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Tramadol Medical Research Studies

Up-to-date List of Tramadol Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Tramadol Medical Research Studies

Rank Status Study
1 Recruiting Postoperative Tramadol/Gabapentin/Acetaminophen Versus Tramadol/Placebo/Acetaminophen
Condition: Pain
Interventions: Drug: gabapentin;   Drug: Tramadol;   Drug: Ibuprofen
Outcome Measures: Efficacy of scheduled Tramadol + PRN ibuprofen vs. scheduled Tramadol + scheduled gabapentin + PRN ibuprofen;   Side effects of scheduled Tramadol + PRN ibuprofen vs. scheduled Tramadol + scheduled gabapentin + PRN ibuprofen
2 Recruiting Comparison of Tramadol Orally Versus an Optimized Dose of Intravenous Tramadol for Postoperative Pain Relief in Ambulatory Surgery
Condition: Pain
Interventions: Drug: Tramadol per os (Tradonal Odis® orodispersible tablets);   Drug: Tramadol IV (Tradonal® IV)
Outcome Measures: Difference in pain score between groups;   Difference in side-effects between the groups
3 Recruiting Evaluation of the Role of Tramadol 50mg as an Analgesic During Outpatient Hysteroscopy
Condition: Pain
Interventions: Drug: Tramadol;   Drug: Placebo
Outcome Measures: Pain perceived by the patient during the procedure;   Pain perceived by the patient 30 minutes after the procedure.
4 Recruiting Tramadol Extended-Release (ER) for Posttraumatic Stress Disorder (PTSD)
Condition: Post-Traumatic Stress Disorder
Interventions: Drug: Tramadol;   Drug: Placebo
Outcome Measures: Efficacy as measured by a reduction in PTSD symptoms.;   Efficacy as measured by a reduction in anxiety, "nervousness", irritability, mood, sleep, and pain.;   Efficacy as measured by a reduction in depressive symptoms.
5 Recruiting Tramadol Versus Celecoxib for Reducing Pain in Outpatient Hysteroscopy
Condition: Pain
Interventions: Drug: Tramadol;   Drug: Celecoxib;   Drug: Placebo
Outcome Measures: Pain perception during the procedure;   Pain perception after the procedure
6 Recruiting Mepivacaine-Tramadol on the Success of Inferior Alveolar Nerve Block in Symptomatic Irreversible Pulpitis
Condition: Symptomatic Irreversible Pulpitis
Interventions: Drug: Mepivacaine;   Drug: Mepivacaine plus Tramadol
Outcome Measures: success of the inferior alveolar nerve block;   Anesthetic effect duration
7 Recruiting Tramadol Infiltration for Tonsillectomy
Condition: Postoperative Pain
Interventions: Drug: Tramadol 2mg/kg;   Drug: Saline solution
Outcome Measure: Analgesic effect
8 Not yet recruiting Penthrox Versus Tramadol for SCDF
Condition: Acute Pain
Interventions: Drug: Penthrox Inhaler;   Drug: Tramadol Injection
Outcome Measures: Change in Pain Score assessed by Visual Analogue Scale (VAS);   Change in Ramsay sedation Scores
9 Unknown  RCT on Ketorolac and Tramadol in Bone Fractures Pain of Child
Conditions: Fracture;   Pain
Interventions: Drug: ketorolac;   Drug: Tramadol
Outcome Measures: estimation of pain reduction in every arm of the trial with linear 1-10 pain scale or for children 4 - 6 years old with analogic MacGrath type scale;   comparison between the two groups on effectiveness on pain, measured with linear and analogic scale (see above)
10 Recruiting Usage of Tramadol With Levobupivacaine for Pain Treatment After Cesarean Section
Condition: Postoperative Pain Following Cesarean Section
Interventions: Drug: Tramadol infusion via wound catheter;   Drug: Levobupivacaine
Outcome Measures: lowering of pain as measured by visual analogue scores;   total additional analgesic consumption
11 Unknown  Comparison of Tramadol Vs Remifentanyl Patient Controlled Analgesia for Second Trimester Abortions
Condition: Abortion,Induced
Interventions: Drug: Tramadol;   Drug: remifentanyl;   Device: patient contolled analgesia
Outcome Measures: Satisfaction;   VAS scores;   Nausea;   Sedation
12 Unknown  Safety and Effectiveness of Tramadex-OD After Knee Arthroscopy
Condition: Postoperative Pain
Interventions: Drug: extended-release Tramadol;   Drug: paracetamol
Outcome Measures: Safety and effectiveness of TRAMADEX-OD will be evaluated by recording adverse events and using a visual analogue score for pain evaluation;   Patient satisfaction will be evaluated by a telephone interview
13 Recruiting Compare the Efficacy and Safety of NORSPAN to Tramadol/Acetaminophen With Prolonged Postoperative Pain (PASSION)
Condition: Pain
Intervention: Drug: buprenorphine, Tramadol/acetaminophen
Outcome Measures: efficacy;   life of quality
14 Recruiting Combined Behavioral and Analgesic Trial for Fibromyalgia
Condition: Fibromyalgia
Interventions: Drug: Tramadol;   Drug: Placebo;   Behavioral: Cognitive Behavior Therapy for FM;   Behavioral: Health Education
Outcome Measure: Change in mean pain severity derived from 5-days of daily pain diaries and change in physical function assessed from the Fibromyalgia Impact Questionnaire-Revised (FIQ-R).
15 Unknown  The Effect of Adding Pain Relievers to Local Anesthesia Before Preforming Drainage in Peritonsillar Abscess
Condition: Peritonsillar Abscess
Intervention: Drug: dypiron, Tramadol
Outcome Measure: the vas scale
16 Recruiting Effect of COX-2 Selective Inhibitors on Postoperative Insulin Resistance After Gastrointestinal Laparoscopic Surgery
Condition: Gastrointestinal Cancer
Intervention: Drug: parecoxib
Outcome Measures: Insulin resistance in perioperative period of gastrointestinal laparoscopic surgery;   The consumption of total and incremental Tramadol after surgery.;   The tolerated dose of enteral nutrition every day after surgery;   Postoperative inflammatory factors (IL-4, IL-6 and TNF-α) and levels of stress hormone (glucocorticoids and catecholamines) in perioperative period of gastrointestinal laparoscopic surgery;   Rest energy metabolism was measured in perioperative period to evaluate the caloric and substrate needs of our patients;   The time of the first bowel movements and anal exhaust time after surgery;   Pain intensity at rest and during leg raising recorded daily after surgery using Visible Numeric Rating Scale;   Incidence of adverse events throughout the treatment period including nausea, vomiting, headache, urinary retention, somnolence, flatulence, and pruritus;   Liver and renal function tests in perioperative period;   Self-rating anxiety scale and self-rating questionnaire for depression before surgery
17 Unknown  Assessment and Prevention of Acute Post-herniotomy Pain
Condition: Hernia
Intervention: Drug: postoperative analgesic treatment
Outcome Measures: Assessment of the acute post-herniotomy pain during the treatment with two different therapeutical protocols per os: ketorolac versus association of acetaminophene+Tramadol;   Number of participants with adverse events as a measure of safety and tolerability;   Difference in recovering daily activity;   Assessment of any connections between the two therapeutical strategies and the recurrence of surgical complications;   Development of persistent postoperative pain
18 Recruiting Medications Development for Drug Abuse Disorders
Conditions: Opioid Related Disorders;   Opioid Dependence;   Opioid Addiction
Interventions: Drug: Buprenorphine/naloxone;   Drug: Clonidine;   Drug: Tramadol ER
Outcome Measure: change between groups over time in scores on a standard measure of opioid withdrawal signs and symptoms
19 Recruiting Opioid-based Analgesic Regimen Versus Non-opioid Analgesic Regimen for Better Immune Responses After Laparoscopic Colorectal Surgery
Condition: Colorectal Surgery
Intervention: Drug: opioid based analgesia (fentanyl and pethidine) versus non-opioid based analgesia (ropivacaine and Tramadol)
Outcome Measures: NK cell activity;   Cytokine level
20 Unknown  Patient Preferences, Analgesic Delivery Method and Pain Reduction in Spine Patients
Condition: Pain Relief
Interventions: Drug: Diclofenac hydroxyethylpyrrolidine;   Drug: orphenadrine;   Drug: Tramadol;   Drug: Dipyrone
Outcome Measures: pain scores on visual analog scale;   Patient Questionnaire assessing pain and pain relief;   patient preference Questionnaire

These studies may lead to new treatments and are adding insight into Tramadol etiology and treatment.

A major focus of Tramadol research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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