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Malaise Medical Research Studies

Up-to-date List of Malaise Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Malaise Medical Research Studies

Rank Status Study
1 Recruiting Optimal Dosage of Caspofungin in Critically Ill Patients
Conditions: Critically Ill;   Suspected Invasive Candidiasis
Intervention: Drug: Caspofungin
Outcome Measures: The optimal dosage of caspofungin in relation to adequate exposure (measured as AUC) in critically ill patients.;   Pharmacokinetic parameters of caspofungin in critically ill patients.;   Correlation of pharmacokinetic parameters and the plasma concentration of caspofungin with disease severity scores.;   Correlation of the plasma concentration of caspofungin with candida eradication.;   Correlation of the plasma concentration of caspofungin with inflammation parameters.;   AUC/MIC ratio and highest observed plasma concentration (Cmax)/MIC ratio.;   Constructing a pharmacokinetic model of caspofungin in critically ill patients.;   Drug-related adverse events of caspofungin.
2 Unknown  The Effect of Prophylactic Probiotic Lactobacilli in Enteral Feeding on Nosocomial Pneumonia Rates in Critically Ill Patients
Condition: Critical Illness
Intervention: Drug: Probiotic Lactobacillus
Outcome Measures: To determine if enteral feeding plus probiotic Lactobacilli are associated with a reduced rate of nosocomial pneumonia in critically ill patients.;   To determine the incidence of complications of enteral feeding with and without added probiotic Lactobacilli.;   To assess if the efficacy of enteral feeding in critically ill patients is improved by the addition of probiotic Lactobacilli.
3 Not yet recruiting Tissue Near InfraRed Spectroscopy (NIRS) in Critically Ill Patients
Conditions: Sepsis;   Inflammation;   Shock
Outcome Measures: tNIRS Reperfusion slope of VOT;   tNIRS for Management of Critically Ill Patients with Sepsis
4 Recruiting Pancreatic Exocrine Insufficiency and Pancreatic Enzyme Supplementation in Critically Ill Adult Patients
Conditions: Critical Illness;   Sepsis;   Diabetes;   Cardiac Arrest;   Acute Renal Failure;   Shock
Intervention: Dietary Supplement: Enteral nutrition (EN)
Outcome Measures: Screening and risk factors of exocrine pancreatic insufficiency in critically ill adult patients receiving enteral nutrition;   Effects of pancreatic enzyme supplementation on nutritional status and clinical outcomes in critically ill patients with sepsis
5 Recruiting Transplanted-like Heart in Critical Ill Patients
Condition: Autonomic Nervous System Dysfunction in Critically Ill
Intervention: Other: Gravitational sympathetic stimulus
Outcome Measures: Incidence of autonomic nervous system dysfunction in critical ill patients;   to measure the occurrence of ANS failure in subgroups;   Length of stay in ICU and in Hospital;   mortality;   days free from mechanical ventilation
6 Recruiting Effects of AN69 ST Hemofilter on Coagulation During Continuous Renal Replacement Therapy in Critically Ill
Conditions: Critically Ill;   Acute Kidney Injury;   Septic Shock
Interventions: Device: AN 69 ST hemofilter;   Device: AN 69 hemofilter
Outcome Measures: The using time of hemofilters;   activated partial thromboplastin time
7 Recruiting Prevention of Nosocomial Infections in Critically Ill Patients With Lactoferrin: The PREVAIL Study
Condition: Critically Ill
Interventions: Dietary Supplement: Lactoferrin;   Other: Placebo
Outcome Measures: Antibiotic free days.;   Feasibility of conducting a Phase 3 study powered on clinically important outcomes such as mortality, length of stay and duration of mechanical ventilation.
8 Unknown  Family Involvement in The Treatment Of a Mentally Ill Relative
Condition: Families of Mentally Ill
Intervention: Behavioral: filling the "Experience of Caregiving Inventory"
Outcome Measure: Score on the "Experience of Caregiving Inventory" following 8 weeks of participation in the group.
9 Recruiting 2012_PharmacoCRRT-study:Pharmacokinetics of Anti-infectives /Antibiotics in Critically Ill Patients in Need of Continuous Renal Replacement Therapy (CRRT)
Conditions: Critically Ill;   Acute Renal Failure;   Acute Kidney Injury
Outcome Measure: Sub-therapeutic levels of measured antiinfectiva
10 Recruiting Ultrasound of the Diaphragm in ICU Patients
Condition: Critically Ill
Intervention: Other: diaphragm ultrasound
Outcome Measure: Diaphragmatic dysfunction
11 Recruiting Non-sedation Versus Sedation With a Daily Wake-up Trial in Critically Ill Patients Receiving Mechanical Ventilation - Effects on Physical Function
Conditions: Critically Ill;   Muscular Atrophy
Interventions: Other: Non-sedation;   Other: Sedation, control
Outcome Measures: Physical function;   6 minute walk;   Handgrip;   Thigh muscle size;   Biomechanical data
12 Unknown  ICG- Livertest Versus New Biomarkers as Prognostic Markers in Critically Ill ICG- Livertest Versus New Biomarkers as Prognostic Markers in Critically Ill
Condition: Critically Ill Patients
Intervention: Procedure: Observational
Outcome Measure:
13 Recruiting Pharmacokinetics of Micafungin in Critically Ill Patients
Conditions: Critical Illness;   Invasive Candidiasis
Outcome Measures: Correlation of pharmacokinetic parameters/plasma concentrations of micafungin with disease severity.;   Pharmacokinetic parameters of micafungin in ICU patients.;   Time (in days) to culture conversion.;   Correlation of the plasma concentration of micafungin with response to treatment.;   Correlation of the plasma concentration of micafungin with inflammation parameters.;   Area under the concentration-time curve (AUC)/minimal inhibitory concentration (MIC) ratio.;   Composing a pharmacokinetic model of micafungin in critically ill patients.;   Highest observed plasma concentration (Cmax)/minimal inhibitory concentration (MIC) ratio.
14 Not yet recruiting Observational Prospective Study of the Predicted Value of Immature Thrombocytes Counts in Three Different Groups of Critically Ill Patients
Conditions: Critically Ill Patients;   Neutropenic Fever Patients;   Patients With Hip Fractures
Intervention: Other: Immature Platelet Fraction
Outcome Measures: Time to recovery from sepsis or time to death;   Predicting value of IPF for prognosis
15 Recruiting Predictors of Upper Airway Function and Sleep-disordered Breathing in the Critically Ill
Conditions: Critically Ill;   Obstructive Sleep Apnea
Interventions: Device: Ventilator;   Device: Alice PDx;   Other: Pulmonary function test;   Other: Muscle strength tests;   Other: Grip strength measurement;   Drug: Sedatives and muscle relaxants given in the ICU
Outcome Measure: Apnea-hypopnea index (AHI)
16 Not yet recruiting Optimal Protein Supplementation for Critically Ill Patients
Condition: Critical Illness
Intervention: Dietary Supplement: Beneprotein
Outcome Measures: Cumulative Organ failure free days;   Mortality
17 Not yet recruiting Bioavailability of Voriconazole
Conditions: Voriconazole;   Bioavailability;   Critically Ill
Intervention: Other: Dosage form of voriconazole
Outcome Measures: The bioavailability of voriconazole in critically ill patients;   Correlation of bioavailability of voriconazole with disease severity;   Correlation of bioavailability of voriconazole with the degree of inflammation
18 Recruiting Transfusion Requirements in Critically Ill Oncologic Patient
Condition: Anemia
Intervention: Biological: Red blood cell transfusion
Outcome Measures: To compare mortality between groups 28 day after ICU admission;   To compare length of stay in ICU between groups;   To compare length of stay in hospital between groups;   To compare days free of organ dysfunction between groups;   Adverse effects of transfusion;   Mortality;   All cause 90 day mortality All cause 90 day mortality Mortality
19 Recruiting Efficiency of a Small-peptide Enteral Feeding Formula Compared to a Whole-protein Formula
Conditions: Traumatic and/or Non-traumatic Brain Injury;   Critically Ill
Interventions: Dietary Supplement: Peptamen® AF;   Dietary Supplement: Sondalis® HP
Outcome Measures: the nutritional efficacy of a small-peptide (Peptamen AF®) to that of a whole-protein (Sondalis HP®) enteral feeding formula in traumatic and non-traumatic brain injured critically ill patients;   impact on morbidity and mortality of a small-peptide (Peptamen AF®) to that of a whole-protein (Sondalis HP®) enteral feeding formula.
20 Unknown  Hypocaloric Nutrition in Critically Ill Patients
Condition: Critically Ill
Interventions: Dietary Supplement: Hypocaloric hyperproteic nutrition;   Dietary Supplement: Standard care
Outcome Measures: SOFA (Sequential Organ Failure Assessment) score;   Insulin requirements

These studies may lead to new treatments and are adding insight into Malaise etiology and treatment.

A major focus of Malaise research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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