Up-to-date List of Syndrome Medical Research Studies

What Research is Being Done?

A clinical study involves research using human volunteers (also called participants) that is intended to add to medical knowledge. There are two main types of clinical studies: clinical trials (also called interventional studies) and observational studies. Following list includes both interventional and observational studies.

Latest Syndrome Medical Research Studies

1 Recruiting Lifestyle Intervention for Polycystic Ovary Syndrome: Pulse-Based Diet and Exercise
Conditions: Polycystic Ovary Syndrome;   Metabolic Syndrome
Interventions: Other: Pulse-based diet;   Other: TLC diet
Outcome Measures: Change in polycystic ovary Syndrome disease measures from baseline;   Change in metabolic Syndrome disease measures from baseline
2 Recruiting Prevalence of Hyperventilation Syndrome in Difficult Asthma
Conditions: Difficult Asthma;   Severe Persistent Asthma;   Hyperventilation Syndrome
Intervention: Other: Diagnostic of chronic hyperventilation Syndrome
Outcome Measures: Diagnostic of the hyperventilation Syndrome;   Assess the diagnosis value of the nijmegen questionnaire.;   Assess the diagnosis value of the blod gases at rest.;   Assess the diagnosis value of the hyperventilation challenge.;   Assess the diagnosis value of the CPET.
3 Unknown  Continuous Positive Airway Pressure in Sleep Apnea Syndrome: Effects on Metabolic Syndrome and Cardiac Damage
Conditions: Sleep Apnea Syndrome;   Metabolic Syndrome;   Cardiac Remodelling;   Continuous Positive Airway Pressure Ventilation
Interventions: Device: continuous positive airway pressure ventilation;   Behavioral: dietary and life style recommendations
Outcome Measures: metabolic Syndrome;   left ventricular mass;   diastolic function
4 Unknown  Immunologic Evaluation in Patients With DiGeorge Syndrome or Velocardiofacial Syndrome
Conditions: DiGeorge Syndrome;   Shprintzen Syndrome;   Chromosome Abnormalities;   Abnormalities, Multiple;   Conotruncal Cardiac Defects
Outcome Measure:
5 Unknown  The Psychiatric and Cognitive Phenotypes in Velocardiofacial Syndrome
Conditions: Velocardiofacial Syndrome;   Williams Syndrome;   Fragile X Syndrome
Intervention: Drug: methylphenidate, fluoxetin, risperidone
Outcome Measure: Measure that are used: psychological measures, molecular tests, responsiveness to medical treatments
6 Unknown  Frequency of Metabolic Syndrome in Down Syndrome Patients
Conditions: Metabolic Syndrome X;   Down Syndrome
Outcome Measures: To asses the frequency of the metabolic Syndrome among Down Syndrome patients. Metabolic Syndrome was defined by Adult Tratment Panel III criteria modified by Halley Castillo.;   Evaluate the insulin resistance and insulin sensitivity using the HOMA and QUICKY methods.
7 Unknown  Mechanisms of Mitochondrial Defects in Gulf War Syndrome
Conditions: Gulf War Syndrome;   Mitochondrial Disease
Interventions: Procedure: Skin biopsy;   Procedure: Blood Collection
Outcome Measures: Characterize mitochondrial cellular energetics in Gulf War Syndrome patients;   Mitochondrial DNA
8 Recruiting Hypoglycemia in Prader-Willi Syndrome
Conditions: Prader Willi Syndrome;   Hypoglycemia
Intervention: Other: Infants with Prader-Willi Syndrome
Outcome Measure: Presence of hypoglycemia
9 Recruiting MEPHISTO (Macrophage Phenotype In Metabolic Syndrome With Iron Overload)
Conditions: Dysmetabolic Iron Overload Syndrome;   Metabolic Syndrome X
Intervention: Other: dysmetabolic iron overload Syndrome
Outcome Measures: Expression (RNA) of macrophagic polarization markers;   characteristics of the subjects
10 Recruiting Factors of Steroid Dependency in Idiopathic Nephrotic Syndrome
Condition: Idiopathic Nephrotic Syndrome
Intervention: Genetic: DNA chip dedicated to the pharmacogenetic of steroids
Outcome Measures: define pharmacogenetic factors of steroid dependency;   parameters of the immune response against herpesvirus, specially the cellular production of interferon induced by specific viral peptides;   Dynamic of the epidemiology of idiopathic nephrotic Syndrome in the Paris Area
11 Recruiting Air Pollution, Inflammation and Acute Coronary Syndrome
Condition: Patients With Acute Coronary Syndrome
Intervention: Other: Particulate air pollutants
Outcome Measure: Impact of air pollution on inflammation, oxidative stress and 1-year prognosis in patients hospitalized for acute coronary Syndrome.
12 Unknown  Head Circumference Growth in Children With Ehlers-Danlos Syndrome Who Develop Dysautonomia Later in Life
Conditions: Ehlers Danlos Syndrome;   External Hydrocephalus;   Dysautonomia;   Postural Orthostatic Tachycardia Syndrome;   Venous Insufficiency
Outcome Measure: Measurement of Head Circumference in Ehlers-Danlos patients (retrospectively), between the ages of birth to 15 months of age.
13 Recruiting Genetic and Physical Characteristics of Rett Syndrome
Condition: Rett Syndrome
Outcome Measures: Genetic and Physical Characteristics of Rett Syndrome;   Genetic and Physical Characteristics of Rett Syndrome
14 Recruiting Aortopathy in Persons With Bicuspid Aortic Valve, Turner and Marfan Syndrome
Conditions: Turner Syndrome;   Bicuspid Aortic Valve;   Marfan Syndrome
Outcome Measures: Histone modifications;   mRNA and non-coding RNAs;   DNA-methylations of CpG-islands;   Electron microscopic evaluation;   Karyotyping by FISH and conventional karyotyping;   Proteomics
15 Recruiting International Guillain-Barré Syndrome Outcome Study
Conditions: Guillain-Barré Syndrome;   Miller Fisher Syndrome
Outcome Measures: Guillain-Barre Syndrome(GBS) disability score and Medical Research Council(MRC) sumscore;   Overall Neuropathy Limitations Scale (ONLS);   Fatigue Severity Scale (FSS);   EurQol EQ-5D Health Questionnaire;   Rasch-built Overall Disability Scale (R-ODS)
16 Recruiting Echocardiography Predictive of the Inefficacy and/or of the Unsafeness of Recruitment Maneuvers in Patients With Acute Respiratory Distress Syndrome.
Condition: Acute Respiratory Distress Syndrome
Intervention: Device: Echocardiography
Outcome Measures: Efficacy and safety of recruitment maneuvers in patients with Acute Respiratory Distress Syndrome.;   Feasibility of the measurement of Longitudinal Strain and Strain Rate of the right ventricle in patients suffering from Acute Respiratory Distress Syndrome.;   Comparison of the results of echocardiographic measurements between the group CONTROL and the group FAILURE.;   Evaluate the effect of the inefficacy and/or of the unsafeness of the recruitment maneuver on the future of the patient suffering from Acute Respiratory Distress Syndrome.
17 Recruiting Social Cognition and Turner Syndrome
Condition: Turner Syndrome
Intervention: Other: Evaluation of 45,X Turner Syndrome patients
Outcome Measures: Overall score to the AQ (Autism Quotient) questionnaire.;   SRS (Social Reciprocity Scale), in comparison to the expected scores for the general population.;   Socio-cognitive profile and parent of origin of the intact X chromosome
18 Recruiting Gait Parameters of Persons With Down Syndrome With and Without Orthotics Using GaitRite
Condition: Down Syndrome
Intervention: Procedure: custom orthotics
Outcome Measures: Gait will be measured with the GaitRite gait evaluation system.;   Elucidate patterns in the development of walking in persons with Down Syndrome using GaitRite®.
19 Unknown  Cardiovascular Phenotype Study in Patients With Obstructive Sleep Apnea Syndrome
Conditions: Obstructive Sleep Apnea Syndrome;   Hypertension
Interventions: Device: Positive airway pressure treatment;   Other: No positive airway pressure treatment
Outcome Measures: cardiovascular phenotype study in patients with non treated obstructive sleep apnea Syndrome;   characterization of arterial blood pressure, sympathetic activity, functional and morphological cardiovascular modifications. Effect of a treatment of obstructive sleep apnea Syndrome on those different parameters.
20 Unknown  Effects of Ezetimibe, Simvastatin, and Vytorin on Reducing L5 a Subfraction of LDL in Patients With Metabolic Syndrome.
Condition: Metabolic Syndrome
Interventions: Drug: Simvastatin;   Drug: Vytorin;   Drug: Placebo;   Drug: Ezetimibe
Outcome Measures: To identify the common factor for L5 prevalence in Metabolic Syndrome patients.;   To determine whether Ezetimibe, Simvastatin, and Vytorin can correct the L5- promoting factor and reduce L5 in Metabolic Syndrome.

These studies may lead to new treatments and are adding insight into Syndrome etiology and treatment.

A major focus of Syndrome research is the development of new drugs and other treatment options. Studies seek to identify new drugs to treat various related disorders and to find safer, more effective doses for medications already being used. Other research is aimed at identifying receptors or drug targets.

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