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Technetium Medical Research Studies

Up-to-date List of Technetium Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Technetium Medical Research Studies

Rank Status Study
1 Not yet recruiting Infrared Lymphangiography as a Method of Sentinel Node Identification
Conditions: Melanoma;   Sentinel Node
Interventions: Drug: Indocyanine green;   Drug: Technetium99;   Drug: Methylene blue
Outcome Measure: Equivalence of ICG and real time lymphangiography to Technetium99 and blue dye in localizing sentinel nodes
2 Recruiting Sentinel Lymph Node Mapping Post-Injection Site Pain
Condition: Breast Cancer
Interventions: Drug: Tilmanocept;   Drug: Sulfur Colloid
Outcome Measures: Change from baseline level of discomfort;   Visualization of Sentinel Lymph Nodes on Lymphoscintigraphy
3 Recruiting Validation of Myocardial Perfusion Imaging
Condition: Coronary Artery Disease
Intervention: Procedure: coronary angiography
Outcome Measure: Accuracy, positive and negative predictive value of Stress Thallium-201/Rest Technetium-99m Sequential Dual Isotope High-Speed Myocardial Perfusion Imaging to detect coronary artery disease
4 Recruiting Aldesleukin Imaging in Viewing Tumor Growth in Patients With Stage IV Melanoma Receiving Ipilimumab Therapy
Conditions: Recurrent Melanoma;   Stage IV Melanoma
Interventions: Procedure: scintigraphy;   Other: laboratory biomarker analysis;   Biological: Technetium Tc 99 hydrazinonicotinamide-tricine-linked interleukin-2
Outcome Measures: Proportion of patients who develop a SLD (grade 2+ allergic reaction; grade 3+ anaphylaxis, grade 2+ injection site reaction, or a grade 3+ non-hematologic toxicity -not attributed to IPI treatment/progression or a co-morbid condition);   Adverse events, based on the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 4.0;   TIL invasion as determined by Technetium Tc 99 hydrazinonicotinamide-tricine-linked interleukin-2 scintigraphy with tumor burden (as determined by RECIST criteria);   Tumor based biomarkers, and peripheral blood biomarkers;   Progression-free survival
5 Recruiting SPECT/CT in Measuring Lung Function in Patients With Lung Cancer Undergoing Radiation Therapy
Conditions: Extensive Stage Small Cell Lung Cancer;   Limited Stage Small Cell Lung Cancer;   Occult Non-small Cell Lung Cancer;   Recurrent Non-small Cell Lung Cancer;   Recurrent Small Cell Lung Cancer;   Stage IA Non-small Cell Lung Cancer;   Stage IB Non-small Cell Lung Cancer;   Stage IIA Non-small Cell Lung Cancer;   Stage IIB Non-small Cell Lung Cancer;   Stage IIIA Non-small Cell Lung Cancer;   Stage IIIB Non-small Cell Lung Cancer;   Stage IV Non-small Cell Lung Cancer
Interventions: Radiation: Technetium Tc 99m-labeled macroaggregated albumin;   Radiation: 99mTc-DTPA;   Device: single photon emission computed tomography;   Device: computed tomography
Outcome Measures: Change in perfusion in lung tissue, assessed using 99mTc-MAA SPECT/CT;   Change in ventilation in lung tissue, assessed using 99mTc-DTPA SPECT/CT;   Changes in tracer uptake at the global lung, regional lung, and lung image voxel scales, assessed using 99mTc-MAA and 99mTc-DTPA SPECT/CT
6 Recruiting Compare Technegas Ventilation-Perfusion SPECT and Xenon Ventilation-Perfusion Planar Imaging for Pulmonary Embolism
Condition: Pulmonary Embolism
Interventions: Drug: Technegas V/Q SPECT;   Drug: Xenon-133
Outcome Measures: Sensitivity of Technegas V/Q SPECT for the diagnosis of PE;   Specificity of Technegas V/Q SPECT for the diagnosis of PE.;   Accuracy of Technegas V/Q SPECT and Xenon V/Q Planar imaging for diagnosis of PE;   Positive predictive value of imaging for diagnosis of PE;   Negative predictive value of imaging for diagnosis of PE;   Likelihood ratio for diagnosis of PE;   Safety of Technegas in patients with possible PE
7 Recruiting Does Alkalinization Reduce Perceived Pain Levels During Sentinel Lymph Node Imaging?
Condition: Pain
Interventions: Drug: Standard of Care First;   Drug: ph Altered first
Outcome Measure: Perceived Pain level
8 Recruiting Pilot Study to Assess Lung Shunting of Yttrium-90 Microspheres Using PET/CT
Conditions: Advanced Adult Primary Liver Cancer;   Liver Metastases;   Localized Unresectable Adult Primary Liver Cancer;   Recurrent Adult Primary Liver Cancer
Interventions: Procedure: positron emission tomography;   Procedure: computed tomography
Outcome Measures: Absolute difference in post-therapy Yttrium-90 microsphere and pre-therapy Technetium-99m macroaggregated albumin hepatopulmonary shunt fraction values;   In vitro Technetium-99m macroaggregated albumin particle size and microsphere size for each patient
9 Recruiting Renal Function Determination in Patients With Liver Cirrhosis
Condition: Liver Cirrhosis
Outcome Measure: Levels of glomerular filtration through several formulas in cirrhotic patients
10 Not yet recruiting Study of Homing of Labelled Stem Cells in Human Heart.
Condition: Homing of Stem Cells in the Infarct Area.
Outcome Measure: homing of labelled cells to infarct zone and scan showing radioactivity in the infarct area
11 Recruiting Safety and Efficacy Study of Intramyocardial Stem Cell Therapy in Patients With Dilated Cardiomyopathy
Conditions: Dilated Cardiomyopathy;   Chronic Heart Failure
Interventions: Procedure: Intramyocardial injection;   Procedure: Intracoronary injection
Outcome Measures: Changes in left ventricular ejection fraction and dimensions;   Changes in exercise capacity;   Change in NT-proBNP levels
12 Recruiting Non-isotope Based Imaging Modalities vs Technetium-99m Single-Photon Emission Computed Tomography(99mTcSPECT)
Condition: Myocardial Ischemia
Outcome Measures: The results (normal (-) or abnormal (+) of the 3 non-isotope based modalities;   Degree of coronary artery stenosis as quantified from the invasive coronary angiography TIMI flow and FFR
13 Unknown  The Effect of Electrode Implantation for Deep Brain Stimulation (DBS) on Brain Function Using Single Photon Emission Computed Tomography (SPECT) With Technetium-99m-ethyl Cysteinatedimer (Tc-ECD)
Conditions: Parkinson's Disease;   Deep Brain Stimulation
Interventions: Radiation: Injection of 15mCi of Tc-ECD and scanning by SPECT camera;   Behavioral: Semantic verbal fluency task performance;   Device: Turning off the stimulator
Outcome Measures: CBF values in different brain regions;   Number of words produced in the semantic fluency task
14 Recruiting 4D-CT-based Ventilation Imaging for Adaptive Functional Guidance in Radiotherapy
Condition: Lung Cancer
Interventions: Device: Real-time Position Management system;   Device: Discovery ST multislice PET/CT scanner;   Device: Infinia Hawkeye SPECT/CT gamma camera;   Device: Pinnacle3 treatment planning system;   Device: SKYLight nuclear camera;   Drug: DTPA;   Drug: Technetium TC 99M MAA
Outcome Measures: The overall correlation between the 4D-CT and the SPECT ventilation images.;   The difference between the local ventilation at simulation and during the treatment. Dose-volume or functional dose-volume metrics. The regression coefficient between the regional ventilation and time. The mean dose to the high-functional lung region.
15 Recruiting Effect of Ventilation Mode on Lung Deposition of a Radiolabeled Aerosol During Mechanical Ventilation: Barometric Versus Volumetric
Condition: Post-operative Neurosurgery
Interventions: Drug: Technetium-99m - Diethylenetriaminepentaacetic acid;   Device: Vibrating-mesh nebulizer;   Other: Gamma scintigraphy;   Other: Preoperative spirometry
Outcome Measures: Pulmonary deposition;   Penetration index;   Mechanical ventilation settings;   Lung function
16 Unknown  The Role of the Novel 99mTc-NC100692 Tracer in Patients at High Risk or Known Breast Cancer
Conditions: Breast Cancer;   Tumor Angiogenesis
Outcome Measure:
17 Recruiting Phase 2 Study to Evaluate the Preliminary Performance of the C13-URA Breath Test Kit in Dyspeptic Subjects
Condition: Dyspeptic Subjects
Intervention: Drug: 13C-uracil and 99mTc sulfur colloid
Outcome Measures: Expired 13CO2 concentrations;   Concentrations of 13C-uracil and its major metabolites in plasma and urine
18 Recruiting Accuracy of Sentinel Lymph Node Biopsy and Gadofosveset-Enhanced MR in Nodal Staging of High Risk Endometrial Cancer
Conditions: High Grade Endometrial Cancer;   Sentinel Lymph Node Mapping;   Ablavar
Intervention: Biological: Gadofosveset Trisodium (Ablavar)
Outcome Measure: Performance Analysis
19 Recruiting Efficacy and Safety of Ad5FGF-4 for Myocardial Ischemia in Patients With Stable Angina Due to Coronary Artery Disease
Condition: Angina, Stable
Intervention: Genetic: Alferminogene tadenovec
Outcome Measures: Change in reversible perfusion defect size (RPDS) as measured by adenosine triphosphate (ATP) single-photon emission computed tomography with Technetium-99m sestamibi (SPECT);   Change in angina frequency and nitroglycerin use;   Change in quality of life using the Seattle Angina Questionnaire;   Change in patient functional class using CCS anginal classification;   Safety of Ad5FGF-4 as assessed by adverse events and clinical laboratory testing;   Long-term safety of Ad5FGF-4 as assessed by serious adverse events
20 Recruiting Sodium Nitrite in Acute Myocardial Infarction
Condition: Acute Myocardial Infarction
Intervention: Drug: Sodium Nitrite
Outcome Measures: Primary efficacy outcome is a to determine whether sodium nitrite safely reduces infarct size normalized for the ischemia area at risk as determined by paired single-photon computed tomography studies with Technetium Tc99m sestamibi.;   Left ventricular volumes, ejection fraction, and infarct size by magnetic resonance imaging.

These studies may lead to new treatments and are adding insight into Technetium etiology and treatment.

A major focus of Technetium research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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