Up-to-date List of Wellbutrin Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Wellbutrin Medical Research Studies

1 Recruiting Phase I Study to Evaluate the Effect of LDE225 on the Pharmacokinetics of Bupropion and Warfarin in Patients
Condition: Advanced Solid Tumor
Interventions: Drug: LDE225;   Drug: Wafarin;   Drug: Bupropion
Outcome Measures: Pharmacokinetics (PK) parameter AUClast for S- and R-warfarin;   PK parameter AUClast for bupropion;   PK parameter AUCinf for bupropion;   PK parameter AUCinf for S- and R-warfarin;   PK parameter Cmax for S- and R-warfarin;   PK parameters Cmax for bupropion;   effects of LDE225 on the pharmacodynamic activity of warfarin;   safety of LDE225 when administered alone and concomitantly with either bupropion or warfarin;   evaluate the preliminary evidence of anti-tumor activity of LDE225 in patients with advanced solid tumors;   assess the effect of LDE225 treatment on cardiac function
2 Unknown  Study of Bupropion Versus Bupropion + Naltrexone for Smoking Cessation
Condition: Tobacco Use Disorder
Interventions: Drug: Bupropion;   Drug: Bupropion + Naltrexone
Outcome Measures: Biochemically-verified point-prevalence abstinence;   Likelihood of progression to a relapse (e.g., return to baseline smoking) following a slip at any time in study.;   Treatment completion.;   Daily cigarette smoking rate.;   Frequency and severity of bupropion and naltrexone side effects.;   Attentional bias.;   Impulsivity.;   Nicotine withdrawal, craving and negative/positive affect.
3 Recruiting Pharmacokinetic Study of Bupropion Hydrochloride Products With Different Release Patterns
Condition: Depression
Intervention: Drug: generic bupropion
Outcome Measure: PK parameters for bupropion formulations: half-life (t1/2), volume of distribution (Vd/F), oral clearance (CL/F), maximum drug concentration (Cmax), time to reach Cmax (Tmax), area under the concentration vs. time curve (AUC), absorption rate constant
4 Recruiting Bupropion for Smoking Cessation During Pregnancy
Conditions: Pregnancy Related;   Tobacco Use Disorder
Interventions: Drug: bupropion SR 150 mg tablets or matched placebo;   Behavioral: Smoking Cessation Counseling
Outcome Measures: Minnesota Nicotine Withdrawal Scale;   7-day point prevalence smoking abstinence
5 Recruiting Effects of Bupropion in Depression
Condition: Depression
Intervention: Drug: Bupropion
Outcome Measures: Change in haemodynamic (i.e. BOLD signal) response;   Change in questionnaire measures of subject mood and anhedonia;   Change in accuracy and reaction time
6 Not yet recruiting Bupropion-Enhanced Contingency Management for Cocaine Dependence
Conditions: Substance Abuse;   Cocaine Dependence
Interventions: Drug: Bupropion XL;   Drug: placebo
Outcome Measures: number of cocaine negative urines;   latency to first cocaine positive urine
7 Recruiting Combination Bupropion / Varenicline for Smoking Cessation in Male Smokers
Condition: Nicotine Dependence
Interventions: Drug: Chantix;   Drug: Zyban;   Drug: Nicotine patches
Outcome Measures: Continuous four-week abstinence from smoking;   Seven day point abstinence from smoking at 6 months post Quit Day;   Continuous abstinence from smoking from Quit Day to end of treatment (week 11)
8 Unknown  Bupropion in the Treatment of Methamphetamine Dependence
Condition: Methamphetamine Use Disorder
Intervention: Drug: bupropion SR
Outcome Measures: Estimate the treatment effect of bupropion for methamphetamine (meth) dependence.;   Compare methamphetamine treatment outcomes between white and non-white participants.;   Assess safety of bupropion in the treatment of persons with meth dependence with and without meth-related psychosis.
9 Recruiting Paroxetine/Bupropion in Depression With Suicide Attempt or Thoughts: fMRI Study
Conditions: Depression;   Suicidal Ideation
Interventions: Drug: Paroxetine CR for Major Depressive Episode;   Drug: Bupropion XL for Major Depressive Episode
Outcome Measures: BOLD Signal;   Change in suicidal ideation (SSI score)
10 Not yet recruiting Smoking Cessation Strategies in Community Cancer Programs for Lung and Head and Neck Cancer Patients
Conditions: Lung Cancer;   Head and Neck Cancer
Interventions: Drug: High Intensity Counseling + Long Acting NRT + PRN NRT;   Drug: High Intensity Counseling + bupropion + PRN NRT;   Drug: High Intensity Counseling + varenicline + PRN NRT;   Drug: High Intensity Counseling + Long Acting NRT;   Drug: High Intensity Counseling + bupropion;   Drug: High Intensity Counseling + varenicline;   Drug: Low Intensity Counseling + Long Acting NRT + PRN NRT;   Drug: Low Intensity Counseling + bupropion + PRN NRT;   Drug: Low Intensity Counseling + varenicline + PRN NRT;   Drug: Low Intensity Counseling + Long Acting NRT;   Drug: Low Intensity Counseling + bupropion;   Drug: Low Intensity Counseling + varenicline
Outcome Measure: Cigarette use
11 Unknown  Comparative Study of SR Bupropion for Adolescent Smoking Cessation
Conditions: Smoking;   Smoking Cessation
Interventions: Drug: Bupropion;   Drug: Placebo
Outcome Measures: Smoking cessation;   Decrease in craving
12 Not yet recruiting Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disorder
Condition: Major Depressive Disorder
Interventions: Drug: bupropion hydrobromide;   Drug: Placebo
Outcome Measure: The primary efficacy endpoint is the mean change from Baseline to EOT in total CDRS-R (raw) score.
13 Not yet recruiting Using Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Bipolar Depression
Condition: Bipolar Disorder
Interventions: Drug: Bupropion;   Device: Active Repetitive Transcranial Magnetic Stimulation;   Other: Placebo;   Device: Sham repetitive transcranial magnetic stimulation
Outcome Measures: Change in Montgomery-Asberg Depression Rating Scale (MADRS) from baseline at 8 weeks;   Change in Beck Depression Inventory (BDI-II) from baseline at 8 weeks;   Change in Young Mania Rating Scale (YMRS) from baseline at 8 weeks;   Alcohol use disorder identification test (AUDIT Assessment);   Drug abuse screen test (DAST Assessment);   Clinical Global Impression (CGI) & Analog scale
14 Not yet recruiting The MATCH (Medication Aids for Tobacco Cessation and Health) Study
Conditions: Tobacco Use Disorder;   Nicotine Dependence
Interventions: Drug: Bupropion;   Drug: Varenicline;   Behavioral: Weekly Motivational Emails
Outcome Measures: Change in smoking status over time;   Pre-post Decisional Balance Scores;   Continuous Abstinence
15 Recruiting VA Augmentation and Switching Treatments for Improving Depression Outcomes
Condition: Major Depressive Disorder
Interventions: Drug: Augmenting: Antidepressant + Aripiprazole;   Drug: Augmenting: Antidepressant + Bupropion-SR;   Drug: Switching: Bupropion-SR
Outcome Measures: Remission of symptoms of major depressive disorder;   Relapse in symptoms of major depression;   Response in symptoms of major depression;   Onset or cessation of akathisia;   Onset or cessation of anxiety;   Onset or cessation of suicide ideation;   Change in Clinical Global Impression Scale;   Emergence of adverse experiences;   Cost and Cost-Effectiveness
16 Recruiting Mood Stabilizer (MS)+ Antidepressant vs MS + Placebo in Maintenance of Bipolar Disorder.
Condition: Bipolar I Disorder
Interventions: Drug: Escitalopram;   Drug: Wellbutrin XL
Outcome Measures: Patients who respond to acute treatment with an antidepressant in combination with a mood stabilizer.;   Does continuing antidepressant treatment for 12 months increase the risk of developing a manic or hypomanic episode?
17 Unknown  Impact of Smoking Cessation on Sleep - 5
Conditions: Tobacco Use Cessation;   Sleep Disorders
Interventions: Drug: Bupropion;   Drug: Transdermal Nicotine Patch;   Drug: Placebo Bupropion;   Drug: Placebo transdermal nicotine patch
Outcome Measures: Pre- and post-cessation sleep measures by in-laboratory polysomnography;   Smoking cessation status confirmed by carbon monoxide levels
18 Recruiting Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders
Condition: Smoking Cessation
Interventions: Drug: Placebo;   Drug: varenicline tartrate;   Drug: bupropion hydrochloride;   Drug: Nicotine Replacement Therapy Patch
Outcome Measures: At least 1 severe AE of anxiety depression, feeling abnormal, or hostility and/or moderate or severe AE of: agitation, aggression, delusions, hallucinations, homicidal ideation, mania, panic, paranoia, psychosis, suicidal ideation/behavior/completed;   4 week Carbon Monoxide (CO) confirmed continuous abstinence for Weeks 9 through 12.;   Carbon Monoxide (CO) confirmed continuous abstinence from Week 9 through Week 24;   The presence or absence of each component comprising the primary neuropsychiatric adverse event endpoint.;   Individual item responses and overall scores for Hospital Anxiety and Depression Scale;   Individual item responses and overall scores for Columbia Suicide Severity Rating Scale;   Individual item responses and overall scores for Global Clinical Impression of Improvement
19 Unknown  Effectiveness of Bupropion for Smokers Recovering From Alcohol Dependence
Conditions: Smoking Cessation;   Alcohol-Related Disorders
Interventions: Drug: Bupropion;   Drug: placebo
Outcome Measure: Smoking abstinence (measured at Week 7)
20 Recruiting Bupropion for the Treatment of Apathy in Alzheimer's Dementia
Condition: Apathy in Dementia
Interventions: Drug: Elontril;   Drug: placebo
Outcome Measures: Change in Apathy Evaluation Scale (AES) score;   NPI total score;NPI caregivers' distress total score;ADCS-ADL; QoL-AD; RUD;ADAScog;MMSE

These studies may lead to new treatments and are adding insight into Wellbutrin etiology and treatment.

A major focus of Wellbutrin research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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