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Tonsillitis Medical Research Studies

Up-to-date List of Tonsillitis Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Tonsillitis Medical Research Studies

Rank Status Study
1 Recruiting Procalcitonin-guided Detection of Streptococcal Acute Tonsillitis
Condition: Streptococcal Acute Tonsillitis
Outcome Measures: Procalcitonin;   Centor score
2 Recruiting A Phase I/II to Assess Safety, Tolerability and Efficacy of DL-lactic Acid Syrup in Children With Recurrent Tonsillitis
Condition: Recurrent Tonsillitis in Children
Interventions: Drug: DL - Lactic Acid;   Dietary Supplement: Raspberry flavored syrup
Outcome Measures: Safety evaluation - Number of participants with adverse events;   Tonsil Size;   Number of Tonsillitis episodes
3 Unknown  Evaluation of Coblation Channeling in Treating Chronic Tonsillitis
Condition: Tonsillitis
Intervention: Procedure: Coblation channeling
Outcome Measures: RF coblation may be promising in treating chronic Tonsillitis.;   RF coblation reduces tonsillar volume and pain in comparison to surgery; may be performed as an out-patient procedure.
4 Recruiting PASS Study To Evaluate The Potential Of Zithromax To Cause Ocular Problems In Pediatric Patients
Conditions: Pharyngitis;   Tonsillitis
Intervention: Drug: Azithromycin
Outcome Measure: Best corrected visual acuity (distance), color vision, Amsler grid testing, anterior segment biomicroscopy, and fundus examination
5 Recruiting Acetaminophen's Efficacy for Post-operative Pain Control
Conditions: Tonsillitis;   Airway Obstruction;   Difficulty Swallowing
Interventions: Drug: IV acetaminophen;   Drug: PO acetaminophen
Outcome Measures: Total pain medication from time of PACU admission until 24 hours post-operatively as documented by all pain given.;   Post-operative FLACC: Face, Legs, Activity, Cry & Consolability (FLACC) pain assessment scores.;   Incidence of post-operative vomiting;   Parental satisfaction with pain control, as measured by a 10 point Likert scale.
6 Unknown  Randomized Controlled Study of Plasmaknife Tonsillectomy Versus Monopolar Tonsillectomy
Conditions: Obstructive Tonsillar Hypertrophy;   Tonsillitis
Interventions: Device: Plasmaknife;   Device: Monopolar
Outcome Measures: pain;   return to normal activity;   return to normal diet;   medication dose taken
7 Not yet recruiting Human Papilloma Virus (HPV) Prevalence in the Mouth and Oropharynx of the General Population
Condition: Chronic Tonsillitis
Outcome Measures: Occurrence of HPV in tonsils and in oral scrape sample;   HPV vaccination status
8 Unknown  Vitamin D Levels in Children Undergoing Adenotonsillectomies and Controls
Condition: Tonsillitis
Outcome Measure:
9 Recruiting Laryngeal Mask Airway in Pediatric Adenotonsillectomy
Conditions: Sleep Apnea, Obstructive;   Tonsillitis
Interventions: Procedure: ETT with non modified retractor;   Other: LMA with modified retractor
Outcome Measures: To determine the number of participants with adverse events with use of LMA and ETT during adenotonsillectomy.;   To determine total length of procedure and recovery time with use the LMA.
10 Recruiting Analgesic Effect of IV Acetaminophen in Tonsillectomies
Conditions: AdenoTonsillitis;   Tonsillitis
Interventions: Drug: Acetaminophen (paracetamol);   Drug: Morphine (hydromorphone)
Outcome Measures: Analgesic efficacy of single dose intravenous acetaminophen in pediatric patients undergoing tonsillectomy to measure opioid consumption and pain scores in the first 8-12 postoperative hours.;   To observe recovery characteristics in the PACU and floor in patients following tonsillectomy.
11 Recruiting Auricular Acupuncture for The Treatment of Post-Tonsillectomy Pain
Conditions: Recurrent Tonsillitis;   Recurrent Peritonsillar Abscess;   Obstructive Sleep Apnea
Intervention: Procedure: Auricular Acupuncture
Outcome Measure: Reduction in VAS scores between experimental and control group
12 Unknown  KITS Study -Ketorolac In Tonsillectomy Surgery: a Double Blinded, Randomized Clinical Trial
Condition: Recurrent Acute Tonsillitis
Interventions: Drug: Ketorolac;   Drug: Normal Saline
Outcome Measure: Pain
13 Recruiting CLEARI (Clinical Efficacy Assessment on Recurrent Upper-Respiratory Tract Infections) Study
Condition: Recurrent Upper-Respiratory Tract Infections
Interventions: Drug: J022X ST;   Drug: Placebo
Outcome Measure: Number of Upper-Respiratory Tract Infections (URTI) episodes medically assessed over year 2
14 Recruiting Thermographic Characteristics of Sore Throat by Thermographic Camera
Conditions: Fever;   Sore Throat
Intervention: Device: Thermal camera by Flir -HM series.
Outcome Measures: Correlation between the symptoms of sore throat and fever and the temperature of the tonsils as measured by the thermal photograph.;   Correlation between clinical diagnosis of Tonsillitis and thermal camera photo
15 Unknown  Coblation-Tonsillotomy vs Electrocautery-Tonsillectomy for the Treatment of Obstructive Sleep Apnea (OSA) in Children
Condition: Obstructive Sleep Apnea
Interventions: Procedure: Electrocautery-tonsillectomy;   Procedure: Coblation-tonsillotomy
Outcome Measures: Compare coblation-tonsillotomy to electrocautery-tonsillectomy as a treatment of obstructive sleep apnea (OSA), as assessed by apnea-hypopnea index (AHI) measured on polysomnography (PSG);   Evaluate post-operative pain and analgesic use associated with electrocautery-tonsillectomy and coblation-tonsillotomy;   Evaluate quality of life following coblation-tonsillotomy and electrocautery-tonsillectomy for the treatment of OSA
16 Recruiting Invasive Group A Streptococcus (GAS) Infection in Children: Bacterial Virulence Factors and Detection of Host Immunological and/or Genetic Factors of Predisposition to Infections
Condition: Invasive GAS Infection
Intervention: Genetic: DNA samples, GAS strains
Outcome Measures: virulence factors of GAS;   Assess the frequency and type of hereditary immune deficiency or Mendelian susceptibility to infections associated with invasive GAS infections in children without risk factors;   describe and compare the GAS emm genotypes and virulence factors with the profiles of strains isolated with invasive GAS infection with known risk factors and with the profile of strains isolated with a non-invasive GAS infections;   compare GAS emm genotypes and profiles of virulence strains responsible for invasive SGA infections with strains causing noninvasive infections
17 Unknown  The Effect of Adding Pain Relievers to Local Anesthesia Before Preforming Drainage in Peritonsillar Abscess
Condition: Peritonsillar Abscess
Intervention: Drug: dypiron, tramadol
Outcome Measure: the vas scale
18 Recruiting Assessing the Necessity of Prescribing Antibiotics (Clavulin or Clindamycin Versus Placebo) Post-peritonsillar Abscess Drainage
Condition: Peritonsillar Abscess
Interventions: Drug: Clavulin;   Drug: Randomization to Placebo;   Drug: Clindamycin
Outcome Measure: Re-accumulation of the patient's peri-tonsillar abscess

These studies may lead to new treatments and are adding insight into Tonsillitis etiology and treatment.

A major focus of Tonsillitis research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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