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Rocephin Medical Research Studies

Up-to-date List of Rocephin Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Rocephin Medical Research Studies

Rank Status Study
1 Unknown  Moxifloxacin Versus Ceftriaxone in the Treatment of Primary Pyogenic Liver Abscess
Condition: Liver Abscess
Interventions: Drug: Moxifloxacin (Avelox);   Drug: ceftriaxone (Rocephin/Cefin)
Outcome Measures: Treatment efficacy;   Clinical response;   Clinical and radiological response;   All cause mortality;   Mortality attributable to liver abscess during treatment;   Rates of complication (metastatic infections to the central nervous system and/or eyes);   Rates of gastrointestinal colonization of Klebsiella pneumoniae in patients and rates of resistance post-antibiotic use.
2 Unknown  A Placebo-controlled Efficacy Study of IV Ceftriaxone for Refractory Psychosis
Conditions: Psychosis;   Schizophrenia;   Schizoaffective Disorder
Interventions: Drug: ceftriaxone;   Drug: Normal Saline
Outcome Measures: PANNS Score (Total and Positive Symptom);   MR Spectroscopy;   MATRICS;   SAPS/SANS;   Hamilton Depression Scale;   Side Effect Checklist;   Hamilton Anxiety Scale;   MMSE;   CDSS;   CGI Change;   YMRS
3 Unknown  The Role of Short-course Ceftriaxone Therapy in the Treatment of Severe Nontyphoidal Salmonella Enterocolitis
Condition: Diarrhea
Intervention: Drug: ceftriaxone
Outcome Measures: To evaluate if short-course of ceftriaxone therapy could shorten the clinical courses of severe NTS enterocolitis in children and the excretion of Salmonella in feces.;   PCR detection will be used for Salmonella in stool samples.
4 Recruiting Pharmacological Study of High Doses of Ceftriaxone in Meningitidis
Conditions: Meningitis;   Neurological Infections
Intervention: Drug: Ceftriaxone treatment
Outcome Measures: plasmatic concentration of ceftriaxone, measured at the steady state (after 48 hours of treatment at least).;   Neurological troubles;   clinical evolution
5 Unknown  Doxycycline and Ceftriaxone in Suspected Early Lyme Neuroborreliosis
Condition: Suspected Early Lyme Neuroborreliosis
Interventions: Drug: doxycycline;   Drug: ceftriaxone
Outcome Measure: Objective sequelae and post-treatment subjective symptoms in patients treated for suspected early Lyme neuroborreliosis with normal CSF cell count with doxycycline or ceftriaxone for 14 days.
6 Recruiting Comparison of Delafloxacin Versus Ceftriaxone for the Treatment of Uncomplicated Gonorrhea
Condition: Gonorrhea
Interventions: Drug: delafloxacin;   Drug: ceftriaxone
Outcome Measures: Microbiological outcome of urogenital gonorrhea;   Microbiological response at all anatomical sites;   Resolution of signs and symptoms
7 Recruiting Antibiotic Treatment of Multiple Erythema Migrans
Condition: Multiple Erythema Migrans
Interventions: Drug: ceftriaxone;   Drug: doxycycline;   Other: erythema migrans patients treated with doxycycline
Outcome Measures: Objective sequelae and post-treatment subjective symptoms such as fatigue, malaise, arthralgias, headache, myalgias, paresthesias, dizziness, or irritability in patients treated for multiple erythema migrans with ceftriaxone or doxycycline for 15 days.;   Comparison of subjective symptoms such as fatigue, malaise, arthralgias, headache, myalgias, paresthesias, or irritability between patients treated with antibiotic for multiple erythema migrans and control subjects without a history of Lyme borreliosis.;   Objective sequelae and post-treatment subjective symptoms such as fatigue, malaise, arthralgias, headache, myalgias, paresthesias, dizziness, or irritability in patients with solitary versus multiple erythema migrans after antibiotic treatment.
8 Not yet recruiting Comparisons of Intravenous Ceftriaxone With Intravenous Moxifloxacin in ERCP
Condition: Cholangitis
Interventions: Drug: Moxifloxacin;   Drug: ceftriaxone
Outcome Measures: cholangitis;   30 day mortality
9 Unknown  Ceftriaxone in the Management of Bipolar Depression
Condition: Bipolar Depression
Interventions: Drug: ceftriaxone;   Drug: Saline solution
Outcome Measures: Change in Hamilton Depression Rating Scale (HDRS) score from baseline.;   Change in score on the 16-item Quick Inventory of Depressive Symptoms (QIDS) from baseline.;   Number of subjects who achieve remission as defined by a HDRS score < 7.;   Change in Montgomery Asberg Depression Rating Scale (MADRS)score from baseline.;   Change in ratings on the Clinical Global Impressions Scale for Bipolar Disorder (CGI-BP).
10 Unknown  Pharmacokinetic of Ceftriaxone in Septic ICU Patients
Conditions: Sepsis;   Severe Sepsis;   Septic Shock
Intervention: Drug: ceftriaxone
Outcome Measures: serum drug concentration;   pharmacokinetics parameter (plasmatic half-life, clearance, ...);   ratio of serum drug concentration on MCI
11 Unknown  Comparison of 3 Days and 7 Days Intravenous Ceftriaxone Prophylaxis for Variceal Bleeding
Conditions: Esophageal and Gastric Varices;   Gastrointestinal Hemorrhage
Intervention: Drug: ceftrioxone
Outcome Measures: rebleeding rate within 14 days;   motarlity rate within 28 days
12 Recruiting Gatifloxacin Versus Ceftriaxone in the Treatment of Enteric Fever
Conditions: Enteric Fever;   Typhoid Fever
Interventions: Drug: Ceftriaxone;   Drug: Gatifloxacin
Outcome Measures: Rate of treatment failure;   Time to fever clearance;   S.typhi or S.paratyphi carriage;   Number of adverse events;   Household transmission
13 Recruiting Comparison of Efficacy of Cefotaxime, Ceftriaxone, and Ciprofloxacin for the Treatment of Spontaneous Bacterial Peritonitis in Patients With Liver Cirrhosis
Conditions: SBP;   Liver Cirrhosis
Interventions: Drug: Cefotaxime;   Drug: Ceftriaxone;   Drug: Ciprofloxacin
Outcome Measures: Infection resolution rates within 5 days of treatment;   Infection resolution rates within 5 days;   Mortality & recurrence rates within 1 month
14 Not yet recruiting Prehospital Antibiotics Against Sepsis
Conditions: Sepsis;   Severe Sepsis;   Septic Shock
Intervention: Drug: Ceftriaxone 2000 mg
Outcome Measures: mortality;   length of stay
15 Recruiting Study on Early Lyme Neuroborreliosis
Condition: Nervous System Lyme Borreliosis
Intervention: Drug: ceftriaxone
Outcome Measures: Objective sequelae and post-treatment subjective symptoms in patients treated with ceftriaxone for early Lyme neuroborreliosis;   Comparison of subjective symptoms between patients treated with ceftriaxone for early Lyme neuroborreliosis and control subjects without a history of Lyme borreliosis
16 Recruiting Impact of Ceftriaxone and/or Fluoroquinolone (FQ) Treatment on the Gut Microbiota of Hospitalized Patients.
Condition: Bacterial Infections
Intervention:
Outcome Measures: Describe the changes in the composition of the gut microbial flora in relation to the initial flora (T0) in patients receiving antibiotics, by date of sampling, treatment received, dose, duration of therapy, ward, and duration of hospital stay.;   A secondary endpoint is to describe the changes in the gut microbiota of hospitalized patients not receiving antibiotics.
17 Unknown  Efficacy and Safety Study of Short-term Antibiotic for Pyelonephritis in Women
Condition: Acute Uncomplicated Pyelonephritis
Intervention: Drug: Ceftriaxone
Outcome Measures: Microbiological cure at the 9th day;   Microbiological cure at the 3 rd day;   Number of recurrence of acute pyelonephritis during the month after the treatment between the 9 th and the 37 th day
18 Recruiting Efficacy and Safety Study of Antibiotic Treatment to Treat Hip Prosthetic Joint Infection
Condition: Hip Prosthetic Joint Infection
Interventions: Drug: VANCOMYCIN;   Drug: CEFTRIAXONE;   Drug: CLINDAMYCIN;   Drug: SULFAMETHOXAZOLE AND TRIMETHOPRIM (CO-TRIMOXAZOLE);   Drug: FLUOROQUINOLONE;   Drug: LINEZOLID;   Drug: RIFAMPIN
Outcome Measures: Clinical cure rate;   Cure rate
19 Recruiting The Importance of Anti-anaerobic Therapy for Acute Pelvic Inflammatory Disease (PID)
Condition: Pelvic Inflammatory Disease
Interventions: Drug: ceftriaxone, doxycycline, and placebo;   Drug: ceftriaxone, doxycycline, metronidazole
Outcome Measures: Clearance of anaerobic organisms from the endometrium;   The prevalence of M. genitalium in the cervix and endometrium from women with acute PID.;   The eradication of M. genitalium from the lower and upper genital tract following antibiotic therapy for acute PID.;   Resolution of clinical signs and symptoms of acute PID;   Identification of endometrial microorganisms present obtained from women with or without evidence of endometritis using a combination of culture methods, rRna sequencing and whole genomic sequencing. The aim is to identify the etiology of endometritis.;   Determine immune response to Chlamydia trachomatis and other PID pathogens;   Identify frequencies of specific leukocyte cell populations in the endometrium of women with and without infection due to PID pathogens and determine the local cellular response to PID pathogens.
20 Not yet recruiting Study of Lyme Neuroborreliosis
Condition: Lyme Neuroborreliosis
Interventions: Drug: Doxycycline;   Drug: Ceftriaxone
Outcome Measure: The condition of study subjects

These studies may lead to new treatments and are adding insight into Rocephin etiology and treatment.

A major focus of Rocephin research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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