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Tildiem Medical Research Studies

Up-to-date List of Tildiem Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Tildiem Medical Research Studies

Rank Status Study
1 Recruiting Randomized Trial Comparing Diltiazem and Metoprolol For Atrial Fibrillation Rate Control
Conditions: Atrial Fibrillation;   Atrial Flutter
Interventions: Drug: Metoprolol;   Drug: Diltiazem
Outcome Measures: Conversion to sinus rhythm;   Heart rate control;   Home discharges from Emergency Department (ED);   Total hospital cost;   Rehospitalization for Atrial Fibrillation
2 Unknown  Low Dose of Diltiazem for Rate Control of Atrial Fibrillation
Condition: Atrial Fibrillation
Intervention: Drug: low dose diltiazem
Outcome Measure: Success rate of rate control
3 Recruiting Efficacy Study of Cardizem in Pulmonary Arterial Hypertension
Conditions: Idiopathic Pulmonary Arterial Hypertension;   Primary Pulmonary Hypertension;   Pulmonary Arterial Hypertension;   Familial Primary Pulmonary Hypertension
Interventions: Drug: Diltiazem Hydrochloride;   Drug: Sugar Pill
Outcome Measures: Six Minute Walk Distance;   Dyspnea Score;   Quality of Life Score;   Pulse Oximetry
4 Recruiting Effect of Diltiazem on Coronary Artery Ectasia
Condition: Coronary Artery Ectasia
Interventions: Drug: intracoronary administration of diltiazem;   Drug: intracoronary injection of 5 mL saline
Outcome Measures: Myocardial blush grade;   TIMI (Thrombolysis in myocardial infarction) flow grade;   TIMI (Thrombolysis in myocardial infarction) frame count
5 Unknown  A Drug Interaction Study of Boceprevir in Combination With Amlodipine or Diltiazem in Healthy Volunteers
Conditions: Hepatitis C;   Hypertension
Interventions: Drug: Amlodipine;   Drug: Diltiazem
Outcome Measures: pharmacokinetics;   number of participants with adverse events
6 Not yet recruiting Treatment Of Chronic Anal Fissure
Condition: Chronic Anal Fissure
Interventions: Other: Levorag Emulgel;   Drug: Diltiazem
Outcome Measures: Complete healing at week 12;   Complete healing at week 8;   Defecation pain at day 3;   Defecation pain at day 7;   Adverse events
7 Recruiting Regulatory T Cells in Type 1 Diabetes Patients Treated With IL-2
Condition: Type 1 Diabetes
Intervention: Drug: Aldesleukin (Proleukin)
Outcome Measures: The primary endpoint is based upon the percentage of CD4+T regulatory (defined as CD3+CD4+CD25highCD127low) cells within the CD3+CD4+T cell gate following treatment with IL-2.;   T regulatory cell phenotype and stability;   T effector cell number and phenotype;   T cell subset proliferation and populations;   Intracellular T cell and natural killer(NK) cell signalling;   T regulatory cell function;   IL-2 pathway genotype;   Lymphocyte Subsets;   Serum Cytokines;   Glycaemic control;   Number of Participants with Adverse Events as a Measure of Safety and Tolerability
8 Not yet recruiting Comparison of Vascular Remodeling Between Different Antianginal Medication Evaluated by Noninvasive ECG-gated Fundus Photographic Evaluation
Condition: Stable Angina
Interventions: Drug: Diltiazem treated group;   Drug: Bisoprolol treated group;   Drug: Candesartan treated group
Outcome Measures: Wall to lumen ratio of fundus vessel;   lipid parameter;   Serum markers of inflammation;   Change of nitrate need
9 Recruiting Treatment of Supine Hypertension in Autonomic Failure
Condition: Hypertension
Interventions: Drug: Clonidine;   Drug: Nitroglycerin transdermal;   Drug: Dipyridamole/ Aspirin (Aggrenox);   Drug: Desmopressin (DDAVP);   Drug: Sildenafil;   Drug: Nifedipine;   Drug: Hydralazine;   Drug: Hydrochlorothiazide;   Drug: Placebo;   Drug: Bosentan;   Drug: Diltiazem;   Drug: Eplerenone;   Drug: guanfacine;   Dietary Supplement: L-arginine;   Drug: captopril;   Drug: carbidopa;   Drug: losartan;   Drug: metoprolol tartrate;   Drug: nebivolol hydrochloride;   Drug: prazosin hydrochloride;   Drug: tamsulosin hydrochloride;   Other: Head-up tilt.;   Drug: aliskiren;   Other: Local heat stress
Outcome Measures: Decrease in supine systolic blood pressure;   Decrease in pressure natriuresis
10 Unknown  Sevoflurane Versus Intravenous Anaesthetic Agents in Morbid Obese Patients
Condition: Morbid Obesity
Interventions: Drug: Sevoflurane;   Drug: Propofol- Remifentanyl;   Drug: Propofol, Remifentanyl
Outcome Measures: Change from baseline of perioperative haemodynamic measurements (HR, MAP), recovery scores (Aldrete, White,Chung);   Drug Consumption, Drug Cost.
11 Recruiting Ranolazine and Microvascular Angina by PET in the Emergency Department
Condition: Microvascular Angina
Interventions: Drug: Ranolazine;   Drug: Placebo
Outcome Measures: Coronary Flow Reserve;   SAQ(Seattle Angina Questionnaire) Scores
12 Recruiting Suppression Of Atrial Fibrillation With Ranolazine After Cardiac Surgery
Condition: Heart; Dysfunction Postoperative, Cardiac Surgery
Intervention: Other: Atrial fibrillation
Outcome Measures: Freedom from any episode of post operative atrial fibrillation longer than 6 hours duration occurring during the study period.;   Telemetry monitoring strips
13 Recruiting Non Invasive Measurements of Fibrosis, Inflammation and Steatohepatitis in Morbidly Obese Patients
Conditions: Morbid Obesity;   Non Alcoholic Steatohepatitis
Outcome Measures: To validate the use of serum tests, FibroScan / CAP abdominal MRI for the diagnosis of severe steatosis and / or NASH (specificity, sensitivity, positive and negative predictive values);   Histological lesions of liver fibrosis and quantification of abdominal fat by MRI
14 Recruiting Catheter Ablation vs Anti-arrhythmic Drug Therapy for Atrial Fibrillation Trial
Conditions: Atrial Fibrillation;   Arrhythmia
Interventions: Device: Left atrial ablation;   Drug: Rate or Rhythm Control Therapy
Outcome Measures: LA catheter ablation is superior to rate or rhythm control drug therapy for decreasing the incidence of the composite endpoint of total mortality, disabling stroke, serious bleeding, or cardiac arrest in patients warranting therapy for AF.;   LA catheter ablation is superior to rate or rhythm control drug therapy for reducing total mortality;   Total mortality or cardiovascular hospitalization;   Cardiovascular death;   Cardiovascular death or disabling stroke;   Arrhythmic death or cardiac arrest;   Heart failure death;   Freedom from recurrent AF;   Cardiovascular hospitalization;   Medical costs, resource utilization, and cost effectiveness;   Quality of Life;   Composite adverse events;   Left atrial size, morphology and function and its relationship to morbidity and mortality

These studies may lead to new treatments and are adding insight into Tildiem etiology and treatment.

A major focus of Tildiem research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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