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Spasms Medical Research Studies

Up-to-date List of Spasms Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Spasms Medical Research Studies

Rank Status Study
1 Recruiting Addition of Pyridoxine to Prednisolone in Infantile SPASMS
Condition: Infantile SPASMS
Interventions: Drug: Pyridoxine plus prednisolone;   Drug: Prednisolone
Outcome Measures: Proportion of children who achieved complete cessation spasm for at least 48 hours as per parental reports at the end of 2 weeks in both the groups.;   • Proportion of children who achieved more than 50 % reduction of clinical SPASMS as per parental reports at the end of 2 weeks
2 Recruiting Evaluation of Neuroinflammation in Children With Infantile SPASMS
Condition: Infantile SPASMS
Intervention: Drug: ACTH
Outcome Measure: Neuroinflammation in cortical and/or subcortical structures
3 Recruiting Genetic Studies in Patients and Families With Infantile SPASMS
Condition: Infantile SPASMS
Outcome Measures: Apply novel genetic analyses to determine possible causes of cryptogenic IIS and evaluate adding novel genetic analyses to standard practice for determining causes of IIS;   Determine genes, through novel genetic analyses, that may play a role in determining ACTH responsiveness for IIS
4 Recruiting Levocarnitine in Treating Patients With Vismodegib-Associated Muscle SPASMS
Condition: Musculoskeletal Complications
Interventions: Dietary Supplement: levocarnitine;   Other: placebo;   Other: questionnaire administration
Outcome Measures: Mean difference in muscle spasm number in a week;   Mean severity of muscle spasm;   Proportion of participants who answered "yes" to functional and psychosocial effects of muscle SPASMS
5 Unknown  Testing the Effect of Zinc Supplementation to Improve the Treatment Effect of Botulinum Toxin for Oculofacial Spasm
Conditions: Blepharospasm;   Hemifacial Spasm
Interventions: Drug: Zinc Supplement;   Drug: Sugar pill
Outcome Measures: Jankovic Rating Scale;   Treatment Duration Cycle;   Blepharospasm Disability Index (BDI)
6 Unknown  Effect on Tear Functions of Pretarsal and Preseptal Techniques of Botulinum Toxin Type A Injection in Hemifacial Spasm
Condition: Hemifacial Spasm
Interventions: Drug: preseptal injection of botulinum toxin type A;   Drug: pretarsal injection of Botulinum toxin type A
Outcome Measures: tear break up time;   schirmer's test
7 Unknown  Botulinum Toxin Injection to Treat Diffuse Esophageal Spasm
Condition: Esophageal Spasm, Diffuse
Interventions: Drug: Placebo;   Drug: Botulinum Toxin Type A
Outcome Measures: Dysphagia severity score;   Manometry pattern
8 Recruiting Botulinum Toxin for Pelvic Pain in Women With Endometriosis
Conditions: Endometriosis;   Botulinum Toxin A;   Chronic Pelvic Pain;   Pelvic Muscle SPASMS;   Quality of Life
Intervention: Drug: Botuninum toxin A
Outcome Measures: Improvement in pain - a binary measurement of improvement/no improvement will be used.;   1) Need for re-injection at 1 month as a binary measurement of yes/no; 2) Change in Pelvic Pain: Pain visual analog score; 3) Botulinum toxin patient response inventory; 4) Standardized Pelvic Pain questionnaire; 5) Standardized QOL questionnair...
9 Recruiting The Effect of Sarpogrelate and High Dose Statin on the Reduction of Coronary Spasm
Condition: Variant Angina
Interventions: Drug: Sarpogrelate;   Drug: Atorvastatin
Outcome Measures: Ergonovine provocation test 12months later;   C-reactive protein lever 12months later
10 Unknown  Blood Markers for Inflammation and Coronary Artery Vasoreactivity Testing in Patients With Chest Pain and Normal Coronary Arteries
Conditions: Endothelial Dysfunction;   Atherosclerosis;   Inflammation;   Myocardial Ischemia
Interventions: Drug: Acetylcholine;   Drug: Adenosine
Outcome Measure: Endothelial Dysfunction
11 Recruiting Randomized Trial of NSAID vs Placebo Prior to Ureteral Stent Removal
Conditions: Disorder of Urinary Stent;   Ureteral Spasm;   Ureteropelvic Junction Obstruction;   Urolithiasis
Interventions: Drug: Ibuprofen;   Drug: Placebo
Outcome Measures: Incidence of post-operative severe pain (pain score ≥ 7);   Incidence of "significantly worsening" pain;   Change in pre- and post-operative pain score;   Opioid usage post-operatively
12 Unknown  Ultrasound Guided Pudendal Block in Transurethral Prostatectomies
Condition: Pain, Postoperative
Intervention: Procedure: Pudendal nerve block
Outcome Measures: postoperative bladder spasm;   postoperative pain
13 Recruiting Addition of Pudendal Blocks to Pelvic Floor Physical Therapy for the Treatment of Pelvic Floor Tension Myalgia
Condition: Pelvic Floor Muscle Spasm
Interventions: Drug: Pudendal block;   Drug: Placebo
Outcome Measures: Visual analog pain score after 6 weekly injections;   Improvement in pelvic floor symptoms as assessed through standardized questionnaires
14 Unknown  Techniques to Enhance Patient Comfort in Sedation-risk Free Colonoscopy
Condition: Screening of Colonic Polyps
Interventions: Other: Warm water;   Other: Control
Outcome Measures: abdominal discomfort;   colonoscopy-related outcomes
15 Recruiting Low Intensity Ultrasound Therapy for Upper Back Pain Relief
Condition: Muscle Spasm
Interventions: Device: Sam Ultrasonic Diathermy Device (Active Device);   Device: Sam Ultrasonic Diathermy Device (Placebo Device)
Outcome Measures: Change in pain on the visual analog scale (VAS);   Comparison of pain level using Global Rating of Change (GROC) scale.;   Change in trigger point depth
16 Unknown  Endolumenal Partial Myotomy for Esophageal Motility Disorders
Condition: Esophageal Motility Disorders
Intervention: Procedure: Per oral endolumenal myotomy
Outcome Measures: Esophageal Function Tests;   Quality of life score
17 Recruiting Prevention of West Syndrome With Low-dose Adrenocorticotropin Hormone (ACTH)
Condition: West Syndrome
Intervention: Drug: adrenocorticotropin hormone
Outcome Measures: Evidence for improvement in the EEG one month following initiation of the 2 week course of low-dose ACTH.;   Diagnosis of West syndrome during the study period.
18 Unknown  Preoperative Use of Darifenacin (Enablex) to Alleviate Postoperative Ureteral Stent Pain
Conditions: Bladder SPASMS;   Ureteral Stent Pain;   Postoperative
Intervention: Drug: Darifenacin
Outcome Measures: Decreased post operative ureteral stent pain, evidenced by decreased pain scores, less ER visits/hospital admits, or patient phone calls for stent pain/difficulty;   Decreased use of narcotic and anticholinergic medication use postoperatively.
19 Recruiting CSF Leak Following Microvascular Decompression: the Benefit of Routine Postoperative Lumbar Tap
Conditions: Cranial Nerve Diseases;   Facial Neuralgia;   Trigeminal Neuralgia;   Hemifacial Spasm
Interventions: Procedure: prophylactic spinal tap;   Procedure: no prophylactic spinal tap
Outcome Measures: cerebrospinal fluid leakage;   overall complication risk;   Specific complication risk;   days in hospital
20 Not yet recruiting ASIS for Botox in Upper Limb Spasticity
Conditions: Upper Limb Spasticity Unilaterally in Adults With History of Stroke;   Increased Muscle Tone in Elbow, Wrist, Finger, and Thumb Flexors.
Interventions: Drug: Gadolinium;   Drug: Efficacy of Botox intramuscularly at Week 6;   Drug: Efficacy of Botox intramuscularly at Week 12,;   Drug: Efficacy of Botox intramuscularly at Week 18;   Drug: Efficacy of Botox intramuscularly at Week 24;   Drug: Efficacy of Botox intramuscularly at Week 30;   Drug: Efficacy of Botox subdermally at Week 6;   Drug: Efficacy of Botox subdermally at Week 12;   Drug: Efficacy of Botox subdermally at Week 18;   Drug: Efficacy of Botox subdermally at Week 24;   Drug: Efficacy of Botox subdermally at Week 30;   Drug: Adverse Reactions of Botox intramuscularly;   Drug: Adverse Reactions of Botox subdermally
Outcome Measures: Relative Prolongation Ability Score for Gadolinium subdermally injected.;   Efficacy of Botox intramuscularly vs. subdermally in Upper Limb Spasticity.

These studies may lead to new treatments and are adding insight into Spasms etiology and treatment.

A major focus of Spasms research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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