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Sciatica Medical Research Studies

Up-to-date List of Sciatica Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Sciatica Medical Research Studies

Rank Status Study
1 Recruiting Electroacupuncture for Sciatica Due to Intervertebral Disc Displacement
Condition: Sciatica Due to Intervertebral Disc Disorder
Interventions: Other: Electroacupuncture (EA);   Other: Traction;   Drug: Voltaren;   Drug: Vitamin B1
Outcome Measures: Visual Analog Scale(VAS) of Leg Pain;   Visual Analog Scale(VAS) of Low Back Pain;   Simplified McGill Pain Questionnaire (ST-MPQ);   Improved Roland Functional questionaire(RDQ);   Likert Overall Recovery Self Rating Scale (7 points);   The Medical Outcomes Study 36-Item Short -Form Health Survey Questionnaire (SF-36);   Sciatica Frequency and Bothersome Index (SFBI)
2 Recruiting Efficacy of corticoïd Infiltration Via Sacro-coccygien Hiatus in Discal Sciatica
Condition: Discal Sciatica
Interventions: Drug: Prednisolone acetate;   Drug: sham procedure;   Drug: comparator : physiological solution
Outcome Measures: difference between the mean leg pain during the latest 24 hours preceding the infiltration and that preceding the visit S4;   determine whether medical intervention improve status of patients;   To determine whether intervention can decrease the number of surgeries (follow-up of 6 months);   To determine whether intervention can decrease the intake of drugs;   To determine whether intervention can decrease the functional handicap
3 Recruiting PET/MRI Imaging of Neuraxial Inflammation in Sciatica Patients
Condition: Sciatica
Interventions: Drug: Radioactive dye;   Radiation: PET/MRI;   Other: Blood draw
Outcome Measures: Inflammation in the spine;   Pain Scores on the Visual Analog Scale (VAS)
4 Recruiting Safety and Efficacy of Nonsteroidal Antiinflammatory (NSAI)Drug and Glucocorticoids in Acute Sciatica
Condition: Sciatica
Interventions: Drug: methylprednisolone;   Drug: Ketoprofen;   Drug: Sodium Chloride
Outcome Measures: Mean visual analogue scale (VAS) for leg pain (radicular pain) in 3 groups;   Mean visual analogue scale (VAS) for back pain in 3 groups;   Assess drug compliance;   The effect of treatment on the EIFEL Questionnaire;   Improvement in Lasegue's sign compared to baseline;   Assess Schober's test;   Analgesic consumption;   Surgery or lumbar epidural injection;   Clinical tolerance: adverse events and/or high blood pressure;   Biological tolerance;   Glycemic levels;   Number of days of hospitalisation sick leave, number of days lost to illness
5 Recruiting Comparison of a Cortivazol (ALTIM®) Infiltration of Posterior Epidural Space at L3-L4 Stage Versus an Epidural Infiltration of Cortivazol (ALTIM®) on Contact With Disco Radicular Conflict in Discal Sciatica
Condition: Discal Sciatica
Interventions: Procedure: Non target epidural infiltration done at L3-L4 stage;   Procedure: Epidural infiltration on contact of disco radicular conflict
Outcome Measures: Pain evolution on analogic visual scale (EVA) ay Day 30;   Pain evolution on analogic visual scal (EVA) at Day 7;   Pain evolution on analogic visual scal (EVA) at month 3;   Pain evolution on analogic visual scal (EVA) at month 6;   Pain evolution on analogic visual scal (EVA) at month 12;   drug consumption at day 7;   drug consumption at month 3;   drug consumption at month 6;   drug consumption at month 12;   functional handicap at Day 7;   functional handicap at month 3;   functional handicap at month 6;   functional handicap at month 12;   professional activity recovery at Day 7;   professional activity recovery at month 3;   professional activity recovery at month 6;   professional activity recovery at month 12;   new epidural infiltration or surgery of discal hernia at Day 7;   new epidural infiltration or surgery of discal hernia at month 3;   new epidural infiltration or surgery of discal hernia at month 6;   new epidural infiltration or surgery of discal hernia at month 12
6 Not yet recruiting Chiropractic Spinal Manipulative Therapy for Acute Sciatica Secondary to Lumbar Disc Herniation
Conditions: Acute Sciatica;   Lumbar Disc Herniation
Interventions: Other: Chiropractic Spinal Manipulative Therapy;   Other: Usual Care
Outcome Measures: Rate of recruitment of eligible patients;   Cytokine and cytokine mRNA levels in serum.;   Cytokine and cytokine mRNA levels in serum;   Total mRNA levels (isolated from disc tissue and disc / periradicular lavage samples) of interleukins 1,10 and 11, MIP-1 beta TNF alpha, and chemotactic protein alpha.;   Modified Roland Disability Questionnaire (mRDQ) score and Visual Analogue Scale (VAS) pain scale.;   mRDQ and VAS;   mRMQ and VAS
7 Recruiting Ischia Spinous Fascia Fixation Procedure Versus Modified Total Pelvic Floor Reconstructive Surgery for Pelvic Organ Prolapse Stage III
Condition: Pelvic Organ Prolapse
Interventions: Procedure: ischia spinous fascia fixation;   Procedure: Modified Pelvic Floor Reconstruction Surgery with Mesh;   Device: polypropylene mesh(Gynemesh)
Outcome Measures: •Anatomical improvement according to POP-Q score.;   •Hospital data including operative time, estimated blood loss, length of stay, maximum temperature, time of voiding recovery.;   •Pain score measured using Visual Analog Scale (VAS).;   •Presence/absence of complications (composite score).;   •Change from baseline in PFIQ-7 scores.;   •In subjects sexually active at baseline, assessment of sexual function using PISQ-12 (mean scores and change from baseline);   •Subject global impression assessed on a 5 point Likert scale;   •Presence/absence of complications (composite score)
8 Unknown  Efficacy of Intravenous Dexamethasone for Acute Disc Herniation-Induced Sciatica
Condition: RADICULAR PAIN
Interventions: Drug: DEXAMETHASONE;   Other: PLACEBO
Outcome Measure:
9 Recruiting Ischia Spinous Fascia Fixation Surgery for Pelvic Organ Prolapse
Condition: Pelvic Organ Prolapse
Intervention: Procedure: ISFF
Outcome Measures: Anatomical improvement according to POP-Q Score;   Hospital data including operative time, estimated blood loss, length of stay, postoperative mortality, time of voiding recovery
10 Not yet recruiting Prolotherapy Versus Epidural Steroid Injections (ESI) for Lumbar Pain Radiating to the Leg
Conditions: Sciatica;   Spinal Stenosis of Lumbar Region;   Degeneration of Lumbar or Lumbosacral Intervertebral Disc
Interventions: Drug: prolotherapy solution of 20% dextrose;   Drug: Epidural Steroid Injection
Outcome Measures: Visual Analogue Pain Score;   Oswestry Back Disability Questionnaire Score
11 Not yet recruiting The Effectiveness of Lower Limb Neurodynamic Techniques on Pain and Disability in Subjects With Lower Limb Radicular Pain
Conditions: Radicular Pain;   Sciatica;   Entrapment Neuropathies
Interventions: Procedure: neurodynamic;   Procedure: Sham-neurodynamics
Outcome Measures: Pain (numeric pain rating scale);   Pain (Numeric Pain Rating Scale);   Straight leg raise range of motion;   Oswestry Disability Index
12 Recruiting Prediction of Inter-individual Differences in the Response to Morphine Versus Milnacipran in Patients With Sciatica
Condition: Pharmacological Action (PA)
Interventions: Drug: Morphine;   Drug: Milnacipran
Outcome Measures: Neuropathic pain intensity (NPS);   Heat pain intensity in a remote area (Opioid induced hyperalgesia);   The McGill Pain Questionnaire;   Assessment of Adverse events
13 Recruiting Surgery Versus Standardized Non-operative Care for the Treatment of Lumbar Disc Herniations: A Canadian Trial
Conditions: Lumbar Spine Disc Herniation;   Lumbar Radiculopathy
Interventions: Procedure: Lumbar Microdiscectomy;   Other: Physiotherapy, Epidural injections, Education, Pain Medications, Anti-inflammatories
Outcome Measure: Visual Analogue Scale for intensity of Sciatica
14 Recruiting BG00010 (Neublastin) Phase 2 Multiple Dose Adaptive Design in Subjects With Painful Lumbar Radiculopathy
Conditions: Painful Lumbar Radiculopathy;   Sciatica;   Radiculopathy
Interventions: Drug: BG00010;   Drug: Placebo
Outcome Measures: change from Baseline in the mean 24-hour average general pain intensity (AGPI) score;   Change from Baseline in the mean 24-hour average back pain intensity (ABPI) score;   Change from Baseline in the mean 24-hour average leg pain intensity score (ALPI);   Change from Baseline in the individual mean 24-hour average general pain intensity (AGPI);   Change from Baseline in the individual mean 24-hour average back pain intensity (ABPI);   Change from Baseline in the individual mean 24-hour average leg pain intensity (ALPI);   Maximum observed serum concentration (Cmax) of BG00010;   Number of subjects with adverse events (AEs) and serious adverse events (SAEs);   Change from Baseline in Incidence of neutralizing antibodies in serum
15 Recruiting Steroids Versus Gabapentin
Conditions: Sciatica;   Radiculopathy
Interventions: Procedure: epidural steroid injection;   Procedure: Sham epidural steroid injection;   Drug: Gabapentin;   Drug: Placebo gabapentin
Outcome Measures: leg pain;   Back pain;   Oswestry disability index;   satisfaction
16 Recruiting A Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of MDT-15 in Subjects With Lumbosacral Radiculopathy
Conditions: Sciatica;   Lumbosacral Radiculopathy
Intervention: Drug: MDT-15
Outcome Measures: Cmax;   Tmax;   AUC0-t;   AUC0-∞;   Incidence of Adverse Events;   Change in Radicular Leg Pain;   Change in Physical Function;   Change in Back Pain;   Change in Neuropathic Type Symptoms;   Change in Medical Outcomes study - Sleep Scale;   Change in Emotional Function;   Change in Work Function;   Global Rating of Improvement
17 Unknown  Neuraxial Pethidine After Lumbar Surgery Trial
Condition: Sciatica
Interventions: Drug: Pethidine;   Drug: Placebo
Outcome Measures: Cumulative 24-hour pethidine consumption;   Patient data:;   Age;   Gender;   Body mass index;   Current medications;   Preoperative opioid analgesic use (none, low, high - high dose being > 300 mg codeine or dextropropoxyphene daily or oral morphine or parenteral opioid use);   Compensable status (HNC, TAC, WCV or PMI/SUR) 22;   Surgical data:;   Anatomical extent of surgery (number of spinal levels);   Highest anatomical surgical level;   Experience level of primary surgeon (trainee or consultant);   Anatomical level of epidural tip (identified from postoperative X-Ray when taken as routine care only);   Dural tear at the time of surgery (yes/no);   Spinal instrumentation (yes/no);   Other end-points (all at 1, 4, 24 and 48 hours unless stated):;   Cumulative pethidine dose;   Cumulative morphine dose;   VAS scores for pain at rest and during movement;   Sedation score (1 - 4) 16;   VAS scores for nausea, pruritis;   Other adverse events: agitation, tremor, hallucinations, seizure;   Patient satisfaction scale for pain control during study (48 hours);   (very dissatisfied, dissatisfied, neutral, satisfied, very satisfied) 17;   Plasma pethidine and norpethidine levels (24 hours);   Physiotherapy assessment of ability to deep breathe & cough (unable, poor, adequate, good);   Length of inpatient stay
18 Recruiting Analgesic Effect of a Prototype Device of Virtual Reality in a Population of Patients With Chronic Low Back Pain
Condition: Low Back Pain
Interventions: Procedure: Virtual reality;   Procedure: Usual care
Outcome Measures: Low back pain in the last 48 hours;   Disability (Quebec questionnaire);   Anxiety and depression (HAD);   Quality of life (SF-12);   Overall serum antioxidant defenses
19 Recruiting Phase 1 Subcutaneous Single and Multiple Ascending Dose Study of BG00010
Conditions: Painful Lumbar Radiculopathy;   Healthy
Interventions: Biological: BG00010;   Drug: Placebo
Outcome Measures: The incidence of Adverse Events (AEs)/Serious Adverse Events (SAEs);   Maximum observed concentration (Cmax);   Time to maximum serum concentration (Tmax);   Half life (t1/2);   Area under the serum concentration time curve (AUC) from zero to infinity AUC(0-∞);   Subcutaneous (SC) bioavailability;   Incidence of anti-BG00010 antibodies in serum;   Pain, as measured by an 11-point NRS, and by the VAS of SF-MPQ
20 Recruiting Hypothalamic-Pituitary-Adrenal Axis Suppression and Metabolic Effects of Repeated Epidural and Sacroiliac Joint Corticosteroid Injections
Conditions: Neck Pain;   Back Pain
Intervention:
Outcome Measures: Time to Normalization of Hypothalamic-Pituitary-Adrenal Axis (HPAA) Function Following Epidural or Sacroiliac Joint Corticosteroid Injection;   Incidence of Hypothalamic-Pituitary-Adrenal Axis (HPAA) Suppression in Patients Presenting for Corticosteroid Injection;   Incidence of Prolonged (≥ 3 weeks) Hypothalamic-Pituitary-Adrenal Axis (HPAA) Suppression Following Corticosteroid Injection;   Change in Glycosylated HbA1c (%) from Baseline to 3 months;   Change in Glycosylated HbA1c (%) from Baseline to 6 months;   Change in Systolic Blood Pressure from Baseline to 3 weeks;   Change in Systolic Blood Pressure from Baseline to 6 weeks;   Change in Systolic Blood Pressure from Baseline to 3 months;   Change in Systolic Blood Pressure from Baseline to 6 months;   Change in Diastolic Blood Pressure from Baseline to 3 weeks;   Change in Diastolic Blood Pressure from Baseline to 6 weeks;   Change in Diastolic Blood Pressure from Baseline to 3 months;   Change in Diastolic Blood Pressure from Baseline to 6 months;   Change in Body Weight from Baseline to 3 weeks;   Change in Body Weight from Baseline to 6 weeks;   Change in Body Weight from Baseline to 3 months;   Change in Body Weight from Baseline to 6 months

These studies may lead to new treatments and are adding insight into Sciatica etiology and treatment.

A major focus of Sciatica research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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