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Seasonal Medical Research Studies

Up-to-date List of Seasonal Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Seasonal Medical Research Studies

Rank Status Study
1 Not yet recruiting Study to Evaluate the Pharmacokinetics of an Oral Contraceptive Containing Levonorgestrel and Ethinyl Estradiol When Co-administered With GSK1265744 in Healthy Adult Female Subjects
Condition: Infections, Human Immunodeficiency Virus and Hepatitis
Interventions: Drug: Ethinyl Estadiol;   Drug: Levonorgestrel;   Drug: GSK1265744
Outcome Measures: Plasma (AUC[0-tau]);   Safety and tolerability of 744 when given with and without OC as assessed by adverse events (AE);   Safety and tolerability of 744 when given with and without OC as assessed by clinical laboratory tests;   Safety and tolerability of 744 when given with and without OC as assessed by Electrocardiogram (ECG);   Safety and tolerability of 744 when given with and without OC as assessed by vital signs;   Composite of plasma pharmacokinetic (PK) parameters of 744;   Predose serum levels of Progesterone, Luteinizing hormone (LH) and follicle stimulating hormone (FSH);   Composite of plasma PK parameters of 744 - AUC(0-tau), Cmax, tmax, Ctau and CL/F
2 Not yet recruiting Evaluation Of The Product Ciclo® 21 Pharmacodynamics (Levonorgestrel + Ethinyl Estradiol), Marketed By União Química Farmacêutica Nacional S / A, Compared To Nordette® Product To The Lab Wyeth Pharmaceutical Industries Ltd.
Conditions: Pregnancy Prevention;   Control of Menstrual Irregularities
Interventions: Drug: Ciclo 21 (LNG + EE2); União Química Farmacêutcia Nacional S/A;   Drug: Nordette (LNG + EE2); Laboratory Wyeth Pharmaceutical Ltda
Outcome Measures: The primary efficacy endpoint will be the changes in FSH and LH secretion induced by daily administration of the drug for 21 consecutive days during the 28 days of participation in the trial.;   Safety of drugs: type, frequency and intensity of adverse events between groups during the 28 day trial. Exploratory investigation of the pharmacokinetics of the drug administered through the dosage of hormones in serum LNG and EE2 for 28 days.
3 Recruiting Relationship Between the Menstrual Cycle and Heart Disease in Women
Condition: Coronary Heart Disease
Interventions: Drug: Ethinyl Estradiol-Levonorgestrel combination;   Drug: leuprolide acetate;   Drug: Estradiol;   Drug: Progesterone
Outcome Measures: Change from baseline in total cholesterol to high density lipoprotein cholesterol ratio following ovarian suppression and steroid replacement;   Change from baseline in total cholesterol to high density lipoprotein cholesterol ratio after estradiol and progesterone replacement;   Change from baseline in total cholesterol to high density lipoprotein cholesterol ratio after monophasic hormonal oral contraceptive use;   Change from baseline in serum low density lipoprotein cholesterol following ovarian suppression and steroid replacement;   Change from baseline in serum low density lipoprotein cholesterol after estradiol and progesterone replacement;   Change from baseline in serum low density lipoprotein cholesterol after monophasic combined hormonal oral contraceptive use;   Change from baseline in serum high density lipoprotein cholesterol following ovarian suppression and steroid replacement;   Change from baseline in serum high density lipoprotein cholesterol after estradiol and progesterone replacement;   Change from baseline in serum high density lipoprotein cholesterol after monophasic combined hormonal oral contraceptive use;   Change from baseline in serum triglycerides following ovarian suppression and steroid replacement;   Change from baseline in serum triglycerides after estradiol and progesterone replacement;   Change from baseline in serum triglycerides after monophasic combined hormonal oral contraceptive use
4 Recruiting Quartet™ Bad Oeynhausen Trial
Conditions: Congestive Heart Failure;   Cardiac Resynchronization Therapy
Intervention: Device: Application of quadripolar / bipolar LV electrodes
Outcome Measures: Increase in peak oxygen consumption;   Reduction of New York Heart Association (NYHA) functional class;   Survival
5 Recruiting Selected Site Pacing to Avoid Phrenic Nerve Stimulation in Cardiac Resynchronization Patients With Quadripolar Left Ventricular Leads
Condition: Heart Failure
Intervention: Device: quadripolar LV lead (Quartet)
Outcome Measures: Percentage of patients with at least one acceptable lead vector;   Quality of Life;   Phrenic nerve stimulation (PNS);   LV pacing thresholds;   Number of acceptable LV lead vectors per patient;   Finally programmed LV lead vector
6 Recruiting Changes in Oral Contraceptive Hormones After Gastric Bypass Surgery
Conditions: Bariatric Surgery Candidate;   Contraception
Intervention: Drug: ethinyl estradiol-levonorgestrel
Outcome Measures: Serum hormone levels of Ethinyl estradiol and levonorgestrel, as assessed by area under the curve (AUC);   Endometrial thickness on transvaginal ultrasound;   Serum levels of FSH, LH, E and P;   Cervical mucus score;   Presence of ovarian follicles on transvaginal ultrasound
7 Recruiting Treatment of Unacceptable Bleeding Patterns in ETG Implant Users With an Oral Contraceptive
Conditions: Abnormal Uterine Bleeding, Unspecified;   Uterine Bleeding Heavy
Interventions: Drug: EE 30mcg/LNG 150mcg;   Drug: Placebo
Outcome Measures: Bleeding Improvement;   Adverse Events
8 Recruiting Hormonal Therapy for Teens With Anorexia Nervosa
Condition: Anorexia Nervosa (AN)
Interventions: Drug: DHEA (Prasterone) + ERT (Aviane);   Other: Placebo
Outcome Measures: Bone Marrow Fat by MRI/MRS;   BMD by DXA (spine, hip, whole body);   Bone biomarkers;   BMD by pQCT of tibia;   Hormonal panel (serum)
9 Recruiting Study Evaluating Levonorgestrel and Ethinyl Estradiol for Oral Contraception
Condition: Oral Contraceptive
Interventions: Drug: Levonorgestrel 100 mcg and Ethinyl Estradiol 20 mcg;   Drug: Levonorgestrel 150 mcg and Ethinyl Estradiol 30 mcg
Outcome Measures: The primary efficacy variable is the number of unintended pregnancies as measured by the Pearl Index (PI) during 13 cycles of treatment;   Menstrual Cycle Control;   Weight changes
10 Unknown  Estrogen Treatment in Acromegalic Women
Condition: Acromegaly
Intervention: Drug: Alesse
Outcome Measure:
11 Unknown  Oral Estradiol Valerate Versus Oral Contraceptive Pill in Invitro Fertilization Patients
Condition: Infertility
Interventions: Drug: Levonorgestrel and ethinylestradiol;   Drug: Estradiol valerate
Outcome Measure: Implantation rate
12 Not yet recruiting BAY63-2521,Oral Contraceptiva Drug Interaction Study
Condition: Drug Interactions
Interventions: Drug: Mycrogynon;   Drug: Riociguat (Adempas,BAY63-2521)
Outcome Measures: Area under the plasma concentration time curve (AUC) of Ethinylestradiol (EE);   Area under the plasma concentration time curve (AUC) of Levonorgestrel (LNG);   Maximal concentration (Cmax) of Ethinylestradiol (EE);   Maximal concentration (Cmax) of Levonorgestrel (LNG);   Number of participants with adverse events as a measure of safety and tolerability
13 Recruiting Quantification of Immune Cells in Women Using Contraception (CHIC II)
Conditions: HIV;   Immune Cells (Mucosal and Systemic);   Contraception
Interventions: Drug: levonorgestrel exposure;   Drug: DMPA exposure;   Drug: etonogestrel exposure;   Device: IUD insertion;   Device: subdermal contraceptive implant insertion
Outcome Measures: Quantification and characterization of immune cell populations and HIV-tropic receptor expression;   Assessing changes in the vaginal microflora within the first 6 months of contraceptive use

These studies may lead to new treatments and are adding insight into Seasonal etiology and treatment.

A major focus of Seasonal research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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