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Flexeril Depression Side Effects

Flexeril Depression Side Effect Reports


The following Flexeril Depression side effect reports were submitted by healthcare professionals and consumers.

This information will help you understand how side effects, such as Depression, can occur, and what you can do about them.

A side effect could appear soon after you start Flexeril or it might take time to develop.



Suicidal Ideation, Psychiatric Symptom, Skin Papilloma, Physical Assault, Depression, Stress, Anxiety, Insomnia, Apathy

This Depression side effect was reported by a physician from UNITED STATES. A patient (weight:NA) experienced the following symptoms/conditions: NA. The patient was prescribed Flexeril (dosage: 10 Mg, 1x/day), which was started on May 25, 2011. Concurrently used drugs:
  • Aspirin (325 Mg, 1x/day)
  • Lortab (7.5mg/500mg, 1x/day, As Needed)
  • Chantix (1 Mg, 2x/day)
  • Valium (5 Mg, 3x/day)
  • Prilosec (20 Mg, 1x/day)
  • Effexor Xr (75 Mg, 1x/day)
  • Risperdal (1 Mg, 1x/day)
  • Hydrochlorothiazide (1 Tablet, 1x/day)
When starting to take Flexeril the consumer reported the following symptoms:
  • Suicidal Ideation
  • Psychiatric Symptom
  • Skin Papilloma
  • Physical Assault
  • Depression
  • Stress
  • Anxiety
  • Insomnia
  • Apathy
The patient was hospitalized. These side effects may potentially be related to Flexeril.
Diabetes Mellitus Inadequate Control, Essential Hypertension, Musculoskeletal Pain, Gastrooesophageal Reflux Disease, Arthralgia, Blood Cholesterol Increased, Depression

This Depression Flexeril side effect was reported by a consumer or non-health professional from UNITED STATES on Sep 06, 2011. A male , 34 years of age, was treated with Flexeril. The patient presented the following health conditions:
  • Diabetes Mellitus Inadequate Control
  • Essential Hypertension
  • Musculoskeletal Pain
  • Gastrooesophageal Reflux Disease
  • Arthralgia
  • Blood Cholesterol Increased
  • Depression
. Flexeril dosage: NA. Additional drugs used at the same time:
  • Diovan Hct (160-12.5 Mg)
  • Niaspan Extended Release
  • Crestor
  • Januvia
  • Aciphex
  • Glucotrol Xl
  • Lovaza
  • Actos
Unresponsive To Stimuli, Overdose, Depression, Fall

This is a Flexeril side effect report of a 25-year-old female patient (weight:NA) from UNITED STATES, suffering from the following symptoms/conditions: NA, who was treated with Flexeril (dosage:NA, start time: NS), combined with:
  • Zyprexa
  • Xanax
, and developed a serious reaction and a Depression side effect. The patient presented with:
  • Unresponsive To Stimuli
  • Overdose
  • Depression
  • Fall
which developed after the beginning of treatment. This side effect report can indicate a possible existence of increased vulnerability to Flexeril treatment in female patients suffering from NA, resulting in Depression.

Anxiety, Injury, Anhedonia, Pain, Depression, Pulmonary Embolism, Deep Vein Thrombosis

A 42-year-old female patient (weight: NA) from UNITED STATES with the following symptoms: back pain started Flexeril treatment (dosage: 1 Tablet) on Apr 01, 2009. Soon after starting Flexeril treatment, the consumer experienced several side effects, including:
  • Anxiety
  • Injury
  • Anhedonia
  • Pain
  • Depression
  • Pulmonary Embolism
  • Deep Vein Thrombosis
. Concurrently used drugs:
  • Naproxen (aleve) (2 Tablets, Qd)
  • Yaz (Unk)
  • Yaz
  • Zyrtec (2 Tablets Weekly)
  • Midrin
  • Yaz
  • Nabumetone
  • Yaz
The patient was hospitalized. This finding indicates that some patients can be more vulnerable to developing Flexeril side effects, such as Depression.
Lethargy, Depression

A patient from UNITED STATES was prescribed and started Flexeril on Apr 01, 2011. Patient felt the following Flexeril side effects: lethargy, depression Additional patient health information: male , 63 years of age, The consumer reported the following symptoms: . Flexeril dosage: NA. Concurrently used drugs:
  • Ibuprofen
  • Xanax
  • Methylphanidate Hydrochloride (10 Mg)
Constipation, Cholecystectomy, Thrombosis, Jugular Vein Thrombosis, Axillary Vein Thrombosis, Flatulence, Depression, Cholecystitis Chronic, Subclavian Vein Thrombosis

This report suggests a potential Flexeril Depression side effect(s) that can have serious consequences. A 35-year-old female patient from UNITED STATES (weight:NA) was diagnosed with the following health condition(s): back pain and used Flexeril (dosage: 10 Mg, Tid) starting Jan 01, 1994. Soon after starting Flexeril the patient began experiencing various side effects, including:
  • Constipation
  • Cholecystectomy
  • Thrombosis
  • Jugular Vein Thrombosis
  • Axillary Vein Thrombosis
  • Flatulence
  • Depression
  • Cholecystitis Chronic
  • Subclavian Vein Thrombosis
Drugs used concurrently:
  • Lorazepam
  • Levsin Sl (0.125 Mg, Qid)
  • Vitamin Tab
  • Rhinocort (32 ?g, Qid)
  • Yasmin (Unk)
  • Trazodone Hcl
  • Ambien (10 Mg, Qd)
  • Lexapro (10 Mg, Qd)
Although Flexeril demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Depression, may still occur.
Disease Recurrence, Depression, Product Substitution Issue

An adverse event was reported by a health professional on Aug 26, 2011 by a Female taking Flexeril (dosage: NA) . Location: UNITED STATES , weighting 183.0 lb, patient began experiencing various side effects, including: Directly after treatment started, patient experienced the unwanted or unexpected Flexeril side effects: disease recurrence, depression, product substitution issue. Additional medications/treatments:
Associated medications used:
  • Buproprion Hcl (Bupropion Xl 150mg Qday Po)
  • Lithium Carbonate
  • Trazodone Hydrochloride
Tongue Biting, Tinnitus, Glomerular Filtration Rate Decreased, Hypertension, Spinal Column Stenosis, Dehydration, Middle Insomnia, Paraesthesia, Depression

This Depression problem was reported by a consumer or non-health professional from UNITED STATES. A 66-year-old female patient (weight: NA) was diagnosed with the following medical condition(s): NA.On Mar 06, 2009 a consumer started treatment with Flexeril (dosage: NA). The following drugs/medications were being taken at the same time:
  • Allopurinol
  • Menest
  • Oxycontin
  • Prednisone
  • Protonix
  • Ambien
  • Buspar
  • Antivan
When commencing Flexeril, the patient experienced the following unwanted symptoms /side effects:
  • Tongue Biting
  • Tinnitus
  • Glomerular Filtration Rate Decreased
  • Hypertension
  • Spinal Column Stenosis
  • Dehydration
  • Middle Insomnia
  • Paraesthesia
  • Depression
Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Depression, may become evident only after a product is in use by the general population.
Sinus Tachycardia, Rhinitis Allergic, Pulmonary Embolism, Vaginal Disorder, Haemorrhagic Anaemia, Pneumonia, Depression, Dyspnoea, Back Pain

This is a Flexeril side effect report of a 19-year-old female patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: back pain and was treated with Flexeril (dosage: ^10^/three Times Per Day As Needed) starting Jul 27, 2007. Concurrently used drugs:
  • Keflex
  • Red Blood Cells
  • Ancef
  • Effexor Xr (Daily Dose 75 Mg)
  • Yasmin (1 Tab(s), 1x/day [daily Dose: 1 Tab(s)] [total Dose: 1 Tab(s)])
  • Venlafaxine Hcl (Unk, Unk)
Soon after that, the consumer experienced the following of symptoms:
  • Sinus Tachycardia
  • Rhinitis Allergic
  • Pulmonary Embolism
  • Vaginal Disorder
  • Haemorrhagic Anaemia
  • Pneumonia
  • Depression
  • Dyspnoea
  • Back Pain
The patient was hospitalized. This opens a possibility that Flexeril could cause Depression and that some female patients may be more susceptible.
Osteonecrosis Of Jaw, Atrioventricular Block, Spinal Osteoarthritis, Gallbladder Disorder, Myocardial Infarction, Cervical Vertebral Fracture, Sinus Disorder, Depression, Spinal Disorder

This Depression side effect was reported by a physician from UNITED STATES on May 20, 2011. A female patient from UNITED STATES , 49 years of age, weighting 160.9 lb, was diagnosed with and was treated with Flexeril. Directly after treatment started, patient experienced the unwanted or unexpected Flexeril side effects: osteonecrosis of jaw, atrioventricular block, spinal osteoarthritis, gallbladder disorder, myocardial infarction, cervical vertebral fracture, sinus disorder, depression, spinal disorder. Flexeril dosage: NA.
Associated medications used:
  • Fosamax
  • Celebrex
The patient was hospitalized. These side effects may potentially be related to Flexeril.
Anxiety, Depression, Muscle Rigidity

This Depression side effect was reported by a consumer or non-health professional from UNITED STATES. A patient (weight:NA) experienced the following symptoms/conditions: muscle spasms. The patient was prescribed Flexeril (dosage: NA), which was started on NS. Concurrently used drugs: NA. When starting to take Flexeril the consumer reported the following symptoms:
  • Anxiety
  • Depression
  • Muscle Rigidity
These side effects may potentially be related to Flexeril.
Depression, Gastrooesophageal Reflux Disease, Migraine, Osteoporosis

This Depression Flexeril side effect was reported by a consumer or non-health professional from UNITED STATES on Nov 14, 2008. A Female , weighting 169.0 lb, was diagnosed with and was treated with Flexeril. The patient presented the following health conditions:
  • Depression
  • Gastrooesophageal Reflux Disease
  • Migraine
  • Osteoporosis
. Flexeril dosage: NA. Additional drugs used at the same time:
  • Topamax
  • Axert
  • Synthroid
  • Celebrex
  • Phenergan Hcl
  • Imitrex
  • Aciphex
  • Actonel
Cardiac Failure, Depression, Sinus Disorder, Suicide Attempt

This is a Flexeril side effect report of a patient (weight:NA) from UNITED STATES, suffering from the following symptoms/conditions: back pain,neck pain, who was treated with Flexeril (dosage:NA, start time: NS), combined with: NA., and developed a serious reaction and a Depression side effect. The patient presented with:
  • Cardiac Failure
  • Depression
  • Sinus Disorder
  • Suicide Attempt
which developed after the beginning of treatment. The patient was hospitalized. This side effect report can indicate a possible existence of increased vulnerability to Flexeril treatment in patients suffering from back pain,neck pain, resulting in Depression.
Depression, Hypersomnia, Intentional Overdose, Intentional Self-injury

A 43-year-old patient (weight: NA) from UNITED STATES with the following symptoms: NA started Flexeril treatment (dosage: NA) on NS. Soon after starting Flexeril treatment, the consumer experienced several side effects, including:
  • Depression
  • Hypersomnia
  • Intentional Overdose
  • Intentional Self-injury
. Concurrently used drugs: NA. This finding indicates that some patients can be more vulnerable to developing Flexeril side effects, such as Depression.
Alopecia, Back Disorder, Depression, Diabetes Mellitus, Feeling Abnormal, Gastric Disorder, Headache, Heart Rate Increased

A patient from UNITED STATES was prescribed and started Flexeril on Aug 07, 2008. After Flexeril was administered, patient encountered several Flexeril side effects: alopecia, back disorder, depression, diabetes mellitus, feeling abnormal, gastric disorder, headache, heart rate increased Additional patient health information: male , weighting 180.0 lb, The consumer reported the following symptoms: was diagnosed with and. Flexeril dosage: NA. Concurrently used drugs:
  • Cymbalta
  • Cymbalta
The patient was hospitalized.
Back Injury, Blood Cholesterol Increased, Depression, Fall, Hypertension

This report suggests a potential Flexeril Depression side effect(s) that can have serious consequences. A female patient from UNITED STATES (weight:NA) was diagnosed with the following health condition(s): muscle spasms and used Flexeril (dosage: NA) starting NS. Soon after starting Flexeril the patient began experiencing various side effects, including:
  • Back Injury
  • Blood Cholesterol Increased
  • Depression
  • Fall
  • Hypertension
Drugs used concurrently:
  • Duragesic-100 (Two 12.5 Ug/hr Patches)
  • Duragesic-100
  • Xanax
  • Xanax (.25 Mg Three Times/day And .5 Mg At Bedtime)
  • Lomotil
  • Levothyroxine Sodium
The patient was hospitalized. Although Flexeril demonstrated significant improvements in a number of clinically relevant cases, troublesome symptoms, such as Depression, may still occur.
Back Injury, Blood Cholesterol Increased, Depression, Fall, Hypertension

An adverse event was reported by a consumer or non-health professional on Jun 02, 2008 by a Female taking Flexeril (dosage: NA) was diagnosed with and. Location: UNITED STATES , weighting 128.0 lb, patient began experiencing various side effects, including: Patient felt the following Flexeril side effects: back injury, blood cholesterol increased, depression, fall, hypertension. Additional medications/treatments:
Multiple prescriptions taken:
  • Duragesic-100 (Two 12.5 Ug/hr Patches)
  • Duragesic-100
  • Xanax
  • Xanax (.25 Mg Three Times/day And .5 Mg At Bedtime)
  • Lomotil
  • Levothyroxine Sodium
The patient was hospitalized.
Alopecia, Back Disorder, Depression, Diabetes Mellitus, Feeling Abnormal, Gastric Disorder, Headache, Heart Rate Increased, Hyperadrenalism

This Depression problem was reported by a consumer or non-health professional from UNITED STATES. A patient (weight: NA) was diagnosed with the following medical condition(s): back disorder.On NS a consumer started treatment with Flexeril (dosage: NA). The following drugs/medications were being taken at the same time:
  • Cymbalta
  • Cymbalta
When commencing Flexeril, the patient experienced the following unwanted symptoms /side effects:
  • Alopecia
  • Back Disorder
  • Depression
  • Diabetes Mellitus
  • Feeling Abnormal
  • Gastric Disorder
  • Headache
  • Heart Rate Increased
  • Hyperadrenalism
The patient was hospitalized. Although all drugs are carefully tested before they are licensed for use, they carry potential side effect risks. Some side effects, such as Depression, may become evident only after a product is in use by the general population.
Back Pain, Blood Triglycerides Increased, Depression, Gastric Ulcer, Insomnia, Oedema Peripheral, Osteoporosis

This is a Flexeril side effect report of a female patient (weight: NA) from UNITED STATES. The patient developed the following symptoms/conditions: muscle spasms,depression,anxiety,pain,rheumatoid arthritis and was treated with Flexeril (dosage: NA) starting NS. Concurrently used drugs:
  • Cymbalta
  • Xanax
  • Hydrocodone Bitartrate
  • Plaquenil
  • Celebrex
Soon after that, the consumer experienced the following of symptoms:
  • Back Pain
  • Blood Triglycerides Increased
  • Depression
  • Gastric Ulcer
  • Insomnia
  • Oedema Peripheral
  • Osteoporosis
This opens a possibility that Flexeril could cause Depression and that some female patients may be more susceptible.
Anxiety, Depression, Inflammation, Thyroid Disorder

This Depression side effect was reported by a consumer or non-health professional from UNITED STATES on Jan 02, 2008. A female patient from UNITED STATES , weighting 210.0 lb, was diagnosed with and was treated with Flexeril. Patient felt the following Flexeril side effects: anxiety, depression, inflammation, thyroid disorder. Flexeril dosage: NA.
Multiple prescriptions taken:
  • Phenergan Hcl
  • Phenergan Hcl (One As Needed)
These side effects may potentially be related to Flexeril.

DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

Flexeril Depression Causes and Reviews


Depression is a serious medical illness. It's more than just a feeling of being sad or "blue" for a few days. If you are one of the more than 19 million teens and adults in the United States who have Depression, the feelings do not go away. They persist and interfere with your everyday life. Symptoms can include

  • Feeling sad or "empty"
  • Loss of interest in favorite activities
  • Overeating, or not wanting to eat at all
  • Not being able to sleep, or sleeping too much
  • Feeling very tired
  • Feeling hopeless, irritable, anxious, or guilty
  • Aches or pains, headaches, cramps, or digestive problems
  • Thoughts of death or suicide

Depression is a disorder of the brain. There are a variety of causes, including genetic, biological, environmental, and psychological factors. Depression can happen at any age, but it often begins in teens and young adults. It is much more common in women. Women can also get postpartum Depression after the birth of a baby. Some people get seasonal affective disorder in the winter. Depression is one part of bipolar disorder.

There are effective treatments for Depression, including antidepressants, talk therapy, or both.

NIH: National Institute of Mental Health


Flexeril Depression Reviews

Mon, 18 Apr 2011
I was taking Flexeril after I was diagnosed with a rib contusion following heavy lifting. I am taking Lexapro, Adderall and Trazadone already for A.D.D. Depression and sleep deprivation. The Flexeril made me extremely tired, irritable, so much so that after a 24 hour period, I was nearly suicidal, possibly homicidal. I threw the medication away after reoccuring this feeling several times.
Sun, 25 Dec 2011
I broke my back as a child (I am now 32) and have had two back surgeries and I have been visiting doctors my whole life. I rarely take any medications but I recently had a severe set back. My job requires me to travel and work frequently. My back doctor prescribed me Flexeril for the first time. The Flexeril was probably one of the most effective medications I have ever used. I had two side effects which were severe dry mouth and a mild case of Depression. I had never taken a drug which made me feel so down. The drugs effectiveness out weighed the side effects.
DISCLAIMER: ALL DATA PROVIDED AS-IS, refer to terms of use for additional information.

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Top Flexeril Side Effects

Pain (103)
Pulmonary Embolism (74)
Fatigue (71)
Nausea (70)
Fall (68)
Pain In Extremity (66)
Dyspnoea (66)
Oedema Peripheral (65)
Feeling Abnormal (65)
Depression (65)
Somnolence (64)
Headache (64)
Muscle Spasms (64)
Overdose (63)
Dizziness (61)
Deep Vein Thrombosis (54)
Anxiety (50)
Convulsion (48)
Confusional State (46)
Asthenia (44)
Back Pain (13)
Loss Of Consciousness (11)
Hypertension (11)
Heart Rate Increased (11)
Abdominal Pain Upper (10)
Amnesia (10)
Malaise (10)
Injury (10)
Blood Pressure Increased (10)
Cerebrovascular Accident (9)
Cardiac Failure (9)
Death (9)
Injection Site Pain (9)
Weight Increased (9)
Pneumonia (9)
Lethargy (9)
Diarrhoea (8)
Completed Suicide (8)
Muscular Weakness (8)
Urinary Tract Infection (8)
Vision Blurred (8)
Vomiting (8)
Incorrect Dose Administered (7)
Hallucination (7)
Liver Disorder (7)
Hypotension (7)
Paraesthesia (7)
Suicidal Ideation (7)
Rhabdomyolysis (7)
Myocardial Infarction (7)

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