Up-to-date List of Trazodone Medical Research Studies
What Research is Being Done?
A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.
The number of days patients are without delirium during the study period (delirium-free days); Daily prevalence of delirium as indicated by a positive Confusion Assessment Method in the ICU (CAM-ICU); Resolution of delirium as indicated by a negative Confusion Assessment Method in the ICU (CAM-ICU) for more than 24 hours; The number of patients who require rescue medications, the type of rescue medications utilized, and the amount of rescue medications per day; The number of patients who receive sedative agents, amount of midazolam equivalents per day, and the number of days in which patients receive a sedative agent; The number of patients who receive pain medications, amount of fentanyl equivalents per day, and the number of days in which patients receive a pain medication; The number of hours spent agitated (RASS score between +4 and +2) as a percent of the time that the study drug was administered; The number of hours spent excessively sedated or in a coma state (RASS score between -4 to -5) as a percent of the time that the study drug was administered; The duration of mechanical ventilation from initial intubation to extubation as long as the patient remained extubated for more than 48 hours.; The number of days that the patients were alive and breathing without assistance during the study period (ventilator-free days); The number of episodes and number of patients who experience clinically significant QTc prolongation (≥ 500 msec or an increase of more than 60 msec from baseline); The number of episodes and number of patients who experience clinically significant extrapyramidal effects (as evidenced by a positive Simpson-Angus Scale Score); All-cause mortality and 28-day mortality
Change in Hamilton Depression Rating Scale-17 score; Changes in HAMA-14 score; CGI-Severity of illness and CGI-Global improvement; Changes in evaluation of sleep quality and sexual dysfunction; Rate changes of responders/patients
Remission defined as endpoint 17-item Hamilton Rating Scale for Depression (HRSD-17) total score ≤ 7; Remission defined as endpoint the Quick Inventory of Depressive Symptomatology (16-item) (QIDS-SR16) total score ≤ 5; Frequency and intensity of adverse events; Quality of life
Frequency of chest pain episodes; Frequency of chest pain in treatment group vs baseline; Intensity of chest pain episodes; Sensory thresholds for first sensation; Frequency of reactive esophageal contractions; Amplitude of reactive esophageal contractions; Area under the curve of reactive esophageal contractions; Duration of chest pain episodes; Sensory thresholds for discomfort; Sensory thresholds for pain
These studies may lead to new treatments and are adding insight into Trazodone etiology and treatment.
A major focus of Trazodone research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.