ACIDOSIS and Dopamine


ACIDOSIS Symptoms and Causes

You have two kidneys, each about the size of your fist. They are near the middle of your back, just below the rib cage. Inside each kidney there are about a million tiny structures called nephrons. They filter your blood. They remove wastes and extra water, which become urine. The urine flows through tubes called ureters. It goes to your bladder, which stores the urine until you go to the bathroom.

Most kidney diseases attack the nephrons. This damage may leave kidneys unable to remove wastes. Causes can include genetic problems, injuries, or medicines. You have a higher risk of kidney disease if you have diabetes, high blood pressure, or a close family member with kidney disease. Chronic kidney disease damages the nephrons slowly over several years. Other kidney problems include

  • Cancer
  • Cysts
  • Stones
  • Infections

Your doctor can do blood and urine tests to check if you have kidney disease. If your kidneys fail, you will need dialysis or a kidney transplant.

NIH: National Institute of Diabetes and Digestive and Kidney Diseases

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Dopamine Side Effects

Renal Failure (24)
Injury (23)
Unevaluable Event (21)
Fear (20)
Pain (19)
Renal Injury (18)
Death (17)
Emotional Distress (16)
Renal Impairment (15)
Anxiety (15)
Multi-organ Failure (14)
Stress (14)
Hypotension (11)
Device Failure (11)
Anhedonia (10)
Blood Pressure Decreased (10)
Device Malfunction (9)
Cardiac Arrest (9)
Depression (7)
Cardio-respiratory Arrest (5)
Loss Of Consciousness (5)
Incorrect Dose Administered (5)
Electrocardiogram St Segment Elevation (4)
Hypernatraemia (4)
Cerebrovascular Accident (4)
Bradycardia (4)
Renal Failure Acute (4)
Myocardial Infarction (4)
Ventricular Fibrillation (4)
Ventricular Tachycardia (4)
Pulse Absent (4)
Acidosis (3)
Accidental Overdose (3)
Acute Respiratory Distress Syndrome (3)
Blood Pressure Systolic Decreased (3)
Choreoathetosis (3)
Condition Aggravated (3)
Blood Pressure Immeasurable (3)
Atrial Fibrillation (3)
Confusional State (3)
Encephalitis (3)
Depressed Level Of Consciousness (3)
Tachycardia (3)
Hypertension (3)
Metabolic Acidosis (3)
Rhabdomyolysis (3)
Mitral Valve Incompetence (3)
Nausea (2)
Pancytopenia (2)
Nervousness (2)

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ACIDOSIS Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Recruiting Incidence of Postoperative Ketosis and Metabolic Acidosis
Condition: Metabolic Acidosis
Outcome Measures: Incidence of tissue Acidosis, defined as tissue acids > 5mEq/L (Figge's equation) within one hour of completion of surgery;   Incidence of metabolic Acidosis, defined by base deficit . 2 mEq/L (Henderson-Hasselback) within one hour of completion of surgery.
2 Unknown  Lactic Acidosis During Entecavir(ETV)Treatment
Condition: Lactic Acidosis
Intervention: Drug: entecavir, lamivudine
Outcome Measures: incidence of elevated venous lactate levels more than 2 mmol/L of any etiology;   incidence of elevated venous lactate levels more than 2 mmol/L directly related to NRTI;   Incidence of elevated venous lactate levels more than 2 mmol/L caused by etiologies other than NTRIs;   Frequency of concomitant prescribed medications possibly associated with lactic Acidosis other than NTRIs;   Arterial pH and anion gap in cases with elevated blood lactate levels (at the time of detection and peak levels;   Overall OLT-free survival
3 Recruiting Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media
Conditions: Diabetes Mellitus;   Lactic Acidosis
Intervention: Drug: Metformin
Outcome Measure: Incidence of lactic Acidosis
4 Unknown  Renal Tubular Acidosis in Incident Renal Transplant Recipients
Condition: Renal Transplant Disorder
Outcome Measure:
5 Recruiting Metabolic Acidosis and Vascular Function in Patients With Chronic Kidney Disease
Conditions: Metabolic Acidosis;   Chronic Kidney Disease
Interventions: Drug: Sodium bicarbonate;   Other: Control
Outcome Measure: Brachial artery flow mediated dilation (FMD)
6 Recruiting Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis
Conditions: Acidosis, Renal Tubular;   Nephrolithiasis;   Vacuolar Proton-Translocating ATPases
Intervention: Drug: Furosemide-Fludrocortisone-Test (test for urinary acidification)
Outcome Measures: capability of urinary acidification;   polymorphisms in the ATP6V1 gene
7 Recruiting Uremic Toxins in the Intensive Care Units (ICU): Patients With Lactate Acidosis
Condition: Acute Renal Failure
Interventions: Procedure: Dialysis during 4 hours;   Procedure: Dialysis during 6 hours;   Procedure: Dialysis during 8 hours
Outcome Measure: Toxin removal
8 Unknown  Early Aggressive Correction of Severe Acidosis With Tris-hydroxymethylaminomethane (THAM)
Condition: Resuscitation, Trauma Patients
Outcome Measures: Total amount of fluids and blood products used during the operative and 72 hr post-operative period.;   Intra-operative, intensive care unit and hospital mortality
9 Not yet recruiting Veno-venous Extracorporeal CO2 Removal in ARDS-patients to Treat Respiratory Acidosis
Interventions: Procedure: extracorporeal removal of CO2 (ECCO2-R);   Procedure: No extracorporeal CO2-removal
Outcome Measures: To obtain a reduction of 20% in arterial partial CO2 pressure (PaCO2) after the first two hours of ECCO2-R therapy.;   Reduction in Plateau pressures to levels between 25 and 28 cm H2O.;   • Reduction in tidal volumes to 6ml/kg predicted body weight (PBW) or lower, with a minimum of 3ml/kg PBW.;   Increase in pH to the normal range of 7,35 to 7,45.
10 Recruiting Comparison of High Versus Low Bicarbonate Hemodialysis
Conditions: Chronic Kidney Disease;   End-stage Renal Disease;   Metabolic Acidosis
Intervention: Other: Low Bicarbonate
Outcome Measures: Pre-dialysis serum bicarbonate;   serum beta-hydroxybutyrate;   beta-hydroxybutyrate clearance;   interleukin-6;   serum free fatty acids;   Time to recover from dialysis;   Dialysis symptom questionnaire
11 Recruiting Effect of Goal-directed Fluid Therapy Based on Stroke Volume Variation on Metabolic Acidosis in Patients Undergoing Brain Tumor Surgery
Condition: Brain Tumor
Interventions: Drug: SVV;   Drug: CVP
Outcome Measure: Standard base excess point
12 Recruiting Alkali Therapy in Chronic Kidney Disease
Conditions: Chronic Kidney Disease;   Metabolic Acidosis
Interventions: Drug: Sodium bicarbonate;   Drug: Placebo
Outcome Measures: HOMA-IR;   Sit to stand to sit speed;   DEXA of wrist;   Urinary NGAL and KIM-1;   Glucose disposal rate by euglycemic hyperinsulinemic clamp;   Hand-grip strength;   Serum PTH;   Bone-specific alkaline phosphatase;   Serum calcium;   Serum phosphate;   Serum 1,25-dihydroxyvitamin D;   serum creatinine;   serum cystatin C;   urinary albumin/ creatinine ratio;   urinary cystatin
13 Unknown  Prevention of Dichloroacetate Toxicity
Conditions: Acidosis, Lactic;   Chronic Disease
Interventions: Drug: Nitisinone (NTBC);   Drug: Dichloroacetate;   Behavioral: Low-tyrosin diet
Outcome Measure:
14 Recruiting Clinical Study to Determine the Optimal Operation Parameters During CO2 Removal With the Abylcap® System
Conditions: ARDS (Acute Respiratory Distress Syndrome);   Respiratory Acidosis
Interventions: Device: Abylcap® System: blood flow (QB): 200mL/min; gas flow (QG):7L/min;   Device: Abylcap® System: blood flow (QB): 300mL/min; gas flow (QG):7L/min;   Device: Abylcap® System: blood flow (QB): 400mL/min; gas flow (QG):7L/min;   Device: Abylcap® System: blood flow (QB): 400mL/min; gas flow (QG):1.5L/min;   Device: Abylcap® System: blood flow (QB): 400mL/min; gas flow (QG):3L/min;   Device: Abylcap® System: blood flow (QB): 400mL/min; gas flow (QG):6L/min;   Device: Abylcap® System: blood flow (QB): 400mL/min; gas flow (QG):8L/min
Outcome Measures: calculation of CO2 extraction in blood samples during mechanical ventilation;   Based on the extraction rates, the optimum parameter settings are derived
15 Not yet recruiting Respiratory Muscle Function in COPD Exacerbations
Condition: Chronic Obstructive Pulmonary Disease (COPD)
Intervention: Device: Non-invasive ventilation
Outcome Measures: Respiratory muscle function.;   Days of hospitalization.;   Dyspnea scale questionnaire;   Quality of life;   Blood gases;   Number of hospital readmissions in the next year
16 Unknown  Evaluation of Volume Status, Haemodynamics and Microcirculatory Flow in Adult Patients With Severe Falciparum Malaria
Condition: Severe Falciparum Malaria
Outcome Measures: Metabolic Acidosis;   Acute renal failure;   Acute pulmonary oedema
17 Recruiting Nitroglycerin Infusion During Cardiac Surgery
Conditions: Lactic Acidosis;   Bleeding
Intervention: Drug: Nitroglycerin infusion
Outcome Measures: Plasma lactate level;   Perioperative blood loss;   Mean arterial blood pressure;   Inotropic doses;   Time to extubation
18 Unknown  Autologous Stem Cells in Newborns With Oxygen Deprivation
Conditions: Apgar; 0-3 at 1 Minute;   Metabolic Acidosis;   Hypoxia, Brain;   Multiple Organ Failure
Interventions: Procedure: Application of Stem Cells;   Procedure: Observation
Outcome Measures: Effects of Stem Cell Infusion at 1 week after discharge;   Effects of Stem Cell Infusion at 1 year after discharge
19 Recruiting Efficacy, Safety Study and Benefit of Alkali Therapy in Sickle Cell Disease
Conditions: Sickle Cell Anemia;   Chronic Kidney Disease;   Metabolic Acidosis
Intervention: Drug: Sodium Bicarbonate
Outcome Measures: Serum bicarbonate level;   Hemolysis markers
20 Unknown  Open or Keyhole Surgery Through the Chest for Newborn Babies: Effect on Blood Gases
Conditions: Esophageal Atresia With Tracheo-esophageal Fistula;   Congenital Diaphragmatic Hernia
Interventions: Procedure: Hypercapnia during thoracoscopy;   Procedure: Open surgery
Outcome Measures: Arterial blood carbon dioxide measurement;   oxygenation of the brain;   arterial carbon dioxide levels measured transcutaneously