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ABNORMAL BEHAVIOUR and Adderall

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ABNORMAL BEHAVIOUR Symptoms and Causes

Alcohol can harm your baby at any stage during a pregnancy. That includes the earliest stages, before you even know you are pregnant. Drinking during pregnancy can cause a group of conditions called fetal alcohol spectrum disorders (FASDs). Children who are born with FASD can have a mix of problems, such as medical, behavioral, educational, and social problems. The kinds of problems they have depend on which type of FASD they have. The problems could include

  • Abnormal facial features, such as a smooth ridge between the nose and upper lip
  • Small head size
  • Shorter-than-average height
  • Low body weight
  • Poor coordination
  • Hyperactive behavior
  • Difficulty with attention and memory
  • Learning disabilities and difficulty in school
  • Speech and language delays
  • Intellectual disability or low IQ
  • Poor reasoning and judgment skills
  • Sleep and sucking problems as a baby
  • Vision or hearing problems
  • Problems with the heart, kidneys, or bones

Fetal alcohol syndrome (FAS) is the most serious type of FASD. People with fetal alcohol syndrome have facial abnormalities, including wide-set and narrow eyes, growth problems and nervous system abnormalities.

Diagnosing FASD can be hard because there is no medical test for it. The health care provider will make a diagnosis by looking at the child's signs and symptoms, and will ask whether the mother drank alcohol during pregnancy.

FASDs last a lifetime. There is no cure for FASDs, but treatments can help. These include medicines to help with some symptoms, medical care for health problems, behavior and education therapy, and parent training. A good treatment plan is specific to the child's problems. It should include close monitoring, follow-ups, and changes when needed.

Certain "protective factors" can help reduce the effects of FASDs and help people who have them reach their full potential. They include

  • Diagnosis before 6 years of age
  • Loving, nurturing, and stable home environment during the school years
  • Absence of violence around them
  • Involvement in special education and social services

There is no known safe amount of alcohol during pregnancy. To prevent FASDs, you should not drink alcohol while you are pregnant, or when you might get pregnant.

Centers for Disease Control and Prevention

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ABNORMAL BEHAVIOUR Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting Adderall XR and Processing Speed in Multiple Sclerosis (MS)
Conditions: Impaired Processing Speed;   Cognitive Impairment;   Multiple Sclerosis
Interventions: Drug: Adderall XR 5mg;   Drug: Adderall XR 10 mg;   Drug: Placebo
Outcome Measures: Change in score of Paced Auditory Serial Addition Test (PASAT);   Change in Score of Symbol Digit Modalities Test (SDMT);   Change in Score of Stroop Colour Word Test;   Blood Pressure;   Heart Rate
2 Recruiting Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence
Condition: Cocaine Dependence
Interventions: Drug: Adderall-ER;   Drug: Topiramate;   Other: Placebo
Outcome Measures: Three weeks of Cocaine abstinence;   Proportion of negative urine samples
3 Recruiting Stimulant Enhancement of Well-Being Therapy for Depression
Condition: Major Depressive Disorder
Interventions: Drug: Amphetamine-dextroamphetamine (AMPH);   Drug: Placebo;   Behavioral: Well-being therapy
Outcome Measures: Change in Hamilton-Depression Rating Scale(SIGH-D)-17 items;   Change in Hamilton-Depression Rating Scale(SIGH-D)-31 item;   Change in Psychological Well-being Scale (PWB);   Change in the Snaith-Hamilton Pleasure Scale (SHAPS);   Change in Behavioral inhibition/activation scale (BIS/BAS);   Change in Positive and Negative Affective Scale (PANAS);   Change in functioning on Short Form-12(SF-12)
4 Recruiting Follow up Treatment of Children With Attention Deficit Hyperactivity Disorder (ADHD)
Condition: Attention Deficit Hyperactivity Disorder (ADHD)
Interventions: Behavioral: Academic and Organization skills;   Behavioral: Parent Training;   Behavioral: Social Skills Training;   Drug: Long-acting stimulant
Outcome Measures: Attention Deficit Hyperactivity Disorder (ADHD) symptomatology (measured via Conners' Global Index - Parent and Teacher Version);   Social skills (measured via Parent and Teacher Social Skills Rating Scale);   Academic achievement (measured via Wechsler Individual Achievement Test (WIAT));   Emotional and symptomatic functioning (measured via the Achenbach Child Behavior Check List (CBCL));   Overall functioning (measured via the Weiss Functional Impairment Scale (WFIRS));   Overall functioning (measured via the Clinical Global Impression Scale (CGI))
5 Recruiting Adjunctive Mixed Salts Amphetamine (MSA) for Depressed Adults With Incomplete Response to Current Antidepressant Therapy (ADT)
Condition: Major Depressive Disorder
Intervention: Drug: mixed salts amphetamine
Outcome Measures: Change in scores on the Massachusetts General Hospital Cognitive and Physical Functioning Questionaire;   Change in scores on the Montgomery Asberg Depression Rating Scale;   Change in scores on the Quick Inventory of Depressive Symptomatology Self Report 16
6 Recruiting Omega-3 Fatty Acid Supplementation to ADHD Pharmacotherapy in ADHD Adults With Deficient Emotional Self-Regulation Traits
Conditions: Attention Deficit Hyperactivity Disorder (ADHD);   Deficient Emotional Self-Regulation (DESR)
Interventions: Drug: ADHD Medication;   Drug: Omega-3 Fatty Acids
Outcome Measures: Efficacy assessed by mean change from baseline to endpoint on the BRIEF-A Emotional Control scale;   Efficacy measured by mean change from baseline to endpoint on AISRS total score;   Efficacy measured by mean change from baseline to endpoint on CGI;   Efficacy measured by mean change from baseline to endpoint on BRIEF-A subscales;   Efficacy measured by mean change from baseline to endpoint on GAF
7 Recruiting Interventions for Children With Attention and Reading Disorders
Conditions: Attention Deficit Hyperactivity Disorder;   Reading Disabilities
Interventions: Drug: Methylphenidate;   Behavioral: Intensive reading instruction;   Behavioral: Parent Training;   Drug: Mixed Salt Amphetamine;   Drug: Atomoxetine;   Drug: Guanfacine
Outcome Measures: Wechsler Individual Achievement Test of Word Reading and Pseudoword Decoding;   Swanson, Nolan, and Pelham checklist for DSM-IV;   Stop-Signal Test;   Test of Word Reading Efficiency;   Wechsler Individual Achievement Test of Reading Comprehension;   Dynamic Indicators of Basic Early Literacy Skills Oral Reading Fluency
8 Not yet recruiting A Sequenced Behavioral and Medication Intervention for Cocaine Dependence
Condition: Cocaine Dependence
Interventions: Behavioral: Computer-assisted behavior therapy;   Drug: Mixed amphetamine salts;   Drug: Computer-assisted therapy plus placebo (for mixed amphetamine salts)
Outcome Measures: Three weeks of cocaine abstinence;   Proportion of cocaine positive urines
9 Recruiting Efficacy of Intuniv Extended Release as Adjunctive Therapy With Psycho-stimulant on Executive Function in Children With ADHD
Condition: Attention Deficit Hyperactivity Disorder
Interventions: Drug: Guanfacine extended release;   Drug: Placebo
Outcome Measures: To evaluate the effect of adjunctive INTUNIV extended release treatment on executive function as assessed by the BRIEF-parent questionnaires;   To evaluate the effect of adjunctive INTUNIV extended release treatment on quality of life as assessed by the KINDL®-child and KINDL®-parent questionnaires.;   To examine the congruency of the perceived effect of treatment on EF and quality of life from the perspective of the subject, parent, and teacher.;   To evaluate the effect of adjunct therapy on ADHD symptom control as assessed by the ADHD Rating Scale (ADHD-RS-IV) and Clinical Global Impression (CGI) of Severity (CGI-S) and of Improvement (CGI-I) questionnaires.;   To compare the percentage of subjects experiencing suicidal ideation, suicidal behaviour and self-injurious behaviour without suicidal intent and incident of Serious Adverse Events in each treatment arm
10 Recruiting IMPAACT P1080: Psychiatric and Antiretroviral Medication Concentrations in HIV-infected and Uninfected Children and Adolescents
Conditions: ADHD;   HIV
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