Drug Interaction Study
Condition: Drug Interactions
Interventions: Drug: Mycrogynon;   Drug: Riociguat (Adempas,BAY63-2521)
Outcome Measures: Area under the plasma concentration time curve (AUC) of Ethinylestradiol (EE);   Area under the plasma concentration time curve (AUC) of Levonorgestrel (LNG);   Maximal concentration (Cmax) of Ethinylestradiol (EE);   Maximal concentration (Cmax) of Levonorgestrel (LNG);   Number of participants with adverse events as a measure of safety and tolerability
5 Not yet recruiting Early Signs of Efficacy Study With Riociguat in Adult Homozygous Delta F508 Cystic Fibrosis Patients
Condition: Cystic Fibrosis
Interventions: Drug: Riociguat (Adempas, BAY63-2521);   Drug: Placebo
Outcome Measures: Change of sweat chloride content from baseline to day 14;   Change of sweat chloride content from baseline to day 28
6 Recruiting Relative Bioavailability Study
Condition: Healthy Volunteers
Intervention: Drug: Riociguat(Adempas,BAY63-2521)
Outcome Measures: Pharmacokinetics of Riociguat in plasma by Area under the plasma concentration time curve (AUC);   Pharmacokinetics of Riociguat in plasma by maximal concentration (Cmax);   Number of participants with adverse events as a measure of safety and tolerability
7 Not yet recruiting Pilot Study to Evaluate Right Ventricular Function With Riociguat in CTEPH
Condition: Chronic Thromboembolic Pulmonary Hypertension
Intervention: Radiation: Cardiac PET imaging using F-18-FDG, N-13 ammonia( NH3)
Outcome Measures: Evidence of changes in glucose metabolism and myocardial RV blood flow in patients treated with Riociguat using PET imaging.;   Evidence of improved RV function and volumes using 3D echocardiography and magnetic resonance imagining (MRI)
8 Available Riociguat in Patients With Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
Condition: Hypertension, Pulmonary
Intervention: Drug: Adempas (Riociguat, BAY63-2521)
Outcome Measure:
9 Recruiting EXPERT, EXPosurE Registry Riociguat in Patients With Pulmonary Hypertension
Condition: Hypertension, Pulmonary
Intervention: Drug: Riociguat(BAY63-2521)
Outcome Measures: Number of adverse events/ serious adverse events;   all-cause mortality;   Number of adverse event (AE) and serious adverse event(SAE) in the different pulmonary hypertension(PH) indications (pulmonary arterial hypertension (PAH) chronic thromboembolic pulmonary hypertension(CTEPH);   6 minute walking tes;   Number of hospitalization/outpatient visits
10 Recruiting Efficacy and Safety of Riociguat in Patients With Symptomatic Pulmonary Hypertension (PH) Associated With Idiopathic Interstitial Pneumonias (IIP)
Condition: Idiopathic Interstitial Pneumonias / Hypertension,Pulmonary
Interventions: Drug: Adempas, Riociguat (BAY63-2521);   Device: Placebo
Outcome Measures: The mean change in 6 minute walking distance;   Time to clinical worsening is a composite endpoint. The composite is made up of 4 components - Time to all-cause mortality, - Time to worsening of WHO FC, - Time to 15% decrease in 6MWD, - Time to hospitalization;   Number of participants with adverse events as a measure of safety and tolerability    
11 Not yet recruiting MOTION, Measuring Outcomes in Treatment Naive Patients
Condition: Pulmonary
Intervention: Drug: Riociguat (Adempas,BAY63-2521)
Outcome Measures: Living with Pulmonary Hypertension questionaire(LPH);   Work Limitations Questionnaire-8;   Short Form-12 questionnaire;   Living with Pulmonary Hypertension Questionnarie;   Modified Borg Dyspnea Index;   6- minutes walk distance;   WHO Functional Class;   Safety including adverse events
Conditions: Pulmonary Arterial Hypertension (PAH);   Pulmonary Hypertension (PH)
Outcome Measure:

These studies may lead to new treatments and are adding insight into Riociguat etiology and treatment.

A major focus of Riociguat research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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