Up-to-date List of Santyl Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Santyl Medical Research Studies

1 Recruiting Santyl Applications to Diabetic Foot Ulcers
Conditions: Diabetic Foot Ulcers;   Diabetic Foot Wounds
Interventions: Biological: Collagenase Santyl® Ointment;   Biological: Hydrogel (if needed) and foam dressing
Outcome Measures: Time to Well-established Granulation Tissue;   Adverse Event
2 Unknown  Injectable Collagenase For Burns' Associated Contracture
Condition: Burn's Associated Contracture
Intervention: Drug: Xiaflex (FDA approved collagenase)
Outcome Measures: Increase functionality of involved joint;   Pain assessment
3 Not yet recruiting Collagenase in the Treatment of Cellulite
Condition: Cellulite
Interventions: Drug: Collagenase;   Biological: Biological
Outcome Measure: Reduction and/or elimination of cellulite in the posterolateral thigh
4 Not yet recruiting A Study to Evaluate the Efficacy and Safety of NexoBrid in Subjects With Thermal Burns
Condition: Thermal Burns
Interventions: Drug: NexoBrid;   Drug: Santyl
Outcome Measure: Incidence of complete eschar removal: Demonstrate superiority over SOC for eschar removal as measured by incidence of complete eschar removal
5 Not yet recruiting EZCast-DFU Study With Portal for Application of Topical Medications
Conditions: Foot Ulcer;   Diabetic Foot
Interventions: Drug: Collagenase ointment;   Device: Modified Contact Cast System
Outcome Measure: Proportion of contact cast systems intact by day 14
6 Not yet recruiting Evaluate the Noninferiority of Medicines Treating Uninfected Pressure Ulcers.
Condition: Pressure Ulcer
Interventions: Drug: Collagenase;   Drug: Kollagenase
Outcome Measures: Devitalized tissue reduction.;   Injury reduction.;   Granulation tissue formation.;   Healing process of PU.;   Adverse events.
7 Not yet recruiting Collagenase Total Occlusion Trial
Condition: Chronic Total Occlusions
Interventions: Biological: collagenase;   Drug: saline
Outcome Measures: Anterograde PCI success rate for patients with a target CTO;   Total fluoroscopy time;   Total PCI procedural time;   Soft wire crossing;   Safety
8 Unknown  Phase III Randomized Study of Collagenase in Patients With Residual Stage Dupuytren's Disease
Condition: Dupuytren's Contracture
Intervention: Drug: collagenase
Outcome Measure:
9 Unknown  Phase II Randomized Study of Collagenase in Patients With Residual Type Dupuytren's Disease
Condition: Dupuytren's Contracture
Intervention: Drug: collagenase
Outcome Measure:
10 Recruiting Clinical Study for the Treatment of Adhesive Capsulitis of the Shoulder
Conditions: Adhesive Capsulitis;   Frozen Shoulder
Intervention: Biological: Collagenase Clostridium Histolyticum
Outcome Measures: The change (degrees) from baseline to the Day 95 follow-up in active forward flexion in the affected shoulder.;   Change from baseline to Day 95 in American Shoulder and Elbow Surgeons Standardized Shoulder Assessment (ASES) function sub-scale;   Change (degrees) from baseline to the Day 95 follow-up in abduction;   Change from baseline to the Day 95 follow-up in pain with movement using a 11-point Visual Analogue Scale (VAS);   Change (degrees) from baseline to the Day 95 follow-up in internal rotation;   Change from baseline to the Day 95 follow-up in external rotation;   Change from baseline to the Day 95 follow-up in ASES pain sub-scale;   Investigator satisfaction with treatment at the Day 95 follow-up;   Subject satisfaction with treatment at the Day 95 follow-up
11 Unknown  Dupuytren's Disease and Extracorporeal Shockwave Therapy (DupuyShock-2010)
Condition: Dupuytren Contracture
Interventions: Device: Intervention - ESWT Storz Duolith high energy;   Device: CONTROL SHAM-ESWT Storz Duolith [0.01mJ/mm2]
Outcome Measures: Score of Michigan Hand Outcome Questionnaire (MHQ) [0=poor, 100= perfect];   DASH Score [0=perfect, no impairment, 100=worst];   Range of motion [ROM°];   Grip strength [JAMAR]
12 Recruiting Comparison of Wound Bed Establishment in Facial Burns
Condition: Burns
Intervention: Drug: Collagenase versus Bacitracin
Outcome Measures: Difference in wound bed establishment found;   Relationships between demographic variables, pain, anxiety, itch levels, and wound healing time explored.
13 Recruiting Vaginal Estrogen and Pelvic Floor Physical Therapy in Women With Symptomatic Mild Prolapse
Condition: Pelvic Organ Prolapse
Interventions: Drug: Vaginal estrogen;   Drug: Placebo cream
Outcome Measures: Global impression of improvement in prolapse symptoms, using the PGI-I;   Pelvic floor symptoms, using the PFDI-20;   Quality of life, using the PFIQ-7;   Sexual function, using the PISQ-12;   Pelvic organ prolapse stage, using the POP-Q exam;   Collagenase activity
14 Not yet recruiting Platelet-Rich Plasma Versus Corticosteroid Injection as Treatment for Degenerative Pathology of the Temporomandibular Joint
Condition: Degenerative Joint Disease
Interventions: Drug: Group A (corticosteroid injection group);   Biological: Group B (platelet rich plasma injection group)
Outcome Measures: Pain relief;   Improvement in function
15 Not yet recruiting A Clinical Study of the Efficacy and Safety of MEBO® Wound Ointment in Subjects With Partial Thickness Burns
Condition: Burns (Partial Thickness)
Interventions: Drug: MEBO Wound Ointment (MEBO);   Procedure: Standard practice for partial thickness burns
Outcome Measures: Number of patients having obtained 95% or greater re-epithelialization of target burn at Day 28.;   Degree of scarring at Day 28 and Day 56.
16 Unknown  Plasma Rich Growth Factors in Venous Ulcers
Condition: Venous Ulcers
Interventions: Procedure: PRGF+ Cleaning, debridement of the wound, application of the corresponding dressing and using of antibiotics if necessary;   Procedure: Cleaning, debridement of the wound, application of the corresponding dressing and using of antibiotics if necessary
Outcome Measures: Ulcers closed;   Pruritus (Yes/No);   Pain (through VAS scale);   Signs of infection (Yes/No);   Wound surface (in cm2) measured through PUSH scale
17 Recruiting Effect of Concentrating Endogenous Stromal Cells in the Fat Graft
Conditions: Facial Injuries;   Adipose Tissue
Intervention: Procedure: Fat graft surgical procedure
Outcome Measures: Fat grafting for facial trauma, facilitated by enhancing graft quality with a higher concentration of endogenous autologous adipose stromal cells in the grafted tissue, will enable successful restoration of tissue volume and craniofacial form.;   Measure quality of life in subjects after grafting using validated psychosocial measures.;   Cell assessment will include adipose ASC yield, cell proliferation and characterization, capacity for adipogenic differentiation, interactions with biomaterial scaffolds that may be used in future therapies, and analysis by flow cytometry.

These studies may lead to new treatments and are adding insight into Santyl etiology and treatment.

A major focus of Santyl research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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