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Defined Medical Research Studies

Up-to-date List of Defined Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Defined Medical Research Studies

Rank Status Study
1 Unknown  Clinical Trial With Vinflunine as Maintenance Therapy in Metastatic Urothelial Cancer
Condition: Carcinoma, Transitional Cell
Interventions: Drug: Vinflunine;   Other: Undefined (standard care)
Outcome Measure: Progression Free Survival.
2 Recruiting Molecular and Genetic Studies of Congenital Myopathies
Conditions: Central Core Disease;   Centronuclear Myopathy;   Congenital Fiber Type Disproportion;   Multiminicore Disease;   Myotubular Myopathy;   Nemaline Myopathy;   Rigid Spine Muscular Dystrophy;   Undefined Congenital Myopathy
Outcome Measure:
3 Not yet recruiting A Multicenter Trial, Comparing a 25G EUS Fine Needle Aspiration (FNA) Device With a 20G EUS ProCore Fine Needle Biopsy (FNB) Device
Conditions: Pancreatic Masses;   Lymph Nodes;   Submucosal and Other Undefined Masses (Non-pancreatic)
Interventions: Device: 25G FNA needle;   Device: 20G ProCore FNB needle
Outcome Measures: Diagnostic accuracy, compared to the gold standard diagnosis;   Technical success; tissue acquisition;   Quality and quantity of the tissue sample;   Safety, based on adverse events;   Diagnostic yield of the first needle pass;   Influence of on-site pathological evaluation
4 Recruiting Catheter Early Withdrawal or Maintenance in Sepsis or Septic Shock
Condition: Catheter Related Infection
Interventions: Procedure: CVC exchange;   Drug: CVC maintenance
Outcome Measures: Infection resolution;   Clinical variables
5 Recruiting IBDSL Biobank Project. Molecular Markers for Diagnosis and Therapy Response in IBD.
Conditions: IBD;   Crohns Disease;   Ulcerative Colitis
Outcome Measures: Concentration of seral, fecal, or volatile (exhaled air) biomarkers that reflect disease course and therapy response.;   Epidemiologic parameters
6 Not yet recruiting AutoloGel Therapy to Usual and Customary Care in Pressure Ulcers
Condition: Pressure Ulcer
Intervention: Device: AutoloGel
Outcome Measures: Time to complete wound healing;   Ulcer recurrence;   Proportion of healed ulcers;   W-QOL (Quality of Life with Chronic Wounds) score;   Number of patients with adverse events as a measure of tolerability
7 Recruiting A Cohort Trial Comparing AutoloGel Therapy to Usual and Customary Care in Venous Leg Ulcers
Condition: Venous Leg Ulcer
Intervention: Device: AutoloGel
Outcome Measures: Time to wound closure;   Proportion of wounds healed;   Frequency of ulcer recurrence;   Change in Quality of Life with Chronic Wounds (W-QOL) Score;   Number of patients with adverse events as a measure of tolerability
8 Recruiting Tissue Sample Study for Mitochondrial Disorders
Conditions: Mitochondrial Disorders;   Mitochondrial Disease;   Melas;   Kearns Sayer;   NARP;   MNGIE;   LHON;   Mitochondrial Depletion Syndrome;   Leigh's Disease
Outcome Measures: Respiratory chain enzyme levels;   Number of new genes related to mitochondrial function
9 Recruiting Assessment of Antibodies and Inflammatory Markers in Postural Tachycardia Syndrome
Condition: Postural Orthostatic Tachycardia Syndrome
Interventions: Other: History;   Other: Physical;   Other: blood draw;   Behavioral: Questionnaires
Outcome Measures: Ab titer in POTS patients compared to control subjects;   comparison of the number of POTS patients with viral based Ab versus non-viral based Ab;   comparison of the number of POTS patients with and without Ehlers Danlos syndrome III;   comparison of the number of POTS patients with a history of autoimmune disorders versus no history of auto-immune disorders;   comparison of the number of POTS patients with fatigue versus no history of fatigue based on severity of impact on normal daily activities.;   comparison of pain in POTS patients versus non-POTS patients
10 Recruiting Effectiveness of AutoloGel Therapy in Diabetic Foot Ulcers
Condition: Diabetic Foot Ulcers
Intervention: Device: AutoloGel
Outcome Measures: Time to heal;   Ulcer recurrence;   Incidence of amputations;   Proportion of completely healed ulcers;   W-QOL (Quality of life with Chronic Wounds) score;   Number of patients with adverse events as a measure of tolerability
11 Recruiting Risk Adapted SABR(SABR) in Stage I NSCLC And Lung Metastases
Conditions: Carcinoma, Non-Small-Cell Lung;   Neoplasm Metastasis
Interventions: Radiation: 34 Gy in a single fraction;   Radiation: 54Gy 18Gy/fr. x 3 fractions;   Radiation: 50Gy (12 x 5 fr.s);   Radiation: 60Gy (7.5Gy x 8fr.)
Outcome Measures: probability of not suffering a grade 3 or higher toxicity;   Tumour response;   Incidence of acute and late toxicities;   Overall survival;   Disease-free survival;   Effect in brochopulmonary (COPD) disease.;   Feasibility
12 Unknown  The Addition of Temozolomide to Conditioning for Autologous Transplantation in Relapsed & Refractory Central Nervous System (CNS) Lymphoma
Condition: B-Cell Lymphoma Originating in the CNS
Intervention: Drug: Temozolomide
Outcome Measures: Efficacy of the DRBEAT Regimen;   Safest dose of temozolomide for the DRBEAT Regimen
13 Recruiting Effect of Physical Exercise in Alzheimer Patients
Condition: Alzheimer Disease
Intervention: Other: Aerobic exercise
Outcome Measures: Symbol Digit Modalities Test;   NPI (psychological symptoms.);   Astrand submaximal bicycle test for estimating VO2 max;   Euro-qol-5D-5L (health related quality of life);   Alzheimer's disease Assessment Scale - Cognitive section (ADAS-cog).;   Changes in physical fitness;   Self-efficacy scale;   Verbal fluency;   Stroop;   MMSE (Mini Mental State Examination)
14 Recruiting Analysis of the Mechanisms of Actions of Heat Shock Protein (Hsp27) Responsible of the Androgen-independent Evolution in Prostate Cancer
Condition: Androgen-independent Prostate Cancer
Intervention: Procedure: Realisation of blood sample, urinary sample and tumor biopsy
Outcome Measures: Level of Hsp27 protein;   Targets for OGX-427
15 Unknown  The Addition of Cardiac CT to Exercise Treadmill Testing in the Evaluation of Angina
Condition: Angina
Outcome Measure:
16 Recruiting Epigenetic Effects Elicited By Lactobacillus GG In Children With Cow's Milk Allergy
Condition: Cow's Milk Allergy
Intervention: Dietary Supplement: Lactobacillus GG
Outcome Measure: Change from baseline to 6 months in tolerance acquisition and epigenetic effects in rtwenty children with cow's milk allergy
17 Recruiting 68-Ga-labeled Octreotide Analogues PET in Duodenal-pancreatic Neuroendocrine Tumours
Condition: Neuroendocrine Tumours
Intervention: Drug: Diagnostic work up
Outcome Measures: Accuracy of the diagnostic test.;   Accuracy of the diagnostic test (after exclusion of patients enrolled due to a incidentally diagnosed lesion);   Number of Participants with Adverse Events as a Measure of Safety.;   Sensitivity of the diagnostic tests.;   Specificity of the diagnostic tests.;   Clinical impact of PET.;   Diameter of lesions.
18 Recruiting Bosentan In Exercise Induced Pulmonary Arterial Hypertension in CongenitaL Heart diseasE
Conditions: Pulmonary Arterial Hypertension;   Congenital Heart Disease
Interventions: Drug: Bosentan;   Drug: Placebo
Outcome Measures: Change in mean pulmonary arterial pressure (mPAP) at peak exercise;   Cardiopulmonary exercise capacity;   Pulmonary hemodynamics;   Right ventricular function;   Laboratory parameters;   NYHA functional class;   Quality of life;   Demographics
19 Recruiting Targeting Inflammation to Treat Cardiovascular Aging
Conditions: Vascular Stiffness;   Endothelial Dysfunction;   Diastolic Dysfunction
Interventions: Drug: Salsalate;   Drug: Placebo (for salsalate)
Outcome Measures: Carotid-femoral pulse wave velocity (CFPWV);   Brachial artery flow-mediated dilation (FMD)
20 Recruiting Genetics of Charcot Marie Tooth (CMT) - Modifiers of CMT1A, New Causes of CMT2
Conditions: Charcot-Marie-Tooth Disease, Type Ia (Disorder);   HMSN
Outcome Measures: Charcot Marie Tooth disease type 1A (CMT1A) gene modifiers;   New genetic causes of CMT

These studies may lead to new treatments and are adding insight into Defined etiology and treatment.

A major focus of Defined research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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