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Topamax Medical Research Studies

Up-to-date List of Topamax Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Topamax Medical Research Studies

Rank Status Study
1 Unknown  Aripiprazole and Topiramate on Free-Choice Alcohol Use
Condition: Alcohol Dependence
Interventions: Drug: Double Placebo;   Drug: Aripiprazole 15, placebo;   Drug: Aripiprazole 7.5, Placebo;   Drug: Topiramate 100, Placebo;   Drug: Topiramate 200, Placebo;   Drug: Topiramate 100, Aripiprazole 15;   Drug: Topiramate 100, Aripiprazole 7.5;   Drug: Topiramate 100, Aripiprazole 15mg;   Drug: Topiramate 200, Aripiprazole 7.5mg;   Drug: Topiramate 200, Aripiprazole 15
Outcome Measures: Number of alcoholic drinks consumed in a laboratory setting;   Safety and tolerability of the medications singly and in combination, compared to placebo;   Drinks consumed during the medication titration period
2 Recruiting Topiramate for Alcohol Use in Posttraumatic Stress Disorder
Conditions: Alcohol Dependence;   Alcoholism;   Alcohol Abuse;   Alcohol Use Disorder;   PTSD;   Posttraumatic Stress Disorder
Interventions: Drug: Topiramate;   Drug: Placebo
Outcome Measures: Number of days of Heavy Drinking;   Number of Days Abstinent;   Amount of PTSD Symptoms;   Number of Memory/Cognitive Complaints
3 Recruiting Efficacy and Safety of Topiramate in the Treatment of Sleep-Related Eating Disorder
Condition: Sleep-Related Eating Disorder
Intervention: Drug: Topiramate or Placebo
Outcome Measures: frequency and severity of sleep-related eating episodes;   tolerability of topiramate;   body weight
4 Recruiting Topiramate in Adolescents With Severe Obesity
Conditions: Obesity, Morbid;   Obesity;   Weight Loss
Interventions: Drug: Topiramate;   Other: Placebo
Outcome Measure: Percent Change from Baseline in Body Mass Index at 28-Weeks
5 Recruiting A Controlled Trial of Topiramate Treatment for Alcohol Dependence in Veterans With PTSD
Conditions: Alcohol Dependence;   Posttraumatic Stress Disorder (PTSD)
Interventions: Drug: Topiramate;   Drug: placebo
Outcome Measures: Topiramate in reducing alcohol use in veterans with PTSD using the Timeline Followback (TLFB);   Topiramate in veterans with alcohol dependence using the Timeline Followback (TLFB).;   Topiramate in reducing PTSD symptom severity;   Topiramate in reducing alcohol intake in veterans with PTSD;   Topiramate in reducing alcohol dependence veterans with PTSD
6 Recruiting Adjunctive Topiramate for Treatment of Alcohol Dependence in Patients With Bipolar Disorder
Conditions: Bipolar Disorder;   Alcoholism;   Alcohol Dependence
Intervention: Drug: Topiramate
Outcome Measures: Amount of alcohol consumed;   Safety and tolerability of topiramate.;   Effect of decreased drinking on mood symptoms
7 Recruiting Topiramate in Neonates Receiving Whole Body Cooling for Hypoxic Ischemic Encephalopathy
Condition: Hypoxic Ischemic Encephalopathy
Interventions: Drug: Topiramate;   Drug: Placebo
Outcome Measures: Seizures;   HIE score;   Normalization of aEEG;   S100-beta levels;   MRI score;   Developmental Outcome
8 Unknown  Topiramate for Hospitalized Patients With Alcoholism: a 12-week Study
Condition: Alcohol Dependence
Intervention: Drug: Topiramate
Outcome Measures: Cognition;   Alcohol drink/day
9 Recruiting Alcohol Dependency Study: Combining Medication Treatment for Alcoholism
Condition: Alcoholism
Interventions: Drug: ondansetron + cognitive behavioral therapy;   Drug: topiramate + cognitive behavioral therapy;   Drug: Placebo + cognitive behavioral therapy;   Drug: ondansetron + topiramate + cognitive behavioral therapy
Outcome Measures: Self-report measures of alcohol-related problems and consumption, Objective measures of alcohol consumption;   Medication compliance, alcohol craving, social functioning, quality of life, alcohol withdrawal, attendance at psychosocial services, pre-morbid risk factors
10 Not yet recruiting Topiramate's Effects on Heavy Drinking
Condition: Alcohol Drinking
Interventions: Drug: Topiramate;   Drug: Placebo
Outcome Measures: fMRI response in the ventral striatum/medial orbitofrontal cortex during alcohol cue exposure;   Drinking days;   change in gamma-glutamyl transferase (GGT) or carbohydrate-deficient transferrin (CDT) levels;   Heavy drinking days;   Mean alcohol consumption
11 Recruiting Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease
Conditions: Idiopathic Parkinson's Disease;   Drug Induced Dyskinesia
Intervention: Drug: Topiramate
Outcome Measures: The Unified Dyskinesia Rating Scale (UDysRS);   Clinical Global Impression - Change score
12 Not yet recruiting Topiramate Trial for Compulsive Buying
Condition: Compulsive Shopping
Interventions: Drug: Topiramate;   Drug: placebo
Outcome Measures: Yale-Brown Compulsive-Obsessive Scale Shopping Version;   Clinical Global Impression scale (CGI);   Udvalg for KliniskeUndersøgelser Side Effect Rating Scale (UKU)
13 Recruiting New Treatment for Alcohol and Nicotine Dependence
Conditions: Alcohol Dependence;   Nicotine Dependence
Interventions: Drug: Topiramate with brief behavioral enhancement therapy;   Drug: Placebo with brief behavioral enhancement therapy
Outcome Measures: percent heavy drinking days, continuous abstinence rate for smoking;   Quality of life;   Craving for alcohol and nicotine
14 Recruiting Evaluate Retention Rate of Topiramate, Levetiracetam and Oxcarbazepine in a Long-term Epilepsy Treatment
Condition: Epilepsy
Intervention:
Outcome Measures: Retention rate of topiramate, levetiracetam and oxcarbazepine during 24 months of treatment;   Evaluate the confounding factors affecting the retention rate;   Evaluate the response rate through seizure reduction (≥75%, ≥50%) in 2-year treatment with each antiepileptic drugs (topiramate, levetiracetam, oxcarbazepine)
15 Recruiting Novel Pharmacotherapy for Dual Dependence
Conditions: Alcohol Dependence;   Cocaine Dependence
Interventions: Drug: Topiramate + Cognitive Behavioral Therapy;   Drug: Placebo + Cognitive Behavioral Therapy
Outcome Measures: The topiramate group will be superior to the placebo group on the following outcome measures:increasing the weekly mean proportion of cocaine-free days, decreasing self-reported drinking, and decreasing craving for cocaine and alcohol.;   a. Cocaine free weeks; b. Topiramate, compared with placebo, will be associated with an improvement in psychosocial functioning as exemplified by improved general well-being, social functioning, and quality of life.
16 Recruiting Effects of Topiramate on Adolescent Alcohol Use: Efficacy and Mechanisms
Condition: Alcohol Drinking
Interventions: Drug: Topiramate;   Drug: Placebo
Outcome Measures: Alcohol use;   Alcohol craving;   Cognitive functioning
17 Unknown  Topiramate Treatment for Patients With Epilepsy and Learning Disability : A Prospective Observational Study
Condition: Epilepsy
Intervention: Drug: topiramate
Outcome Measures: Median monthly seizure frequency;   Responder rate;   SIB-R score;   Investigator's global evaluation scale;   Caregivers' global evaluation scale
18 Recruiting The Childhood and Adolescent Migraine Prevention Study
Conditions: Migraine;   Migraine Disorders;   Headache
Interventions: Drug: Amitriptyline;   Drug: Topiramate;   Drug: Placebo
Outcome Measures: Reduction in Migraine Frequency (amitriptyline and topiramate);   Reduction in absolute migraine disability score on PedMIDAS;   Safety and tolerability of amitriptyline and topiramate;   Occurrence of treatment-emergent serious adverse events;   Reduction in absolute migraine frequency days
19 Unknown  Preventing Epilepsy After Traumatic Brain Injury With Topiramate
Conditions: Traumatic Brain Injury;   Epilepsy
Interventions: Drug: topiramate;   Drug: phenytoin
Outcome Measures: Early and late seizures after traumatic brain injury;   Adverse events;   Functional recovery after traumatic brain injury
20 Unknown  A Safety Study of Combination Treatment With Avonex and Placebo-Controlled Dosing of Topamax in Relapsing-Remitting Multiple Sclerosis
Condition: Multiple Sclerosis
Intervention: Drug: Avonex and Topamax
Outcome Measures: Safety and tolerability;   Brain atrophy on nMRI;   Disease progression on EDSS and MSFC;   Relapse rate

These studies may lead to new treatments and are adding insight into Topamax etiology and treatment.

A major focus of Topamax research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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