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ACUTE MYOCARDIAL INFARCTION and Plavix

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ACUTE MYOCARDIAL INFARCTION Symptoms and Causes

Each year almost 800,000 Americans have a heart attack. A heart attack happens when blood flow to the heart suddenly becomes blocked. Without the blood coming in, the heart can't get oxygen. If not treated quickly, the heart muscle begins to die. But if you do get quick treatment, you may be able prevent or limit damage to the heart muscle. That's why it's important to know the symptoms of a heart attack and call 9-1-1 if you or someone else is having them. You should call, even if you are not sure that it is a heart attack.

The most common symptoms in men and women are

  • Chest discomfort. It is often in center or left side of the chest. It usually lasts more than a few minutes. It may go away and come back. It can feel like pressure, squeezing, fullness, or pain. It also can feel like heartburn or indigestion.
  • Shortness of breath. Sometimes this is your only symptom. You may get it before or during the chest discomfort. It can happen when you are resting or doing a little bit of physical activity.
  • Discomfort in the upper body. You may feel pain or discomfort in one or both arms, the back, shoulders, neck, jaw, or upper part of the stomach.

You may also have other symptoms, such as nausea, vomiting, dizziness, and lightheadedness. You may break out in a cold sweat. Sometimes women will have different symptoms then men. For example, they are more likely to feel tired for no reason.

The most common cause of heart attacks is coronary artery disease (CAD). With CAD, there is a buildup of cholesterol and other material, called plaque, on their inner walls or the arteries. This is atherosclerosis. It can build up for years. Eventually an area of plaque can rupture (break open). A blood clot can form around the plaque and block the artery.

A less common cause of heart attack is a severe spasm (tightening) of a coronary artery. The spasm cuts off blood flow through the artery.

At the hospital, health care providers make a diagnosis based on your symptoms, blood tests, and different heart health tests. Treatments may include medicines and medical procedures such as coronary angioplasty. After a heart attack, cardiac rehabilitation and lifestyle changes can help you recover.

NIH: National Heart, Lung, and Blood Institute

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ACUTE MYOCARDIAL INFARCTION treatment research studies

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Plavix Side Effects

Myocardial Infarction (302)
Dyspnoea (270)
Anaemia (263)
Contusion (260)
Asthenia (251)
Death (238)
Cerebrovascular Accident (215)
Gastrointestinal Haemorrhage (207)
Dizziness (204)
Chest Pain (200)
Haemorrhage (176)
Fall (166)
Fatigue (162)
Headache (152)
Haemoglobin Decreased (145)
Diarrhoea (137)
Nausea (132)
Epistaxis (132)
Pruritus (129)
Coronary Artery Occlusion (123)
Pain (117)
Pyrexia (116)
Malaise (112)
Loss Of Consciousness (109)
Rash (108)
Rectal Haemorrhage (106)
Pain In Extremity (105)
Transient Ischaemic Attack (104)
Off Label Use (100)
Weight Decreased (98)
Atrial Fibrillation (98)
Melaena (96)
Arthralgia (93)
International Normalised Ratio Increased (91)
Haematemesis (90)
Abdominal Pain Upper (90)
Pneumonia (89)
Condition Aggravated (89)
Cardiac Failure Congestive (87)
Oedema Peripheral (87)
Renal Failure (85)
Vomiting (85)
Hypertension (85)
Angina Pectoris (85)
Hypotension (84)
Back Pain (83)
Confusional State (81)
Thrombosis (81)
Gait Disturbance (73)
Myalgia (72)

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Recent Reviews

75 mg

A horrible experience taking plavix, i had all the side effects taking this drug ,question ur Dc. before taking it and 9don,t believe him)

About a year ago i had a stroke also bad dry skin,i also had a full head of hair and a full beard lately my beard and hair are both are both falling out

Could plavix be the reason for my hair loss

Deadly stay away

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I AM HAVING HAIR LOSS AND I AM NOT TAKING PLAVIX

I have been on plavix and asparin 4 months, SP cerebral aneurysm repair) this evening I fell hard on my low back(completely missed a chair ), i couldnt move for a few mins, really hurt... got up, applied ice to low back,moving ok but sore, I guess I

I was placed on plavix after a pfo closure surgery. I have felt depressed and have experienced crying spells. Its very unlike my personality. The more people I talk to the more common it seems to be a serious issue.

In 2001 I had heart attack and I was found to have 3 major blockages in my heart arteries.I was offered three choices ie. medication ,stent,or bypass surgery.I opted for a stent and i was put on medication ie. plavix 75mg,caprin 75mg,.lipos

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AGGRENOX SIDE EFFECT. PATIENT WAS PRESCRIBED PLAVIX. AGGRENOX WAS SUBSTITUTED. PATIENT SUFFERED ACUTE RESPIRATORY FAILURE AND CARDIO-RESPIRATORY ARREST. PATIENT WAS HOSPITALIZED. PATIENT DIED 3/29/09.

Citalopram caused me to suffer acute-closed angle Glaucoma CAG,

Dizziness, full body tremors, body aches, racing heart, acute changes in blood pressure

ACUTE MYOCARDIAL INFARCTION Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Not yet recruiting Genotyping Guided Individualized Treatment of Clopidogrel and Ticagrelor in ACS
Condition: CLOPIDOGREL, POOR METABOLISM of (Disorder)
Interventions: Drug: genotyping guided therapy Ticagrelor, Clopidogrel;   Drug: standard therapy clopidogrel
Outcome Measure: Clopidogrel response status as measured by the LTA assay in CYP2C19*2 carriers.
2 Recruiting Comparative Pharmacodynamics and Pharmacokinetics Study of Generic and Reference Clopidogrel Products
Condition: Antiplatelet Agents
Interventions: Drug: Generic clopidogrel product Apolets®;   Drug: Original clopidogrel product Plavix®
Outcome Measures: Pharmacodynamic effect: The platelet inhibition effect of clopidogrel at the various times on day 7 (0-24 hours) (at steady state);   Pharmacokinetic profiles: Area Under the Concentration-Time Curve (AUC 0-24);   Pharmacokinetic profiles: The Maximum Plasma Concentration (Cmax);   Pharmacokinetic profiles: Time to Maximum Plasma Concentration (Tmax)
3 Recruiting Ramipril and Clopidogrel in Oxidative Stress, Vascular Inflammation and Endothelial Dysfunction in Type 2 Diabetes and Diabetic Nephropathy
Conditions: Diabetes Type 2;   Diabetic Nephropathy;   Vascular Disease
Interventions: Drug: Ramipril;   Drug: Clopidogrel
Outcome Measures: Changes in Asymmetric dimethylarginine (ADMA) blood levels after the combined treatment with ramipril and clopidogrel compared with ramipril monotherapy;   Changes in High-sensitivity C-reactive protein (HsCRP) blood levels after the combined treatment with ramipril and clopidogrel compared with ramipril monotherapy;   Changes in soluble CD40 Ligand (sCD40L)blood levels after the combined treatment with ramipril and clopidogrel compared with ramipril monotherapy;   Changes in urine 8-isoprostane-F2 levels after the combined treatment with ramipril and clopidogrel compared with ramipril monotherapy;   Reduction in albumine to creatine ratio after the combined treatment with ramipril and clopidogrel compared with ramipril monotherapy;   Changes in ADMA blood levels after treatment with ramipril;   Increase of Glomerular Filtration Rate (GFR) after combined treatment with ramipril and clopidogrel and after ramipril monotherapy;   Change from baseline in carotid intima-media thickness after combined therapy with ramipril and clopidogrel and after ramipril monotherapy
4 Recruiting Aspirin and Plavix Following Coronary Artery Bypass Grafting
Condition: Coronary Graft Patency
Interventions: Drug: clopidogrel;   Drug: sugar pill
Outcome Measures: Incidence of more than 50% stenosis in graft with combination therapy with aspirin and clopidogrel vs. aspirin alone;   Incidence of bleeding between the two treatment arms;   Percent change major adverse cardiovascular events (angina, any thrombotic events, and myocardial infarction) with combination therapy with aspirin and clopidogrel vs. aspirin alone
5 Not yet recruiting Optimal Anti-platelet Treatment for Patients With Clopidogrel Low Response
Condition: Coronary Artery Disease
Interventions: Drug: Ticagrelor;   Drug: Clopidogrel;   Drug: Cilostazol
Outcome Measures: Inhibition of platelet aggregation (IPA);   Clinical efficacy
6 Recruiting Effectiveness of Clopidogrel Resinate in PCI(PRIDE)
Condition: Coronary Artery Disease
Interventions: Drug: Pregrel®;   Drug: Plavix®
Outcome Measures: composite of death (all cause-mortality), MI (Q wave and non Q wave) and stroke;   composite of death, MI, stroke, or urgent revascularization;   Individual components of death, MI, stroke, or urgent revascularization;   The need for target vessel revascularization or any revascularization;   The incidence of early discontinuation of study drugs;   The incidence of major bleeding events;   Stent thrombosis
7 Not yet recruiting Clopidogrel Resistance and Embolism in Carotid Artery Stenting
Condition: Carotid Stenosis
Interventions: Drug: Ticlopidine + Ginko biloba;   Drug: Clopidogrel
Outcome Measures: New ischemic lesion on diffusion-weighted imaging (DWI);   Number and Volume of new ischemic lesions on DWI;   Benign and malignant microembolic signals (MES) on transcranial Doppler (TCD);   Ischemic stroke or transient ischemic attack (TIA);   Change of clopidogrel resistance;   Pucture site hematoma;   Mycocardial infarction;   Death;   Hematological abnormalities
8 Recruiting Reloading Prasugrel or Clopidogrel on High Platelet Reactivity Before Percutaneous Coronary Intervention
Condition: Acute Coronary Syndrome
Interventions: Drug: Prasugrel;   Drug: Clopidogrel
Outcome Measures: HPR at 24 hours;   MACE;   Bleeding;   HPRs
9 Recruiting Does Continued Use of Clopidogrel Into Surgery Cause Increased Perioperative Bleeding?
Condition: Clopidogrel
Interventions: Drug: Clopidogrel;   Drug: Discontinue Clopidogrel
Outcome Measures: Perioperative Bleeding Complications;   Development of myocardial infarction or thrombosis
10 Unknown  Thromboelastography As An Assessment Tool for Possible Clopidogrel and Aspirin Resistance
Condition: Acute ST SEgment Elevation Myocardial Infarction
Interventions: Drug: Aspirin (200mg) and/or Plavix (150mg) dosage according to TEG;   Drug: Aspirin 100mg and Plavix 75mg
Outcome Measures: To determine usefulness of thromboelastography (TEG) as a valuable tool in assessing platelet response to clopidogrel treatment and post-treatment platelet reactivity during acute ST segment elevation myocardial infarction (STEMI).;   To determine the correlation between platelet response to clopidogrel treatment and the outcome of patients who underwent percutaneous coronary intervention (PCI) for STEMI.
11 Recruiting Antiplatelet Effects of Ticagrelor Versus Clopidogrel in American Indian Patients
Condition: Coronary Artery Disease
Interventions: Drug: Ticagrelor;   Drug: Clopidogrel
Outcome Measures: Compare ticagrelor's versus clopidogrel's inhibition of the P2Y12 receptor as measured by the decrease in P2Y12 Reaction Units (PRU) using VerifyNow TM.;   Compare the decrease of P2Y12 Reaction Units (PRU) by VerifyNow TM from ticagrelor and clopidogrel.;   Compare the decrease in P2Y l2 Reaction Units (PRU) by VerifyNow™ from ticagrelor's and clopidogrel's morning dose on Day 7;   To evaluate and compare the pharmacodynamic effects, measured by the vasodilator-stimulated phosphoprotein (VASP) assay (platelet reactivity index [PRI]), in all subjects;   Assess and to compare the percentage of subjects with High on-treatment Platelet Reactivity (HPR) at all time points after randomized study treatment.
12 Recruiting Evaluation of the Biological Response to Clopidogrel in Patients With Ischemic Stroke
Conditions: Brain Ischemia;   Ischemic Attack
Intervention: Drug: Clopidogrel
Outcome Measures: adrenergic component of the platelet response;   VASP-CMF;   ELISA VASP;   active metabolite of clopidogrel;   Genotyping of MDR-1 and P450 2C19
13 Recruiting Transition From Ticagrelor to Clopidogrel Following Acute Coronary Syndrome: To Bolus or Not?
Condition: Acute Coronary Syndrome
Intervention: Drug: Clopidogrel
Outcome Measures: Platelet inhibition as assessed by P2Y12 reaction Unit (PRU) after transition from Ticagrelor to Clopidogrel.;   The difference in platelet inhibition (as expresses as PRU) between the two groups at specified time points.
14 Recruiting Uninterrupted Clopidogrel Therapy Before Elective Colonoscopy Will Increase the Risk of Post-polypectomy Bleeding
Condition: Gastrointestinal Bleeding
Intervention: Drug: clopidogrel
Outcome Measures: Delayed post-polypectomy bleeding;   Immediate post-polypectomy bleeding
15 Not yet recruiting Comparing Ticagrelor and Clopidogrel Pharmacodynamics After Thrombolysis
Conditions: Acute ST Segment Elevation Myocardial Infarction;   Acute Coronary Syndrome
Interventions: Drug: Ticagrelor;   Drug: Clopidogrel
Outcome Measures: Pharmacodynamics (PRU and IPA) of ticagrelor vs Clopidogrel using VASP and VerifyNow;   Pharmacokinetic (AUC, Cmax, Tmax)
16 Unknown  Plavix, Prasugrel and Drug Eluting Stents Pilot Trial
Conditions: Coronary Artery Disease;   Platelet Aggregation Inhibitors;   PCI- Percutaneous Coronary Intervention
Interventions: Drug: Loading Dose Arm;   Drug: Maintenance Dose Arm
Outcome Measures: Change in platelet reactivity after switching medication regimen of two thienopyridines- clopidogrel and prasugrel;   Occurrence of all bleeding events for subjects enrolled into the trial;   Occurrence of all MACE events for subjects enrolled into the trial
17 Unknown  Clopidogrel Reloading in Patients With NSTEACS Undergoing Percutaneous Coronary Intervention on Chronic Clopidogrel Therapy
Conditions: Acute Coronary Syndrome;   Myocardial Infarction
Interventions: Drug: Clopidogrel;   Drug: Placebo
Outcome Measures: Major Adverse Cardiovascular Events;   Bleeding Events;   Grade of platelet residual reactivity
18 Not yet recruiting Effect of Modifying Anti-platelet Treatment to Ticagrelor in Patients With Diabetes and Low Response to Clopidogrel
Conditions: Diabetes Mellitus;   Coronary Disease
Interventions: Drug: Ticagrelor;   Drug: Continued clopidogrel
Outcome Measures: Rate of elevation of troponin or CK-MB (above the upper limit of normal, and above 3 times the upper limit of normal) measured 20-24 hours after the PCI.;   Rate of major adverse cardiovascular endpoints including death, myocardial infarction or urgent target vessel revascularization at 30 days
19 Recruiting Ticagrelor Versus Clopidogrel in Type 2 Diabetic Patients
Conditions: Type-2 Diabetes Mellitus;   Coronary Artery Disease
Interventions: Drug: Ticagrelor + Aspirin;   Drug: Clopidogrel + Aspirin
Outcome Measures: Thrombus formation;   Platelet reactivity;   Vasodilator-Stimulated Phosphoprotein phosphorylation assay
20 Unknown  Pharmacogenomics and Effective Treatment With Clopidogrel
Condition: Pharmacogenomics
Intervention: Genetic: Pharmacogenomics
Outcome Measure: