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Visipaque Medical Research Studies

Up-to-date List of Visipaque Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Visipaque Medical Research Studies

Rank Status Study
1 Recruiting Renal Toxicity of Iodixanol and Iopromide in Patients With Renal Dysfunction
Condition: Kidney Failure, Chronic
Interventions: Drug: iodixanol;   Drug: iopromide
Outcome Measures: to evaluate the change in Glomerular Filtration Rate levels by Estimated Glomerular Filtration Rate;   In each group(Iodixanol group and Iopromide group), the proportion of patients exhibiting an increases of serum creatinine in different range(<10%,10%~25%, and ≥25%), comparing with baseline level.;   Incidence of hemodialysis;   Changes of Cystatin C level from baseline
2 Unknown  Mechanisms for the Effect of Acetylcysteine on Renal Function After Exposure to Radiographic Contrast Material
Condition: Radiocontrast-Induced Nephropathy
Interventions: Drug: Acetylcysteine;   Drug: Visipaque 320
Outcome Measures: Changes in renal blood flow;   Changes in glomerular filtration rate, tubular function, oxidative balance.
3 Recruiting Single Dose Safety, Tolerability and Pharmacokinetic Study of NCTX in Healthy Volunteers
Condition: Healthy Volunteers
Interventions: Drug: NCTX (PEGylated Liposomal Iodixanol Injection);   Drug: Saline Placebo
Outcome Measures: Assessment of safety by clinical laboratory parameters, vital sign measurements, electrocardiograms, and adverse event monitoring;   Maximum blood concentration (Cmax), half-life (t1/2), and ratio of free to encapsulated circulating iodixanol;   Radiographic density in ROIs by abdominal CT imaging
4 Not yet recruiting Efficacy of Low (30ml) Versus Full Dose (100ml) Contrast CT Pulmonary Angiography in Detecting Emboli
Condition: Multiple Pulmonary Emboli
Interventions: Procedure: Low-Dose IV Contrast;   Device: Siemens Sensation 64-MDCT scanner.;   Drug: Visipaque 320 non-ionic isoosmolar contrast agent
Outcome Measure: CT Image Quality Score
5 Recruiting Aortic Stenosis Pre-Transcatheter Aortic Valve Replacement (TAVR) Procedure CT Scan
Condition: Aortic Valve Stenosis
Intervention: Drug: Low-volume, low-concentration contrast (iodixanol - Visipaque 270) CT scan
Outcome Measures: Clinically Diagnostic CT Assessments;   Image Quality;   Safety;   Long-term Follow-Up
6 Recruiting Contrast-inDuced nephRotoxicity as Assessed by the KIdney Load-to-DAmage RElationship
Condition: Contrast Induced Acute Kidney Injury
Interventions: Drug: Iobitridol 350;   Drug: Iodixanol 320
Outcome Measures: Slope of LDR (as assessed by serum cystatin-C changes);   Slope of LDR (as assessed by serum creatinine changes)
7 Recruiting Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media
Conditions: Diabetes Mellitus;   Lactic Acidosis
Intervention: Drug: Metformin
Outcome Measure: Incidence of lactic acidosis
8 Recruiting Dynamic Contrast Enhanced Computed Tomography (CT) for Head and Neck Cancer
Condition: Head and Neck Cancer
Intervention: Radiation: Dynamic Contrast Enhanced CT scan
Outcome Measures: Sensitivity and specificity of DCE-CT in predicting the presence of residual lymph node disease after the completion of chemotherapy;   Sensitivity and specificity of DCE-CT in predicting presence of lymph node disease at surgery
9 Not yet recruiting Preventing Contrast-induced Nephropathy: Evaluating Hydration Strategies and L-carnitine Administration
Conditions: Acute Kidney Injury;   Renal Insufficiency
Interventions: Drug: Hydration strategy using saline;   Drug: Hydration strategy using sodium bicarbonate;   Drug: L-carnitine;   Procedure: Coronarography
Outcome Measures: Change in glomerular filtration rate;   Contrast induced nephropathy?;   Change in creatinemia;   % Change in creatinemia;   Change in glomerular filtration rate compared to baseline;   Quantity of contrast material injected / glomerular filtration rate;   Quantity of iodine injected / glomerular filtration rate;   Hemodialysis necessary?;   Mortality;   Change in serum ngal
10 Recruiting Renal Sympathetic Denervation in Patients With Chronic Kidney Disease and Resistant Hypertension
Condition: Chronic Kidney Disease
Interventions: Procedure: RSD;   Drug: medicine
Outcome Measures: All-cause mortality, doubling of the serum creatinine level or end-stage renal disease;   Urinary protein excretion and renal function;   Blood pressure;   Blood sugar;   Cardiac function and structure;   Arrhythmia;   Pulse wave velocity;   Life quality;   Rehospitalization rate

These studies may lead to new treatments and are adding insight into Visipaque etiology and treatment.

A major focus of Visipaque research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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