Up-to-date List of Sotalol Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Sotalol Medical Research Studies

1 Not yet recruiting Antiarrhythmic Drugs Assessment in Preventing Atrial Fibrillation
Condition: Atrial Fibrillation
Interventions: Drug: Amiodarone;   Drug: Propafenone;   Drug: Sotalol
Outcome Measures: Average AF burden in minutes per day;   Persistent AF free survival rate;   Left ventricular function;   SF-36 health survey;   comorbidity and mortality
2 Recruiting Trial Comparing Ablation With Medical Therapy in Patients With Ventricular Tachycardia
Conditions: Ventricular Tachycardia;   Coronary Artery Disease
Interventions: Procedure: Catheter Ablation;   Drug: Medical therapy (Sotalol or amiodarone)
Outcome Measures: Recurrence of Ventricular Tachycardia;   Time to First Shock/ATP for VT or to First Presentation of Sustained VT;   Total mortality;   Sudden cardiac death;   Syncope;   Number of hospitalizations;   QOL measures
3 Not yet recruiting Study of the Effects of BMS-919373 on the Electrical Activity of the Heart Using Pacemakers
Condition: Atrial Fibrillation
Interventions: Drug: BMS-919373;   Drug: Sotalol;   Drug: Placebo for BMS-919373
Outcome Measures: The effect of BMS-919373 on Atrial effective refractory period (AERP) in subjects with a dual chamber pacemaker;   The safety assessments will be based on Adverse event reports, vital sign measurements, Electrocardiogram (ECGs), physical examinations and clinical laboratory tests;   Safety assessments based on Ventricular Effective Refractory Period (VERP) and change from baseline;   Safety assessments based on Atrioventricular interval (AVI) and change from baseline;   Safety assessments based on Wenckebach cycle length (WCL) and change from baseline;   Safety assessments based on Intra-atrial conduction time (IACT) and change from baseline
4 Not yet recruiting Anti-arrhythmic Therapy vs Catheter Ablation as First Line Treatment for AICD Shock Prevention
Conditions: Ventricular Tachycardia;   Ventricular Arrhythmia
Interventions: Drug: Antiarrhythmic Drug Therapy;   Procedure: Catheter ablation
Outcome Measures: Appropriate ICD therapy;   Composite Safety Endpoint
5 Recruiting Catheter Ablation Versus Antiarrhythmic Drugs for Outflow Tract Ventricular ARrhythmias
Conditions: Ventricular Tachycardia;   Ventricular Premature Complexes
Interventions: Drug: antiarrhythmic drugs (Flecainide or Propafenone or Sotalol);   Procedure: Catheter Ablation
Outcome Measure: SF-36 score
6 Recruiting Catheter Ablation for Recently Diagnosed Paroxysmal Atrial Fibrillation
Condition: Atrial Fibrillation
Interventions: Drug: Antiarrhythmic drug;   Procedure: Catheter ablation
Outcome Measures: Percentage of AF burden;   All-death death
7 Unknown  Catheter Ablation Versus Medical Treatment of AF in Heart Failure
Conditions: Atrial Fibrillation;   Heart Failure
Interventions: Procedure: Catheter ablation of persistent atrial fibrillation;   Drug: Medical treatment alone
Outcome Measures: Difference in ejection fraction between groups;   Difference in peak VO2 between groups;   Difference in NYHA class between groups;   Difference in BNP between groups;   Difference in Quality of Life between groups;   Reduction in end systolic volume;   Difference in heart failure symptoms
8 Unknown  Vernakalant Versus Ibutilide In Recent-Onset Atrial Fibrillation
Condition: Atrial Fibrillation
Interventions: Drug: Brinavess (Vernakalant);   Drug: Corvert (Ibutilide)
Outcome Measures: Time in minutes until conversion to sinus rhythm (measured from the start of the first study drug administration);   Conversion rate to sinus rhythm within 90 minutes (measured from the start of the first study drug administration)
9 Recruiting Comparison of Reverse Remodeling and PVI Versus CFAE and/or Linear Lesions and PVI for Persistent AF
Condition: Persistent Atrial Fibrillation
Intervention: Procedure: Ablation
Outcome Measure: Freedom of atrial fibrillation/flutter
10 Recruiting Effectiveness Study of Atrial Fibrillation
Condition: Atrial Fibrillation
Outcome Measures: Change from baseline Recurrence of Atrial Fibrillation;   Change from baseline Cardiovascular hospitalisation;   Change from baseline AV node ablation and catheter ablation for Atrial Fibrillation;   Change from baseline Progression to permanent Atrial Fibrillation;   Change from baseline Clinical progression to heart failure and left ventricular systolic dysfunction;   Change from baseline Congestive heart failure;   Change from baseline Interstitial pulmonary disease;   Change from baseline Liver injury/toxicity;   Change from baseline Renal insufficiency/failure;   Change from baseline Cerebrovascular accident/Stroke;   Change from baseline Myocardial infarction;   Change from baseline Torsade de pointes;   Death
11 Recruiting Catheter Ablation vs Anti-arrhythmic Drug Therapy for Atrial Fibrillation Trial
Conditions: Atrial Fibrillation;   Arrhythmia
Interventions: Device: Left atrial ablation;   Drug: Rate or Rhythm Control Therapy
Outcome Measures: LA catheter ablation is superior to rate or rhythm control drug therapy for decreasing the incidence of the composite endpoint of total mortality, disabling stroke, serious bleeding, or cardiac arrest in patients warranting therapy for AF.;   LA catheter ablation is superior to rate or rhythm control drug therapy for reducing total mortality;   Total mortality or cardiovascular hospitalization;   Cardiovascular death;   Cardiovascular death or disabling stroke;   Arrhythmic death or cardiac arrest;   Heart failure death;   Freedom from recurrent AF;   Cardiovascular hospitalization;   Medical costs, resource utilization, and cost effectiveness;   Quality of Life;   Composite adverse events;   Left atrial size, morphology and function and its relationship to morbidity and mortality

These studies may lead to new treatments and are adding insight into Sotalol etiology and treatment.

A major focus of Sotalol research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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