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Zoxan Medical Research Studies

Up-to-date List of Zoxan Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Zoxan Medical Research Studies

Rank Status Study
1 Recruiting Pharmacogenetics of Doxazosin for Cocaine Dependence
Condition: Cocaine Dependence
Interventions: Drug: Doxazosin;   Drug: Placebo
Outcome Measures: The urine drug screen results and self reports of cocaine and other drug use and cravings;   Adverse events reports
2 Recruiting Combination Treatment With Doxazosin Plus TolterodineSR 2 mg Versus 4mg in Men With an Overactive Bladder (OAB) and Benign Prostatic Hyperplasia (BPH)
Conditions: Overactive Bladder;   Benign Prostatic Hyperplasia
Intervention: Drug: doxazosin plus tolterodine SR
Outcome Measures: Numeric change of urgency episodes per 24 hours;   Changes in voiding diary parameters;   Change in symptom questionnaires;   Patient-Rated Global Assessments of Treatment Benefit, Satisfaction, and Willingness to Continue;   Change of uroflowmetry and PVR;   Incidence of acute urinary retention
3 Recruiting Phenoxybenzamine Versus Doxazosin in PCC Patients
Condition: Pheochromocytoma
Interventions: Drug: Phenoxybenzamine;   Drug: Doxazosin
Outcome Measures: The number of patients demonstrating more than three intraoperative episodes of 5 minutes with blood pressure outside the predefined target range after pretreatment with either phenoxybenzamine or doxazosin.;   To attain preoperative blood pressure target values without co-medication;   Resolution of (paroxysmal) symptoms and signs of pheochromocytoma.;   Need for additional antihypertensive agents;   Adverse effects of study medication;   Length of preoperative treatment in either outpatient or inpatient clinic.;   Control of blood pressure and heart rate.;   Length of hospital stay.;   Composite semi-quantitative score of intra- and postoperative hemodynamic control.;   Postoperative hypoglycaemia;   Perioperative mortality.;   Perioperative cardiovascular morbidity.;   Composite endpoint of perioperative mortality and perioperative cardiovascular morbidity.
4 Recruiting A Pilot Study to Assess the Effects of Doxazosin on Polysomnography in PTSD
Condition: Stress Disorders, Post-Traumatic
Intervention: Drug: Doxazosin XL
Outcome Measures: Change in mean total sleep time and wake-time after sleep onset as measured by polysomnography and actigraphy;   Change in REM sleep time and REM period duration as measured by polysomnography;   Change in mean scores on the CAPS, CAPS sleep and distressing dreams items, PCL, BDI, ISI, PSQI, PSQI-A and QOLI
5 Recruiting Does Doxazosin Attenuate Stress-induced Smoking and Improve Clinical Outcomes?
Condition: Smoking
Interventions: Drug: Doxazosin;   Drug: Placebo
Outcome Measures: Latency (min) to initiate ad-lib smoking session;   Number of cigarettes smoked during ad-lib session;   Days to first lapse during quit attempt;   End of treatment 7-day point prevalence
6 Not yet recruiting Pharmacogenetic Trial of Doxazosin for Treatment of Cocaine Abuse
Condition: Cocaine Dependence
Interventions: Drug: Doxazosin;   Drug: Placebo
Outcome Measures: Reduction in cocaine use;   Treatment Retention;   Adverse events;   Changes in cocaine craving
7 Unknown  Doxazosin an a1 Antagonist for Alcohol Dependence
Conditions: Alcohol Dependence;   Anxiety
Interventions: Drug: Doxazosin;   Drug: Placebo
Outcome Measures: drinking days per week (DDW);   drinks per week (DPW);   alcohol craving;   anxiety;   Adverse Events
8 Recruiting Cyclooxygenase-2 (COX-2) Inhibitor Reduces Serum Prostatic Specific Antigen (PSA) Levels
Condition: Benign Prostatic Hyperplasia
Interventions: Drug: Celecoxib 200mg and Doxazosin 4mg;   Drug: Doxazosin 4mg
Outcome Measures: Change from Baseline in the serum prostate specific antigen (PSA) level;   Change from Baseline in the International Prostate Symptom Score (IPSS) questionnaires;   Change from Baseline in the total prostate volume (TPV);   Change from Baseline in the transitional zone index (TZI);   Change from Baseline in the maximum flow rate (Qmax);   Change from Baseline in the voided volume;   Change from Baseline in the postvoid residual volume (PVR);   Change from Baseline in the serum free prostate specific antigen (PSA) level;   Change from Baseline in the serum serum C-reactive protein level
9 Recruiting Alpha-Blockers in Allergic Rhinitis (MAN 01)
Condition: Allergic Rhinitis
Intervention: Drug: Doxazosin XL
Outcome Measures: Change in peak nasal inspiratory from baseline as compared with acute and chronic dosing of doxazosin versus placebo;   Nasal histamine challenge response as measured by peak nasal inspiratory flow after chronic dosing;   Nasal airways resistance after single and chronic dosing;   Domiciliary peak nasal inspiratory measurements after chronic dosing;   Symptoms after chronic dosing;   Mini Rhinoconjunctivitis Quality of Life Questionnaire after chronic dosing
10 Unknown  Alfuzosin for Medical Expulsion Therapy of Ureteral Stones
Condition: Kidney Stones
Interventions: Drug: Alfuzosin;   Drug: nifedipine;   Drug: doxazosin;   Drug: prazosin
Outcome Measure: The primary measures are percent of stones passed and rates of occurrence of various side effects (categorical variables), and time to pass, pain scale, and amount of pain medication taken (continuous variables).
11 Recruiting Antimuscarinics as the First-line Treatment for Male With IPSS-V/S≤1
Condition: Bladder Outlet Obstruction
Interventions: Drug: Detrusitol 4 mg QD;   Drug: Doxazosin 4 mg QD
Outcome Measures: The efficacy will be assessed using Patient Perception of Bladder Condition (PPBC) after the treatment day;   The efficacy will be assessed using International Prostate Symptom Score (IPSS) questionnaires after the treatment day;   The efficacy will be assessed using Overactive Bladder Symptom Score (OABSS) questionnaires after the treatment day;   To evaluate change of the total prostate volume (TPV) at different time points;   To evaluate change of Transition zone index (TZI) at different time points;   To evaluate change of Maximum flow rate (Qmax) at different time points;   To evaluate change of voided volume at different time points;   To evaluate change of postvoid residual volume (PVR) at different time points
12 Unknown  Extracellular Fluid in Resistant Hypertension
Condition: Hypertension
Interventions: Drug: Cardura XL 4 mg bd;   Drug: Amiloride 5 mg bd;   Drug: Furosemide 40 mg bd
Outcome Measure: Change in ECV; change in BP
13 Recruiting Randomized, Open Labeled Clinical Trial to Compare the Effectiveness of Amlodipine/Valsartan vs Hydrochlorothiazide/Telmisartan on Glucose Tolerance in Patients With Hypertension With Metabolic Syndrome
Condition: Hypertension
Interventions: Drug: amlodipine/valsartan;   Drug: hydrochlorothiazide/telmisartan
Outcome Measure: To assess the glucose change

These studies may lead to new treatments and are adding insight into Zoxan etiology and treatment.

A major focus of Zoxan research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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