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Serotonin Medical Research Studies

Up-to-date List of Serotonin Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Serotonin Medical Research Studies

Rank Status Study
1 Recruiting Hiperemezis and Serotonin Elevated Serum Serotonin Levels in Hyperemesis
Conditions: Nausea;   Vomiting;   Markedly Reduced Food Intake;   Severe Dehydration
Outcome Measures: serum Serotonin levels in hiperemezis gravidarum;   ıs there any assosiation between Serotonin levels and severity of symptoms in pregnant women with hiperemezis
2 Recruiting Investigating Serotonin Signalling in IBD Patients
Condition: Inflammatory Bowel Disease
Outcome Measures: Colonic 5-HT levels;   Receptor expressions;   Colonic cytokine levels
3 Recruiting Fosaprepitant + 5HT3 Receptor Antagonists + Dexamethasone in Germ Cell Tumors
Condition: Chemotherapy-Induced Nausea and Vomiting
Interventions: Drug: Fosaprepitant;   Drug: Dexamethasone;   Drug: 5HT3
Outcome Measures: Determine the Complete Response (CR) Rate of No Emetic Episodes or Use of Rescue Medications;   Measure the Incidence of Vomiting or Retching;   Describe Detailed Use of Rescue Medications.;   Describe the Patient's Self-Reported Assessment of Nausea;   Determine the Number of Participants with Adverse Events as a Measure of Safety and Tolerability
4 Unknown  Effectiveness of the Dual Serotonin Norepinephrine Reuptake Inhibitor Desvenlafaxine Succinate in Healthy Volunteers
Condition: Healthy
Intervention: Drug: Desvenlafaxine succinate
Outcome Measures: The degree of norepinephrine reuptake in response to the increasing levels of the study medication will be assessed and compared between genders;   The degree of Serotonin reuptake in response to the increasing levels of the study medication will be assessed and compared between genders
5 Recruiting Evaluation of [11C]Cimbi-36 as an Agonist PET Radioligand for Imaging of 5-HT2A Receptors
Condition: Healthy
Interventions: Drug: Citalopram and Pindolol;   Dietary Supplement: Acute tryptophan depletion
Outcome Measure: Cerebral Cimbi-36 receptor binding in terms of binding potential (BP) at (1) baseline (2)acute tryptophan depletion (3) acute SSRI and pindolol (4) placebo
6 Recruiting Study of Dopamine and Serotonin Transporters in Patients With Amyotrophic Lateral Sclerosis and Controls
Condition: Amyotrophic Lateral Sclerosis
Intervention: Drug: SPECT : 123 I-FP-CIT (DATSCAN) and 123I-ADAM
Outcome Measures: Dopamine transporter binding potential;   Serotonin transporter binding potential;   Relationships between transporter binding potential and the clinical scores
7 Recruiting Major Depressive Disorder - Understanding The Link Between The Brain And The Heart
Condition: Major Depressive Disorder
Intervention: Drug: Participants will be prescribed an approved selective Serotonin re-uptake inhibitor (SSRI) antidepressant.
Outcome Measures: Proportion of MDD patients carrying the s allele of the 5-HTT transporter that have higher sympathetic activity than homozygous ll patients.;   To determine the association between sympathetic activity and left ventricular hypertrophy.;   Change from baseline in the magnitude of morning surge in blood pressure.;   Change from baseline in insulin resistance.;   Change from baseline on markers of cardiac risk.
8 Recruiting Mechanism of tDCS-induced Learning Enhancement - the Role of Serotonin
Condition: Healthy Young and Older Adults
Interventions: Procedure: tDCS;   Drug: Citalopram
Outcome Measures: Recall score after learning under tDC stimulation + SSRI compared to learning under tDC stimulation + placebo.;   prolongation of the atDCS induced learning enhancement by SSRI;   Increase of learning enhancement by atDCS + placebo or sham-tDCS + SSRI vs. sham-tDCS + placebo;   prolongation of learning enhancement by atDCS + placebo or sham-tDCS + SSRI vs. sham-tDCS + placebo;   genotyping of learning related polymorphisms
9 Recruiting Do Serotonin Reuptake Inhibitors (SSRIs) Affect Bone Mass in Adolescents
Condition: The Skeletal Effects of SSRIs
Outcome Measures: Total body less head bone mineral content (TBLH BMC);   Trabecular volumetric bone mineral density at the ultradistal radius;   Total body less head bone mineral density (TBLH BMD);   Lumbar Spine bone mineral density (BMD);   Lumbar spine bone mineral content (BMC);   Cortical volumetric BMD at 20% radius;   Cortical thickness at 20% radius
10 Recruiting Modeling Between Plasma Concentration and Serotonin Transporter Occupancy Induced by Escitalopram in Obsessive-compulsive Disorder(OCD) Patients
Condition: OCD
Outcome Measures: Serotonin transporter occupancy;   genotype;   Yale-Brown Obsessive Compulsive Scale(Y-BOCS) Score;   escitalopram plasma concentration
11 Recruiting SSRI Study for Functional Dyspepsia (SS)
Conditions: Dyspepsia;   Anxiety;   Depression
Interventions: Drug: Escitalopram;   Other: Placebo
Outcome Measures: To evaluate the change of Serotonin and ghrelin level in blood plasma before and after treatment;   To measure expression of Serotonin and ghrelin blood plasma, the rate of adequate relief using global symptom assessment, symptom scores and the fullness rating of the Fullness Rating Scale (FRS) during satiety test
12 Recruiting Mood, Serotonin and Social Interaction
Conditions: Mood;   Social Behavior
Intervention: Dietary Supplement: tryptophan depletion
Outcome Measures: Empathic Accuracy;   Behavioral mimicry;   Emotional Prosody (EP);   blood;   heart rate variability
13 Recruiting Safety of Percutaneous Tracheostomy in Clopidogrel and Selective Serotonin Reuptake Inhibitors
Condition: Tracheostomy Complication
Outcome Measure: a retrospective review of our experience with bleeding complication in the presence of antiplatelet and SSRI therapy and compare the complications with those who were not on antiplatelet agents or SSRI
14 Recruiting A Study of Pregabalin (Lyrica) Augmentation in Serotonin Reuptake Inhibitor-Refractory Obsessive Compulsive Disorder
Condition: Obsessive-Compulsive Disorder
Interventions: Drug: pregabalin;   Drug: Placebo
Outcome Measures: Yale-Brown-Obsessive-Compulsive-Scale;   Clinical Global Impression - Improvement;   Montgomery Asberg Depression Rating Scale;   Sheehan Disability Scale;   Beck Depression Inventory;   Clinical Global Impression - Severity;   Saving Inventory - Revised;   Dimensional Yale-Brown-Obsessive Compulsive Scale (D-Y-BOCS);   Padua Inventory
15 Unknown  ECT Schizophrenia Serotonin Study
Condition: Schizophrenia
Outcome Measure:
16 Recruiting Estrogen and Serotonin on Changing Brain Chemistry
Condition: Menopause
Interventions: Drug: estradiol transdermal system;   Drug: Amino acid;   Drug: Placebo Patch;   Drug: Placebo
Outcome Measures: To replicate and extend our previous behavioral findings of an interaction between estrogen therapy (ET) and tryptophan depletion on verbal memory in a group of early menopausal women randomized to receive ET.;   To evaluate the extent to which effects of ET (estrogen therapy) and TRP-D (tryptophan depletion) on verbal working memory are mediated through the dorsolateral prefrontal cortex.
17 Recruiting A Study of Bitopertin (RO4917838) in Combination With Selective Serotonin Reuptake Inhibitors in Patients With Obsessive-Compulsive Disorder
Condition: Obsessive-Compulsive Disorder
Interventions: Drug: bitopertin;   Drug: placebo
Outcome Measures: Change in total score on Yale-Brown Obsessive Compulsive Scale (Y-BOCS);   Change in Clinical Global Impression of Severity (CGI-S) score;   Rate of responders according to changes in Y-BOCS and CGI-C;   Change in global social functioning: Sheehan Disability Scale (SDS);   Change in Obsessive Compulsive Inventory-Revised (OCI-R) score;   Safety: Incidence of adverse events
18 Recruiting Selective Serotonin Reuptake Inhibitors (SSRIs) in Borderline Personality Disorder
Condition: Borderline Personality Disorder
Intervention: Drug: Escitalopram
Outcome Measures: self-harm ideation;   Depressive symptoms
19 Not yet recruiting Study of Drug Combination on Pharmacokinetics in Healthy Volunteers
Condition: Hepatitis C Infection
Interventions: Drug: Escitalopram;   Drug: Sertraline;   Drug: DCV 3DAA FDC;   Drug: BMS-791325
Outcome Measures: Serial blood samples for plasma SSRI (selective Serotonin reuptake inhibitor) of escitalopram or sertraline;   Serial blood samples for determination of plasma concentrations of DCV (daclatasvir), ASV (asunaprevir), BMS-791325, and the metabolite BMS-794712;   Safety assessments based on review of adverse events, vital sign measurements, electrocardiograms, physical examinations, and clinical laboratory tests.
20 Recruiting The Role of Serotonin in Seizures
Conditions: Epilepsy;   Seizures
Outcome Measure:

These studies may lead to new treatments and are adding insight into Serotonin etiology and treatment.

A major focus of Serotonin research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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