Up-to-date List of Haemorrhage Medical Research Studies
What Research is Being Done?
A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.
Device: Self-expanding mesh-metal oesophageal stent (SEMS); Other: Standard Therapy
Failure to Control Bleeding; Absence of Bleeding at 14 and 42 days; Participant Survival; Absence of Stent Migration; Requirement for Blood products; Requirement for Analgesia and Sedation whilst Stent in in situ; Presence of Thoracic Pain or Dysphagia; Length of Intensive Care Unit and Total Hospital Stay; Requirement for additional endoscopic therapy or salvage therapy (such as TIPS); Repeated presentation with variceal bleeding within 6 months
Early haemostatic predictors of major obstetric Haemorrhage; Evaluation of ROTEM-based MOH prediction scores as alternative to traditional haemostatic parameters; Incidence of underlying bleeding disorders in patients with MOH; Predictive value bleeding score in pregnancy for MOH
control of postpartum hemorrhage; time of control of bleeding, amount of blood loss till control of bleeding, changes in the hemoglobin and hematocrite levels, use of additional uterotonic drugs, necessity for surgical intervention, and the rate of complications.
Drug: Cilostazol; Drug: Probucol; Drug: Aspirin; Drug: placebo of cilostazol; Drug: placebo of aspirin; Device: ankle-brachial index (ABI); Device: intima-medial thickness (IMT); Device: new asymptomatic brain hemorrhage; Device: new ischemic lesions on follow-up FLAIR images
time to first occurrence of cerebral hemorrhage; time to first occurrence of cardiovascular events; Time to the first occurrence of stroke; Time to the first occurrence of ischemic stroke; Time to the first occurrence of myocardial infarction; Time to the first occurrence of other designated vascular events; time to occurrence of major bleeding complications; occurrence of new microbleedings or asymptomatic new hemorrhage on GRE image; new ischemic lesions on FLAIR images; change of Ankle-Brachial Index; change of intima-medial thickness; time to occurrence of any death
The % of patients requiring invasive measures for postpartum hemorrhage control.; The total cost (€) associated with the postpartum hemorrhage management strategy.; The delay required to stop bleeding post-delivery (min); The delay required to stop bleeding post-diagnosis (min); The percentage of patients still bleeding 30 minutes after sulprostone injection; Blood loss (ml) 30 minutes after diagnosis; Blood loss (ml) 1 hour after diagnosis; Blood loss (ml) 2 hours after diagnosis; Blood loss (ml) 24 hours after diagnosis; Blood pressure; Heart rate; The % of patients requiring blood transfusion.; The % of patients requiring intravenous iron.; The quantity of packed red cells, platelet concentrate and fresh frozen plasma consumed; Fibrinogen (g / l); Hematocrit (%); Hemoglobin (g/dl); Prothrombin (%); Activated partial thromboplastin time (s); Length of hospital stay (days); Length of ICU stay; Antimullerian hormone level; Amenorrhea at 3 months? yes/no; The presence of adhesions detected at hysteroscopy; pain will be assessed in both arms via a visual analog scale, duration, location, and use of analgesics; temperature (°C); FSFI questionnaire (Female Sexual Function Index); Doppler ultrasound: intra-uterine pressure; Doppler ultrasound: thickness of the uterine wall; Doppler ultrasound: inversed diastolic flow; Doppler ultrasound: intraluminal pressure; Doppler ultrasound: uterine artery perfusion pressure; Doppler ultrasound: uterine artery pulsatility index; IES-R scale (symptoms of post-traumatic stress)
The effect of hypercapnia vs. normocapnia on the development of Grade II-IV intraventricular hemorrhage/periventricular leukomalacia (severe brain injury) and/or death; The effect of hypercapnia vs. normocapnia on the development of chronic lung disease (requirement of supplemental oxygen at 36 weeks corrected gestational age); The effect of hypercapnia vs. normocapnia on abnormal results from MRIs; The effect of hypercapnia vs. normocapnia on the development of pulmonary hemorrhage
Other: Screening for risk factors for ulcer bleeding
Admission for ulcer bleeding or haemorrhagic gastritis; Compliance with antithrombotic medicine; Identification of patients with Benefit of Proton pump inhibitor Prophylaxis; Gastrointestinal bleeding; Uncomplicated ulcers; Death; Acute coronary syndrome
Other: Pet AV-45 (Florbetapir F 18) Cerebral Amyloid imaging
Pet-AV45 cortical binding; cerebral microbleeds number and distribution on T2EG MRI sequence; White Matter Lesions Volume on 3D-FLAIR MRI sequence; Cortical thickness and hippocampal volume on 3D-T1 MRI sequence; Neuropsychological performances
Mean ETDRS visual acuity; Percentage patients 15 letters or greater improvement in ETDRS visual acuity; Percentage patients 0 letters or greater improvement in ETDRS visual acuity; Percentage patients 15 letters or greater loss in ETDRS visual acuity; Mean total area of macular Haemorrhage on colour fundus photography; Greatest linear dimension of macular Haemorrhage on colour fundus photography; Presence of subfoveal blood on colour fundus photography
Proportion of women with postpartum blood loss equal to or greater than 500 mL; Mean postpartum blood loss; Proportion of women with postpartum blood loss equal to or greater than 350 mL; Proportion of women with postpartum blood loss equal to or greater than 1000 mL; Mean change in hemoglobin pre-delivery to postpartum; Time to delivery of placenta; Administration of additional oxytocin, other uterotonics or other interventions such as blood transfusion or hysterectomy; Side effects 1 hour postpartum
evaluation of blood pressure varibility on clinical course in patients with cerebral Haemorrhage
These studies may lead to new treatments and are adding insight into Haemorrhage etiology and treatment.
A major focus of Haemorrhage research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.