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Syncope Medical Research Studies

Up-to-date List of Syncope Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Syncope Medical Research Studies

Rank Status Study
1 Unknown  Eastbourne Syncope Assessment Study II
Condition: Syncope
Interventions: Device: Sleuth Implantable Loop Recorder;   Other: Other
Outcome Measures: Primary Outcome 1. Time to ECG (objective) diagnosis of Syncope;   1. Time to ECG directed therapy. 2. Time to introduction of empiric therapy. 3. Time to first post induction Syncope. 4. Cost effectiveness analysis.
2 Recruiting Assessment of Midodrine in the Prevention of Vasovagal Syncope: The Prevention of Syncope Trial IV
Condition: Vasovagal Syncope
Interventions: Drug: midodrine hydrochloride;   Drug: matching placebo
Outcome Measures: The primary outcome measure will be the proportion of patients having at least one Syncope recurrence.;   A secondary outcome will be the time between the first and second Syncope recurrences.;   A secondary outcome will be the frequency of syncopal spells.;   A secondary outcome is the number, duration, and severity of presyncopal spells (as measured with the Calgary PreSyncope Scale(19)).;   A secondary outcomes will be quality of life as measured by the EQ-5D and the ISQL.
3 Not yet recruiting Assessment of Metoprolol in the Prevention of Vasovagal Syncope in Aging Subjects
Condition: Vasovagal Syncope
Interventions: Drug: Metoprolol;   Drug: Matching Placebo
Outcome Measures: The primary outcome measure will be the proportion of patients having at least one Syncope recurrence.;   A secondary outcome will be the time between the first and second Syncope recurrences.;   A secondary outcome will be the frequency of syncopal spells.;   A secondary outcome is the number, duration, and severity of presyncopal spells (as measured with the Calgary PreSyncope Scale);   A secondary outcomes will be quality of life as measured by the EQ-5D and the ISQL.
4 Recruiting Cardioneuroablation for Neurocardiogenic Syncope
Conditions: Neurocardiogenic Syncope;   Vasovagal Syncope
Interventions: Procedure: Cardioneuroablation;   Device: Biosense Webster Navistar ThermoCool Diagnostic/Ablation Deflectable Tip Catheter
Outcome Measures: Recurrence of Syncope;   Incidence of Serious Adverse Events
5 Recruiting Guideline-based Pacing Therapy for Reflex Syncope
Condition: Syncope
Intervention:
Outcome Measures: Syncope recurrence after PM implantation;   Syncope burden after PM implantation
6 Recruiting Stop Vasodepressor Drugs in Reflex Syncope
Condition: Hypotensive Syncope
Interventions: Drug: Vasoactive drug therapies;   Other: Stop/reduce vasoactive drugs
Outcome Measures: Recurrence of Syncope or preSyncope and adverse events;   Syncope;   PreSyncope
7 Recruiting Influence of Yoga in Patients With Neurocardiogenic Syncope
Condition: Syncope, Vasovagal
Intervention: Other: Yoga
Outcome Measures: Change in frequency of recurrent syncopal spells in patients with Neurocardiogenic Syncope (NCS);   Change in Heart Health
8 Recruiting Prevalence of Pulmonary Embolism in Patients With Syncope
Conditions: Syncope;   Pulmonary Embolism
Intervention: Other: Lung CT or V/Q scanning in patients with a high pre-test clinical probability of PE and/or a positive D-dimer
Outcome Measures: To assess the prevalence of PE in a large series of consecutive patients presenting with the first episode of Syncope;   To assess the prevalence of pulmonary embolism in patients with apparently unexplained Syncope
9 Recruiting Syncope: Pacing or Recording in the Later Years
Conditions: Syncope;   Heart Block;   Conduction Disorder of the Heart
Interventions: Procedure: pacemaker;   Procedure: implantable loop recorder
Outcome Measures: The primary outcome measure will be a composite of Major Adverse Study-Related Events (MASRE) in a 2-year observation period.;   Secondary outcome measures will include total number of syncopal spells.;   Secondary outcome measures will include the likelihood of a first recurrence of Syncope.;   Secondary outcome measures will include the physical trauma due to Syncope.;   Secondary outcome measures will include quality of life of the participants.
10 Not yet recruiting Syncope Prediction Study
Condition: Vasovagal Syncope
Intervention:
Outcome Measure: Number of participants with Syncope recurrence predicted by VVS prediction algorithm
11 Recruiting Improving Syncope Risk Stratification in Older Adults
Condition: Syncope
Intervention:
Outcome Measure: Combined death and serious cardiac events
12 Recruiting BAsel Syncope EvaLuation (BASEL IX) Study
Condition: Syncope
Intervention:
Outcome Measure: diagnostic and prognostic value of various novel and established biomarkers, clinical assessment and detailed patient history
13 Unknown  Optimizing Diagnostics Of Syncope Events Using Intelligent Telemetric Solutions.
Conditions: Cardiac Arrhythmia;   Cardiogenic Syncope
Interventions: Device: repeated 24 hours ECG Holter monitoring;   Device: Telemetric ECG monitoring
Outcome Measures: Recording of symptomatic or life threatening arrhythmia event;   Occurrence of silent (asymptomatic) arrhythmia event;   1. Verification of patient self assessment based on the Quality of Life questionnaire and EHRA scale against evidence of cardiac arrhythmia occurrence
14 Recruiting Efficacy of Transcatheter Ablation Using Anatomic Approach of Ganglionated Plexi Located in the Right Atrium to Prevent Neuromediated Cardioinhibitory Syncope
Condition: Neuromediated Cardioinhibitory Syncope
Intervention: Procedure: transcatheter ablation of ganglionated plexi in right atrium
Outcome Measure: neuromediated cardioinhibitory Syncope recurrence
15 Recruiting Mechanisms of Vasovagal Syncope
Conditions: Vasovagal Syncope;   Postural Tachycardia Syndrome
Interventions: Drug: Phenylephrine;   Drug: L-Ng-monomethyl Arginine (L-NMMA)
Outcome Measures: Heart rate and blood pressure in response to Lower Body Negative Pressure(LBNP);   Adrenergic neurotransmission as measured by Muscle Sympathetic Nerve Activity(MSNA), doppler ultrasound blood flow, venous Norepinephrine in response to Phenylephrine infusion
16 Recruiting Point-of-Care Ultrasound in the Emergency Department Evaluation of Syncope
Condition: Syncope
Intervention: Other: Point-of-Care Ultrasound
Outcome Measures: Time to Final Emergency Department Disposition;   Time to therapeutic intervention;   Time to clinical procedure;   Number and Type of other imaging studies;   Information Content provided by Point-of-Care Ultrasound;   Number and type of laboratory studies;   Number of and time to consultant services
17 Unknown  Adenosine Testing to DEtermine the Need for Pacing Therapy
Condition: Syncope
Interventions: Device: Pacemaker implantation (Medtronic);   Device: Implantable Loop Recorder (Medtronic)
Outcome Measures: Syncope Burden;   Time to first Syncope;   Number of patients with recurrent Syncope;   Quality of life;   Health economic analysis;   ECG diagnosis on ILR following syncopal episode in adenosine negative group
18 Recruiting Evaluation of the Efficiency of Hydration by Isotonic Solution in the Prevent of the Fainting Whole Blood Donors
Conditions: Fainting;   PreSyncope;   Syncopal Episode
Interventions: Other: tensing exercises;   Other: No tensing exercises
Outcome Measures: Accumulated incidence of presyncopal and syncopal reactions during blood donation, while still at the blood donation whole and within 48 hours of the blood donation, that required the donor to be placed in a 'Trendelenburg' position;   daily activities;   presyncopal and syncopal reactions of all donors;   presyncopal and syncopal reactions in the population of young donors (in schools);   presyncopal or syncopal reactions influence on subsequent blood donation;   Recurrence of presyncopal or syncopal reactions;   Explanatory variables of presyncopal and syncopal reactions;   subgroup analysis on collection unit characteristics;   medium term impact of the donation;   Restless legs syndrome
19 Unknown  Validation of a Non Invasive Blood Marker of SIDS and Vagal Disorders
Condition: Vagal Syncope
Interventions: Biological: Blood sampling;   Other: ECG-Holter 24 h tape and sino-carotid stimulation test
Outcome Measure:
20 Recruiting Essential Hypotension and Adaptability Registry
Conditions: Blood Pressure;   Depression;   Panic Attack;   Fibromyalgia;   POTS;   Inappropriate Sinus Tachycardia;   Coronary Heart Disease;   Acute Coronary Syndrome (ACS);   Acute Myocardial Infarction (AMI);   Cerebrovascular Disease (CVD);   Transient Ischemic Attack (TIA);   Atrial Fibrillation;   Diabetes Mellitus;   Cancer;   Systolic Heart Failure;   Diastolic Heart Failure;   Chronic Fatigue Syndrome;   Syncope;   Vasovagal Syncope
Intervention:
Outcome Measures: Relationship between Blood pressure group and comorbidities;   Relationship between adaptability group and comorbidities;   Relationship between blood pressure group, adaptability group and comorbidities;   Relationship between blood pressure group, habits and anthropometric, metabolic, endocrine, Electrocardiogram, Holter, ambulatory blood pressure monitoring (ABPM);   Relationship between blood pressure group, adaptability group, habits anthropometric, metabolic, endocrine, electrocardiographic, Holter, ambulatory arterial blood pressure monitoring.;   For metabolic disorders what it matters the most: the anthropometric variables vs blood pressure group vs adaptability group;   Relationship between adaptability group, habits and anthropometric, metabolic, endocrine, Electrocardiogram, Holter, ambulatory blood pressure monitoring (ABPM)

These studies may lead to new treatments and are adding insight into Syncope etiology and treatment.

A major focus of Syncope research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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