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ARTHROPATHY and Methotrexate

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ARTHROPATHY Symptoms and Causes

Osteoarthritis is the most common form of arthritis. It causes pain, swelling, and reduced motion in your joints. It can occur in any joint, but usually it affects your hands, knees, hips or spine.

Osteoarthritis breaks down the cartilage in your joints. Cartilage is the slippery tissue that covers the ends of bones in a joint. Healthy cartilage absorbs the shock of movement. When you lose cartilage, your bones rub together. Over time, this rubbing can permanently damage the joint.

Risk factors for osteoarthritis include

  • Being overweight
  • Getting older
  • Injuring a joint

No single test can diagnose osteoarthritis. Most doctors use several methods, including medical history, a physical exam, x-rays, or lab tests.

Treatments include exercise, medicines, and sometimes surgery.

NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

Check out the latest treatments for ARTHROPATHY

ARTHROPATHY treatment research studies

Methotrexate clinical trials, surveys and public health registries


Find Drug Side Effect reports



Methotrexate Side Effects

Pyrexia (411)
Pancytopenia (356)
Nausea (321)
Pneumonia (304)
Arthralgia (271)
Headache (269)
Injection Site Pain (265)
Rheumatoid Arthritis (260)
Dyspnoea (248)
Mucosal Inflammation (241)
Diarrhoea (238)
Vomiting (231)
Fatigue (223)
Asthenia (198)
Cough (196)
Sepsis (195)
Anaemia (195)
Pain (188)
Renal Failure Acute (177)
Malaise (156)
Febrile Neutropenia (152)
Abdominal Pain (152)
Injection Site Erythema (145)
Pain In Extremity (141)
Convulsion (139)
Rash (139)
Neurotoxicity (138)
Dizziness (131)
Neutropenia (129)
Condition Aggravated (129)
Thrombocytopenia (127)
Toxicity To Various Agents (125)
Oedema Peripheral (121)
Alanine Aminotransferase Increased (121)
Renal Failure (118)
Hypertension (115)
Weight Decreased (114)
Erythema (113)
Interstitial Lung Disease (113)
Stomatitis (108)
Respiratory Failure (108)
Bone Marrow Failure (108)
Leukopenia (104)
Fall (103)
Infection (103)
Aspartate Aminotransferase Increased (99)
Hypotension (95)
Nasopharyngitis (93)
Paraesthesia (93)
Septic Shock (91)

➢ More


Common Meds

Abilify (10132)
Adderall (1304)
Amlodipine (6664)
Amoxicillin (4387)
Benadryl (1568)
Celebrex (12876 )
Celexa (1342)
Cialis (2975)
Cipro (8580)
Citalopram (7792)
Crestor (18839)
Cymbalta (14373)
Doxycycline (1757)
Effexor (7289)
Flexeril (435)
Flomax (2177)
Fluoxetine (4261)
Gabapentin (4593)
Hydrocodone (2469)
Ibuprofen (8222)
Lantus (10968)
Lexapro (3499)
Lipitor (17769)
Lisinopril (8919)
Lyrica (27148)
Medrol (650)
Mirena (41254)
Mobic (957)
Morphine (5356)
Naproxen (538)
Neurontin (6501)
Oxycodone (4438)
Pradaxa (13372)
Prednisone (5926)
Prilosec (2631)
Prozac (1954)
Seroquel (27216)
Simvastatin (8348)
Synthroid (4452)
Tamiflu (5585)
Topamax (3748)
Tramadol (5054)
Trazodone (1458)
Viagra (5394)
Vicodin (1153)
Wellbutrin (6324)
Xanax (2847)
Zocor (5718)
Zoloft(6792)
Zyrtec(1669)

Recent Reviews

Hi I haven't had any side effects for the past six years of Methotrexate. but recently I am having some stomach discomfort like as soon as i eat something i have the slight discomfort on my abdoman. I take a glass of green leaf juice and i am fine ag

I am 60 Years of age. 8 years ago i was falsely diagnosed with Rheumatoid Arthritis, i was started on Methoblastin 5Mg a week, Was not given Folic Acid and Ranitidine within the 5 months of taking the tablets i developed exposed blood vessels and spo

I have been on methotrexate for almost months and last two weeks have had severe pains at times lower back , It feel like the kidneys because one side hurts at times and in the mornings it is worse. I am 3 days shy of talking another blood test. Is

I just started Methotrexate, I started itching in the same areas where I had experienced itching with the chicken pox 2 years ago. I am a 51 year old female who contracted chicken pox at 49 years old. This frightens me as I know this can cause diss

I only took it for 21 days but in that time, it put me into a full panic attack that lasted almost 8 days after I went off the medication. I had mental confusion, could not speak properly (I knew what I wanted to say but the words would not come out

I was diagnosed with Rheumatoid Arthritis about 4 years ago when I was 13 or 14, they looked at me and said I had it, they didn't do any blood tests and when they did, nothing showed. But they started me on about 5 mg of Methotrexate, Prednisone, and

Im a 44yrs old female who took methotrexate for 2yrs with excellent results and no side effects but had to stop taking it when it started lowering my white cells.

My 27 years of MTX therapy have prevented physical deformity but caused me to have damage to my lungs. I am short of breath on any activity. MTX helped the pain somewhat but at the cost of my lungs? I was never told about this possibility nor told it

Painful cough after 2 days of 1st dose lasting-- to date-- 6 days

What did you have?

ARTHROPATHY Clinical Trials and Studies

Treatments might be new drugs or new combinations of drugs, new surgical procedures or devices, or new ways to use existing treatments. The goal of clinical trials is to determine if a new test or treatment works and is safe. Clinical trials can also look at other aspects of care, such as improving the quality of life for people with chronic illnesses. People participate in clinical trials for a variety of reasons. Healthy volunteers say they participate to help others and to contribute to moving science forward. Participants with an illness or disease also participate to help others, but also to possibly receive the newest treatment and to have the additional care and attention from the clinical trial staff.
Rank Status Study
1 Unknown  Validation of Ultrasound as a Diagnostic Tool for Assessment of Hemophilic Arthropathy of Knees and Ankles
Conditions: Hemophilia;   Hemophilic Arthropathy
Intervention:
Outcome Measures: Ultrasound findings according to the International Prophylaxis Study Group (IPSG) scale;   MRI findings according to the International Prophylaxis Study Group (IPSG) scale;   X-ray findings according to the Pettersson radiographic system;   Physical Assessment according to the HJHS and FISH scores
2 Recruiting Safety Study of Univers® Revers Shoulder Prosthesis
Condition: Rotator Cuff Tear Arthropathy
Intervention: Device: Universe Reverse Prosthesis
Outcome Measures: SADE within 2 years po;   Risk of adverse events intra-operatively, and post-operatively up to 2 years follow-up;   Prosthesis survival at 2, 5 and 10 years;   Constant (Murley) score (CS);   The Shoulder Pain and Disability Index (SPADI);   Short version of the Disability of the Arm, Shoulder and Hand questionnaire (QuickDASH);   EuroQoL EQ-5D-5L;   Patient satisfaction;   Radiographic Parameters;   Patient active and passive range of motion (ROM) and shoulder strength
3 Recruiting Osteopathic Manipulation for Female Interstitial Cystitis Patients With Sacroiliac Joint Dysfunction
Conditions: Interstitial Cystitis;   Sacroiliac Joint Somatic Dysfunction
Intervention: Procedure: Osteopathic Manipulation Therapy
Outcome Measure: Improvement in Scores of Validated questionnaires pertaining to Interstitial Cystitis problems and symptoms
4 Recruiting Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease
Conditions: Nervous System Malformations;   Arthropathy, Neurogenic;   Urticaria;   Papilledema
Intervention:
Outcome Measure: Comparison of group mean of total disease diary score before compared to after treatment (3-4 mo); mean change in the area under the curve in SAA in patients before and 3-4 mo after tx as well as before and after drug withdrawal.
5 Unknown  Synvisc Injections for Lumbar Facet Joint Pain
Condition: Joint Pain
Intervention: Procedure: Synvisc viscosupplementation
Outcome Measures: Visual Analogue Scale (VAS) for baseline pain (best, worst, average) and pain while walking;   Oswestry Disability Questionnaire;   Short Form 36-Item (SF-36);   Standing/walking tolerance (defined as time patient can sit for before pain level reaches baseline or distance walked before pain reaches baseline);   Analgesic usage;   Lumbar range of motion;   Patient satisfaction
6 Recruiting Transplantation of Bone Marrow Stem Cells Stimulated by Proteins Scaffold to Heal Defects Articular Cartilage of the Knee
Conditions: Osteoarthritis;   Knee Osteoarthritis;   Osteochondritis Dissecans;   Osteonecrosis
Intervention: Procedure: Transplantation of Bone Marrow Stem Cells Activated in Knee Arthrosis
Outcome Measures: IKS, International Knee Score;   KOOS, Knee Injury and Osteoarthritis Outcome Score
7 Recruiting Studies of the Natural History and Pathogenesis and Outcome of Neonatal Onset Multisystem Inflammatory Disease (NOMID/CAPS, DIRA, CRMO, Still s Disease, Behcet s Disease, and Other Undifferentiated Autoinflammatory Diseases)
Conditions: Urticaria;   Arthropathy;   Lymphadenopathy;   Nervous System Anomalies
Intervention:
Outcome Measure:
8 Recruiting Radiofrequency Nerve Ablation Versus Sham to Treat Chronic Low Back Pain Caused by Sacroiliac Joint Dysfunction
Condition: Sacroiliac Joint Dysfunction
Intervention:
Outcome Measures: Reduction in pain;   Economic outcomes
9 Unknown  Gait Evaluation in Haemophiliac Patients
Conditions: Hemophilia A;   Hemophilia B
Intervention:
Outcome Measure: evaluate specific changes in gait in patients suffering from haemophilic Arthropathy
10 Recruiting A Prospective, Multicenter, Single Arm Feasibility Study of the Safety and Performance of GRADION™ Hip Total Cartilage Replacement (TCR)™ in the Treatment of Degenerative Joint Disease of the Hip
Condition: Degenerative Joint Disease of the Hip
Intervention: Device: GRADION™ Hip Total Cartilage Replacement (TCR)™
Outcome Measure: Adverse events
11 Unknown  Impact of Conservative Treatment by Custom-Made Orthoses in Patients With Haemophilic Ankle Arthropathy
Conditions: Haemophilia A;   Haemophilia B
Intervention: Device: custom-molded insoles and custom-molded shoes
Outcome Measure: Gait analysis, foot pressure measurement, specific joint score
12 Recruiting The Norwegian Antirheumatic Drug Register
Condition: Inflammatory Joint Diseases
Intervention:
Outcome Measures: Disease Activity Score-28 (DAS28);   American College of Rheumatology (ACR) responses (ACR20, ACR50, ACR70);   Simplified Disease Activity Index (SDAI);   American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) remission;   Ankylosing Spondylitis Disease Activity Score (ASDAS);   Assessments of Spondyloarthritis International Society (ASAS) responses (ASAS20, ASAS40);   Bath Ankylosing Spondylitis Disease Activity Index (BASDAI);   Modified Health Assessment Questionnaire (MHAQ);   Rheumatoid Arthritis Impact of Disease (RAID);   Work Productivity and Activity Impairment (WPAI) Questionnaire;   EuroQol 5-dimensions (EQ-5D) questionnaire;   28-Swollen joint count;   28-Tender joint count;   Erythrocyte Sedimentation Rate (ESR);   C-Reactive Protein (CRP);   Sharp/van der Heijde score;   Number of participants with adverse events;   Clinical Disease Activity Index (CDAI)
13 Recruiting Study of Adalimumab to Lower Cardiovascular Risk in RA Patients With Well Controlled Joint Disease
Conditions: Rheumatoid Arthritis;   Cardiovascular Disease
Interventions: Drug: Adalimumab;   Drug: Placebo
Outcome Measures: Change in Endothelial Function;   Change in vascular inflammation
14 Recruiting Treatment of Sacroiliac Dysfunction With SI-LOK® Sacroiliac Joint Fixation SI-SI-LOK
Condition: Joint Dysfunction
Intervention: Device: SI-LOK
Outcome Measures: Radiographic Evaluation;   Hospitalization Data
15 Recruiting Nocipoint Therapy Versus Standard Physical Therapy Using Electrical Stimulation in Treating Pain From TMJ Disorder
Condition: Temporomandibular Joint Disorders
Interventions: Procedure: Nocipoint Therapy;   Procedure: Physical Therapy
Outcome Measures: Visual Analog Scale (VAS) for pain;   Maximal mouth opening range (MMO);   Quality of Life (QoL)
16 Recruiting A Double Blind Study Comparing Hyaluronic Acid, Corticosteroid and Placebo During Arthrocentesis for TMJ
Conditions: Temporomandibular Joint Dysfunction;   Pain;   Arthrocentesis
Interventions: Drug: Hyaluronic acid;   Drug: Corticosteroid;   Drug: Lactated Ringers
Outcome Measures: Pain;   Function
17 Unknown  2-Year Post-Approval Study to Investigate the Scandinavian Total Ankle Replacement System (STAR) Ankle Under Actual Conditions of Use
Conditions: Primary Arthrosis;   Post Traumatic Arthritis;   Rheumatoid Arthritis;   Osteoarthritis
Intervention: Device: Scandinavian Total Ankle Replacement System (STAR Ankle)
Outcome Measures: The principal endpoint consists of evaluating the safety and effectiveness of the STAR Ankle using the same composite definition of patient success used in the IDE study.;   American Orthopaedic Foot and Ankle Society Score questionnaire will be used to evaluate and monitor the progress of patients following foot and ankle surgery.
18 Not yet recruiting Study of Association Between Digital Osteoarthritis and Lower Limb Osteoarthritis
Condition: Digital Arthrosis
Intervention: Radiation: Hand X-rays
Outcome Measures: Kellgren and Lawrence score;   Harris score
19 Recruiting COMPREHENSIVE® REVERSE SHOULDER Mini BasePlate
Conditions: Rotator Cuff Tear Arthropathy;   Osteoporosis;   Osteomalacia;   Joint; Destruction, Sacroiliac
Intervention: Device: COMPREHENSIVE
Outcome Measures: Survivorship;   Adverse Events (including dislocation);   Constant-Murley Shoulder Score;   Radiographic Evaluation (Plain X-ray and CT);   Scapular Notching;   Radiographic Evaluation
20 Unknown  Effects of Masseter Manual Therapy on Temporomandibular Dysfunction
Conditions: Temporomandibular Joint;   Temporomandibular Joint Dysfunction Syndrome;   Temporomandibular Joint Disorder
Intervention: Procedure: Active release techniques
Outcome Measures: Range of Motion;   VAS pain scale