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Versed Medical Research Studies

Up-to-date List of Versed Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Versed Medical Research Studies

Rank Status Study
1 Recruiting Safe and Effective Sedation in Chronic Alcoholic Patients Underwent Diagnostic Endoscopic Procedures: Study Comparing Midazolam and Propofol With Midazolam
Condition: Chronic Alcoholism
Interventions: Drug: Midazolam plus propofol;   Drug: Midazolam
Outcome Measures: Satisfaction of endoscopists, nurses and patients;   completion rate of endoscopy;   number of participants with complications
2 Recruiting To Evaluate the Effect of AZD1722 on the Pharmacokinetics of Oral Midazolam in Healthy Volunteers
Condition: Healthy Volunteers
Interventions: Drug: Midazolam;   Drug: AZD1722;   Drug: AZD1722 and Midazolam
Outcome Measures: To evaluate the pharmacokinetics of midazolam when administered after AZD1722 by assessment of area under the concentration-time curve (AUC) and maximal plasma concentration (Cmax) of midazolam;   • To evaluate the pharmacokinetics of the metabolites 1-OH-midazolam and 4-OH-midazolam when midazolam is administered after AZD1722 by assessment of AUC and Cmax of 1-OH-midazolam and 4-OH-midazolam;   To evaluate the pharmacodynamic outcomes of AZD1722 by assessment of how AZD1722 effects stool consistency and frequency;   To evaluate the plasma concentrations of AZD1722;   To evaluate the pharmacokinetics of midazolam metabolites when administered after AZD1722 by assessment of area under the concentration-time curve (AUC) maximal plasma concentration (Cmax) of 1-OH-midazolam and 4-OH-midazolam
3 Recruiting Efficacy of Propofol or Midazolam Compare to Placebo for Preoperative Medication
Condition: Elective Orthopedic Surgery
Interventions: Drug: Midazolam;   Drug: Propofol;   Drug: Saline
Outcome Measures: reduces anxiety;   reduces sleepiness;   produces amnesia(temporary lack of recall);   Satisfaction
4 Unknown  Propofol and Remifentanyl Versus Midazolam and Fentanyl for Diagnostic Colonoscopy in Patients With Compensated Cirrhosis Child A-B
Condition: Liver Disease
Interventions: Drug: Propofol and Remifentnyl;   Drug: midazolam and fentanyl;   Drug: midazolam anf fentanyl
Outcome Measure: Safety and efficacy of propofol in liver diseases
5 Recruiting A Comparison of Propofol Versus Midazolam to Sedate Critically Brain Injury; Measurement of Cytokine Response and Assessment of Function
Condition: Traumatic Brain Injury
Interventions: Drug: Intravenous sedation using propofol;   Drug: Intravenous sedation with midazolam
Outcome Measures: Neuropsychgologic outcome;   cytokine levels correlating to extent of injury
6 Recruiting A Randomized, Clinical Trial of Oral Midazolam Versus Oral Ketamine for Sedation During Laceration Repair.
Condition: Lacerations
Interventions: Drug: Midazolam - active comparator;   Drug: Experimental Arm: Ketamine
Outcome Measures: Pain score: Visual analog score (VAS)- by a parent;   Number of patients requiring IV sedation;   UMSS - by ED physician;   • VAS by nurse;   Time to reach UMSS > 2;   • Procedure time;   • Time from procedure to full recovery;   The occurrence of adverse effects during the ED stay;   • Patients and parents satisfaction assessed on VAS
7 Recruiting Compare Propofol to Fentanyl and Midazolam for Colonoscopy
Conditions: Colon Cancer;   Rectal Cancer;   Colonic Diverticulosis
Interventions: Drug: Fentanyl;   Drug: Propofol;   Drug: Midazolam
Outcome Measures: Patient satisfaction;   Patient discomfort
8 Recruiting Pilot Study Comparing Treatment With Dexmedetomidine to Midazolam for Symptom Control in Advanced Cancer Patients
Conditions: Pain Intractable;   Delirium;   Dyspnea;   Nausea
Interventions: Drug: Dexmedetomidine;   Drug: Midazolam
Outcome Measures: Number of subjects needed to recruit for a multicenter double blind randomized controlled phase III trial comparing dexmedetomidine to midazolam for symptom control in advanced cancer patients;   Change in pain (0 to 10 numerical scale);   Change in dyspnea (0 to 10 numerical scale);   Change in nausea (0 to 10 numerical scale);   Change in delirium (16 item clinician rated scale);   Rousability (10 point scale);   Acceptable symptom control (yes/no)
9 Recruiting A Single-centre Study of Entonox Versus Midazolam Sedation in Gastroscopy
Condition: Patients Requiring Diagnostic Gastroscopy Suitable for Sedation.
Interventions: Drug: Entonox;   Drug: Midazolam
Outcome Measures: Patient comfort during gastroscopy;   Number of completed procedures in both arms of the study.
10 Not yet recruiting A Comparison of Midazolam and Zolpidem as Oral Premedication in Children
Conditions: Parental/Caregiver Anxiety;   Child's Anxiety
Interventions: Drug: zolpidem;   Drug: Midazolam
Outcome Measures: Patient anxiety at the time of separation;   Other comparison measures will include preoperative parent/caregiver anxiety, anesthesia mask acceptance characteristics at the time of induction, and time to full recovery in the post operative period.
11 Recruiting Oral Midazolam for Sedation in Esophagogastroduodenoscopy(EGD)
Condition: Conscious Sedation Failure During Procedure
Intervention: Drug: Oral midazolam
Outcome Measures: Difference of Anxiety score;   Overall tolerance
12 Recruiting Volumes of Administration for Intranasal Midazolam
Condition: Children Requiring Sedation to Facilitate Laceration Repair.
Intervention: Drug: Intranasal midazolam
Outcome Measures: Time to onset of minimal sedation;   Efficacy of sedation;   Serum concentrations of midazolam;   BIS monitoring;   Satisfaction
13 Unknown  Sedation of Mechanically Ventilated Critically Ill Patients: Midazolam Versus Dexmedetomidine
Conditions: Mechanically Ventilated Patients;   Sedation;   Dexmedetomidine;   Midazolam
Interventions: Drug: Dexmedetomidine;   Drug: Midazolam
Outcome Measures: Incidence of delirium;   PERCENTAGE OF TIME WITHIN THE TARGET SEDATION
14 Not yet recruiting The Effects of Midazolam on the Quality of Postoperative Recovery
Conditions: Postoperative Period;   Anxiety;   Fatigue;   Depression;   Aggression
Interventions: Drug: Midazolam;   Drug: NaCl (sodium chloride) 0,9%
Outcome Measures: Change in Quality of Recovery (QoR-40 Scale);   Change in anxiety measured with a Dutch translated State-Trait Anxiety Inventory (STAI);   Change in depressive moods and anxiety measured by a Dutch translation of the Hospital Anxiety and Depression Scale (HADS);   Change in fatigue measured by a validated Dutch questionnaire Multidimensional Fatigue Index : "Multidimensionele Vermoeidheids Index" (MVI-20);   Change in self-efficacy measured by a Dutch translation of General Self-Efficacy- Schwarzer (GSES).;   Change in Systolic bloodpressure;   Change in self-esteem measured by a Dutch translation of the and Rosenberg self-esteem scale (RSES);   Change in Diastolic Blood pressure;   Temperature after surgery measured with an ear thermometer;   Change in Heart Rate
15 Not yet recruiting Effects of Dabrafenib on the Single Dose Pharmacokinetics (PK) of Rosuvastatin and Midazolam
Condition: Cancer
Interventions: Drug: Rosuvastatin10 mg tablet;   Drug: Midazolam 3 mg syrup;   Drug: Dabrafenib 75 mg capsule
Outcome Measures: Pharmacokinetics (PK) parameter of rosuvastatin and midazolam;   Secondary PK parameters of rosuvastatin and midazolam;   PK parameters of dabrafenib and dabrafenib metabolites;   Number of subjects with adverse events as a measure of safety and tolerability;   Changes in clinical laboratory measurements to access safety;   Changes in vital sign measurements to access safety;   Change from baseline in cardiac assessments
16 Recruiting A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury
Condition: Traumatic Brain Injury
Interventions: Drug: Midazolam;   Drug: Placebo
Outcome Measures: Cerebral metabolic parameters;   Parameters of intracranial inflammatory response;   Ramsay score;   seizure;   one-week mortality
17 Recruiting Comparison of Propofol-fentanyl and Midazolam-fentanyl for Conscious Sedation
Condition: Emergencies
Interventions: Drug: Propofol;   Drug: Midazolam;   Drug: Fentanyl
Outcome Measures: Recovery time;   Patients' Pain perception
18 Recruiting Postoperative Sleep Quality of Patients Sedation With i.v. Dexmedetomidine or Midazolam Undergoing TURP
Condition: Sleep Quality of Patients Undergoing TURP
Interventions: Drug: dexmedetomidine;   Drug: Midazolam
Outcome Measures: The Change of postoperative sleep quality;   The change of interleukin-6 level in cerebrospinal fluid (CSF) and plasma samples
19 Recruiting Safety and Efficacy of Combined Sedation With Midazolam and Dexmedetomidine in ICU Patients
Condition: Delirium
Interventions: Drug: midazolam;   Drug: Dexmedetomidine;   Drug: Fentanyl
Outcome Measures: The total time within target sedation level;   The dosage of sedation/analgesic drug;   Duration of mechanical ventilation;   Economic outcome;   Satisfactory of patients to ICU stay from admitted until discharged from ICU;   Delirium;   Vital signs;   Duration of ICU stay
20 Not yet recruiting Sequential Use of Propofol/Midazolam and Dexmedetomidine for Sedation in Mechenical Ventialtion Patients in ICU.
Condition: Mechanical Ventilation Complication
Interventions: Drug: Fentanyl;   Procedure: Sedation assessment;   Procedure: Screen of weaning;   Drug: Propofol;   Drug: Midazolam;   Drug: Dexmedetomidine
Outcome Measures: Ventilation duration;   Delirium;   Blood pressure;   Cost of sedation drug;   Cost of narcotics;   Cost of ICU stay;   Heart rate;   Respiration Rate;   Pulse blood oxygen saturation

These studies may lead to new treatments and are adding insight into Versed etiology and treatment.

A major focus of Versed research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

Discuss Versed