Up-to-date List of Diarrhea Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Diarrhea Medical Research Studies

1 Recruiting Trial Evaluating Ambulatory Treatment of Travelers' Diarrhea
Conditions: Acute Watery Diarrhea;   Dysentery/Febrile Diarrhea
Interventions: Drug: Single dose rifaximin 1650 mg;   Drug: Single dose azithromycin 500 mg;   Drug: Single dose levofloxacin 500 mg;   Drug: Single dose azithromycin 1000 mg plus loperamide;   Drug: Single dose azithromycin 1000 mg plus placebo
Outcome Measures: Clinical Cure - Acute Watery Diarrhea group;   Clinical Cure - Acute Dysentery/Febrile Diarrhea group;   Time to Last Unformed Stool
2 Recruiting Lactobacillus Reuteri DSM 17938 in Preventing Nosocomial Diarrhea in Children
Condition: Diarrhea
Interventions: Dietary Supplement: Lactobacillus reuteri DSM 17938;   Dietary Supplement: Placebo
Outcome Measures: Incidence of nosocomial Diarrhea (defined as the passage of 3 or more loose or watery stools in a 24-hour period that will occur more than 72 hours after admission);   Incidence of Diarrhea- passage of 3 or more loose or watery stools in a 24-h period;   Duration of Diarrhea (ie, time till the last loose or watery stool from the onset of Diarrhea);   Need and the length of intravenous rehydration due to Diarrhea;   Prolongation of the hospitalization due to nosocomial Diarrhea; Incidence of rotavirus Diarrhea (ie, detection of rotavirus or antigen in the stools);   Incidence of chronic Diarrhea- lasting more than 14 days;   Length of hospital stay;   Adverse effects
3 Recruiting Effects of Probiotics and/or Prebiotics on the Duration of Diarrhea and Hospitalization in Children
Condition: Acute Diarrhea
Interventions: Dietary Supplement: Probiotic;   Dietary Supplement: ORS
Outcome Measures: Duration of Diarrhea;   Percentage of children with Diarrhea at the 3rd day of intervention;   Duration of hospitalization;   Safety of probiotics
4 Recruiting Confocal Laser Endomicroscopy (CLE) in Patients With Diarrhea
Condition: Diarrhea
Interventions: Procedure: Colonoscopy;   Procedure: Confocal Laser Endomicroscopy
Outcome Measures: To determine the frequency of different gastrointestinal disorders as the cause of Diarrhea in patients at a tertiary referral center using confocal laser endomicroscopy.;   To investigate whether CLE has a higher sensitivity and specificity than standard colonoscopy in the diagnosis of the cause of Diarrhea.
5 Recruiting CASAD for Severe Diarrhea in the Emergency Department
Conditions: Cancer;   Diarrhea
Interventions: Drug: Calcium Alumina-Silicate (CASAD);   Other: Placebo;   Behavioral: Questionnaire
Outcome Measure: Time to Resolution of Diarrhea (TTRD)
6 Not yet recruiting The Effectiveness of Co-packaging With Zinc to Improve Treatment of Diarrhea and Pneumonia in Guatemala
Conditions: Diarrhea.;   Pneumonia.
Intervention: Behavioral: Co-packaging and counseling messages
Outcome Measures: Percentage of caregivers who administer zinc to child for at least 8 days.;   Percentage of caregivers who report giving zinc to child for at least 8 days.;   Improved Provision of Care for Treatment of Diarrhea and Pneumonia
7 Recruiting Lactobacillus Reuteri in the Prevention of Antibiotic Associated-Diarrhea and Clostridium Difficile
Conditions: Antibiotic-associated Diarrhea;   Clostridium Difficile
Intervention: Dietary Supplement: Lactobacillus reuteri
Outcome Measures: Diarrhea;   Severity of Diarrhea;   Frequency of stool samples positive for C. difficile toxin A and B;   Frequencies of other gastrointestinal symptoms
8 Recruiting Oral Zinc for the Treatment of Acute Diarrhea in US Children
Conditions: Diarrhea;   Gastroenteritis
Intervention: Drug: Zinc Sulfate
Outcome Measures: Duration of Diarrhea in acute Diarrheal illnesses in a developed nation while taking zinc or placebo.;   Length of hospitalization for children with Diarrheal illness taking zinc or placebo.;   Examine the potential cost benefits of supplementation with zinc in reducing number of work days lost, daycare days not attended and decrease in length of hospitalization;   Assess parent reporting reliability comparing survey responses to phone interview.
9 Unknown  Prospective Randomized Open Label Study of the Treatment of Therapy-Associated Diarrhea During Percutaneous Radiation Therapy of the Small Pelvis. - Comparison of Loperamide and Tincture of Opium -
Conditions: Diarrhea;   Enteritis;   Cancer
Intervention: Drug: Tinctura opii
Outcome Measures: In this study efficacy of loperamide and tincture of opium is linked to the respective proportions of patients where diarrhoea of grade > 2 is successfully averted during (cancer) therapy.;   Should diarrhoea of grade > 2 occur despite the respective drug treatment, the corresponding medicament is assessed as inefficacious in that case.;   Scores from the EORTC-QLQ-C30;   Body composition data (BMI, proportions of fat and water
10 Recruiting ADAM-Afatinib Diarrhea Assessment and Management
Condition: Carcinoma, Non-Small-Cell Lung
Interventions: Drug: afatinib;   Drug: loperamide
Outcome Measures: Occurence of CTCAE Grade >= 2 Diarrhea;   Time to initial onset of Diarrhea grade 2 or higher;   Duration of Diarrhea grade 2 or higher;   Changes in intensity of Diarrhea over time
11 Recruiting Trial Of Azithromycin In Campylobacter Concisus Patients With Diarrhea
Conditions: Diarrhea;   Fever;   Vomiting;   Abdominal Pain
Interventions: Drug: azithromycin;   Drug: Placebo
Outcome Measures: Duration of Diarrhea in days;   number of stools/day
12 Recruiting Lactobacillus Preparation on the Incidence of Diarrhea
Conditions: Diarrhea;   Death;   Pneumonia
Interventions: Drug: Lactobacillus casei variety rhamnosus granules;   Drug: Placebo
Outcome Measures: Diarrhea-free days;   28day-mortality;   Positive results of C.difficile toxin;   ICU-acquired pneumonia
13 Recruiting The Efficacy of CASAD in Patients With Diarrhea Related to Medullary Thyroid Cancer
Conditions: Diarrhea;   Medullary Thyroid Cancer
Intervention: Drug: CASAD
Outcome Measures: Efficacy in treatment of Diarrhea;   Functional impact of CASAD;   Effect on thyroid function tests;   Changes in MDASI-THY scores
14 Unknown  Recombinant Human Lactoferrin Administered Orally for the Prevention of Antibiotic Associated Diarrhea in Adult Patients
Condition: Diarrhea
Intervention: Drug: Lactoferrin
Outcome Measure: Reduction in the number of days of antibiotic associated Diarrhea during the treatment period
15 Not yet recruiting Probiotics in Hospitalized Patients Study
Conditions: Antibiotic Associated Diarrhea;   Clostridium Difficile Associated Diarrhea
Intervention: Dietary Supplement: Go Live
Outcome Measures: Incidence of Clostridium difficle associated Diarrhea in patients randomized to Go Live Rx compared with those randomized to placebo;   Incidence of Antibiotic associated Diarrhea in patients randomized to Go Live Rx compared with those randomized to placebo
16 Not yet recruiting Impact of Bismuth Subsalicylate on Antimicrobial Use Among Adult Diarrhea Outpatients--Pakistan
Condition: Diarrhea
Interventions: Drug: Bismuth subsalicylate;   Other: Placebo
Outcome Measures: use of antimicrobial medications;   Patient's perceived need for antibiotics;   additional care obtained for Diarrhea;   Additional care obtained for Diarrheal illness;   Disease severity and duration;   Patient experience with the study drug
17 Unknown  Efficacy of Zinc Sulfate With Probiotics for the Treatment of Acute Diarrhea in Children
Condition: Acute Watery Diarrhoea
Intervention: Drug: Zinc Sulfate
Outcome Measures: Period of Diarrhea in hours;   number of stools in consequent days
18 Unknown  Role of Probiotics in Preventing Antibiotic Associated Diarrhoea Including c.Difficile
Condition: Antibiotic Associated Diarrhoea Including c.Difficile
Interventions: Dietary Supplement: probiotic drink;   Dietary Supplement: probiotic placebo drink
Outcome Measures: Incidence of diarrhoea;   incidence and duration of Clostridium difficile toxin;   The rate of recurrence of antibiotic associated diarrhoea in the active and placebo groups to the end of the follow up period;   rate of recurrence of Clostridium difficile toxin positive diarrhoea;   The quality of life in the active and placebo groups at enrollment into the study;   The length of hospital stay from enrollment into the study until the end of the follow up period in the active and placebo groups The cost-effectiveness as evidenced by health economic calculations
19 Recruiting Effect of Probiotic Formula on Reducing the Risk for Antibiotic-associated Diarrhoea
Condition: Antibiotic-associated Diarrhoea
Interventions: Dietary Supplement: Probiotic;   Dietary Supplement: Placebo
Outcome Measures: Incidence of AAD;   Duration of diarrhoea;   Fecal microbiota;   Safety profile
20 Unknown  Efficacy of Loperamide in Treating Patients for C. Difficile Colitis and Diarrheal Disease of Unknown Cause Associated With Antibiotic Therapy
Conditions: Antibiotic Associated Diarrhea;   Clostridium Difficile
Interventions: Drug: loperamide;   Drug: placebo
Outcome Measures: To determin symptomatic treatment of Diarrhea with loperamide in antibiotic associated Diarrhea;   To measure the safety and efficacy of loperamide in the control of antibiotic associated Diarrhea in hospitalized patients

These studies may lead to new treatments and are adding insight into Diarrhea etiology and treatment.

A major focus of Diarrhea research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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