Up-to-date List of Depression Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Depression Medical Research Studies

1 Recruiting Evaluation of a Stepped Care Approach to Manage Depression in Diabetes
Conditions: Major Depressive Disorder;   Minor Depressive Disorder;   Sub-Threshold Depression;   Diabetes Mellitus
Interventions: Behavioral: Step 1: Diabetes-Specific CBT (5 group sessions);   Behavioral: Step 2: Depression-Specific CBT (6 single sessions);   Behavioral: Step 3: Referral to Psychotherapist and/or Psychiatrist;   Behavioral: Standard Diabetes Education
Outcome Measures: Depressive Mood - Hamilton Rating Scale for Depression (HAMD);   Diabetes-Related Distress - The Problem Areas in Diabetes Questionnaire (PAID);   Psychological/ Emotional Well-Being - The WHO-5 Well-being Index (WHO-5);   Health-Related Quality of Life - The Short Form-36 Health Survey (SF-36);   Diabetes Self-Care Behavior - The Summary of Diabetes Self-Care Activities Measure (SDSCA);   Glycaemic Control (HbA1c);   Health-Related Quality of Life - The EuroQol-5D (EQ-5D);   Diabetes Self-Care Behavior - The Diabetes Self-Management Questionnaire (DSMQ)
2 Recruiting Psychological Mindedness as a Predictor of Success in Cognitive Behavior Therapy for Depression
Conditions: Major Depressive Disorder;   Dysthymia
Intervention: Behavioral: Cognitive Behavior Therapy for Depression
Outcome Measure: Level of Depression as measured by the Hamilton Rating Scale for Depression
3 Recruiting Depression Management at the Workplace
Condition: Depression
Interventions: Other: Depression Product Detailing;   Other: Depression HEDIS detailing
Outcome Measures: employer purchase of Depression management product;   fidelity of Depression management model purchased to evidence-based models
4 Recruiting New Clinical Applications for Internet-based Cognitive Behavior Therapy for Insomnia and Depression
Conditions: Insomnia; Major Depression;   Minor Depression
Interventions: Behavioral: Therapist guided Internet-CBT for insomnia w. extra support;   Behavioral: Therapist guided Internet-CBT for insomnia;   Behavioral: Therapist guided Internet-CBT for insomnia and Depression;   Behavioral: Therapist Guided Internet-CBT for Depression plus insomnia placebo
Outcome Measures: Change (from baseline) in Insomnia Severity Index (ISI);   Change (from baseline) in Montgomery Asberg Depression Rating Scale, MADRS-S;   Change (from baseline) in Sleep Diary;   Changes (from baseline) in Actigraph data;   Change (from baseline) in Trimbos and Institute of Medical Technology Assessment Cost Questionnaire for Psychiatry (TIC-P);   Change (from baseline) in Cognitive functioning;   Change (from baseline) in EuroQuol. EQ-5D;   Change (from baseline) in Sheehan Disability Scale;   Change (from baseline) in Clinical Outcome in Routine Evaluation - 10, CORE-OM
5 Not yet recruiting Blended Collaborative Care for Heart Failure and Co-Morbid Depression
Conditions: Heart Failure, Systolic;   Depression;   Cardiovascular Disease
Interventions: Behavioral: Collaborative Care for Heart Failure;   Behavioral: Collaborative Care for Depression
Outcome Measures: Medical Outcomes Study (MOS) 12-Item Short Form Health Survey Mental Component Summary (SF-12 MCS);   Kansas City Cardiomyopathy Questionnaire (KCCQ-12);   Hamilton Rating Scale for Depression (17-Item);   Incidence of Rehospitalization;   Mortality;   Health Care Costs;   Employment
6 Recruiting Prevalence Study of Depression in Chinese Patients With Type 2 Diabetes (HK13)
Conditions: Diabetes;   Depression
Interventions: Other: Psychiatrist Interview;   Other: Depression screening - control
Outcome Measures: Depression and psychological well-being;   Percentage of patients who attain 2 or more of the 'ABC' targets;   Self care and Efficacy;   Quality of life
7 Recruiting Can Genetics Predict Treatment Response to a Computerized Self-help Program for Depression?
Conditions: Major Depressive Disorder;   Mood Disorders
Intervention: Behavioral: Computerized self-help program for Depression
Outcome Measures: Quick Inventory of Depressive Symptomatology (Self-Report) (QIDS-SR-16);   Hamilton Depression Rating Scale (HAM-D);   Inventory of Depression and Anxiety Symptoms (IDAS);   Psychiatric Diagnostic Screening Questionnaire (PDSQ);   Risky Families Questionnaire (RFQ);   Massachusetts General Hospital Antidepressant Treatment History Questionnaire (ATRQ);   Sheehan Disability Scale (SDS)
8 Recruiting Management of Depression in Primary Care
Condition: Depression
Intervention: Behavioral: Structured patient-centered follow up of Depression
Outcome Measures: Change in Depressive symptoms;   Change in Quality of life;   Prescriptions for antidepressants;   Change in Activity/work ability;   sick-listing data
9 Unknown  Low Intensity Versus Self-guided Internet-delivered Psychotherapy for Major Depression
Condition: Depression
Interventions: Other: Low Intensity Internet-delivered psychotherapy;   Other: Self-guided Internet delivered psychotherapy;   Other: Improved treatment as usual
Outcome Measures: Severity of depressive symptomatology measured by Beck Depression Inventory II;   Socio-demographic variables.;   Mini-International Neuropsychiatric Interview (MINI).;   EuroQoL-5D questionnaire (EQ-5D - Spanish version);   Client Service Receipt Inventory - adapted (CSRI - Spanish version);   Overall Depression Severity and Impairment Scale;   Positive and Negative Affect Scale (PANAS);   Credibility/expectancy questionnaire
10 Recruiting Study of Web- Based Cognitive Behavioral Therapy for Depressed Korean Adolescents
Conditions: Depression;   Mental Disorder in Adolescence;   Cognitive Behavioral Therapy
Interventions: Behavioral: web-based CBT;   Behavioral: supportive care
Outcome Measures: The Center for Epidemiological Studies of Depression (CES-D) Scale;   Subjective depressed mood scale;   The Korean youth self report (K-YSR);   Acceptability and adherence of Web-based cognitive behavioral treatment program for adolescents with Depression;   satisfaction of Web-based cognitive behavioral treatment program of both adolescents with Depression and their parents;   Columbia suicide severity rating scale;   Adolescent's characteristics that moderate the impact of the program
11 Not yet recruiting Healthy Moms-Healthy Kids: Reducing Maternal Depression for Better Outcomes in Head Start Children
Conditions: Maternal Depression;   Parenting Behavior;   Health;   Interpersonal Relationships;   Goal Directed Behavior,;   Child Behavior;   Child School Readiness
Intervention: Behavioral: Interpersonal Psychotherapy for Depression -Group
Outcome Measure: Beck Depression Inventory
12 Not yet recruiting A Family Depression Prevention Program
Condition: Depression
Interventions: Behavioral: Family Cognitive Behavioral Prevention;   Behavioral: Written information
Outcome Measures: In children, the primary outcome is onset of a depressive episode. In parents, the primary outcome is time in a depressive episode.;   Parents: Patient Health Questionnaire - 9 (PHQ-9);   Children: Youth Self-report (YSR) anxiety/Depression subscale
13 Unknown  Outcome of Postnatal Depression Screening Using Edinburgh Postnatal Depression Scale
Condition: Depression, Postpartum
Intervention: Procedure: Edinburgh Postnatal Depression Scale
Outcome Measures: Mother's mental health at 6 months postpartum, as measured on the EPDS and General Health Questionnaire-12 (GHQ-12), both being self-report questionnaires.;   Mother's parenting stress (measured by the Parenting Stress Index, a self-report questionnaire);   Marital relationship satisfaction (measured by the Chinese Kansas Marital Satisfaction Scale, a self-report questionnaire);   Marital status and employment status (both father and mother, where applicable) at 6 and 18 months postpartum;   Child health measures, including weight at 6 and 18 months, number of hospitalizations and visits to doctors within the first 6 and 18 months as reported by mother;   Mother's mental health outcome (EPDS and GHQ scores) at 18 months postpartum
14 Not yet recruiting African American Depression Intervention Trial (AADI)
Condition: Major Depressive Disorder
Intervention: Behavioral: Coping with Depression Course (CWD) and Oh Happy Day Class (OHDC)
Outcome Measures: Center for Epidemiologic Studies Depression Scale (CES-D);   Quick Inventory of Depressive Symptomatology (QIDS)
15 Not yet recruiting A Family-based Primary Care Intervention to Enhance Older Men's Depression Care
Condition: Major Depression
Interventions: Behavioral: Family-based Depression intervention;   Behavioral: Usual care plus educational materials
Outcome Measures: Depressive symptoms;   Medication adherence;   Family caregiver satisfaction;   Health-related functional disability;   Family self-management support
16 Unknown  Evaluating the Efficacy of Adjunctive Minocycline for the Treatment of Bipolar Depression
Conditions: Bipolar Disorder;   Bipolar Depression;   Bipolar I Depression; Bipolar II Depression
Intervention: Drug: Minocycline
Outcome Measures: Change from baseline to week 8 on the Montgomery Asberg Depression Rating Scale (MADRS);   Change from baseline to week 8 on the Hamilton Depression Rating Scale 17-item (HAMD-17);   Change from baseline to week 8 on the Somatic Symptom Inventory (SSI);   Change from baseline to week 8 on the Clinical Global Impression (CGI) Rating Scale;   Change from baseline to week 8 in the in neurocognitive function;   Monitoring of Side-effects from baseline to week 8 with the Toronto Side Effect Scale (TSES);   Monitoring of suicide severity from baseline to week 8 with the Columbia Suicide Severity Rating Scale (C-SSRS).;   Change from baseline to week 8 in concentrations of pro-and anti-inflammatory cytokines (i.e. TNFα, IL-1β, IL-2, IL-6, IL8, IFNγ, IL-4, IL-5, IL-10)
17 Recruiting Phenotype Depression Study
Condition: Major Depressive Disorder
Outcome Measures: We are using clinician administered and self report psychiatric measurements to compare relevant symptom domains in patients with major Depression and increased inflammation versus patients with major Depression without increased inflammation.;   We are measuring immune markers for the identification of relevant immunologic patterns of activation in patients with major Depression and increased inflammation versus patients with major Depression without increased inflammation.
18 Not yet recruiting Evaluation of an Integrated Microfinance and Depression Care Program for Women
Conditions: Depression;   Anxiety
Interventions: Behavioral: LIFE-DM;   Drug: Guideline Antidepressant Care
Outcome Measures: Change in Patient Health Questionnaire-9;   Change in MINI Diagnostic Interview;   Change in Quality of Life Enjoyment and Satisfaction Questionnaire;   Change in Self-Efficacy;   Change in Medical Outcome Study (MOS)-Social Support Survey;   Change in Medical Outcomes Study (MOS) 12-Item Short Form Health Survey (SF-12);   Change in Generalized Anxiety Disorder (GAD-7);   Change in Behavior Activation for Depression Scale (BADS);   Change in income
19 Recruiting Fevarin® Effectiveness in Treatment of Depression in Patients With Neurological Disorder
Condition: Depression
Outcome Measures: Prevalence of different neurological disorders associated with Depression treated with fluvoxamine (Fevarin®).;   Demographics of patients (age, gender, race, family status, education, employment).;   Change in the Hospital Anxiety and Depression Scale (HADS) Depression Subscale Score;   Number and proportion of patients with Depression symptoms change measured by Hospital Anxiety and Depression Scale (HADS);   Change in the Hospital Anxiety and Depression Scale (HADS) Anxiety Subscale Score;   Global severity of illness and change in the clinical condition measured by Clinical Global Impression scale;   Number and proportion of patients with change in Clinical Global Impression scale;   Anxiety and Depression symptoms score measured by Hospital Anxiety and Depression Scale (HADS);   Number and proportion of patients with anxiety symptoms change measured by Hospital Anxiety and Depression Scale (HADS)
20 Recruiting Bending Adolescent Depression Trajectories Through Personalized Prevention
Condition: Depression
Interventions: Behavioral: Interpersonal Psychotherapy- Adolescent Skills Training;   Behavioral: Coping with Stress
Outcome Measures: Presence of a Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL);   Presence of A Major Depressive Episode or Dysthymia on the Schedule for Affective Disorders for School Aged Children - Present and Life Time Version (K-SADS-PL);   Children's Depression Inventory (CDI);   Children's Global Assessment Scale (CGAS)

These studies may lead to new treatments and are adding insight into Depression etiology and treatment.

A major focus of Depression research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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