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Zemuron Medical Research Studies

Up-to-date List of Zemuron Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Zemuron Medical Research Studies

Rank Status Study
1 Unknown  MgSO4 Combined With Rocuronium Priming
Condition: Muscle Relaxation
Interventions: Drug: magnesium sulfate;   Drug: priming;   Drug: magnesium sulfate and priming
Outcome Measures: time from injection of induction dose of rocuronium until 95% depression of TOF;   rocuronium duration;   intubating condition
2 Recruiting Rapid Sequence Intubation With Magnesium-rocuronium Compared With Succinylcholine - A Randomised Clinical Study
Condition: Intubation Conditions
Interventions: Drug: Magnesium perfusion;   Drug: Rocuronium;   Drug: Placebo perfusion;   Drug: Succinylcholine
Outcome Measures: Intubation score;   Signs of histamine release;   awareness and muscle pain
3 Unknown  The Effect of Rocuronium on the Response of Composite Variability Index (CVI) to Laryngoscopy
Condition: Laryngoscopy
Interventions: Drug: remifentanil infusion;   Drug: rocuronium dose + remifentanil infusion
Outcome Measure: Variable response to medication given.
4 Recruiting The Effect of Neuromuscular Blockade on the Composite Variability Index (CVI) During Laryngoscopy
Conditions: Anesthesia;   Neuromuscular Blockade
Interventions: Drug: Remifentanil infusion;   Drug: Rocuronium dose + Remifentanil infusion
Outcome Measures: The difference between the mean CVI value prior to laryngoscopy to the maximal CVI reading following laryngoscopy.;   The average CVI level during the maintenance phase of surgery.
5 Not yet recruiting Effect of Esmolol on Pain Due to Rocuronium
Condition: Injection Site Irritation
Interventions: Drug: Lidocaine;   Drug: Esmolol;   Drug: rocuronium;   Drug: Placebo
Outcome Measures: The injection pain due to rocuronium;   Score on pain due to injection of rocuronium
6 Not yet recruiting A Pilot Study Using Rocuronium to Prevent Intermediate Syndrome After Organophosphorus Insecticide Poisoning
Condition: Organophosphate Poisoning
Interventions: Drug: Rocuronium;   Drug: Sugammadex
Outcome Measure: Number of intubated days
7 Not yet recruiting Comparing Intubating Conditions Using Succinylcholine or Rocuronium for Rigid Bronchoscopy
Conditions: Intubating Conditions;   Postoperative Myalgia;   Patient Satisfaction
Interventions: Drug: Succinylcholine;   Drug: Rocuronium 0,3;   Drug: Rocuronium 0,6
Outcome Measures: Intubating Condition;   Postoperative Myalgia
8 Recruiting The Use Of Solid Phase Micro-extraction (SPME) For Metabolomics And Concomitant Measurements Of Rocuronium Bromide Levels In Liver Transplantation
Condition: Liver Failure
Intervention: Drug: Rocuronium
Outcome Measure: Plasma drug and drug metabolite concentrations
9 Recruiting Effects of Magnesium Sulfate on Onset and Duration of Low Dose Rocuronium
Conditions: Observation of Neuromuscular Block;   Intubation Condition;   Surgical Condition
Interventions: Drug: magnesium sulfate 30 mg/kg;   Drug: saline
Outcome Measures: onset time of rocuronium;   maximal suppression time and duration of rocuronium
10 Not yet recruiting CURES: The Effect of Deep Curarisation and Reversal With Sugammadex on Surgical Conditions and Perioperative Morbidity
Conditions: Obesity;   Laparoscopic Gastric Bypass Surgery;   Surgical Conditions;   Respiratory Function;   Cerebral Tissue Oxygenation
Interventions: Drug: deep neuromuscular blockade with rocuronium, reversal with sugammadex;   Drug: normal neuromuscular blockade reversal with rocuronium, reversal with neostigmine
Outcome Measures: Subjective evaluation of the view on the operating field by the surgeon;   Number of intra-abdominal pressure rises > 15cmH2O;   Respiratory function;   Oxygen saturation;   Effect of pneumoperitoneum on cerebral tissue oxygenation.;   Effect of neuromuscular blockade on cerebral tissue oxygenation;   The effect of reversal of neuromuscular blockade (with sugammadex or neostigmine) on cerebral tissue oxygenation
11 Recruiting Succinylcholine or Rocuronium for Rigid Bronchoscopy Under General Anesthesia
Condition: Anesthesia
Interventions: Drug: succinylcholine;   Drug: rocuronium
Outcome Measures: Score of quality of the surgical procedure;   Score of quality of anesthesia
12 Recruiting Skeletal Muscle Paralysis in Hypothermic Patients After Cardiac Arrest
Conditions: Cardiac Arrest With Successful Resuscitation;   Hypothermia;   Skeletal Muscle Relaxant Overdose
Interventions: Drug: rocuronium;   Other: placebo
Outcome Measures: Number of shivering episodes;   Elapsed time to target temperature;   Dissipated energy to reach the target temperature;   Changes in basal metabolism due to shivering or elevated stress levels;   Depth of relaxation;   Changes in serum levels of midazolam, fentanyl and rocuronium;   Number of necessary boli of rocuronium
13 Recruiting Appropriate Dose of Neostigmine for Reversal of Rocuronium and Cisatracurium
Condition: Observation of Neuromuscular Block
Intervention: Drug: Injection of neostigmine
Outcome Measures: time to reverse from light muscle relaxation;   time to reverse from TOF ratio 0.5 to 0.9
14 Recruiting Succinylcholine vs Rocuronium for Prehospital Emergency Intubation
Conditions: Coma;   Major Trauma;   Respiratory Distress;   Shock
Interventions: Drug: Succinylcholine : 1mg/kg;   Drug: Rocuronium : 1.2 mg/kg
Outcome Measures: First-pass intubation success rate;   Incidence of difficult intubation;   Intubation conditions assessment;   Need for alternate airway devices;   early intubation-related complications
15 Recruiting Recovery of Diaphragmatic Function After Neuromuscular Blockade and Sugammadex
Conditions: Diaphragmatic Dysfunction;   Muscle Weakness;   Muscle Fatigue
Interventions: Drug: sugammadex 2mg/kg;   Drug: neostigmine;   Drug: sugammadex 4mg/kg;   Drug: placebo;   Drug: Single rocuronium dose;   Drug: Repeated rocuronium dose;   Drug: Continuous rocuronium infusion
Outcome Measures: Electric activity of the diaphragm (microvolts) and tidal volume (milliliter) in a breath-by-breath analysis;   Number of events with oxygen saturation below 90% measured by pulse oximetry
16 Unknown  Valproic Acid, Magnesium Sulphate, Rocuronium Requirement, Postoperative Analgesia
Condition: Cerebral Aneurysm
Interventions: Drug: Magnesium Sulfate;   Drug: 0.9% saline
Outcome Measures: Rocuronium;   hemodynamics;   total amount of anesthetics;   Magnesium concentration;   side effects;   pain, nausea & vomiting, analgesics use, antiemetics use, nicardipine use
17 Recruiting Effect of Deep BLock on Intraoperative Surgical Conditions
Conditions: Prostate Hypertrophy;   Renal Disease
Intervention: Drug: Surgical block (rocuronium; atracurium/mivacurium)
Outcome Measures: Surgical rating scale;   Breathing;   Postoperative pain;   Postoperative sedation score;   nausea and vomiting
18 Recruiting Modern Myorelaxation Procedure and Reversal of Neuromuscular Blockade With General Anesthesia for Caesarean Section
Conditions: Caesarean Section;   Pregnancy
Interventions: Drug: Rocuronium + sugammadex;   Drug: Succinylcholine + Neostigmine
Outcome Measures: time needed to tracheal intubation;   total procedure time
19 Unknown  Neuromuscular Blockade and Surgical Conditions
Condition: Morbid Obesity
Intervention: Drug: Profound neuromuscular blockade (Rocuronium, Rocuronium bromide, sugammadex, Bridion)
Outcome Measures: Subjective surgeon feedback on the exposure and surgical field.;   Incidence of respiratory adverse events
20 Recruiting Optimal Relaxation Technique for Laparotomies With Rocuronium Infusion Followed by Sugammadex Reversal
Conditions: Underdosing of Skeletal Muscle Relaxants for Laparotomy;   Reversal of Skeletal Muscle Relaxant
Interventions: Drug: Neostigmine, atropine;   Drug: Sugammadex
Outcome Measures: speed of reversal;   Vital signs, i.e. heart rate and blood pressure;   intraoperative events;   incidence of residual neuromuscular blockade

These studies may lead to new treatments and are adding insight into Zemuron etiology and treatment.

A major focus of Zemuron research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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