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Sweat Medical Research Studies

Up-to-date List of Sweat Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Sweat Medical Research Studies

Rank Status Study
1 Recruiting Excessive Sweating Caused by Antidepressants: Measurement and Treatment With Glycopyrrolate (AIDES-G)
Conditions: Hyperhydrosis;   Depression
Intervention: Drug: Glycopyrrolate
Outcome Measures: Clinical Global Impression- Improvement scores;   change in mean of patient rated severity of Sweating for each week, and change in mean skin conductance for each week
2 Recruiting Efficacy and Safety of Sage Tablets Compared to Placebo in Menopausal Patients With Hot Flushes and Sweating
Condition: Menopausal Hot Flushes
Intervention: Drug: Sage extract, 3400 mg , DER 1:17
Outcome Measures: Change from Baseline Hyperhidrosis Disease Severity Scale;   Change from Baseline Menopause Rating Scale / MRS;   Change from Baseline Modified Dem Tect
3 Recruiting Histological Analysis Following Ulthera System Treatment for Hyperhidrosis
Condition: Hyperhidrosis
Intervention: Device: Ulthera System Treatment
Outcome Measures: Reduction in the number of sweat glands from baseline to 90-days post-treatment.;   Reduction in spontaneous axillary sweat production assessed by gravimetric method at 90-days post treatment;   HDSS score reduction;   Starch iodine test
4 Recruiting Oral Micronized Progesterone for Perimenopausal Vasomotor Symptoms
Conditions: Hot Flushes;   Night Sweats
Interventions: Drug: Oral micronized progesterone;   Drug: placebo
Outcome Measures: Vasomotor Symptoms (VMS)/ VMS Score;   Frequency of VMS;   Severity of VMS;   Sleep problems;   Mood;   Health-related Quality of Life
5 Recruiting Short Term Effects of Ivacaftor in Non-G551D Cystic Fibrosis Patients
Condition: Cystic Fibrosis
Intervention: Drug: ivacaftor
Outcome Measures: Sweat chloride concentration;   Spirometry;   Multibreath washout testing
6 Recruiting A Safety, Tolerability and Preliminary Efficacy Study of BBI-4000 in Subjects With Axillary Hyperhidrosis
Condition: Hyperhidrosis
Intervention: Drug: BBI-4000
Outcome Measures: Percent change in the gravimetrically measured sweat production from baseline;   Absolute change in the gravimetrically measured sweat production from baseline;   Proportion of subjects who have a minimum of 2-grade improvement in HDSS from baseline.;   Proportion of subjects who have a minimum of 1-grade improvement in HDSS from baseline
7 Unknown  Standardization of a Heat Tolerance Test for Young Women as a Basis for Heat Tolerance Tests in Female Soldiers
Condition: Heat Tolerance
Intervention:
Outcome Measures: The physiological load in women;   Rectal temperature;   Skin temperature;   Heart rate;   Sweat rate
8 Recruiting Heat Stress and Physiological Strain of Permeable vs. Impermeable CB Protective Garment
Condition: Heat Tolerance
Intervention:
Outcome Measures: The physiological burden of different CB Protective Garments;   Rectal temperature;   Skin temperature;   Heart rate;   Sweat rate
9 Recruiting Tx Axillary Hyperhidrosis 1210nm Diode Laser
Condition: Axillary Hyperhidrosis
Intervention: Device: 1210nm Diode Laser treatments
Outcome Measures: subjective global assessment questionnaire;   gravimetric analysis;   modified starch-iodine test
10 Recruiting Comparator Study of the Effect of DRM04B and DRM 04 in Subjects With Axillary Hyperhidrosis
Condition: Hyperhidrosis
Interventions: Drug: Dose 1 of DRM04B;   Drug: Dose 2 of DRM04B;   Drug: Dose 1 of DRM04;   Drug: Dose 2 of DRM04;   Other: Vehicle
Outcome Measures: Proportion of subjects who have a minimum 1-grade improvement in HDSS from Baseline at Week 4;   Proportion of subjects who have a minimum 2-grade improvement in HDSS from Baseline at Week 4;   Absolute change in the gravimetrically measured sweat production from Baseline to Week 4;   Absolute change in the gravimetrically measured sweat production from Baseline to Week 6;   Proportion of subjects who have a minimum 1-grade improvement in HDSS from Baseline at Week 6
11 Not yet recruiting Botulinum Toxin Treatment in Craniofacial, Inguinal, Palmar, Plantar and Truncal Hyperhidrosis
Condition: Hyperhidrosis
Interventions: Drug: Botox (onabotulinumtoxinA);   Drug: NeuroBloc/Myobloc (rimabotulinumtoxinB);   Drug: NaCl (placebo)
Outcome Measures: DLQI (Dermatology Life Quality Index);   AE (Adverse Events);   Gravimetry;   HDSS (Hyperhidrosis Disease Severity Scale);   Health outcome (EQ-5D);   LSAS-SR (Liebowitz Social Anxiety Scale-Self Report);   MADRS-S (Montgomery-Asberg Depression Rating Scale-Self report);   Global Assessment of Therapy
12 Recruiting Identifying Unique Scent Signature of Lung Cancer Through Body Odor
Condition: Lung Neoplasms
Intervention:
Outcome Measure: Number of patients with lung neoplasms
13 Recruiting Growth Hormone, IGF-1 and Medical Treatment in Acromegaly: Are There Effects on Gut Hormone Physiology and Postprandial Substrate Metabolism?
Condition: Acromegaly
Intervention:
Outcome Measures: change in insulin sensitivity;   insulin sensitivity;   fasting and postprandial glucose;   fasting and postprandial insulin;   fasting and postprandial gut hormone levels;   fasting adipokine levels;   fasting lipid levels;   change in fasting and postprandial glucose;   change in fasting and postprandial insulin levels;   change in fasting and postprandial gut hormone levels;   change in fasting adipokine levels;   change in fasting lipid levels
14 Recruiting Treatment of Orthostatic Hypotension in Autonomic Failure
Conditions: Autonomic Failure;   Orthostatic Hypotension
Interventions: Drug: Atomoxetine;   Drug: Acarbose;   Drug: Pyridostigmine Bromide;   Drug: Yohimbine;   Drug: Midodrine HCl;   Drug: placebo;   Drug: Modafinil;   Drug: Octreotide;   Other: water intake;   Drug: Diphenhydramine Hydrochloride;   Drug: Ranitidine HCL;   Drug: Tranylcypromine;   Drug: Ergotamine/ Caffeine;   Drug: Celecoxib;   Drug: Pseudoephedrine;   Drug: Methylphenidate;   Drug: Indomethacin;   Drug: Ibuprofen;   Drug: Oxymetazoline 0.05% nasal solution;   Dietary Supplement: Bovril;   Drug: Acetazolamide;   Drug: Rivastigmine tartrate;   Drug: Carbidopa/levodopa;   Device: Inflatable abdominal binder;   Device: inflatable abdominal binder (sham)
Outcome Measures: Increase in seated systolic blood pressure 1-hr post drug compared to baseline.;   Increase in standing time 1-hr post drug compared to baseline
15 Unknown  Omega 3 Supplementation in Cystic Fibrosis Patients
Condition: Cystic Fibrosis
Interventions: Dietary Supplement: omega-3 triglycerides;   Dietary Supplement: Placebo
Outcome Measures: LTB4/LTB5 ratio from baseline to the end of treatment assessment.;   To explore the change in other inflammatory biomarkers such as TNF-alpha, IL-6, IL-8, IL-17 & alpha-1 anti-trypsin.;   To evaluate the incorporation into cell membrane phospholipids.;   To evaluate the effects on the pulmonary function (FEV1) and on the exercise tolerance (VO2 max).;   To evaluate the effects on the clinical status and the nutritional status.;   To investigate the properties of transepithelial ion transport (sweat test).;   To evaluate the long term overall safety and tolerability of Omega-3 EFA supplementation in CF patients.
16 Recruiting Improving Autonomic Function and Balance in Diabetic Neuropathy
Conditions: Diabetes;   Neuropathy;   Impaired Glucose Tolerance
Intervention: Behavioral: lifestyle modification
Outcome Measures: Autonomic Function: heart rate variability;   balance
17 Recruiting Pathophysiology of Orthostatic Intolerance
Conditions: Tachycardia;   Postural Orthostatic Tachycardia Syndrome
Interventions: Radiation: DAXOR;   Procedure: QSweat;   Drug: Intrinsic Heart Rate
Outcome Measures: Physiological abnormalities in orthostatic intolerance;   blood volume;   intrinsic heart rate;   quantitative sweat testing;   residual sympathetic function after pharmacological autonomic blockade;   norepinephrine spillover
18 Unknown  Comparison of Hormonal Therapy: Mediating Hot Flashes Tapering Regimens for Mediating Hot Flashes
Conditions: Hot Flashes;   Night Sweats
Intervention: Drug: Estradiol
Outcome Measures: To evaluate whether there is a difference in the proportion of women who report a worsening severity of their hot flashes between three tapering schedules for one accepted HT/ET regimen.;   frequency, severity, and "Severity Index" of hot flashes.
19 Unknown  Cognitive Behavioral Therapy (CBT) and Physical Exercise for Climacteric Symptoms in Breast Cancer Patients Experiencing Treatment-Induced Menopause: a Multicenter Randomized Trial
Condition: Menopausal Symptoms in Breast Cancer Patients With Treatment-Induced Complaints
Interventions: Behavioral: CBT and relaxation;   Behavioral: Physical activity;   Behavioral: CBT and physical activity;   Other: Control group
Outcome Measures: Menopausal symptoms;   Vasomotor symptoms; urinary symptoms; sexuality; body- and self image; psychological distress; quality of life
20 Recruiting Extension Study of XLHED-Affected Male Subjects Treated With EDI200 in Protocol ECP-002
Condition: X-linked Hypohidrotic Ectodermal Dysplasia
Intervention: Drug: EDI200
Outcome Measures: Growth and development;   Dentition;   Mortality;   Hospitalizations;   Infections;   Unexplained fevers;   Heat intolerance;   Sweat gland density;   Sweat function;   Skin health;   Hair growth;   Respiratory health;   Ocular health;   Number of participants with adverse events

These studies may lead to new treatments and are adding insight into Sweat etiology and treatment.

A major focus of Sweat research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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