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SHEATH Medical Research Studies

Up-to-date List of SHEATH Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest SHEATH Medical Research Studies

Rank Status Study
1 Recruiting A Pilot Trial of an Individualized Web-Based Condom Use Intervention
Condition: HIV
Intervention: Behavioral: Condom-HIM
Outcome Measures: Change from Baseline in participants self-efficacy in condom use at 2-weeks post-intervention;   Change from Baseline in participants intention to use condoms at 2-weeks post-intervention
2 Recruiting Efficacy of Autologous Outer-Root-Sheath Melanocytes Transplantation in the Treatment of Vitiligo
Condition: Vitiligo
Interventions: Biological: Outer-Root-Sheath Melanocytes Suspension;   Biological: Placebo
Outcome Measures: Repigmentation equal to or greater than 50% of the treated areas from baseline as assessed by image analysis;   Any repigmentation of the treated areas from baseline as assessed by physician according to an ordinal 6-points scale;   Any repigmentation of the treated areas from baseline as assessed by patient according to an ordinal 6-points scale;   Overall patient satisfaction to the proposed therapy as assessed by visual analogue scale;   Any repigmentation of the treated areas from baseline as assessed by image analysis;   Any repigmentation of other areas affected by vitiligo from baseline as assessed by physician according to an ordinal 6-points scale (evaluation of a possible systemic effect)
3 Unknown  Education Program to Promote Female Condom Use
Condition: HIV Infections
Intervention: Behavioral: Female condom skills training
Outcome Measures: percent of sex acts protected by female condoms;   percent of sex acts protected by male or female condoms
4 Recruiting Comparison of Optic Nerve Sheath Diameter on Retrobulbar Ultrasound Before and After Drainage of Cerebrospinal Fluid in Patient With Hydrocephalus
Condition: Hydrocephalus
Intervention: Procedure: retrobulbar ultrasound
Outcome Measure: both optic nerve Sheath diameter (the posterior 3mm of the papilla)
5 Unknown  A Self-Guided Intervention to Promote Condom Use Among African American Males
Condition: Correct and Consistent Condom Use.
Intervention: Behavioral: Homework Intervention Strategy
Outcome Measures: Change from baseline in number of unprotected sex events at 2 months;   Change from baseline in number of unprotected sex events at 4 months;   Change from baseline in number of unprotected sex events at 7 months;   Change from baseline in condom use errors/problems score as measured by the Condom Use Errors/Problems Survey (CUES) at 2 months.;   Change from baseline in condom use errors/problems score as measured by the Condom Use Errors/Problems Survey (CUES) at 4 months.;   Change from baseline in condom use errors/problems score as measured by the Condom Use Errors/Problems Survey (CUES) at 7 months.;   Change from baseline in self-efficacy for correct condom use score as measured by the Correct Condom Use Self-Efficacy Scale(CCUSES) at 2 months.;   Change from baseline in self-efficacy for correct condom use score as measured by the Correct Condom Use Self-Efficacy Scale (CCUSES) at 4 months.;   Change from baseline in self-efficacy for correct condom use score as measured by the Correct Condom Use Self-Efficacy Scale(CCUSES) at 7 months.
6 Recruiting Comparison of Optic Nerve Sheath Diameter on Retrobulbar Ultrasonography Before and After Drainage of Cerebrospinal Fluid in Pediatric Patient With Hydrocephalus
Condition: Hydrocephalus
Intervention: Procedure: retrobulbar ultrasound
Outcome Measure: both optic nerve Sheath diameter (the posterior 3mm of the papilla)
7 Not yet recruiting Perioperative Evaluation of Intracranial Hypertension by Ultrasound Measurement of Variations in the Diameter of the Sheath of the Optic Nerve in the Excision of a Tumor or Biopsy Supratentorial Brain
Condition: Supratentorial Brain Tumor
Intervention: Procedure: ultrasound measurement of variations in the diameter of the Sheath of the optic nerve
Outcome Measures: Difference in mean changes that the Sheath of postoperative optic nerve;   Difference in diameter of the Sheath of the pre-and postoperative optic nerve
8 Recruiting Intracranial Hypertension and Optic Nerve Sheath Diameter
Conditions: Cerebral Stroke;   Cerebral Venous Thrombosis
Intervention: Other: ONSD ultrasound
Outcome Measures: Primary (sensitivity and specificity of echographic measurement of ONSD);   Secondary outcome (1. To draw learning curves before the study begins to find out the number of ultrasound measurement needed)
9 Recruiting The Effect of Stellate Ganglion Block on Intracranial Pressure Predicted by Ultrasonographic Assessment of Optic Nerve Sheath Diameter
Conditions: Pain;   Intracranial Pressure
Intervention: Procedure: ultrasonographic measurement of optic nerve Sheath diameter
Outcome Measure: ultrasonographic measurement of optic nerve Sheath diameter
10 Recruiting Female Condom Functionality
Condition: Condom Functionality
Intervention: Drug: vaginal ring
Outcome Measure: Total clinical failure rate
11 Recruiting Whole Body Magnetic Resonance Imaging With Diffusion Weighted Imaging : Potential Role in Neurofibromatosis
Conditions: Whole Body Imaging;   Magnetic Resonance Imaging;   Neurofibromatosis 1;   Diffusion Magnetic Resonance Imaging;   Peripheral Nerve Sheath Tumors, Malignant
Intervention: Other: Additional imaging or surgery
Outcome Measures: Estimation of total tumor load and diagnosis of high-risk neurofibromas;   To diagnose high-risk neurofibroma
12 Recruiting A Trial of Ganetespib Plus Sirolimus: Phase 1 Includes Multiple Sarcoma Subtypes and Phase 2 MPNST
Conditions: Malignant Peripheral Nerve Sheath Tumors (MPNST);   Sarcoma
Interventions: Drug: ganetespib;   Drug: Sirolimus
Outcome Measures: Grade the toxicity of ganetespib when administered in combination with sirolimus.;   Clinical benefit of combined study drugs.
13 Recruiting Subclavian Vein catheterization_Seldinger Vs Modified Seldinger
Conditions: Brain Neoplasm;   Intracranial Aneurysm;   Cerebrovascular Moyamoya Disease
Interventions: Procedure: Seldinger technique;   Procedure: Modified Seldinger technique
Outcome Measures: Major complication rate of subclavian catheterization;   primary success rate of subclavian catheterization;   Total insertion time
14 Recruiting Natural History Study of Patients With Neurofibromatosis Type I
Conditions: Neurofibromatosis Type 1;   Malignant Peripheral Nerve Sheath Tumor;   Plexiform Neurofibroma;   Optic Glioma;   Neurofibroma
Intervention:
Outcome Measure: To serve as an umbrella protocol for ongoing NF1 clinical trials program to longitudinally characterize and analyze NF1 related tumor and non-tumor manifestations, and to develop a better understanding of the biology of NF1 related manifestation...
15 Recruiting ENB-GS-TBLB for the Diagnosis of PPLs
Condition: Lung Cancer
Interventions: Procedure: ENB;   Procedure: GS-TBLB-X-ray
Outcome Measures: The difference of diagnostic value of ENB-GS-TBLB with fluoroscopy as compared to GS-TBLB with fluoroscopy alone;   The difference of complications of ENB-GS-TBLB with fluoroscopy as compared to GS-TBLB with fluoroscopy alone
16 Recruiting Topical Anesthesia Versus Placebo to Decrease Pain in Rubber Band Ligation for Treatment of Internal Hemorrhoids
Conditions: Hemorrhoids;   Pain
Interventions: Drug: Topical 2,5% lidocaine + 2,5% prilocaine gel;   Drug: Placebo
Outcome Measures: Pain measured in analog visual scale;   Procedure morbidity
17 Recruiting A Trial on the Effect of Sino-implant (II) Use on Condom Use Among Women in Kingston, Jamaica
Condition: Women Wanting Contraceptive Implant for Pregnancy Prevention
Intervention: Device: Sino-implant (II)
Outcome Measures: Prostate-specific antigen (PSA);   Self-reported exposure to semen;   Side effects;   Product discontinuation;   Acceptability
18 Not yet recruiting Assessment of Radial Artery Patency Following Catheterization With a 7F Sheath
Conditions: Coronary Catheterization;   Transradial Patency
Intervention:
Outcome Measures: Normal reverse Allen test;   Antegrade flow in the radial artery by ultrasound
19 Recruiting Proton Radiation Therapy for Spinal Tumors
Conditions: Nerve Sheath Tumors;   Neurofibroma
Interventions: Radiation: Proton Radiation for MPNST;   Radiation: Proton Radiation for neurofibromas
Outcome Measures: Local Control;   Progression or palliation of pain, numbness, or weakness;   Number of adverse events;   Quality of Life;   Rate of malignant transformation within the high-dose volume;   Rate of second malignant primaries outside of high dose volume, but located in tissues exposed to radiation within the beam path
20 Not yet recruiting Using Implementation Intentions to Increase Safe Sex Practices in MSM
Conditions: HIV;   Sex
Intervention: Behavioral: Planning tasks
Outcome Measures: Self reports of anal sex with and without condoms;   Variables in the Theory of Planned Behaviour: attitude, subjective norm, perceived behavioural control, and intention

These studies may lead to new treatments and are adding insight into SHEATH etiology and treatment.

A major focus of SHEATH research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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