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Sinusitis Medical Research Studies

Up-to-date List of Sinusitis Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Sinusitis Medical Research Studies

Rank Status Study
1 Recruiting Sinusitis in Children and the Nasopharyngeal Microbiome
Condition: Sinusitis
Intervention:
Outcome Measures: Incidence of acute bacterial Sinusitis in children 49 to 84 months of age (which is the peak age incidence of Sinusitis) as a complication of an antecedent viral URI.;   Define relationships between the nasopharyngeal microbiome, viral illnesses, and progression to clinical Sinusitis.
2 Recruiting Efficacy of Azithromycin Prophylaxis in Preventing Recurrent Acute Sinusitis in Children
Condition: Sinusitis
Interventions: Drug: placebo;   Drug: azithromycin
Outcome Measure: frequence of acute Sinusitis during 12 mouths of study period
3 Not yet recruiting Pulmozyme in Cystic Fibrosis With Sinusitis
Conditions: Sinusitis;   Cystic Fibrosis
Interventions: Drug: Pulmozyme single use ampule;   Drug: placebo
Outcome Measure: 1. To assess changes in quality of life of patients with Cystic Fibrosis while on DNASE as compared to placebo.
4 Not yet recruiting Association of Periostin Levels and Chronic Sinusitis
Conditions: Sinusitis;   Nasal Polyps
Intervention: Other: Blood draw
Outcome Measure: Difference in circulating serum periostin levels pre and post sinus surgery
5 Recruiting Short (5 Days) Versus Long (14 Days) Duration of Antimicrobial Therapy for Acute Bacterial Sinusitis in Children
Condition: Sinusitis
Interventions: Drug: Amoxicillin-Potassium Clavulanate Combination;   Drug: Placebo
Outcome Measure: Comparison of short course to long course antimicrobials.
6 Recruiting Genetic Factors in Chronic Sinusitis
Condition: Chronic Sinusitis
Intervention:
Outcome Measure: Association of genetic variation with CRS disease status
7 Recruiting Development and Validation of a NIRS-based Sinusitis Screening
Condition: Sinusitis
Intervention: Device: Optical imaging NIR
Outcome Measure: Optical imaging NIR tool to assess of Sinusitis
8 Recruiting Xylitol Versus Saline in Chronic Sinusitis
Condition: Chronic Sinusitis
Interventions: Drug: Xylitol;   Drug: Saline
Outcome Measures: SNOT-20;   antibiotic use
9 Unknown  The Clinical Efficacy of Topical Nasal Pomegranate Fruit Extract for Patients With Chronic RhinoSinusitis
Conditions: Rhinitis;   Sinusitis;   Nasal Polyps
Intervention:
Outcome Measure:
10 Recruiting Vitamin D for Chronic Sinusitis
Condition: Chronic Sinusitis
Interventions: Dietary Supplement: vitamin D placebo;   Dietary Supplement: Vitamin D
Outcome Measures: score on the Sinonasal Outcome Test-22 (SNOT-22);   Quality of life as measured by SF-36
11 Recruiting Effects of Endoscopic Sinus Surgery for Chronic Sinusitis on Asthma Control
Conditions: Asthma;   Chronic Sinusitis
Interventions: Procedure: Endoscopic Sinus Surgery;   Other: medical therapy
Outcome Measure: Asthma Control Score
12 Recruiting Study Evaluating the Safety of Intranasal Administration of 400 μg of Fluticasone Propionate Twice a Day (BID) Using a Novel Bi-Directional Device in Subjects With Chronic Sinusitis With or Without Nasal Polyps
Condition: Chronic Sinusitis With or Without Nasal Polyps
Intervention: Drug: Fluticasone Propionate
Outcome Measure: Summary of Safety Evaluations
13 Recruiting Study Evaluating the Safety of Intranasal Administration of 400 μg of Fluticasone Propionate Twice a Day (BID) Using a Novel Bi-Directional Device in Subjects With Chronic Sinusitis With or Without Nasal Polyps
Condition: Chronic Sinusitis With or Without Nasal Polyps
Intervention: Drug: Fluticasone Propionate
Outcome Measure: Summary of Safety Data
14 Recruiting An Evaluation of Dupilumab in Patients With Nasal Polyposis And Chronic Symptoms Of Sinusitis
Condition: Nasal Polyps
Interventions: Drug: dupilumab SAR231893 (REGN668);   Other: placebo;   Drug: mometasone furoate nasal spray
Outcome Measures: Change from baseline in endoscopic Nasal Polyp Score (NPS);   Change from baseline in NPS in sub-group of co-morbid asthma;   Change from baseline in patient reported symptoms of Sinusitis;   Change from baseline in nasal peak inspiratory flow;   Change from baseline in smell test;   Change from baseline in CT scan;   Time to first response in NPS
15 Unknown  Nasal Packing as a Drug Delivery System Postoperatively in Chronic Sinusitis With Polyposis
Conditions: Chronic;   Sinusitis;   Polyposis
Intervention: Drug: pulmicort
Outcome Measures: olfaction;   Sinonasal health;   Olfaction
16 Recruiting Clinical Study to Improve Diagnosis and Treatment of Sinusitis
Condition: Chronic Sinusitis
Intervention:
Outcome Measure:
17 Recruiting Comparison of Balloon Sinuplasty In-Office Versus Medical Management for Recurrent Acute Sinusitis Patients (CABERNET)
Condition: Recurrent Acute RhinoSinusitis
Interventions: Device: balloon sinus dilation;   Other: medical therapy
Outcome Measures: Change in disease-specific patient-reported quality of life (QOL);   Change in disease-specific patient-reported quality of life;   Change in disease-specific and general health-related quality of life;   Change in disease-specific medication usage;   Missed days work/school and medical care visits due to Sinusitis;   Number of sinus infections;   Number of subjects electing procedure (cross-over);   Post-procedure return to normal activity (RTNA)
18 Recruiting Chronic RhinoSinusitis With or Without Nasal Polyps Steroid Study
Conditions: Chronic Sinusitis;   RhinoSinusitis;   Nasal Polyps
Intervention: Drug: Prednisone
Outcome Measure: Alterations of inflammatory cells, levels of key antibodies and cytokines, and expression of key epithelial genes
19 Unknown  Efficacy and Complication of Gentamicin Nasal Irrigation in Chronic RhinoSinusitis
Condition: Chronic Sinusitis
Intervention:
Outcome Measures: Frequency of Sinusitis;   Complications of gentamicin nasal irrigation usage;   Frequency of antibiotic usage
20 Recruiting Duration of Antibiotic Therapy as Part of Maximal Medical Therapy for Chronic RhinoSinusitis
Condition: Sinusitis
Interventions: Drug: Doxycycline;   Drug: Azithromycin;   Drug: Augmentin
Outcome Measures: Number of patients recommended for sinus surgery after 3 weeks of antibiotic therapy;   Number of patients recommended for sinus surgery after 6 weeks of antibiotic therapy;   Change in Quality of Life after 3 weeks of antibiotics;   Change in Quality of Life after 6 weeks of antibiotics;   Change in Nasal endoscopy scores after 3 weeks of antibiotics;   Change in Nasal Endoscopy Score following 6 weeks of antibiotics;   Change in CT Score after 3 weeks of antibiotics;   Change in CT Score after 6 weeks of antibiotics;   Number of patients with antibiotic side effects after a 3 week course of antibiotics;   Number of subjects with antibiotic side effects after a 6 week course of antibiotics

These studies may lead to new treatments and are adding insight into Sinusitis etiology and treatment.

A major focus of Sinusitis research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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