Up-to-date List of Headache Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Headache Medical Research Studies

RankStatusStudy
1 Unknown  Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache
Conditions: Episodic Cluster Headache;   Chronic Cluster Headache
Intervention: Drug: Sumatriptan 4mg Statdose injection
Outcome Measures: The primary efficacy parameters will be the percentage of cluster Headache attacks that result in the cluster Headache pain being reduced to mild or none following a single dose of 4 mg subcutaneous sumatriptan at 15 minutes and at 30 minutes.;   The time meaningful relief of cluster Headache.;   The percentage of attacks that produce a pain free response to a single dose of sumatriptan 4 mg subcutaneous at 15 minutes, 30 minutes and at 1 hour.;   The percentage of attacks of migraine that result in resolution of all associated symptoms of cluster Headache present at the time of treatment with the study medication as well as achieving a pain free response within 1hour.;   The number of patients reporting adverse effects to study medication, the type of adverse event reported and the percentage of attacks that are associate with the adverse effect.;   The percentage of patients who achieve pain reduced to mild or none at 15 minutes or at 30 minutes respectively for all three treated Headache attacks.;   The percentage of patients who achieve pain reduced to mild or none at 15 minutes or at 30 minutes respectively for two out of three treated Headaches.;   The percentage of patients who become pain free at 15 minutes or 30 minutes or at 1 hour respectively or at any combination of the three time points for all three Headache attacks.;   Patient evaluation of subcutaneous sumatriptan 4 mg regarding satisfaction with their treatment using the PPMQR assessment.;   The percentage of attacks in which the pain was reduced to moderate or mild and for which the patient took a second and or a third dose of the study medication.;   The percentage of attacks in which the patient became pain free at or before 1 hour and experienced a recurrence of cluster Headache and in which a second or third dose of study medication was taken.;   The percentage of cluster Headaches in which the patient became free at or before 1 hour and experienced a recurrence of cluster Headache.;   The mean time to meaningful pain relief across three treated Headache attacks.
2 Recruiting Frovatriptan as a Transitional Therapy in Medication Overuse Headache
Conditions: Medication Overuse Headache;   Analgesic Overuse Headache
Interventions: Drug: Frovatriptan;   Drug: Placebo
Outcome Measures: The mean Headache intensity in the 10 day transitional period in the Frovatriptan group as compared to the placebo group.;   The difference in mean Headache intensity between the 10 day transitional period and the baseline period.;   The number of day segments with Headache of grade 6 or higher during the 10 day transitional period and during days 11-20 of the study.;   Number of Headache-free days (grade zero) for first two months of study.;   Proportion of patients free of medication overuse for first two months of study (i.e. less than 15 days of simple analgesic use or less than 10 days of other analgesic use per month).
3 Not yet recruiting IndoProCaf Effervescent Tablets Effectiveness in Acute Treatment of Migraine and/or Episodic Tension-type Headache and Patients' Satisfaction With the Treatment in Routine Clinical Practice
Conditions: Headache Disorders, Primary;   Migraine With Aura;   Migraine Without Aura;   Tension-Type Headache
Intervention:
Outcome Measures: Proportion of patients with significant pain reduction;   Proportion of patients who are satisfied with IndoProCaf treatment;   Time to significant pain reduction;   Proportion of patients with significant pain reduction in case of first dose no response;   Proportion of patients with significant pain reduction in case of Headache relapse;   Proportion of patients who are satisfied with different medicines previously used for Headache attack
4 Recruiting A Non-Invasive Neuromodulation Device for Treatment of Migraine Headache
Condition: Migraine Headache, Episodic
Intervention: Device: neuromodulation for episodic migraine Headache
Outcome Measures: Number of monthly migraine Headache days;   Number of monthly migraine Headache days (reduction by by 50% or more);   Total monthly pain score;   Mood and cognition measures - Change in mood scores;   Verify the absence of material dizziness;   Mood and cognition measures - Change in cognitive speed scores;   Mood and cognition measures - Change in memory scores
5 Unknown  Chiropractic and Acupressure for Headaches
Conditions: Cervicogenic Headache;   Tension-type Headache;   Migraine Headache
Interventions: Other: chiropractic treatment;   Device: Dr. Zaxx pillow
Outcome Measures: Headache frequency from a Headache Diary;   Headache disability;   Treatment satisfaction;   Adverse events
6 Not yet recruiting Civamide Nasal Solution for Cluster Headache
Condition: Episodic Cluster Headache
Intervention: Drug: Civamide nasal solution 0.01%
Outcome Measures: The Percent Change in the Number of Cluster Headaches per Week from Baseline to Weeks 1 through 3 of the Post-Treatment Observation Period for the Modified Intent-to-Treat Population;   The Percent Change in the Number of Cluster Headaches per Week from Baseline to Weeks 1 through 3 of the Post-Treatment Observation Period for the Intent-to-Treat and Per Protocol Populations;   The Percent Change in the Number of Cluster Headaches per Week from Baseline to Individual Weeks 1, 2, and 3 of the Post-Treatment Observation Period for the Modified Intent-to-Treat and the Per Protocol Populations;   The Change in the Number of Cluster Headaches per Week from Baseline to Weeks 1 through 3 and to Individual Weeks 1, 2, and 3 for the Post-Treatment Observation Period for the Modified Intent-to-Treat and the Per Protocol Populations
7 Recruiting Amitriptyline to Prevent Headache After Traumatic Brain Injury
Conditions: Brain Injuries;   Post-Traumatic Headache
Intervention: Drug: Amitriptyline
Outcome Measures: Frequency and severity of Headaches;   Headache Impact Test - 6;   Rivermead Post-Concussion Symptoms Questionnaire (RPQ);   Short Form-12® Health Survey (SF-12);   Number of participants with adverse events;   Headache characteristic survey;   Insomnia Severity Index;   Patient Health Questionnaire-9 (PHQ-9;   Rey Auditory Verbal Learning Test;   Trail Making Test;   Wechsler Adult Intelligence Scale (WAIS) IV Digit Symbol
8 Recruiting Carbon Monoxide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow
Conditions: Headache;   Migraine
Interventions: Other: Carbon monoxide;   Other: Placebo
Outcome Measures: Headache scores;   Blood flow velocity;   Artery circumference;   Facial blood flow
9 Unknown  Galantamine in the Treatment of Post-Traumatic Headache
Conditions: Post-Traumatic Headache;   Head Trauma,Closed;   Retention Disorders,Cognitive
Intervention: Drug: Galantamine
Outcome Measures: Primary Headache Efficacy Measure; number of pain free days after 3 months;   Consumption of rescue medication;   Number of days with moderate or severe Headache after 3 months.
10 Unknown  Efficacy and Safety Study to Compare Ibuprofen + Caffeine With Ibuprofen Alone in the Treatment of Headache
Condition: Headache
Interventions: Drug: Ibuprofen plus caffeine;   Drug: Ibuprofen
Outcome Measures: Efficacy of study treatment compared with control to relieve Headache symptoms.;   Tolerability of study treatment compared with control to relieve Headache symptoms.
11 Recruiting Cervicogenic Headache Dose-Response
Condition: Cervicogenic Headache
Interventions: Other: Spinal Manipulation;   Other: Light Massage
Outcome Measures: Headache days change from baseline for cervicogenic Headache;   Average pain change from baseline for cervicogenic Headache;   Headache-related disability change from baseline for cervicogenic Headaches;   Headache-related disability days change from baseline;   EuroQol-5D change from baseline;   Average pain change from baseline for neck;   Neck pain days change from baseline;   medication use change from baseline;   Outside Care change from baseline;   Patient Satisfaction;   Objective biomechanical measures change from baseline;   Quality-adjusted life years change from baseline;   Direct & Indirect costs change from baseline;   Perceived Headache average pain change from baseline for cervicogenic Headache;   Perceived Headache improvement from baseline for cervicogenic Headache
12 Recruiting Prevention and Acute Treatment of Chronic Cluster Headache Compared to Standard of Care
Condition: Chronic Cluster Headache
Intervention: Device: GammaCore
Outcome Measures: Decrease frequency of cluster Headache attacks per week;   Pain relief of Headache attacks;   Adverse events;   EQ-5D-3L
13 Recruiting Non-invasive Neurostimulation of the Vagus Nerve for the Treatment of Cluster Headache
Condition: Cluster Headache
Interventions: Device: GammaCore;   Device: Sham GammaCore device
Outcome Measures: Headache pain intensity;   Sustained Headache intensity pain;   Average mean attack intensities experienced per subject;   Incidence and occurrence of serious adverse events related to active or sham study treatment and / or to cluster Headache events.
14 Unknown  A Pilot Study of Demand Valve Oxygen Inhalation Therapy for Cluster Headache
Condition: Cluster Headache
Intervention: Drug: Oxygen
Outcome Measures: Reduction in Headache pain;   Headache relief and pain free
15 Recruiting Incidence of Headache Following an Unintentional Dural Puncture
Conditions: Postdural Puncture Headache;   Post-Lumbar Puncture Headache;   Cerebrospinal Fluid Leaks
Interventions: Drug: Morphine;   Drug: Saline
Outcome Measures: Incidence of post dural puncture Headaches;   Severity of Headache;   Need for Epidural Blood Patch
16 Recruiting The Effect of Specific Strength-Training on Tension-Type Headache in Children 9-17 Years
Condition: Tension-Type Headache
Interventions: Device: Specific Strength Training;   Behavioral: Lifestyle Counseling
Outcome Measures: Headache;   Muscle Capacity;   TTS;   Physical fitness
17 Recruiting Sumatriptan as Treatment for Post-traumatic Headache
Condition: Post-traumatic Headache
Intervention: Drug: Sumatriptan 100 mg
Outcome Measures: Headache relief;   Adverse events;   Compliance
18 Recruiting Ibudilast in the Treatment of Medication Overuse Headache
Condition: Medication Overuse Headache
Interventions: Drug: Ibudilast;   Drug: Placebo
Outcome Measures: Headache Index;   Medication frequency;   Headache frequency;   Duration of Headache;   Intensity of Headache;   Frequency of probable migraine attacks;   Headache related impact on quality of life;   Allodynia symptom checklist score;   Von Frey filament test;   Brush allodynia test;   Response rate;   Relapse rate
19 Unknown  Randomized Placebo Controlled Trial With Etoricoxib That is Taken to Prevent the Yom Kippur Headache
Condition: Headache
Interventions: Drug: etoricoxib;   Drug: placebo
Outcome Measure: Incidence of Fasting Headache
20 Recruiting Is Chiropractic Spinal Manipulative Therapy an Efficient Treatment Option in Cervicogenic Headache
Condition: Cervicogenic Headache
Interventions: Other: Chiropractic;   Other: Sham Chiropractic
Outcome Measures: Number of Headache days;   Headache duration;   Self reported VAS;   Headache index;   Headache medication

These studies may lead to new treatments and are adding insight into Headache etiology and treatment.

A major focus of Headache research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.


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