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Dependence Medical Research Studies

Up-to-date List of Dependence Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Dependence Medical Research Studies

Rank Status Study
1 Not yet recruiting Studying the Effects of Administration of Polyunsaturated Fatty Acids (PUFAS) of Omega-3 Series in Nicotine Dependence
Conditions: Tobacco Dependence;   Nicotine Dependence
Intervention: Drug: fish oil
Outcome Measure: Reduction on the nicotine Dependence
2 Recruiting A Controlled Trial of Topiramate Treatment for Alcohol Dependence in Veterans With PTSD
Conditions: Alcohol Dependence;   Posttraumatic Stress Disorder (PTSD)
Interventions: Drug: Topiramate;   Drug: placebo
Outcome Measures: Topiramate in reducing alcohol use in veterans with PTSD using the Timeline Followback (TLFB);   Topiramate in veterans with alcohol Dependence using the Timeline Followback (TLFB).;   Topiramate in reducing PTSD symptom severity;   Topiramate in reducing alcohol intake in veterans with PTSD;   Topiramate in reducing alcohol Dependence veterans with PTSD
3 Recruiting Combination of Dronabinol and Clonidine for Cannabis Dependence in Patients With Schizophrenia
Conditions: Cannabis Dependence;   Marijuana Dependence
Interventions: Drug: Dronabinol;   Drug: Clonidine;   Drug: Placebo
Outcome Measures: Change from baseline in cannabis use at 10 weeks;   Change in withdrawal symptoms from baseline at 10 weeks;   Change from baseline in cannabis use at 14 weeks;   Change in withdrawal symptoms from baseline at 14 weeks
4 Recruiting Novel Pharmacotherapy for Dual Dependence
Conditions: Alcohol Dependence;   Cocaine Dependence
Interventions: Drug: Topiramate + Cognitive Behavioral Therapy;   Drug: Placebo + Cognitive Behavioral Therapy
Outcome Measures: The topiramate group will be superior to the placebo group on the following outcome measures:increasing the weekly mean proportion of cocaine-free days, decreasing self-reported drinking, and decreasing craving for cocaine and alcohol.;   a. Cocaine free weeks; b. Topiramate, compared with placebo, will be associated with an improvement in psychosocial functioning as exemplified by improved general well-being, social functioning, and quality of life.
5 Unknown  Varenicline for Alcohol Dependence
Condition: Alcohol Dependence
Interventions: Drug: Varenicline;   Drug: Placebo
Outcome Measures: Number of total alcohol abstinent days during he 12 weeks study period, percentage of the treatment days;   Time in days to first alcoholic drink, assessed by the time-line-follow-back-interview;   Proportion of abstinent patients during the study, percentage of all patients;   Number of standard drinks per drinking day, assessed by the time-line-follow-back-interview.;   Time in days to first heavy drinking, assessed by the time-line-follow-back-interview.;   Number of days with heavy drinking as percentage of all treatment days, assessed by time-line-follow-back-interview.;   Changes in gamma-glutamyl transpeptidase levels;   Occurrence of adverse events;   Compliance of the subjects;   alcohol craving assessed by the obsessive compulsive drinking scale (OCDS) and a visual analog scale (VAS);   Severity of the alcohol Dependence assessed by the European Addiction Severity Index (EuropASI);   Absolute change in the Clinical Global Impression of Change (CGI);   Quality of life, assessed by the questionnaire for health condition Fragebogen zum allgemeinen Gesundheitszustand (SF-12);   Number of cigarettes per day;   Number of nicotine abstinent days, percentage of the treatment days;   Severity of the nicotine Dependence, assessed by the Fagerstrom test for nicotine Dependence;   Intensity of depressive symptoms, assessed by the Beck Depression Inventors (BDI)
6 Recruiting Treatment for Caffeine Dependence
Condition: Caffeine Use Disorder (DSM-5 Condition for Further Study)
Intervention: Behavioral: Manual-based treatment for caffeine Dependence
Outcome Measures: Change in self-reported caffeine use;   Change in biological measure of caffeine use
7 Unknown  5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence
Conditions: Opioid Withdrawal;   Physical Dependence
Intervention: Drug: Ondansetron
Outcome Measures: Change in baseline of Objective Opioid Withdrawal Score;   Change in the Baseline of Subjective Opioid Withdrawal Score;   Beck Depression Inventory;   Pain Inventory;   Change in Baseline of Physical Vital Signs;   Serum Factors;   Pain Sensitivity
8 Not yet recruiting Study of Long-Acting Injectable Naltrexone to Treat Cannabis Dependence
Condition: Cannabis Dependence
Intervention: Drug: Long-acting injectable naltrexone
Outcome Measures: Reduction in marijuana use;   Proportion of participants receiving the second injection of study medication;   Number and severity of adverse events associated with naltrexone and its injection;   Reduction in marijuana use as measured by urine toxicology
9 Recruiting Preload Dependence During Prone Position In ARDS Patients
Intervention: Procedure: Trendelenburg position
Outcome Measures: Area under ROC curve of the variation in continuous cardiac output during Trendelenburg position, to detect preload Dependence;   Area under ROC curve of the variation in continuous cardiac output during end-expiratory occlusion to detect preload Dependence;   Area under ROC curve of the respiratory variation in pulse pressure to detect preload Dependence
10 Recruiting Smokers' Response to Nicotine Dependence Genotyping
Conditions: Cigarette Smoking;   Nicotine Dependence
Interventions: Behavioral: Receipt of Genetic Results;   Behavioral: No results given
Outcome Measures: Change in Baseline Smoking Abstinence at 2, 6, and 10 Weeks after Genotyping Results;   Change in Baseline Use of Pharmacotherapy at 2, 6, and 10 Weeks after Genotyping Results
11 Recruiting Psychopharmacology for Cocaine Dependence - Buspirone
Condition: Cocaine Dependence
Intervention: Drug: Buspirone
Outcome Measures: Cocaine-Stroop;   Risky decision making;   ARCI;   POMS;   DEQ;   VAS;   cardiovascular
12 Unknown  Efficacy of Caffeine, With and Without Biperiden, as a Maintenance Treatment for Cocaine Dependence
Condition: Cocaine Dependence
Interventions: Drug: caffeine;   Drug: Biperiden;   Drug: Placebo
Outcome Measures: survival;   cocaine use
13 Recruiting Open-Label Pilot Study of Guanfacine-Extended Release for the Treatment of Cannabis Dependence
Condition: Cannabis Dependence
Intervention: Drug: Guanfacine
Outcome Measure: Reduction in cannabis use
14 Recruiting Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging
Condition: Nicotine Dependence
Interventions: Drug: Nicotine patch - transdermal;   Drug: placebo
Outcome Measures: Mu-opioid receptor binding potential;   Nicotine craving;   Nicotine withdrawal
15 Recruiting Quetiapine Pharmacotherapy for Cannabis Dependence
Condition: Cannabis Dependence
Interventions: Drug: Quetiapine;   Drug: Placebo
Outcome Measures: Marijuana Use;   Marijuana Abstinence;   Urine toxicology;   Marijuana withdrawal symptoms;   Marijuana craving;   Sleep disturbance
16 Recruiting Telephone-Based Continuing Care for Alcohol Dependence
Condition: Alcohol Dependence
Intervention: Behavioral: Telephone-based counseling
Outcome Measure: Number of days of alcohol abstinence
17 Not yet recruiting Citicoline for Alcohol Dependence
Condition: Alcohol Dependence
Interventions: Drug: Placebo;   Drug: Citicoline
Outcome Measure: Heavy Drinking Days per Week
18 Recruiting Gabapentin Treatment of Cannabis Dependence
Conditions: Cannabis Dependence;   Cannabis Withdrawal;   Cognitive Deficits
Interventions: Drug: gabapentin 1200mg/day;   Drug: Placebo
Outcome Measure: Cannabis Use
19 Unknown  Combination of Psychosocial Intervention and Slow Prosecutions for the Treatment of Methamphetamine Abuse/Dependence
Conditions: Amphetamine Abuse;   Amphetamine Dependence;   Methamphetamine Abuse;   Methamphetamine Dependence
Interventions: Behavioral: Psychosocial intervention;   Behavioral: Telephone reminding
Outcome Measures: Endpoint abstinence rate;   Retention rate;   Length of retention;   The longest period of abstinence
20 Recruiting Duloxetine Versus Pregabalin for Alcohol Dependence
Condition: Alcohol Dependence
Interventions: Drug: Pregabalin;   Drug: Duloxetine;   Behavioral: Standardized behavioral therapy;   Drug: Placebo
Outcome Measure: Drinking Quantity and Frequency

These studies may lead to new treatments and are adding insight into Dependence etiology and treatment.

A major focus of Dependence research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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